Clinical trials: Bacteria
Drug Resistance, Bacterial, Antimicrobial Drug Resistance
Fecal Microbiota Transplantation (FMT) to Decolonize Antibiotic - Resistant Bacteria (ARB) - New Protocol
The aim of the study is to assess the safety and efficacy of new protocol fecal microbiota transplantation (FMT) in the eradication of antibiotic resistant bacteria, including those featuring of resistance to new generation…
- Trial name
- STOP-ARB2 (NCT06156956)
- Testing
- Fecal Microbiota Transplantation
- Where
- 5 sites in Poland
- Volunteers
- 200 people
- Sponsor
- Human Biome S.A.
Escherichia Coli Infections, Staphylococcus Aureus
Role of the NLRP3 Inflammasome in Escherichia Coli and Staphylococcus Aureus Bacteria
Our previous studies delineate a novel pathway of immune activation in animals that the investigators have named Anti-Virulence Immunity (AVI).
- Trial name
- NLRP3-Bact (NCT03869593)
- Testing
- Sample analysis
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Acute Bacterial Skin and Skin Structure Infection
Retrospective Effectiveness Study of Dalbavancin and Other Standard of Care of the Same Class in Patients With ABSSSI
The aim of this study is to collect the data on the effectiveness of dalbavancin in terms of save of hospitalization days on patients treated between June 2017 and June 2019 in two countries (Italy and Greece) vs the other…
- Trial name
- REDS (NCT04298463)
- Testing
- Xydalba, vancomycin, teicoplanin or daptomycin
- Where
- 16 sites in Greece, Italy
- Volunteers
- 184 people
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Obsessive-Compulsive Disorder
A Clinical Trial of Fecal Microbiota Transplantation in a Population With Obsessive-compulsive Disorder
Obsessive-compulsive disorder (OCD) is a psychiatric condition marked by recurrent intrusive thoughts (obsessions) and ritualistic behaviors aimed at reducing distress (compulsions).
- Trial name
- FOCUSED (NCT05720793)
- Testing
- FMT Capsule + SIMBA Capsule
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Valerie Taylor
Bloodstream Infection Multidrug-resistant Gram-negative Bacteria
Combating Multidrug-resistant Gram-negative Bacteria in Africa Through Diagnostic and Antimicrobial Stewardship
Antimicrobial resistance (AMR) is a major threat to public health and the well-being of humans, with high mortality rates of infections caused by MDR GNB.
- Trial name
- ComBac (NCT07820332)
- Testing
- Treatment according to AMR algorithm
- Volunteers
- 1,320 people
- Sponsor
- Universität des Saarlandes
Periodontal Disease
Periodontal Disease and Circulatory Microbial Components
The goal of this project is to study the immune activity of certain proteins present in the blood of patients with severe periodontal disease. Periodontal disease (gum disease) is the major cause of tooth loss among adults.
- Trial name
- CirCo (NCT01154855)
- Testing
- Prophylaxis ; Gross debridement for diseased patients
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Infection Resistant to Drugs, Gram-Negative Bacterial Infection
Burden of Antibiotic Resistance in Gram-Negative Infections in Dutch Hospitals
This study aims to assess how large an additional disease burden and what extra costs are generated by antibiotic resistance in patients suffering from infections caused by gram-negative bacteria, such as Escherichia coli and…
- Trial name
- GRAND-ABC (NCT02007343)
- Where
- 8 sites in Netherlands
- Volunteers
- 3,895 people
- Sponsor
- UMC Utrecht
Alzheimer Disease, Dementia
Periodontitis and Periodontal Bacteria in Dementia
The study is designed to inquire whether the presence of periodontitis and different periodontopathogenic bacterial strains are associated with dementia diagnosis and with the degree of cognitive impairment in participants…
- Conditions
- Alzheimer Disease, Dementia, Periodontitis
- Trial name
- NCT05557617
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Region Örebro County
Bone and Joint Prosthetic Infections
BJI Inoplex 2 : Test for Diagnosis of Prosthetic Infections
A national, prospective, open-label, non-interventional, multicentre, controlled study designed to evaluate a diagnostic method in patients undergoing hip, knee or shoulder prosthetic removal regardless of whether or not…
- Trial name
- NCT02222792
- Where
- 2 sites in France
- Volunteers
- 540 people
- Sponsor
- Diaxonhit
Molecular Analysis
Report of a New Method Used to Identify the Bacteria Present in a Human Colon Biopsy Sample
The method used for the biopsy analysis may be able to provide important insights into the complex microbial communities found in the human colon or in complex human infections.
