Clinical trials: Bacteraemia
Bacteremia
Exposure to Antibiotics and Incidence of Bacteraemia Caused by Resistant Bacteria
The primary objective of the study is to identify the risk factors of community-acquired bacteremia to resistant bacteria. As the secondary objectives, the study aims to describe the episodes of epidemiology of bacteremia…
- Trial name
- BactHub (NCT04065750)
- Volunteers
- 45,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Major Depressive Disorder, Inflammation
The Relations Among Endotoxin, Inflammatory Cytokines, Cognitive Markers and Brain MRI Changes in Subjects With Depressive Disorder
Major depressive disorder (MDD) is a chronic mental illness, with 60% lifetime risk of recurrence after the first MDD episode. Despite available treatment options for MDD, only about half to two-thirds of patients respond to…
- Conditions
- Major Depressive Disorder, Inflammation, Cognitive Dysfunction, Endotoxemia
- Trial name
- NCT06203015
- Testing
- The Cambridge Neuropsychological Test Automated Battery., Venous blood samples, brain MRI
- Where
- 2 sites in Lithuania
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Bacteremia
Increasing the Yield of Blood Cultures in Neonates
The purpose of this study is to determine whether the use of a single blood sample of 1cc in an aerobic bottle will provide a better yield and time to positivity than 2 samples of 0.5 cc in 2 (aerobic and anaerobic) bottles for…
- Trial name
- NCT01023555
- Testing
- 1cc of blood in a single aerobic culture bottle
- Volunteers
- 1,500 people
- Sponsor
- Shaare Zedek Medical Center
Bacteremia
Impact of BacT/Alert® VIRTUO®, BioFire® Blood Culture Identification 2-BCID2 and REVEAL® (bioMérieux) on the Optimization of Antibiotic Therapy for Gram-negative Bacteremia in the ICU
Bacteremia is a frequent infection in intensive care units. It is associated with a high mortality rate and the rapid implementation of appropriate antibiotic therapy is strongly correlated to patient clinical outcomes.
- Trial name
- BacteREVEAL (NCT05741424)
- Testing
- Innovative diagnostic technologies, Reference diagnostic technique
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Bacteremia, Infection, Bacterial
Ertapenem for Initial Empirical Treatment of Third Generation Cephalosporin Resistant Enterobacteriaceae Bacteremia
This study aims to assess whether ertapenem as an empiric treatment of third-generation-cephalosporin resistant Enterobacteriaceae (3GCRE) bacteremia is non-inferior to other carbapenems in term of 30-day mortality.
- Trial name
- NCT03925402
- Testing
- Ertapenem, Carbapenems
- Where
- Thailand
- Volunteers
- 427 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Bacteremia
Study to Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S in Participants With Staphylococcus Aureus Bacteremia Receiving Standard-of-Care (SOC) Antibiotics
This is a Phase Ib, randomized double-blind, placebo-controlled multiple-ascending dose study to investigate the safety, tolerability, and pharmacokinetics of multiple doses of DSTA4637S when given in addition to…
- Trial name
- NCT03162250
- Testing
- DSTA4637S, SOC
- Where
- 16 sites in United States, South Korea and 1 more
- Volunteers
- 27 people
- Sponsor
- Genentech, Inc.
Endotoxemia, Intestinal Microbiota
Dietary Intervention to Reduce Metabolic Endotoxemia
The goal of this randomized clinical trial is to compare an antiinflammatory and environmentally friendly dietary strategy (AIA-D) designed based on the planetary health diet recommendations translated to the regional context and…
- Conditions
- Endotoxemia, Intestinal Microbiota, Dietary Habits, Clinical Trial
- Trial name
- NCT05776329
- Testing
- AIA-D, CONV-D
- Where
- 2 sites in Mexico
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Centro de Investigación en Alimentación y Desarrollo A.C.
Endothelial Dysfunction
The Association Between Food Timing and Composition on Gastrointestinal Injury, Stress Hormone and Gastrointestinal Complains.
The study aimed to check the influence of timing and composition of diet on markers of gut injury, endotoxemia and stress.
- Trial name
- NCT06403241
- Testing
- 2000 meter ergometer test
- Where
- Poland
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Bacteremia Sepsis
Resistell Phenotech AST to Determine the Antibiotic Susceptibility of Gram-negative Bacteria Causing Bacteremia
The aim of this study is to assess the sensitivity, specificity, and accuracy of the Resistell Phenotech device in testing antibiotic susceptibility of Gram-negative bacteria (i.e., E. coli or K.
- Trial name
- PHENOTECH-1 (NCT05613322)
- Testing
- Resistell Phenotech
- Where
- 3 sites in Austria, Spain and 1 more
- Volunteers
- 246 people
- Sponsor
- Resistell AG
Staphylococcus Aureus Infection
Staphylococcus Aureus Bacteremia Antibiotic Treatment Options
Increasing resistance to antibiotic agents has been recognized as a major health problem worldwide that will even aggravate due to the lack of new antimicrobial agents within the next decade [1].
