Clinical trials: Back Pain Lower Back
Chronic Low-back Pain
The BEST Trial: Biomarkers for Evaluating Spine Treatments
The BEST Trial (Biomarkers for Evaluating Spine Treatments) is a National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)-sponsored clinical trial being conducted through the NIH Helping to End Addiction…
- Trial name
- BEST (NCT05396014)
- Testing
- Enhanced Self-Care (ESC), Acceptance and Commitment Therapy (ACT), Evidence-Based Exercise and Manual Therapy (EBEM)
- Where
- 12 sites in United States
- Volunteers
- 1,014 people
- Sponsor
- University of North Carolina, Chapel Hill
Low Back Pain, Lumbar Spine Injury
Second Opinion in Spinal Surgery Indications: Cost-Effectiveness Evaluation
Low back pain is a common symptom, which often affects the adult population. Studies show that over the past two decades, costs related to spinal surgery have increased significantly, leading to speculation about what would be…
- Trial name
- NCT03082248
- Testing
- Physical Therapy, Spinal Surgery
- Where
- Brazil
- Volunteers
- 190 people
- Sponsor
- Hospital Israelita Albert Einstein
Low Back Pain
Translation of Robotic Apparel for Alleviating Low Back Pain
This is a NIAMS-sponsored clinical trial being conducted through the NIH Helping to End Addition Long-term (HEAL) Initiative's Back Pain Consortium (BACPAC) Research Program.
- Trial name
- NCT05736393
- Testing
- Back Exosuit
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Boston University Charles River Campus
Low Back Pain
Development and Validation of the Italian Version of the Waddell Chronic Disability Index for People With Low Back Pain
This prospective observational study aims to develop and validate an Italian version of the Waddell Disability Index (WDI-I), a self-administered questionnaire designed to assess disability related to chronic low back pain.
- Trial name
- NCT07413107
- Where
- 2 sites in Italy
- Volunteers
- 115 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Non-specific Chronic Low Back Pain, Chronic Low-back Pain (cLBP)
Mindfulness-Based Therapy for Chronic Low Back Pain in Office Workers
This study evaluated whether a mindfulness-based therapy program could reduce pain severity in office workers with non-specific chronic low back pain.
- Conditions
- Non-specific Chronic Low Back Pain, Chronic Low-back Pain (cLBP), Mindfulness Meditation
- Trial name
- NCT07621302
- Testing
- Mindfulness-Based Therapy Program
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Dokuz Eylul University
Degenerative Disc Disease, Chronic Low-back Pain
Discure Technologies Feasibility Study for DDD
The objective of this study is to evaluate the safety and performance of the Discure System therapy in subjects with early to moderate degeneration of the disc (DDD).
- Conditions
- Degenerative Disc Disease, Chronic Low-back Pain, Discogenic Pain
- Trial name
- NCT06127745
- Testing
- Discure System
- Volunteers
- 20 people
- Sponsor
- Discure Technologies Ltd.
Chronic Low-back Pain
The Benefits of Posterior Joint Infiltration in Chronic Low Back Pain
Lumbar facet joints have been implicated in chronic low back pain in over 45% of patients with isolated chronic common low back pain. Low back pain is the most common form of spinal pain, more chronic and severe than cancer pain.
- Trial name
- InCHO (NCT06347328)
- Testing
- echo-guided infiltration, non-echo-guided infiltration
- Where
- 2 sites in France
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Low Back Pain
Effects of Bilateral Asymmetrical Limbs Proprioceptive Neuromuscular Facilitation on Multifidus Muscle in CLBP.
The low back pain is a leading cause to limit individual functional activities worldwide and 60%-80% of adults are probable to get low back pain at least once in life time.
- Trial name
- NCT04206137
- Testing
- Group A (PNF rhythmic initiation group ), Group B (Swiss ball exercises)
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- University of Karachi
Low Back Pain
Effects of Pain Neuroscience Education With Sensory Discrimination Training Among Patients With Chronic Low Back Pain
The current study is a double-blind, parallel-group randomized controlled trial involving 80 participants with chronic low back pain.
- Trial name
- NCT07284407
- Testing
- Pain Neuroscience Education with Sensory Discrimination Training and Core Stability Exercises, Pain Neuroscience Education and Core stability Exercises
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Osteoarthritis, Knee, Diabetic Neuropathic Pain
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
The purpose of the chronic pain master protocol is to compare independent pain interventions and establish an overarching structure for the disease-state addenda (DSA) and intervention-specific appendices (ISAs).
