Clinical trials: BRONCHIAL ASTHMA
Asthma in Children
SMART Implementation-Effectiveness Trial 1
While single maintenance and reliever therapy (SMART) has been the preferred management strategy for Step 3 and 4 (moderate/severe) asthma management since the 2020 NIH asthma guideline updates, adoption of SMART has not been…
- Trial name
- SMART & SIMPLE (NCT07137923)
- Testing
- Clinical decision support + education (CDS+), Control
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Children's Hospital of Philadelphia
Asthma, Perennial Allergic Rhinitis
Subcutaneous Immunotherapy for Mouse in Adults
This is an open label trial of mouse allergenic extract administered by subcutaneous injection in adults with asthma and mouse sensitivity.
- Trial name
- SCITMO (NCT02532179)
- Testing
- Mouse Allergenic Extract
- Where
- 4 sites in United States
- Volunteers
- 12 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Exercise-induced Bronchospasm
Bronchoprotective Effect of Arformoterol in Children With Exercise-Induced Bronchospasm (EIB)
It is our primary hypothesis that pretreatment with arformoterol will provide superior protection against EIB in children with mild-moderate asthma compared to placebo added to the current asthma regimen.
- Trial name
- EIB (NCT00662779)
- Testing
- arformoterol, formoterol
- Where
- United States
- Sponsor
- University of New Mexico
Allergy, Respiratory Disease
Impact of AIT on Allergic Rhinitis and Asthma
The study will assess the effectiveness of AIT treatment in real clinical practice in Germany.
- Trial name
- NCT04125888
- Testing
- Allergy immunotherapy (AIT)
- Where
- Denmark
- Volunteers
- 92,048 people
- Sponsor
- ALK-Abelló A/S
Asthma
Multicentre Post-market Study of Ectoin® Inhalation Solution in Treatment of Asthma.
The goal of this multi-centre, prospective, open-label, single-arm, post-market clinical follow-up study is to further strengthen the already existing clinical evidence for supportive treatment and symptoms alleviation in asthma…
- Trial name
- EIL-AST (NCT05699941)
- Testing
- Ectoin® Inhalation Solution
- Where
- 5 sites in Poland
- Volunteers
- 204 people
- Sponsor
- Bitop AG
Asthma
A Study to Evaluate the Efficacy and Safety of AK120 in the Treatment of Subjects With Moderate-to-severe Asthma
This is a randomized, double-blind, placebo-controlled, multicenter, phase II clinical study to evaluate the efficacy and safety of AK120 in the treatment of subjects with moderate-to-severe asthma.
- Trial name
- NCT05155020
- Testing
- AK120
- Where
- 19 sites in China
- Volunteers
- 1 people
- Sponsor
- Akeso
Allergic Rhinitis, Asthma
An Exploratory Study of Nasonex in Patients With Moderate to Severe Persistent Allergic Rhinitis and Intermittent Asthma
The primary objective of this study is to explore the efficacy of Nasonex (mometasone furoate nasal spray) in comparison with placebo in improving the quality of life of subjects with moderate to severe persistent allergic…
- Trial name
- NCT00599027
- Testing
- Mometasone furoate nasal spray (MFNS)
- Volunteers
- 51 people
- Sponsor
- Organon and Co
Asthma, COPD
The Effect of FP-025, on Allergen-induced Airway Responses in Mild Eosinophilic House Dust Mite (HDM)-Allergic Asthma.
This study is a Phase IIa, randomized, placebo-controlled, double-blind, 2-way crossover, 2-center (conducted in EU; The Netherlands) study in male and female subjects with stable, mild HDM-allergic asthma.
- Trial name
- NCT03858686
- Testing
- FP-025 capsules
- Where
- 2 sites in Netherlands
- Volunteers
- 27 people
- Sponsor
- Foresee Pharmaceuticals Co., Ltd.
Asthma
A Nurse Led Programme to Improve Adherence in Difficult Asthma
Approximately 5% of adults with asthma have difficult to control disease but these account for up to 80% of total cost of asthma due to recurrent healthcare contact including hospital admission.
- Trial name
- NCT01064869
- Testing
- Pyscho-behavioural
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Belfast Health and Social Care Trust
Chronic Rhinosinusitis (Diagnosis), Chronic Rhinosinusitis With Nasal Polyps
Tissue Immune Interaction in Nasal Polyposis
This is a cross-sectional study of up to 100 subjects who are undergoing clinically indicated sinus procedures to treat chronic rhinosinusitis.
