Clinical trials: Bacteria
Upper Respiratory Tract Infections
LiveSpo Navax® Supports the Treatment of Acute Rhinosinusitis and Otitis Media
Acute respiratory tract infections (ARTIs), such as acute rhinosinusitis (ARS) and acute otitis media (AOM), are common worldwide and caused by viruses or bacteria entering the body through the mouth and nose.
- Trial name
- NCT05804123
- Testing
- 0.9% NaCl physiological saline Nasal-spraying, LiveSpo Navax®, Augmentin 500Mg Tablet
- Where
- Vietnam
- Volunteers
- 175 people
- Sponsor
- Anabio R&D
Chronic Leg Ulcers, Wound Healing
Clinical Trial to Investigate Treatment With Photodynamic Therapy to Reduce Levels of Bacteria in Leg Ulcers
Some leg ulcers do not seem to respond that well to the standard treatments that we currently use. One reason for this may be that there are high levels of bacteria in the ulcer which may be slowing down the rate of healing.
- Trial name
- NCT00825760
- Testing
- Topical PPA904 gel and light
- Where
- 4 sites in United Kingdom
- Volunteers
- 57 people
- Sponsor
- Photopharmica
Healthy
Genomic Tools for Studying the Ecology of the Human Vaginal Microflora
The human vagina contains a large number of normal bacteria. These bacteria are important because provide protection against other bacteria that may cause disease.
- Trial name
- VM (NCT00576797)
- Where
- 3 sites in United States
- Volunteers
- 396 people, healthy volunteers welcome
- Sponsor
- Emory University
Patients With Multi Drug Resistant Gram-negative Bacteria, Colistin Resistance in Bacteria
Phenotypic and Genotypic Detection of Colistin Resistance
Evaluation of the disk elution test as reliable routine method for detection of colistin resistant among multidrug resistant gram-negative bacteria compared with broth microdilution.
- Trial name
- NCT07487116
- Testing
- disk elution test
- Volunteers
- 90 people
- Sponsor
- Assiut University
Oral Bacteria Levels in the Mouth
Clinical Investigation to Examine Toothpaste Effect on Oral Bacteria
The primary objective was to evaluate the antibacterial effects of two toothpastes containing 0.3% triclosan, 2% copolymer and 0.234% sodium fluoride in a silica base as compared to a control regular fluoride toothpaste on…
- Trial name
- NCT02194621
- Testing
- Total Flavor option 1, Total Flavor option 2
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Nosocomial Infections
Effect of Metallic Nanoparticles on Nosocomial Bacteria
This research aims to study the properties of metallic nanoparticles"MNPs" (silver nanoparticles "AgNps" and copper nanoparticles "CuNps") on the 2 most common nosocomial bacteria which are highly resistant to antibiotics…
- Trial name
- NCT04775238
- Testing
- Silver nanoparticles, Copper nanoparticles
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Critical Illness
Optimization Dose Study on Pharmacokinetics and Pharmacodynamics of Colistin in Critically Ill Patients
Phase II clinical trial, open-labelled, prospective and single-center study directed to obtain blood samples in experimental detailed conditions in order to compare and optimize the dose of colistin in critically ill patients…
- Trial name
- COLPHAR (NCT02408185)
- Testing
- Colistin 6 million units + 240mg/8h, Colistin 6 million units + 360mg/12h
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Healthy
Symbiotic & Colonization
The clinical trial aims at showing efficacy of prebiotics and the probiotic on microbiota balance. Together, the prebiotic solution in combination with the probiotic is expected to harmonize the microbiota of formula fed neonates…
- Trial name
- NCT01983072
- Testing
- Infant formula, Breastfeeding
- Where
- 4 sites in France, Poland
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Urinary Tract Infection(UTI)
E. Coli for Prevention of Catheter UTI in SCI Patients
The overall goal of this project is to develop a new approach for the prevention of urinary tract infection (UTI) in persons who rely on indwelling catheters for bladder drainage.
- Trial name
- NCT00458471
- Testing
- Insertion of a urinary catheter coated with benign E. coli
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Hysterectomy
Vaginal Preparation Prior to Hysterectomy
This is a randomized controlled trial to determine the influence of chlorhexidine gluconate surgical/topical antiseptic solutions on the bacterial environment of the vagina during hysterectomy and compare that to the effect of…
- Trial name
- NCT03412734
- Testing
- Chlorhexidine, Iodine
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- TriHealth Inc.