- Conditions
- Osteoarthritis, Knee, Diabetic Neuropathic Pain, Chronic Low-back Pain
- Trial name
- CPMP (NCT05986292)
- Testing
- LY3016859 ISA, LY3556050 ISA, LY3526318 ISA
- Where
- 64 sites in United States, Puerto Rico
- Volunteers
- 10,000 people
- Sponsor
- Eli Lilly and Company
Chronic Low-back Pain, Disc Degeneration
Evaluation of Safety, Tolerability, and Efficacy of CordSTEM-DD in Patients With Chronic Low Back Pain
The purpose of this clinical study is to evaluate the safety, tolerability, and efficacy of CordSTEM-DD, an allogeneic umbilical cord-derived mesenchymal stem cell, as a cell-therapeutic drug in patients with chronic low back…
- Trial name
- NCT04530071
- Testing
- CordSTEM-DD (0.7 x 10^7 cells), CordSTEM-DD (2.1 x 10^7 cells)
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- CHABiotech CO., Ltd
Pain, Physical Function
Digitally Delivered Exercise and Education Treatment for Low Back Pain: 3 Months Follow-up
Exercise and education is recommended as the first-line treatment by evidence-based, international guidelines for low back pain (LBP).
- Trial name
- Back3months (NCT05226156)
- Testing
- Digitally delivered exercise and education treatment Joint Academy
- Where
- Sweden
- Volunteers
- 2,593 people
- Sponsor
- Joint Academy
Osteoarthritis, Rheumatoid Nodule
Cellular & Biocellular Regenerative Therapy in Musculoskeletal Pain, Dysfunction,Degenerative or Inflammatory Disease
Musculoskeletal disorders and degeneration represent injuries or pain in the body's joint ligaments, tendons, muscles, nerves, and skeletal elements that support extremities, spine and related tissues.
- Conditions
- Osteoarthritis, Rheumatoid Nodule, Degenerative Joint Disease, Tendinopathy
- Trial name
- BRT (NCT03090672)
- Testing
- Normal Saline, Tissue Stromal Vascular Fraction, Platelet Rich Plasma
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Robert W Alexander, MD
Low Back Pain
Effectiveness of Dry Needling in Patients With Chronic Nonspecific Low Back Pain
Low back pain is a major health problem that affects psychosocial, economical, functional and physical aspects of the patients' life.
- Trial name
- NCT05100381
- Testing
- dry needling
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Iran University of Medical Sciences
Metabolic Syndrome, Physical Activity
The Effectiveness of Dry Needling and Classic Physiotherapy Programs in The Patients Suffering From Chronic Low Back Pain Caused by Lumbar Disc Hernia
Aim: This study was planned for comparing physical activity levels, nutrition quality and quality of life of the individuals that are diagnosed with and without metabolic syndrome (MetS) and that live in the Turkish Republic of…
- Conditions
- Metabolic Syndrome, Physical Activity, Quality of Life
- Trial name
- NCT02865200
- Testing
- Dry Needling Application, Classic Physiotherapy Program
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Chronic Low-back Pain (cLBP)
Combined and Aquatic Exercise in Chronic Low Back Pain
The goal of this randomized clinical trial is to evaluate the effects of a combined aquatic- and land-based exercise program, as well as an aquatic-exercise program, compared with a control group receiving home-based exercise, on…
- Trial name
- NCT07732595
- Testing
- Aquatic-exercise Program, Land-based Exercise Program, Home-based Exercise Program
- Where
- Portugal
- Volunteers
- 90 people
- Sponsor
- University of Beira Interior
Low Back Pain, Type of Leg Pain (Radicular, Non-radicular)
The Course of Low Back Pain
This study aims to research the possible associations of education level, sedentary lifestyle, and type of low back pain (radicular vs non-radicular) with the course of low back pain and recovery rate.
- Conditions
- Low Back Pain, Type of Leg Pain (Radicular, Non-radicular), Lifestyle (Sedentary Behavior and Physical Activity), Start Back Screening Tool
- Trial name
- NCT04419675
- Testing
- Observational Cohort, usual care = physical therapy
- Where
- 6 sites in Netherlands
- Volunteers
- 347 people
- Sponsor
- Radboud University Medical Center
Chronic Low Back Pain
Pain Neuroscience Education Delivered During Aerobic Exercise Versus Exercise Alone
Chronic musculoskeletal pain is a common health condition that reduces quality of life and increases disability. Pain neuroscience education (PNE) has shown positive effects on pain perception, beliefs, and function, especially…
- Trial name
- PNE-MOVE (NCT07152171)
- Testing
- Pain Neuroscience Education During Aerobic Exercise, Aerobic Exercise Alone
- Where
- Chile
- Volunteers
- 24 people
- Sponsor
- University of Chile
Lower Back Pain
Assessment of Chiropractic Treatment for Low Back Pain and Smoking Cessation in Military Active Duty Personnel.
The purpose of this study is to evaluate the effectiveness of chiropractic manipulative therapy for pain management and improved function in active duty service members with low back pain that do not require surgery.
- Trial name
- NCT01692275
- Testing
- Medical Care + Chiropractic Care, Conventional Medical Care Only
- Where
- 3 sites in United States
- Volunteers
- 750 people
- Sponsor
- RAND
Low Back Pain
Urdu Version of Fear Avoidance Belief Questionnaire: Reliability and Validity Study
The study aims to translate and culturally adapt Fear Avoidance Belief Questionnaire into the Urdu language and to investigate the reliability and validity in the Pakistani population and check its correlation with Visual Analog…
- Trial name
- NCT05432037
- Where
- Pakistan
- Volunteers
- 180 people
- Sponsor
- Riphah International University
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