Clinical trials: BRONCHIAL ASTHMA
Allergic Asthma
Role of RhuMab-E25 in Reducing Exhaled Nitric Oxide (NO) in Allergic Asthma
A single center pilot study to determine the protective effects of RhuMAB-E25 on airway physiology and biology in allergic asthmatics that undergo bronchoprovocation with methacholine.
- Trial name
- NCT00829179
- Testing
- RhuMab-E25
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Aspergillosis
A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of PC945
PC945 is a new medicine being developed for treatment of fungal lung diseases. The main purpose of this study is to investigate the safety, tolerability and pharmacokinetics of single and repeat doses of PC945
- Trial name
- NCT02715570
- Testing
- PC945 - single doses, PC945 - repeat doses
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Pulmocide Ltd
Pulmonary Diseases, Obstructive, Asthma
Assessment of the Effects of Strenght Exercise With Active Video Game Games in Asthmatic Children
Asthma is a chronic inflammatory disease of the Airways of recurring character. The obstruction to the airflow carries the short-and long-term consequences that require prophylactic interventions and in emergency many times.
- Trial name
- NCT03014154
- Testing
- Training
- Where
- Brazil
- Volunteers
- 17 people
- Sponsor
- University of Nove de Julho
Atopic Asthma
Effect of Supplemental Oral Curcumin in Patients With Atopic Asthma
Curcumin has antioxidant properties and in animal models has numerous molecular targets, many of which are intracellular, such as transcription factors AP-1 and NF.
- Trial name
- CURCUMIN (NCT01179256)
- Testing
- CURCUMIN, no intervention other than stopping study
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of South Florida
Asthma, Chronic Obstructive Pulmonary Disease
Effectiveness of Influenza Vaccine Reminder Systems
Influenza disease causes significant morbidity and mortality in the Unites States each year. Although influenza can cause morbidity in otherwise healthy individuals, adults with chronic lung disease have significantly increased…
- Trial name
- NCT01852656
- Testing
- Postcard and IVR Reminder Group, Postcard Only Reminder Group, IVR Only Reminder Group
- Where
- United States
- Volunteers
- 12,255 people
- Sponsor
- Kaiser Permanente
Asthma, Gastroesophageal Reflux Disease
Reflux Disease Therapy in the Management of Childhood Asthma-data Entry and Analysis Only
There have been a number of studies which attribute causality between reflux disease and asthma. In addition, clinicians typically treat chronic asthmatics with high dose acid suppressing medications (e.g. lansoprazole).
- Trial name
- NCT01536457
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Children's Center for Digestive Health Care
Asthma
Adapting and Expanding the Asthma-Educator App
This project seeks to test and refine an adapted/expanded version of a previously created ASTHMAXcel app.
- Trial name
- NCT03930381
- Testing
- ASTHMAXcel App
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Montefiore Medical Center
Asthma in Children, Depression
The Exhale Study: Treating Maternal Depression in an Urban Pediatric Asthma Clinic
The goal of this clinical trial is to test the effectiveness and implementation of delivering Enhanced Brief Interpersonal Psychotherapy (IPT-B), an evidence-based maternal depression treatment, to mothers of children under the…
- Trial name
- NCT06623981
- Testing
- Enhanced Brief Interpersonal Psychotherapy, Supplemented Usual Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's National Research Institute
Asthma
Specific Use-result Surveillance of Spiriva Respimat in Asthmatics
The safety of Spiriva® 2.5 µg Respimat® 60 puffs (hereinafter referred to as Spiriva® Respimat®) in patients with severe persistent asthma under the real-world use was not confirmed in clinical trials.
- Trial name
- NCT02489981
- Testing
- Spiriva
- Where
- Brazil
- Volunteers
- 359 people
- Sponsor
- Boehringer Ingelheim
Asthma, Panic Disorder
LUCHAR - Latinos Using Counseling for Help With Asthma and Anxiety Reduction
The research plan involves two aims: 1) Cultural adaptation of the Panic-Asthma Treatment and 2) a randomized, placebo-controlled pilot study.
