Clinical trials: Bacteraemia
End Stage Renal Failure on Dialysis
Hemodialysis Infection Prevention Using Polysporin Ointment With Shower Technique in Satellite Centres Pilot Study
Background: The investigators developed a Shower Technique protocol (STP) for hemodialysis (HD) patients with healed central venous catheter (CVC) exit sites, designed to permit showering but not increase infection risk.
- Trial name
- HIPPO-SAT (NCT02002169)
- Testing
- Shower Technique Protocol, Standard CVC Care
- Where
- Canada
- Volunteers
- 78 people
- Sponsor
- University Health Network, Toronto
Cardiac Output, Endotoxemia
Echocardiographic Changes After 3-hydroxy Butyrate+Whey Intake
This study evaluates the cardiovascular effects of adding the ketone body 3-hydroxy butyrate (3-OHB) to whey protein during human endotoxemia.
- Conditions
- Cardiac Output, Endotoxemia, Catabolic State, Echocardiography
- Trial name
- NCT04037722
- Testing
- Whey, 3-OHB + Whey
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Sepsis, Infection
Improving Dosing of Vancomycin in Young Infants With Infections
Current dosing regimens for vancomycin result in many young infants not reaching the target level of vancomycin in the blood at steady state (when the blood is in equilibrium at 24-48 hours).The purpose of this study is to assess…
- Conditions
- Sepsis, Infection, Bacteremia
- Trial name
- VANCAPP (NCT04044703)
- Testing
- Vancomycin - model-based dosing regimen
- Where
- 4 sites in Australia
- Volunteers
- 44 people
- Sponsor
- Murdoch Childrens Research Institute
Sepsis, Bloodstream Infection
Process Mapping and Data Collection to Inform a Computer Simulation Model of Hospitalised Patients With Bloodstream Infection, Sepsis and Systemic Infection
The goal of this study is to create a computer simulation of patients with bloodstream infection to understand how changes in healthcare policies and resources affect patient treatment.
- Conditions
- Sepsis, Bloodstream Infection, Bacteraemia
- Trial name
- CSM-BSI (NCT06271031)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Autoimmune Diseases
Concentration/Meditation Limits Inflammation
Auto-immune diseases are characterized by an inappropriate inflammatory response against tissues in the body and represent a major health care burden.
- Trial name
- NCT01835457
- Testing
- Lipopolysaccharide, Concentration/meditation
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Staphylococcus Aureus Infection
Plasma Pharmacological Monitoring of M Penicillins in Methicillin-sensitive Staphylococcus Aureus Bacteremia
The treatment of Methicillin-sensitive Staphylococcus aureus bacteremia is based on the first-line use of cefazolin or M penicillins (oxacillin and cloxacillin).
- Trial name
- DOSESACLOXA (NCT06495697)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Bacteremia
BALANCE on the Wards: A Pilot RCT
The burden of bloodstream infections is large and increasing over time. Antibiotic overuse continues to drive increased rates of antimicrobial-resistant pathogens across Canada.
- Trial name
- BALANCE-Wards (NCT02917551)
- Testing
- 7 days of adequate antibiotic treatment, 14 days of adequate antibiotic treatment
- Where
- 6 sites in Canada
- Volunteers
- 134 people
- Sponsor
- Sunnybrook Health Sciences Centre
Drug Resistance, Bacterial
Epidemiology of Antimicrobial-use and Antimicrobial-resistant Infections in Four Hospitals in Thailand
The main goal of this retrospective observational study is to understand how stepping down antibiotic treatment (called antibiotic de-escalation) affects patients who receive it compared to those who don't after received a…
- Conditions
- Drug Resistance, Bacterial, Bacteremia
- Trial name
- NCT07082465
- Where
- 4 sites in Thailand
- Volunteers
- 108,000 people
- Sponsor
- University of Oxford
Sepsis, Infection
C-reactive Protein Information and Blood Cultures for Emergency Department Patients With Sepsis
Patients with sepsis (2 or more systemic inflammatory response syndrome criteria and suspected infection) assessed in the emergency department have blood cultures obtained to identify potential blood stream infections (BSI).
- Conditions
- Sepsis, Infection, Bacteremia
- Trial name
- NCT03714841
- Testing
- CRP
- Where
- 2 sites in Canada
- Volunteers
- 208 people
- Sponsor
- University of British Columbia
Sepsis, Infection
RCT of Continuous Versus Intermittent Infusion of Vancomycin in Neonates
Babies aged 0 to 90 days with a suspected infection requiring treatment with vancomycin will be recruited. They will be randomised to receive vancomycin as an intermittent infusion (over 1 hour) or as a continuous infusion (over…
- Conditions
- Sepsis, Infection, Bacteremia
- Trial name
- NCT02210169
- Testing
- Continuous infusion of vancomycin
- Where
- 2 sites in Australia
- Volunteers
- 111 people
- Sponsor
- Murdoch Childrens Research Institute
Bacteremia
Spanish Bacteriemia Cohort 2016: Epidemiology, Clinical Management and Prognosis Factors
Bacteremia The Hypothesis of the study are the followings: To demonstrate relevant epidemiologic and clinical changes with potentially impact in the management and prognosis of the patients with bacteremia.