- Conditions
- Chronic Rhinosinusitis (Diagnosis), Chronic Rhinosinusitis With Nasal Polyps, Asthma
- Trial name
- TIP (NCT04628442)
- Testing
- Sinonasal Debridement Procedure, Nasal Polyp Removal, Biopsy
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of California, San Francisco
Asthma
Extension Study to Evaluate the Safety and Tolerability of Tezepelumab in Adults and Adolescents With Severe, Uncontrolled Asthma
Subjects who completed either D5180C00007 or D5180C00009 will be offered the opportunity to consent for the Multicentre, Double-blind, Randomized, Placebo Controlled, Parallel Group, Phase 3, Safety Extension Study to Evaluate…
- Trial name
- DESTINATION (NCT03706079)
- Testing
- Tezepelumab
- Where
- 180 sites in United States, Argentina and 16 more
- Volunteers
- 951 people
- Sponsor
- AstraZeneca
Severe Asthma
Reslizumab in Patients With Severe Asthma Who Failed to Respond to Omalizumab
Approximately, 5% of the patients with asthma suffer a difficult-to-control severe variant of the disease. Despite being treated with inhaled corticosteroids (ICs), long-acting β2-agonists (LABA), oral corticosteroids or…
- Trial name
- NCT03074942
- Testing
- Reslizumab
- Where
- 10 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Asthma Chronic, Adherence, Medication
Pictograms to Facilitate Comprehension of Medical Indications
SIMAP is a triple-masked randomised trial aimed at assessing whether an automated system of pictograms associated to medical indications results in better comprehension and adherence of said indications.
- Conditions
- Asthma Chronic, Adherence, Medication, Primary Health Care
- Trial name
- SIMAP (NCT05609760)
- Testing
- SIMAP, Usual Care
- Where
- 4 sites in Chile
- Volunteers
- 22 people
- Sponsor
- Universidad de Concepcion
Asthma
Safety, Tolerability, and Efficacy of AIN457 in Patients With Uncontrolled Asthma
This study is a preliminary proof of efficacy study of AIN457 in patients with bronchial asthma that is poorly controlled with the current standard of care.
- Trial name
- NCT01478360
- Testing
- AIN457 (secukinumab)
- Where
- 9 sites in Germany, United Kingdom
- Volunteers
- 46 people
- Sponsor
- Novartis Pharmaceuticals
Pulmonary Arteriovenous Malformations, Hereditary Hemorrhagic Telangiectasia
Cardiopulmonary Exercise Testing to Evaluate Pulmonary AVMs With and Without Airflow Obstruction
Pulmonary arteriovenous malformations (PAVMs) are a rare vascular condition affecting the lungs. PAVMs lead to low blood oxygen levels, yet are very well tolerated by patients.
- Conditions
- Pulmonary Arteriovenous Malformations, Hereditary Hemorrhagic Telangiectasia, Asthma, COPD
- Trial name
- ExercisePAVM2 (NCT02458703)
- Testing
- Cardiopulmonary exercise test
- Volunteers
- 60 people
- Sponsor
- Imperial College London
Asthma
BALLOON (Corticosteroid/laBA inhaLers in adoLescents' Asthma: Assessment Of Patients satisfactiON) Study
Patients' satisfaction with their asthma medication devices is usually decided by using properly designed questionnaires. These questionnaires are to be used to evaluate patients' opinion, which is considered very important for…
- Trial name
- BALLOON (NCT01708486)
- Where
- Greece
- Volunteers
- 35 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Asthma
Intensity, Specificity and Reversibility of Inspiratory Muscle Training in Asthmatics
Inspiratory muscle training (IMT) can reverse or delay the complications from the deterioration of inspiratory muscle function in asthma. Thus, the IMT has been considered a treatment option for people with asthma.
- Trial name
- NCT02917824
- Testing
- High-intensity IMT, Low-intensity IMT
- Where
- Brazil
- Volunteers
- 29 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
Asthma
Long-term Safety and Efficacy Evaluation of Lunsekimig (SAR443765) in Adult Participants With Asthma
This is a phase 2, open-label extension study to evaluate the long-term safety and efficacy of lunsekimig in adult participants with asthma who have previously completed the parent studies.
- Trial name
- AIRPHRODITE (NCT06609239)
- Testing
- Lunsekimig
- Where
- 150 sites in United States, Argentina and 18 more
- Volunteers
- 900 people
- Sponsor
- Sanofi
Asthma
Investigation of Lung Ventilation Inhomogeneity in Pediatric Asthma
The primary objective of this study is to determine if well-controlled asthmatic patients followed in subspecialty asthma clinics between the ages of 3 - 18 years can be distinguished from healthy controls using lung clearance…
- Trial name
- NCT01095354
- Testing
- Sodium Chloride Inhalation
- Where
- Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Asthma
Symptoms Control and adhErenCe Assessment During Treatment With MepolizUmab New pREfilled Devices
Asthma is a common pathology, with a prevalence of 6 to 8% and more than 4 million patients in France. Its management is based on different therapeutic axes.
- Trial name
- SECURE (NCT05626777)
- Testing
- Pre-filled syringe, mepolizumab 100 mg/month, Auto-injector pen, mepolizumab 100 mg/month
- Where
- 8 sites in France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
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