- Trial name
- SABATO (NCT01792804)
- Testing
- Trimethoprim-Sulfamethoxazole, Clindamycin, Linezolid
- Where
- 40 sites in France, Germany and 3 more
- Volunteers
- 215 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Bacteremia
Daptomycin Pharmacokinetics in Continuous Veno-venous Hemodiafiltration
The purpose is to investigate daptomycin pharmacokinetics in critically ill patients with suspected or verified bacteremia with Gram-positive cocci undergoing combined continuous hemodiafiltration at a filtration rate of…
- Trial name
- NCT01171547
- Testing
- Daptomycin
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- University of Zurich
Cholangitis, Bacteremia
Factors Associated With Increased Risk of Bacteremia and Cholangitis in ERCP With Cholangioscopy
An Endoscopic retrograde cholangio pancreatography (ERCP) with cholangioscopy (endoscope to directly visualize the bile duct ) is a procedure (a small flexible tube that is inserted into the participants mouth to the participants…
- Trial name
- NCT02543957
- Testing
- Cholangioscopy
- Where
- United States
- Sponsor
- Baylor College of Medicine
Malaria, Bacteremia
Empirical ANtibiotic THErapy in Adults Hospitalised With Malaria
While World Health Organization (WHO) guidelines recommend empirical antibacterial therapy as the standard of care in all African children with severe falciparum malaria, there are fewer data to guide the management of adults…
- Conditions
- Malaria, Bacteremia, Sepsis
- Trial name
- ANTHEM (NCT03224052)
- Where
- Burma
- Volunteers
- 20 people
- Sponsor
- Menzies School of Health Research
Clinically Significant Bacteremia
Impact of Specific Antimicrobials and MIC Values on the Outcome of Bloodstream Infections Due to Extended-spectrum Beta-lactamase (ESBL) or Carbapenemase-producing Enterobacteriaceae: an Observational Multinational Study
Main objective: to observationally assess the efficacy of different antimicrobials in Bloodstream Infection (BSI) due to Enterobacteriaceae producing ESBLs or carbapenemases.
- Trial name
- INCREMENT (NCT01764490)
- Where
- Spain
- Volunteers
- 1,344 people
- Sponsor
- JESUS RODRIGUEZ BAÑO
Bacterial Infections, Urinary Tract Infections
Host RNA Profiles to Detect Infections in Young Infants
This study seeks to identify and test host RNA expression profiles as markers for infections in young infants. Preliminary studies have shown high sensitivity and specificity for the discrimination of bacterial from non-bacterial…
- Conditions
- Bacterial Infections, Urinary Tract Infections, Sepsis, Fever
- Trial name
- CHILD_YIC (NCT04823026)
- Where
- 4 sites in Denmark
- Volunteers
- 152 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Urinary Tract Infections
Comparative Study of the Genomic Characteristics of Uropathogenic Escherichia Coli According to the Severity of Community-Acquired Urinary Tract Infections in Guadeloupe (COLIGENURI)
The aim is to identify genomic determinants (genes or gene clusters) associated with the severity of community-acquired E. coli urinary tract infections in Guadeloupe through a comparative approach integrating clinical…
- Trial name
- COLIGENURI (NCT07905638)
- Testing
- Whole-genome sequencing (WGS) of E. coli isolates (applies to all 3 groups)
- Volunteers
- 210 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Febrile Illness Acute, Meningitis, Bacterial
Febrile Infants Swedish Study
Approximately one million febrile infants aged ≤60 days present annually to pediatric emergency departments (PEDs) in Europe and the United States.
- Conditions
- Febrile Illness Acute, Meningitis, Bacterial, Urinary Tract Infection (Diagnosis), Invasive Bacterial Infection
- Trial name
- FISS (NCT07134751)
- Where
- 11 sites in Sweden
- Volunteers
- 2,000 people
- Sponsor
- Region Skane
Staphylococcus Aureus Endocarditis, Prosthetic Valve Endocarditis
Adjunctive Rifampin for the Treatment of Prosthetic Valve Endocarditis Due to S. Aureus
This is a sub-study of the S. aureus Network Adaptive Platform (SNAP) trial (NCT05137119) wherein we will evaluate whether not giving rifampin in patients with probable or definite prosthetic valve endocarditis due to S.
- Trial name
- RIFA-SNAP (NCT07253688)
- Testing
- Rifampin, No rifampin
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Todd C. Lee MD MPH FIDSA
Type 2 Diabetes, Healthy
Type 2 Diabetes and the Effect of Probiotics
Insulin-resistance in type 2 diabetes is associated with chronic inflammation. Anti-inflammatory actions might increase sensitivity to insulin.
- Conditions
- Type 2 Diabetes, Healthy, Endotoxemia
- Trial name
- NCT00413348
- Testing
- Lactobacillus acidophilus NCFM
- Where
- Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Endotoxemia, Inflammation
The Effects of Atazanavir-induced Hyperbilirubinemia During Human Endotoxemia
Excessive inflammation, production of free radicals and vascular injury are considered the main contributors to the development of organ dysfunction in patients with severe infections and sepsis.
- Conditions
- Endotoxemia, Inflammation, Multi Organ Dysfunction Syndrome, Sepsis
- Trial name
- NCT00916448
- Testing
- Atazanavir, E. coli endotoxin
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center