Clinical trials: BRONCHIAL ASTHMA
Asthma
Montelukast in Pediatric Patients Aged 6 to 24 Months With Asthma--Safety Study (0476-176)
A study of Montelukast compared to placebo in asthmatic children aged 6-24 months.
- Trial name
- NCT00943683
- Testing
- montelukast sodium
- Volunteers
- 256 people
- Sponsor
- Organon and Co
Asthma
The Impact of Implementing a Nursing-driven Clinical Pathway for Inpatient Management of Children With Asthma
Asthma is the most common chronic disease of childhood and is responsible for large portion of pediatric admissions to Canadian hospitals.
- Trial name
- NAP (NCT02037841)
- Testing
- Nursing-driven clinical pathway for management of inpatient asthma
- Where
- Canada
- Volunteers
- 113 people
- Sponsor
- Children's Hospital of Eastern Ontario
Status Asthmaticus, Asthma
Montelukast With Status Asthmaticus, Ages 6-18
The purpose of this study is to determine if montelukast, in addition to standard treatment is helpful in treating patients ages 6-18 who are in the hospital because of status asthmaticus.
- Trial name
- NCT00494572
- Testing
- Montelukast, sterile water
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Severe Asthma
Study in Portuguese Hospitals to Describe Patient Characteristics, Treatment Patterns and Outcomes
Benralizumab is indicated as an add-on maintenance treatment in adult patients with severe eosinophilic asthma inadequately controlled despite high-dose inhaled corticosteroids plus long-acting β2-agonists.
- Trial name
- Betreat (NCT07159295)
- Where
- 16 sites in Portugal
- Volunteers
- 74 people
- Sponsor
- AstraZeneca
Uncontrolled Asthma
Efficacy and Safety of Tanimilast in Asthmatics uNcontrolled on ICS-containinG backgrOund Maintenance Therapy
The purpose of this study is to evaluate the efficacy and safety of CHF6001 (Tanimilast) as add-on to maintenance of inhaled corticosteroids in combination with Long-acting ß2-agonists in the target patient population. (TANGO)
- Trial name
- TANGO (NCT06029595)
- Testing
- Experimental: CHF6001 3200 μg
- Where
- 187 sites in Argentina, Bulgaria and 12 more
- Volunteers
- 517 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Asthma, Asthma in Children
Diagnostic and Translational Values of Point-of-care Blood Eosinophils and Exhaled Nitric Oxide (FeNO) in People Referred by Primary Care for Suspected Asthma
Asthma is characterised by episodic symptoms (attacks) caused by airway inflammation and decreased airflow to the lungs. It affects 10% of the Canadian population and is the most common chronic disease in childhood.
- Conditions
- Asthma, Asthma in Children, Diagnosis, Inflammation
- Trial name
- DIVE (NCT05992519)
- Testing
- ¸FeNO
- Where
- Canada
- Volunteers
- 123 people
- Sponsor
- Université de Sherbrooke
Diabetes, Asthma
Integrated Care (IC) Models for Patient-Centered Outcomes
Multiple chronic conditions (MCC) are widely recognized as the U.S. public health challenge of the 21st century. These physical and behavioral health conditions take a large toll on those living with chronic diseases, including…
- Conditions
- Diabetes, Asthma, Chronic Obstructive Pulmonary Disease, Hypertension
- Trial name
- IC (NCT03451630)
- Testing
- High-Touch, High-Tech, Optimal Discharge Planning
- Where
- United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Status Asthmaticus
Non Invasive Positive Pressure Ventilation in Status Asthmaticus
Status Asthmaticus is recognized as a common cause of morbidity in children in the United States (CDC). In recent years, hospitalization rates have reached an all time high.
- Trial name
- NCT01403428
- Testing
- Noninvasive positive pressure ventilation
- Where
- United States
- Sponsor
- Southern Illinois University
Asthma
Efficacy of LAMA Added to ICS in Treatment of Asthma (ELITRA)
Primary objective The primary objective was to evaluate the superiority of CHF 5259 (glycopyrronium bromide [GB]) in a pressurised metered dose inhaler (pMDI) (50 μg total daily dose) versus placebo in terms of forced expiratory…
- Trial name
- ELITRA (NCT02296411)
- Testing
- CHF 5259 12.5 µg + Qvar
- Where
- 28 sites in Bulgaria, Germany and 3 more
- Volunteers
- 98 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Coronary Artery Disease, Congestive Heart Failure
Prognostic Indicators as Provided by the EPIC ClearView
The objective of this study is to determine whether the finger tip images captured by the EPIC ClearView device, when analyzed via the ClearView software, produce a Response Scale that characterizes trends consistent with known…
- Conditions
- Coronary Artery Disease, Congestive Heart Failure, Valvular Heart Disease, Atrial Fibrillation
- Trial name
- GBMC (NCT01476995)
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Epic Research & Diagnostics, Inc.