- Trial name
- LUCHAR (NCT01583296)
- Testing
- Music Relaxation Therapy (MRT), CBT and HRVB
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Albert Einstein College of Medicine
Asthma, Bronchial
The Effects of Exercise on Physiological and Psychological Parameters in an Asthmatic Population
Exercise has been shown to have extensive health benefits both in normally functioning adults as well as in adults with asthma. A program of regular aquatic exercise may have unique benefits in the asthmatic population because of…
- Trial name
- NCT00825903
- Testing
- Exercise
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Washington State University
Pulmonary Disease, Asthma
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cells for Pulmonary Diseases
This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for the treatment of Pulmonary Diseases
- Conditions
- Pulmonary Disease, Asthma, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT05147688
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Lower Respiratory Tract Infection (LRTI), Recurrent Wheezing
Prevent Wheeze Trial
This trial investigates whether a single dose of dexamethasone will prevent recurrent wheezing in children at high-risk for asthma admitted to hospital with a lower respiratory tract infection (LRTI).
- Trial name
- PRE-WHEE (NCT07858773)
- Testing
- Dexamethasone 0.6 mg/kilogram body weight single dose
- Where
- 2 sites in Nepal, South Africa
- Volunteers
- 486 people
- Sponsor
- Norwegian University of Science and Technology
Asthma
The Importance of Tailored Education And Device Handling for Asthmatic Patients
Significant advancements have been made in asthma medication over the past decades. Highly effective treatments are available for patients; however, both adherence and proper device usage remain below the desired levels, based on…
- Trial name
- TEACH (NCT06840522)
- Where
- 6 sites in Hungary
- Volunteers
- 250 people
- Sponsor
- Chiesi Hungary Ltd.
Respiratory Muscle Weakness, Quality of Lifte
Effects of a Pulmonary and Cardiovascular Rehabilitation Program
Non-communicable chronic diseases (NCDs) affect approximately 30% of the adult global population, significantly impacting respiratory function and quality of life.
- Conditions
- Respiratory Muscle Weakness, Quality of Lifte, Dyspnea; Asthmatic, Dyspnea; Cardiac
- Trial name
- NCT06772922
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- University of Campinas, Brazil
Childhood Asthma
More Relaxation by Deep Breath on Methacholine
Deep inhalation (DI) dilates normal airway precontracted with methacholine. The fact that this effect is diminished or absent in asthma could be explained by the presence of bronchial inflammation.
- Trial name
- SouProvocBro (NCT03696602)
- Testing
- bronchial provocation test
- Volunteers
- 78 people
- Sponsor
- Central Hospital, Nancy, France
Asthma in Children, Sleep Hygiene
Impact of Sleep Duration on Immune Balance in Urban Children With Asthma
Urban children with asthma are at high risk for short sleep, due to an environment that jeopardizes both sleep and asthma management.
- Conditions
- Asthma in Children, Sleep Hygiene, Sleep, Inadequate
- Trial name
- AIMS (NCT05420766)
- Testing
- Shortened Sleep, Stabilized sleep
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Rhode Island Hospital
Respiratory Failure, Status Epilepticus
Pilot Simulation RCT of Telemedical Support for Paramedics
This study evaluates the impact of video communication via telemedicine on the quality of emergency care provided to children by paramedic teams supported by a remote physician in a simulated out-of-hospital setting.
- Conditions
- Respiratory Failure, Status Epilepticus, Status Asthmaticus, Cardiopulmonary Arrest
- Trial name
- NCT03742167
- Testing
- Telemedicine
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Boston Medical Center
Asthma in Children
The Duke-Reinvestment Partners Community Collaborative (DRC)- Healthy Homes
The goal of this open-label, single arm home intervention feasibility study is to improve quality of life for children ages 4-16 years with asthma.
- Trial name
- DRC (NCT05934370)
- Testing
- Home-Based Environmental Interventions (HEI)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Duke University
Asthma, Insomnia Chronic
Feasibility and Acceptability of an Internet-based Cognitive-behavioral Treatment for Insomnia in Adults With Asthma
The purpose of the proposed study are to explore changes in sleep and asthma outcomes from baseline to post-treatment in adults with asthma and comorbid insomnia who underwent Internet-based cognitive-behavioral treatment for…
- Trial name
- NCT03002402
- Testing
- Internet-based CBT-I
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Pittsburgh
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