Clinical trials: Bacteremia and Sepsis
Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Septicemia
Combination Cefazolin With Ertapenem for Methicillin-susceptible Staphylococcus Aureus Bacteremia
There is a variety of in vitro, in vivo (animal model), and human case series data which suggests that the addition of ertapenem to cefazolin could improve outcomes in methicillin-susceptible S. aureus bacteremia.
- Conditions
- Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Septicemia, Staphylococcal Sepsis, Staphylococcus Aureus Endocarditis
- Trial name
- CERT (NCT04886284)
- Testing
- Ertapenem
- Where
- 8 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Todd C. Lee MD MPH FIDSA
Endotoxemia, Sepsis
Anti-inflammatory Effects of GTS-21 After LPS
Rationale: The vagus nerve exerts an anti-inflammatory effect in in vitro and animal experiments. This 'vagal anti-inflammatory pathway' is mediated by the nicotinergic α7nACh receptor that can be selectively stimulated by…
- Conditions
- Endotoxemia, Sepsis, Vagal Activity
- Trial name
- NCT00783068
- Testing
- GTS-21, [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride], Lipopolysaccharide E. Coli 113:H 10:K negative
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Bacteremia
The Impact of Material on Microbiota in Association With Tongue and Lip Piercing
Biofilms on oral piercings may serve as a bacterial reservoir and lead to systemic bacteraemia or local transmission of periopathogenic microbiota.
- Trial name
- NCT01039259
- Testing
- piercings of four different materials
- Where
- Austria
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Bacteremia
Prevalence of CVC-associated Sepsis and Use of Blood Cultures in Berlin - Brandenburg
Structured web-based survey in selected hospitals with intensive care units in Berlin- Brandenburg to collect data on the overall number of blood cultures (used) and the prevalence of (positive blood cultures in patients with)…
- Trial name
- NCT01388686
- Where
- Germany
- Volunteers
- 13 people
- Sponsor
- Charite University, Berlin, Germany
Bacteriemia, Methicillin Susceptible Staphylococcus Aureus (MSSA) Infection
Cefazolin Versus Antistaphylococcal Penicillins for Methicillin Susceptible Staphylococcus Aureus Bacteremia
Background Methicillin-susceptible Staphylococcus aureus (MSSA) bacteraemia is a common and serious infection, associated with significant morbidity and high mortality rates.
- Trial name
- TriPasCef (NCT07186894)
- Testing
- Antistaphylococcal penicillins, Cefazolin
- Volunteers
- 5,000 people
- Sponsor
- Central Hospital, Nancy, France
Endotoxemia
Effect of Selective iNOS Inhibition During Human Endotoxemia
Sepsis or endotoxemia is manifested by hypotension, resistance to vasopressors, myocardial depression,and altered organ blood flow distribution.
- Trial name
- NCT00184990
- Testing
- Aminoguanidine, endotoxin
- Where
- Netherlands
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia)
A Placebo-Controlled, Dose-Escalating Study to Examine the Safety and Tolerability of Single Intravenous Doses of CF-301 in Healthy Subjects
A Phase 1, Placebo-Controlled, Dose-Escalating Study to Examine the Safety and Tolerability of Single Intravenous Doses of CF-301 in Healthy Subjects.
- Trial name
- NCT02439359
- Testing
- CF-301
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ContraFect
Bacteremia
Temocillin vs Meropenem for the Targeted Treatment of Bacteraemia Resistant to Third Gen Cephalosporins
A Phase 3, Multicenter, Randomised, Controlled, Open-Label Study to demonstrate noninferiority of temocillin (unauthorized investigational medicinal product IMP in Spain, but authorized in Belgium and UK) vs a carbapenem…
- Trial name
- ASTARTÉ (NCT04478721)
- Testing
- Temocillin, Meropenem
- Where
- 29 sites in Spain
- Volunteers
- 334 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Escherichia Coli Bacteremia, Klebsiella Bacteraemia
Switch to Oral Antibiotics in Gram-negative Bacteremia
Eligible subjects will be those age 18 years or more with mono-microbial blood stream infection caused by E. coli, Klebsiella species, Enterobacter species, Serratia species, Citrobacter species, or Proteus species, who have…
- Conditions
- Escherichia Coli Bacteremia, Klebsiella Bacteraemia, Enterobacter Bacteraemia, Serratia Bacteraemia
- Trial name
- SOAB (NCT04146922)
- Testing
- Step down to oral antimicrobial therapy, IV antimicrobial therapy
- Where
- 7 sites in Bahrain, Kuwait and 2 more
- Volunteers
- 176 people
- Sponsor
- Hamad Medical Corporation
Bacteremia, Healthcare-associated Pneumonia
Randomized-controlled Trial (RCT) on Combination Antibiotic for Infections Caused by Gram-negative Bacteria
Background and rationale: Antimicrobial resistance is a global public health threat. An increasing number of Gram-negative bacteria isolates worldwide are resistant to virtually all antibiotics including carbapenems.