Airway Inflammation
Airborne Ultrafine and Fine Particulate Matter: A Cause for Endothelial Dysfunction in Man?
The purpose of this study is to examine biological pathways of altered blood vessel function resulting from breathing airborne particulate.
- Trial name
- NCT00814281
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Marywood University
Asthma
Study of Treatment of Depression in Refractory Asthma
Purpose and design: The relationship between psychological morbidity and asthma has been previously recognised, however there is little evidence regarding the link between poor mental health and asthma control in people with…
- Trial name
- NCT01153165
- Testing
- Citalopram
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Liam Heaney
Rhinitis, Allergic, Asthma, Allergic
Food-specific IgG4-guided Elimination Diets Improve Allergy Symptoms in Children
Allergic diseases in children are major public health concerns due to their widespread and rising prevalence. The most classic pathway to trigger allergy is type I allergy mediated by immunoglobulin E(IgE), but the role of…
- Conditions
- Rhinitis, Allergic, Asthma, Allergic, Conjunctivitis, Allergic, Atopic Dermatitis
- Trial name
- NCT06063044
- Where
- China
- Volunteers
- 407 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Asthma, Atopy
Imaging Study of the Lungs During an Allergic Asthma Attack
Asthma is a disease of rapidly increasing incidence that already affects more than 17 million people in the United States alone.
- Trial name
- NCT01547286
- Testing
- Standardized Cat Allergen Extract and Standardized Dust Mite Allergen, Computed Tomography imaging, functional Positron Emission Tomography imaging, Nebulized methacholine inhalation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
T Cell Response to Asthma in HIV-infected Patients Before and After Starting Treatment
Children With HIV and Asthma (CHIVAS)
To explore allergen-specific effector and regulatory T cell response in HIV-infected children before and after HAART initiation
- Trial name
- NCT01644370
- Testing
- HAART
- Where
- 2 sites in Thailand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
Asthma.
Effect of Aerobic Training in Moderate or Severe Asthmatic Patients
Exercise training has been proposed as adjunctive therapy in asthma to improve many clinical outcomes; however its effects on bronchial hyperresponsiveness (BHR) and inflammation, characteristic features in asthma, remains poorly…
- Trial name
- ETA1 (NCT02033122)
- Testing
- Aerobic training, Breathing exercise
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- Instituto de Investigação em Imunologia
Asthma
Development and Validation of a Sputum Biomarker mRNA Panel for the Diagnostic Work-up of Asthma 2
The main objectives of the study are: -to unravel the importance of molecular phenotyping in predicting the response to classical anti-asthma treatment (inhaled corticosteroids) The investigators have developed a non-invasive…
- Trial name
- BioSput-Air (NCT01224951)
- Testing
- Beclomethasone
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Allergic Asthma, Airway Remodelling
Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma
Asthma is a major noncommunicable chronic inflammatory disorder which is characterized by airway inflammation and related to pathological modifications of the bronchial wall structure so called airway remodeling.
- Conditions
- Allergic Asthma, Airway Remodelling, Extracellular Matrix Alteration
- Trial name
- ECMA (NCT03388359)
- Testing
- Bronchial challenge with allergen, Co-culture formation, Inhibition of Wnt and Smad signaling pathways
- Where
- Lithuania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Asthma
Budesonide/Formoterol for Maintenance and Reliever Therapy Among Asthma Patients in Thailand
The purpose of this study is to determine the incidence of misuse, i.e., over-use and under-use, of Budesonide/formoterol for maintenance and reliever therapy in usual-care setting.
- Trial name
- NCT00800241
- Where
- 14 sites in Thailand
- Volunteers
- 1,020 people
- Sponsor
- AstraZeneca
Childhood Asthma
Chinese Herbal Medicine Formula Combined With Inhaled Corticosteroids for the Treatment of Mild to Persistent Asthma in Children
The purpose of study is to provide an objective data for evaluating the efficacy and safety of Chinese medicine (CM) formula combined with inhaled corticosteroid in the treatment of asthmatic children.
- Trial name
- NCT05066841
- Testing
- CM (Ma-Hsing-Kan-Shih-Tang in combination with Liu-Jun-Zi-Tang), 10% CM (Ma-Hsing-Kan-Shih-Tang in combination with Liu-Jun-Zi-Tang)
- Where
- Taiwan
- Volunteers
- 86 people
- Sponsor
- China Medical University Hospital
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