Clinical trials: Bacteria
Oral Odor (Halitosis), The Study Want to Know if Site Specific Mouth Rinsing With Oral Mouth Disinfectants Can be Better Than Paonoral Mouth Rinsing
Comparing Site Specific Mouth Disinfection With Commercial Oral Mouth Rinse With Traditional Oral Maouth Disinfection
Objectives: To determine whether site-specific mouth rinsing with oral disinfectants can improve oral odor beyond the traditional panoral mouth disinfection with mouth rinses by targeting specifically oral malodor implicate…
- Trial name
- NCT02221193
- Testing
- traditional mouth rinsing and site-specific mouth rinsing (crossover)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Baha University
Healthy
Comparison of Ertapenem Distribution in the Muscle of Six Healthy Volunteers and Six Critically Ill Patients by Microdialysis
Ertapenem is an antibiotic that is highly bound to plasma protein (> 95%). The effects of this high protein binding on tissue distribution of antibiotics have been few evaluated yet.
- Trial name
- NCT01061047
- Testing
- Ertapeneme
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Wound Heal, Wound Healing Disturbance of
Evaluating Safety and Biological Effect on Wound Healing of ILP100-Topical in Subjects With Diabetic Foot Ulcers
A randomized, double-blind, placebo-controlled, parallel, exploratory phase 2a study to evaluate safety and biologic efficacy on wound healing of ILP100-Topical in subjects with diabetic foot ulcers during 26 weeks with a 5-year…
- Conditions
- Wound Heal, Wound Healing Disturbance of, Wound Healing Disorder, Wound Healing Delayed
- Trial name
- NCT05608187
- Testing
- ILP100-Topical (emilimogene sigulactibac) 5x10^7 CFU/cm^2, ILP100-Topical (emilimogene sigulactibac) 1x10^9 CFU/cm^2
- Where
- 2 sites in Sweden
- Volunteers
- 1 people
- Sponsor
- Ilya Pharma
Ulcerative Colitis
The Role of Gut Bacteria in the Immune Response to Vaccination in Patients With Ulcerative Colitis
Patients with the inflammatory bowel disease ulcerative colitis (UC) are a high-risk group encouraged to get vaccinated against seasonal influenza. It is also known that UC patients may have an altered gut microbiota.
- Trial name
- NCT06504784
- Testing
- Dietary Fiber Mixture
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
HELICOBACTER PYLORI INFECTIONS, Gastrointestinal Disease
Evaluation of IgY Antibody Efficacy in Egg Yolk Against Helicobacter Pylori in Bacterial Elimination and Clinical Symptoms Improvement of Gastrointestinal Patients
1. Investigating its effectiveness in removing bacteria in invivo conditions 2. Investigating the effectiveness in improving the clinical symptoms of patients
- Trial name
- Hp IgY (NCT06973889)
- Testing
- Helicobacter pylori eradication therapy
- Where
- 2 sites in Iran
- Volunteers
- 60 people
- Sponsor
- Mashhad University of Medical Sciences
Breathing, Mouth, Pneumonia
Mouth Odor on Preventing Pneumonia by Oral Frailty
This research plan aims to first collect data on the oral function and oral hygiene status of the elderly population in the community and to understand the normal model of oral frailty among the older adults in the community.
- Conditions
- Breathing, Mouth, Pneumonia, Frailty
- Trial name
- NCT05987982
- Testing
- Oral exercises and oral hygiene, Oral care
- Where
- Taiwan
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Chronic Granulomatous Diseases (CGD) and Liver Lesions
Radiofrequency Ablation for Liver Abscesses From Chronic Granulomatous Disease
Background: Abscesses are a pocket of infection in an organ or tissue. Patients with a disease called chronic granulomatous disease (CGD) often develop these abscesses.
- Trial name
- NCT01851460
- Testing
- Cool-tip RF Ablation System
- Where
- United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Enviroment Cleaning
Comparision of Different Methods of Enviromennt Disinfection
Multidrug resistance bacteria infection is common in ICU. Infection incidence is associated with age, organ dysfunction, invasive treatment and enviroment cleaning.
- Trial name
- NCT02795091
- Testing
- manual cleaning, machine clean
- Volunteers
- 480 people
- Sponsor
- Chun Pan
Autism Spectrum Disorder
Microbiome and Mycobiome Registry of Volunteers With and Without Autism Spectrum Disorder
Analyze, describe, and understand how the human gut microbiome (i.e. bacteriome and mycobiome) and Autism Spectrum Disorder (ASD) are related.
- Trial name
- NCT03819439
- Testing
- Microbiome and Autism Questionnaire
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Isolation, Identification
Isolation of Probiotic Lactic Acid Bacteria From Bangladeshi Fermented Foods
Brief Summary This study focus on the presence of probiotic LAB in traditional Bangladeshi fermented foods such as Modhubhat, pickles, and yogurt.
