Clinical trials: Bacteria
Clostridium Difficile Infection
Harnessing the Healthy Gut Microbiota to Cure Patients With Recurrent C. Difficile Infection
CDI (Clostridium difficile infection) causes diarrheal illness and can cause colitis which may be fatal. A patient being treated for CDI has a 10-25% chance of developing relapse. Recurrent CDI is on the rise.
- Trial name
- NCT01372943
- Testing
- "synthetic stool" or pure cultures of probiotic intestinal bacteria
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- Queen's University
Bacterial Colonization
Oral Bacteria on Suture Materials - Clinical Comparison of an Antibacterial-coated and a Non-coated Suture Material
Antibacterial Triclosan-coated suture material (VICRYL PLUS®, Ethicon) and non-coated (VICRYL®) was compared for bacterial colonization after third molar extraction.
- Trial name
- NCT00946049
- Testing
- Vicryl Plus, Vicryl
- Where
- Germany
- Sponsor
- University Hospital Freiburg
Eravacycline, Pharmacokinetics
Real-World Pharmacokinetic/Pharmacodynamic Study of Eravacycline in Critically III Patients
The aim of this study is to evaluate the efficacy of Eravacycline in the treatment of patients with bacterial infection and to assess the pharmacokinetics of Eravacycline and to establish a population pharmacokinetic model of…
- Conditions
- Eravacycline, Pharmacokinetics, Bacteria Infection, Bacterial Resistance to Antimicrobial
- Trial name
- NCT06666998
- Volunteers
- 100 people
- Sponsor
- Sichuan Provincial People's Hospital
Vulvovaginal Candidiasis, Bacterial Vaginosis
Study of the Microbiota, Metabolome, and Environmental Toxins in Relation to Reproductive Health in Rwandan Women
The overall objective of this clinical pilot study is to determine at a random sampling time, the vaginal microbiome and metabolome of pregnant women, and to see if infection (bacterial vaginosis, vulvovaginal candidiasis…
- Trial name
- RVMM (NCT02150655)
- Testing
- Lactobacillus GR-1 and Lactobacillus RC-14 oral capsules
- Where
- Rwanda
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Cirrhosis, Spontaneous Bacterial Peritonitis
Early Ascitis Parencentesis in SBP
Paracentesis at 48 hours, as recommended in international guidelines, could delay the time to effective antibiotic therapy in cases of SBP with germs resistant to empirical antibiotic therapy.
- Trial name
- PAPISLA (NCT06679842)
- Testing
- ascitis paracentesis
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Cirrhosis, Ascites
Daptomycin + Meropenem Versus Ceftazidime in the Treatment of Nosocomial Spontaneous Bacterial Peritonitis
Nosocomial spontaneous bacterial peritonitis (SBP) is frequently caused by multi drug resistant bacteria. Standard treatment of SBP could be ineffective.
- Conditions
- Cirrhosis, Ascites, Nosocomial Spontaneous Bacterial Peritonitis
- Trial name
- NCT01455246
- Testing
- Daptomycin + Meropenem, Ceftazidime
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- University of Padova
E. Coli Infection, Multi-antibiotic Resistance
Perinatal Transmission of MDR Bacteria
The investigators aim to conduct a prospective surveillance study of mothers and their infants born vaginally or by scheduled C-section and who are admitted to Northwestern Medicine Prentice Women's Hospital to determine the…
- Trial name
- ACQUIRE (NCT06148480)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Reduction in Bacterial Counts Through the Use of Mouthwash
Dental Implants and Mouth Rinse
The primary aim of this study is to evaluate and compare the efficacy of a 60 second rinse with chlorhexidine, essential oil-based mouthwash, cetylpyridinium chloride mouthwash, or saline solution on bacterial contamination in…
- Trial name
- NCT02002442
- Testing
- Mouthwash
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tufts University
Iron Deficiency (Without Anemia)
Effect of Low-dose Versus Standard-dose Iron Supplementation on the Gut Microbiome
Iron deficiency is a common problem that is often treated with the administration of oral iron. Most of the iron is not absorbed and remains in the intestine, where it influences the balance of gut bacteria.
- Trial name
- NCT05467423
- Testing
- Iron
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Infections, Streptococcal
Study to Characterize and Identify Bacteria Causing Acute Otitis Media in Young Egyptian Children
The purpose of this epidemiological study is to identify and characterize the bacteria causing Acute Otitis Media episodes in children aged >= 3 months to < 5 years in Egypt.
- Trial name
- NCT01160055
- Testing
- Middle ear fluid and urine.