Sepsis, Pneumonia
Benefit of Clarithromycin in Patients With Severe Infections Through Modulation of the Immune System
High mortality associated with sepsis and Multiple Organ Dysfunction Syndrome (MODS) calls for alternative, individualized therapies in selected patients that might benefit form specific interventions.
- Conditions
- Sepsis, Pneumonia, Gram-Negative Bacteria Infection, Multiple Organ Failure
- Trial name
- INCLASS (NCT03345992)
- Testing
- Clarithromycin, Water for injection
- Where
- 12 sites in Belgium, Greece
- Volunteers
- 110 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Obesity, Abdominal Obesity
Study of Safety and Efficacy of a Probiotic and Postbiotic in Overweight Individuals
Investigate the effect of a probiotic (live bacteria) and postbiotic (heat-treated bacteria) strains in overweight individuals.
- Trial name
- KOBI (NCT05428137)
- Testing
- Probiotic, Postbiotic
- Where
- South Korea
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Infections
Effect of Antibiotic Rotation in the ICU on the Prevalence of Antibiotic Resistant Gram-negative Colonisation
The SATURN ICU-trial studies the effect of antibiotic rotation on the prevalence of antibiotic resistant Gram-negative colonisation.
- Trial name
- SATURN (NCT01293071)
- Testing
- Antibiotic rotation
- Where
- Netherlands
- Volunteers
- 10,000 people
- Sponsor
- UMC Utrecht
Urinary Tract Infections
Treatment of Extended Spectrum Betalactamase Producing Bacteria Causing Urinary Tract Infections in General Practice
The prevalence of extended spectrum beta-lactamase (ESBL) producing bacteria found in urine sample cultures has been increasing over the past decades.
- Trial name
- NCT01531023
- Where
- 7 sites in Norway
- Volunteers
- 168 people
- Sponsor
- University of Oslo
Complicated Intra-Abdominal Infections
Antibiotic Resistant Bacteria Among Patients With Severe Intraabdominal Infections
The objectives of the study were: 1. To study risk factors for colonization and infection with antibiotic resistant bacteria among patients with severe IAI before and after antibiotic treatment and surgical intervention. 2.
- Trial name
- Bakki (NCT00860587)
- Volunteers
- 200 people
- Sponsor
- University Hospital, Linkoeping
Wounds
Impact of Oxidized Silver Wound Dressings on Wound Bacteria
Chronic non-healing wounds considerably impact quality of life in affected patients and are a substantial burden on the Canadian health care system.
- Trial name
- NCT02662101
- Testing
- Exsalt SD7, Exsalt T7 Wound Dressing
- Volunteers
- 17 people
- Sponsor
- Exciton Technologies Inc.
Oropharynx Abnormality, Pneumonia, Ventilator-Associated
Microbial and Pharmacological Assessment of Chlorhexidine
Ventilator-associated pneumonia (VAP) is the most frequent life-threatening nosocomial infection in the ICU. Oropharyngeal colonization with bacterial pathogens is the first step toward lung infection.
- Conditions
- Oropharynx Abnormality, Pneumonia, Ventilator-Associated, Chlorhexidine, Bacterium; Agent
- Trial name
- NCT03290105
- Volunteers
- 30 people
- Sponsor
- Hôpital Louis Mourier
Intestinal Infections, Dysbacteriosis
INVESTIGATION of the EFFICACY and SAFETY of the DRUG "AS-PROBIONORM"
The subject of this clinical trial is the medicine "AS-Probionorm". Pharmacological group - Antidiarrheal drugs. Antidiarrheal microorganisms. Microorganisms that produce lactic acid.
- Trial name
- NCT06886399
- Testing
- "AS-Probionorm"
- Where
- Kazakhstan
- Volunteers
- 210 people
- Sponsor
- Industrial Microbiology LLP
Oral Bacteria
Investigate Oral Bacteria in Adult Population
To compare the antimicrobial efficacy of three dentifrices on oral bacteria
- Trial name
- NCT00762177
- Testing
- Fluoride, Fluoride, Triclosan, Stannous Fluoride
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Intestinal Helminth Infection, Filarial Infection
The Effect of Parasitic Worm Infections on the Immune Response to Tuberculosis Bacteria
This study, sponsored by the National Institutes of Health and the Tuberculosis Research Centre in Chennai, India, will examine how helminth and filarial infections affect the immune response to mycobacteria (the bacteria that…
- Trial name
- NCT00342017
- Where
- India
- Volunteers
- 5,200 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)