- Conditions
- Isolation, Identification, Probiotic Characterization
- Trial name
- ProLab-BD (NCT07917065)
- Where
- Bangladesh
- Volunteers
- 45 people
- Sponsor
- Bangladesh Bioscience Research Group
Acute Upper Respiratory Tract Infection and Acute Bacterial Rhinosinusitis
Acute Upper Respiratory Tract Infection - When is Bacteria Involved?
The purpose of this study is to find out if we can predict the progress of acute upper respiratory tract infection to acute bacterial rhinosinusitis in Finnish conscripts by symptoms, clinical, endoscopic or radiological…
- Trial name
- NCT01580137
- Where
- Finland
- Volunteers
- 48 people
- Sponsor
- Oulu University Hospital
Irritable Bowel Syndrome
Manipulation of Visceral Hypersensitivity With Probiotic Bacteria in Irritable Bowel Syndrome
Irritable bowel syndrome is a common digestive disorder worldwide. However, there is no effective treatment of irritable bowel syndrome.
- Trial name
- NCT01139736
- Testing
- VSL#3
- Where
- Hong Kong
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Extended Spectrum Beta-Lactamase Producing Bacteria Infection, Microbial Colonization
Gut Microbiota Association With ESBL-E Colonisation and Subsequent ESBL-E Infection
Antimicrobial resistance is a major threat worldwide and extended-spectrum beta-lactamase producing Enterobacteriales (ESBL-E) are a leading cause because of their wide dissemination.
- Conditions
- Extended Spectrum Beta-Lactamase Producing Bacteria Infection, Microbial Colonization, Critical Illness
- Trial name
- Microbe (NCT04131569)
- Testing
- ESBL-E fecal carriage screening according to routine care
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University of Bordeaux
Oral Squamous Cell Carcinoma, Oral Cancer
Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer
The goal of this phase II single arm clinical study is to evaluate the effect of antibiotics (metronidazole) and oral chlorhexidine (CHX) in reducing the bacteria load within tumors of patients undergoing surgery for oral cancer.
- Conditions
- Oral Squamous Cell Carcinoma, Oral Cancer, Head and Neck Cancer, Head and Neck Carcinoma
- Trial name
- NCT06627270
- Testing
- Metronidazole, Chlorhexidine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Case Comprehensive Cancer Center
Colorectal Neoplasms Malignant, Surgical Procedures, Operative
Tracheal Colonization and Outcome After Major Abdominal Cancer Surgery
The goals of this study were to investigate whether two anesthesia regimens, with and without N2O, and bacterial colonization influence respiratory complications after major abdominal surgery for cancer.
- Conditions
- Colorectal Neoplasms Malignant, Surgical Procedures, Operative, Stomach Neoplasms, Pancreatic Cancer, Adult
- Trial name
- NCT04002128
- Testing
- Tracheal aspirates and nasal smears were taken in all the patients. Laparotomies were performed in all patients.
- Volunteers
- 120 people
- Sponsor
- Osijek University Hospital
Complications of Organ Transplant Stem Cells, Gram-Negative Bacterial Infections
Survey of Severe Infections by Gram Negative Bacteria in Patients Submitted to Stem Cell Transplant
All patients undergoing autologous or allogeneic stem cell transplant (SCT) for any underlying disease will be monitored for severe infections by gram negative bacteria (SIGNB) during the engraftment period.
- Trial name
- GITMO-SIGNB (NCT02088840)
- Where
- 54 sites in Italy
- Volunteers
- 2,769 people
- Sponsor
- Gruppo Italiano Trapianto di Midollo Osseo
Gram-Negative Bacterial Infections
Multicenter Open-label Randomized Controlled Trial (RCT) to Compare Colistin Alone Versus Colistin Plus Meropenem
The purpose of this study is to determine whether the addition of meropenem to colistin is better than colistin alone in the treatment of clinically significant infections caused by multi-drug resistant bacteria
- Trial name
- NCT01732250
- Testing
- Colistin, Meropenem
- Where
- 7 sites in Greece, Israel and 1 more
- Volunteers
- 406 people
- Sponsor
- Mical Paul
Eczema, Atopic Dermatitis
Studies of Skin Microbes in Healthy People and in People With Skin Conditions
This study will examine microbes (e.g., bacteria, fungi, viruses) that live on human skin and how microbes contribute to health and disease.
- Trial name
- NCT00605878
- Where
- United States
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Xerostomia, Autoimmune Diseases
Study of Oral Bacteria in Patients With Dry Mouth
This study will examine the types of bacteria present in the dental plaque of patients with persistent dry mouth. Saliva is essential for digestion and swallowing and for maintaining the normal mineralization of teeth.
- Trial name
- NCT00048685
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Helicobacter Pylori
Development of a Laboratory Test for the Detection of a Fluorescent-labeled Urease Inhibitor Marker Attached to Helicobacter Pylori
The aim of this study is to compare the usual rapid urease test (RUT) to a new florescent-labeled urease inhibitor marker to diagnose Helicobacter Pylori.
- Trial name
- NCT04937426
- Testing
- Fluorescent-labeled Urease Inhibitor Marker to Detect Helicobacter Pylori
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Hillel Yaffe Medical Center