- Trial name
- PRO-BAC (NCT03148769)
- Where
- 29 sites in Spain
- Volunteers
- 5,320 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Healthy Volunteers, Endotoxemia
Defibrotide in the Human Endotoxemia Model --- an Exploratory Trial Investigating the Effects and the Mechanisms of Defibrotide
Defibrotide is an anti-inflammatory and anti-coagulatory agent approved for treatment of veno-occlusive disease. Although it has been in clinical use for almost 30 years, the exact mechanism of action has never been fully…
- Trial name
- LPS_DF (NCT02876601)
- Testing
- Defibrotide, Lipopolysaccharide
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bernd Jilma
Sepsis, Gram-Positive Bacteremia
CRP and PCT as Predictors of Sepsis Cause
The aim of this retrospective study is to determine the predictive role of serum level of procalcitonin (PCT) and c-reactive protein (CRP) in determining the causative agent of sepsis in surgical intensive care unit (ICU)…
- Conditions
- Sepsis, Gram-Positive Bacteremia, Gram-negative Bacteremia
- Trial name
- NCT05605275
- Testing
- PCT levels, CRP levels, White blood cell count
- Where
- Croatia
- Volunteers
- 81 people
- Sponsor
- Osijek University Hospital
Sepsis, Bacteremia
Efficacy of Cefepime Continuous Infusion Versus an Intermittent Dosing Regimen
To determine the efficacy of the administration of 7 to 14 days of cefepime in a continuous infusion vs an intermittent (every 8 hours) administration, in adult patients hospitalized in Bogotá with sepsis and bacteremia caused by…
- Trial name
- CEFPK/PD (NCT00609375)
- Testing
- cefepime
- Where
- 7 sites in Colombia
- Volunteers
- 30 people
- Sponsor
- Javeriana University
Infection, Bacterial, Infection, Fungal
How to Reduce Unnecessary Blood Cultures: Construction and Validation of a Predictive Score for Blood Culture Positivity in Intensive Care
Prospective observational cohort consisting of all adult patients admitted to participating critical care units (ICU and CCU) during the study period, with blood cultures collected as part of their care, and who did not express…
- Conditions
- Infection, Bacterial, Infection, Fungal, Bacteremia
- Trial name
- PROBIty (NCT05686577)
- Testing
- no intervention
- Where
- 10 sites in France
- Volunteers
- 2,411 people
- Sponsor
- University Hospital, Tours
Staphylococcus Aureus Bacteremia
Identification and Validation of Clinical Phenotypes in Staphylococcus Aureus Bacteremia and Their Association With Mortality and Development of Complicated Bacteremia
The goal of this observational study is to determine retrospectively whether different patient clinical phenotypes (adults and children) develop Staphylococcus aureus bacteremia.The main questions it aims to answer qre: 1.
- Trial name
- FEN-AUREUS (NCT06574399)
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Diabetic Foot, Foot Ulcer
Immune Response of Patients With Chronic, Staphylococcus Aureus-infected Wounds
The primary objective of this study is to detect differences in anti-S. aureus antibody assays (IgM, IgA, IgG and its subclasses) between (1) a group of patients with bacteremia due to a chronic wound (cases) and (2) a group of…
- Conditions
- Diabetic Foot, Foot Ulcer, Leg Ulcer, Bacteremia
- Trial name
- ORISA (NCT01551667)
- Testing
- Antibody assays for S. aureus, Basic blood work
- Where
- 6 sites in France
- Volunteers
- 69 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Bacteraemia Caused by Gram-Negative Bacteria
Antibiotic Durations for Gram-negative Bacteremia
Gram-negative bacteremia (GNB) is a frequent hospital \& community-acquired infection, yet there is as yet no evidence from randomized studies on the optimal duration of antibiotic therapy.
- Trial name
- PIRATE (NCT03101072)
- Testing
- "Fixed long" antibiotic course of 14 days, "Fixed short" antibiotic course of 7 days, "Individualized duration" of antibiotic therapy
- Where
- 3 sites in Switzerland
- Volunteers
- 504 people
- Sponsor
- University of Geneva, Switzerland
Infection, Heart; Surgery, Heart, Functional Disturbance as Result
Device for Bacteremia Prevention in Post Cardiac Surgical Intensive Care Unit Patients
Intravenous catheters are often placed in large (central) veins in critically ill patients to provide special medications or frequent blood sampling.
- Conditions
- Infection, Heart; Surgery, Heart, Functional Disturbance as Result, Bacteremia
- Trial name
- CHG-Lock™ (NCT03309137)
- Testing
- Chlorhexidine flush
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Alison Fox-Robichaud
Enterococcal Bacteraemia, Enterococcus Faecalis Infection
Combination Treatment for Enterococcus Faecalis Bacteriemia Multicenter, Observational Study"
Prospective, multicenter, observational study on the evaluation of efficacy of appropriate monotherapy vs combination treatment for non-complicated Enterococcus faecalis bloodstream infection (EF-BSI).
- Conditions
- Enterococcal Bacteraemia, Enterococcus Faecalis Infection, Enterococcal Endocarditis, Bloodstream Infection
- Trial name
- NCT04070820
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Bologna