- Sponsor
- GlaxoSmithKline
Onchocerciasis
Clinical Trial of Rifampin and Azithromycin for the Treatment of River Blindness
The purpose of this study is to determine whether rifampin and/or azithromycin are effective in the treatment of river blindness (onchocerciasis).
- Trial name
- NCT00127504
- Testing
- Rifampin, Azithromycin
- Where
- Guatemala
- Volunteers
- 80 people
- Sponsor
- Centers for Disease Control and Prevention
Intestinal Bacteria Flora Disturbance
Allium Extracts on the Intestinal Microbiota in Healthy Resident Volunteers.
To evaluate the effect of daily consumption of a combination of garlic and onion extracts on the intestinal microbiota and the production of short chain fatty acids in elderly healthy volunteers living in a residence.
- Trial name
- NCT05016999
- Testing
- Garlic and onion concentrate
- Where
- Spain
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- DOMCA S.A.
Organ Failure, Multiple
Impact of Fourier Transform Infrared Spectroscopy (FTIRS) in ICUs
This study will assess the impact of FTIRS typing on the spread of ESBL-E in intensive care units
- Trial name
- ECLA'IR (NCT05872152)
- Testing
- FTIR results
- Where
- France
- Volunteers
- 900 people
- Sponsor
- University Hospital, Caen
Healthcare Associated Infection, Clostridium Difficile Infection
Pulsed UV Xenon Disinfection to Prevent Resistant Healthcare Associated Infection
The objective is to conduct a prospective, sham controlled, double-blinded, interventional crossover trial to compare standard terminal cleaning plus PX-UV (intervention) with standard terminal cleaning plus sham PX-UV (control)…
- Conditions
- Healthcare Associated Infection, Clostridium Difficile Infection, Infection Due to Multidrug Resistant Bacteria
- Trial name
- NCT03349268
- Testing
- Pulsed xenon ultraviolet (PX-UV) Device
- Where
- United States
- Volunteers
- 25,732 people
- Sponsor
- University of Michigan
Overweight, Healthy
The Effects of a Ruminococcus Torques Strain Bacterium in Healthy Adults.
A randomized, placebo controlled crossover study investigating the potential metabolic effects of the naturally occurring gut microbe Ruminococcus torques in healthy, overweight adults.
- Trial name
- NCT05448274
- Testing
- Ruminococcus torques
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Oluf Pedersen
Bacteremia, Healthcare-associated Pneumonia
Randomized-controlled Trial (RCT) on Combination Antibiotic for Infections Caused by Gram-negative Bacteria
Background and rationale: Antimicrobial resistance is a global public health threat. An increasing number of Gram-negative bacteria isolates worldwide are resistant to virtually all antibiotics including carbapenems.
- Conditions
- Bacteremia, Healthcare-associated Pneumonia, Ventilator-associated Pneumonia
- Trial name
- XDR-GNB (NCT02134106)
- Testing
- Polymyxin B, Polymyxin B + Doripenem
- Where
- 2 sites in Singapore
- Sponsor
- Tan Tock Seng Hospital
Intestinal Transit
Gut Transit Effect on Enterohepatic Circulation
A study to determine the influence of changing intestinal transit time of the enterohepatic recirculation of bile acids.
- Trial name
- NCT03501498
- Testing
- Loperamide, Senna
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University Hospital Plymouth NHS Trust
Diarrhea
Rifaximin Versus Placebo in the Prevention of Travelers' Diarrhea
The purpose of this study is to evaluate the effectiveness of poorly absorbed rifaximin in the prevention of travelers' diarrhea among U.S. college students in Mexico for five weeks.
- Trial name
- NCT00098384
- Testing
- rifaximin
- Where
- Mexico
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- DuPont, Hurbert L., MD
Lung Diseases
Investigating Novel Strategies in Pediatric Immune Responses and Microbiome Environment: Comprehensive Lung Disease Investigation in Children.
The INSPIRE CHILD-study is a clinical research project focused on understanding lung diseases in children. The study aims to explore how the presence of certain bacteria, immune responses, and inflammatory markers in the lungs…
- Trial name
- INSPIRE CHILD (NCT06746077)
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Aarhus University Hospital
Diet Modification
Antimicrobial-free Production of Beef Cattle's Affect on Gut Microbiome
The primary purpose of this study is to assess whether consuming foods from animals raised with antimicrobial medications influences gut health in adults between the ages of 21-69 years old.
- Trial name
- S54 (NCT04023604)
- Testing
- Controlled diet with beef raised without antibiotics, Controlled diet with beef produced in conventional systems
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Purdue University