- Conditions
- Bacteremia, Healthcare-associated Pneumonia, Ventilator-associated Pneumonia
- Trial name
- XDR-GNB (NCT02134106)
- Testing
- Polymyxin B, Polymyxin B + Doripenem
- Where
- 2 sites in Singapore
- Sponsor
- Tan Tock Seng Hospital
Urinary Tract Infection Complicated, Acute Pyelonephritis
Efficacy, Safety, Tolerability of Vabomere Compared to Best Available Therapy in Treating Serious Infections in Adults
Vabomere™, (meropenem-vaborbactam) is being compared to the Best Available Therapy in the treatment of adults with selected serious infections due to Carbapenem Resistant Enterobacteriaceae
- Conditions
- Urinary Tract Infection Complicated, Acute Pyelonephritis, Hospital Acquired Bacterial Pneumonia, Ventilator-associated Bacterial Pneumonia
- Trial name
- NCT02168946
- Testing
- Vabomere, Best Available Therapy
- Where
- 50 sites in United States, Argentina and 6 more
- Volunteers
- 77 people
- Sponsor
- Rempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.)
Acinetobacter Baumannii-calcoaceticus Complex, Hospital-acquired Bacterial Pneumonia
Study to Evaluate the Efficacy and Safety of Intravenous Sulbactam-ETX2514 in the Treatment of Patients With Infections Caused by Acinetobacter Baumannii-calcoaceticus Complex
This is a 2-part study, with Part A being the randomized, controlled portion of the study in patients with ABC hospital-acquired bacterial pneumonia (HABP), ventilator-associated bacterial pneumonia (VABP), or bacteremia.
- Conditions
- Acinetobacter Baumannii-calcoaceticus Complex, Hospital-acquired Bacterial Pneumonia, Ventilator-associated Bacterial Pneumonia, Bacteremia
- Trial name
- ATTACK (NCT03894046)
- Testing
- Sulbactam, Durlobactam, Colistin
- Where
- 90 sites in United States, Belarus and 15 more
- Volunteers
- 207 people
- Sponsor
- Entasis Therapeutics
Endotoxemia, Inflammation
Short-Chain Fatty Acids in Lypopolysaccharide-Induced Inflammation and Executive Function
Short-chain fatty acids (SCFAs) are substances produced by gut bacteria when they ferment dietary fiber. They can act as signals between the gut and the brain and may help regulate the body's immune and stress responses.
- Conditions
- Endotoxemia, Inflammation, Executive Function (Cognition)
- Trial name
- NCT07713641
- Testing
- Short-Chain Fatty Acid Colon-Delivery Capsules, Lipopolysaccharide (LPS)
- Where
- Belgium
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Febrile, Neutropenia
Assessment of New Blood Culture Methods on the Microbiological Documentation of Febrile Neutropenia
Febrile neutropenia are microbiologically documented in only 30% of the cases, and almost exclusively by blood cultures. The reasons for this low documentation are likely multiple: (1) some of these fevers are of non-infectious…
- Conditions
- Febrile, Neutropenia, Post-chemotherapy
- Trial name
- HEMATOCPLUS (NCT00913042)
- Testing
- sample blood
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dietary Habits, Endotoxemia
Effects of Non-calorie Sweeteners, Mono- and Disaccharides on Intestinal Barrier Function
The aim of the present study is to determine the effect of non-nutritive sweeteners on intestinal barrier function and inflammatory markers in healthy subjects in comparison to mono- and disaccharides.
- Trial name
- NCT04788680
- Testing
- Dietary intervention 1, Dietary Intervention 2, Dietary Intervention 3
- Where
- Austria
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Bacteremia
Incidence of Bacteremia Following Argon Plasma Coagulation in Patients With Endobronchial Lesions
Incidence of Bacteremia Following Argon Plasma Coagulation in Patients with Endobronchial Lesions
- Trial name
- NCT01179022
- Where
- Israel
- Volunteers
- 46 people
- Sponsor
- Meir Medical Center
Bacteremia
A Cluster-randomized Cross-over Trial Evaluating the Comparative Effectiveness of Three Skin Antiseptic Interventions
Background: Contaminated blood cultures result in unnecessary antibiotic use, increased length of stay, and additional laboratory tests, all of which increase healthcare costs.
- Trial name
- NCT01216761
- Testing
- Iodine tincture, Chlorhexidine gluconate, Povidone iodine
- Volunteers
- 3,879 people
- Sponsor
- University of Michigan
Bacteremia, Sepsis
Epidemiology and Determinants of Outcomes of Hospital Acquired Blood Stream Infections in the Intensive Care
Eurobact II will investigate the mortality and morbidity of hospital-acquired blood stream infections in patients treated in intensive care units (ICU).
- Conditions
- Bacteremia, Sepsis, Hospital Acquired Condition, Resistance Bacterial
- Trial name
- EurobactII (NCT03937245)
- Where
- 2 sites in Australia, France
- Volunteers
- 3,058 people
- Sponsor
- Outcome Rea
Bacteremia
Design of a Predictive Score for Contamination of Pediatric Blood Cultures
The contamination rate for blood cultures is high in pediatrics, due to different sampling techniques and the difficulty of sampling small-weight children, thus favoring contamination of the devices at the time of sampling.
- Trial name
- HEPIC (NCT06300736)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Bacteremia and Sepsis, Toll-Like-Receptors (TLRs)
Bacteremia in Intensive Care Unit (ICU)
The presence of bacteremia and sepsis in percent of critically ill patients and none at all, associated with different expression and faction of Toll-Like-Receptors (TLRs.
- Trial name
- NCT00932243
- Where
- Greece
- Volunteers
- 300 people
- Sponsor
- University of Thessaly