- Trial name
- NCT00882752
- Testing
- molecular analysis
- Volunteers
- 1 people
- Sponsor
- Southwest Regional Wound Care Center
Foot Ulcer, Diabetic, Bacteria
Evaluation of Fluorescence-image Guided Wound Assessment vs. Standard Practice
The current trial aims to compare the assessment of diabetic foot ulcers by fluorescence image guidance to standard practice. The device will be used to acquire fluorescence images of diabetic foot ulcers: when wounds are…
- Trial name
- NCT02315092
- Testing
- Fluorescence Imaging
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University Health Network, Toronto
Bronchitis, Chronic
A Study of the Safety and Effectiveness of Oral Levofloxacin Compared With Cefuroxime Axetil in the Treatment of Adults With Persistent Bronchitis Experiencing Rapid Onset of Severe Worsening of Symptoms Caused by Bacteria
The purpose of this study is to evaluate the safety and effectiveness of levofloxacin, an antibiotic, compared with cefuroxime axetil, another antibiotic, in the treatment of adults with chronic bronchitis experiencing rapid…
- Trial name
- NCT00269932
- Testing
- levofloxacin
- Volunteers
- 485 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Periodontal Diseases
Hypochlorous Acid Mouthwash, Oral Bacteria, and Staphylococcus Aureus
Mouthwash is one method of maintain oral health and to reduce the dental plaque and gum inflammation. However, the effects of mouthwash on oral bacteria were not consistent among different brands of them.
- Trial name
- NCT05372835
- Testing
- La Chlogen mouthwash, water, La Chlogen mouthwash and La Chlogen periodontal flosser
- Where
- Taiwan
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University
Infections Caused by Anaerobic Bacteria, Renal Impairment
Pharmacokinetics and Safety Study of Levornidazole Disodium Phosphate for Injection in Subjects With Renal Impairment and Normal Renal Impairment
To evaluate the pharmacokinetics and safety of a single intravenous dose of levornidazole disodium phosphate for injection in subjects with moderate and severe renal impairment and healthy subjects.
- Trial name
- NCT07033182
- Testing
- Levornidazole Disodium Phosphate for Injection
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Yangtze River Pharmaceutical Group Jiangsu Zilong Pharmaceutical Co. Ltd
Infections, Streptococcal
Study to Identify and Characterize the Bacteria Causing Acute Otitis Media Episodes in Young Children in Saudi Arabia
The purpose of the study is to identify the bacterial aetiology of acute otitis media episodes in young children aged ≥ 3 months to < 5 years in Saudi Arabia.
- Trial name
- NCT01204385
- Testing
- Sample collection
- Where
- Saudi Arabia
- Volunteers
- 66 people
- Sponsor
- GlaxoSmithKline
Preterm Labor
Phospholipase A2 Producing Bacteria and Pre-Term Labor
The purpose of this study is to better understand (1) if phospholipase A2 producing microorganisms and cytokines (IL-1, IL-4, IL-6, IL-10, and IL-13) are associated with premature labor (2) if pregnant teens are more likely to…
- Trial name
- NCT00855543
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- CAMC Health System
Microbiota Analysis in Healthy Subjects
Analysis of the Gut Microbiota Composition After Consumption of Probiotic Bacteria
The goal of this intervention study is to evaluate the beneficial effect of the probiotic bacterium Bacillus coagulans in healthy volunteers.
- Trial name
- NCT07046897
- Testing
- Consumption of probiotics strain 5, Consumption of probiotics strain 6
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lund University
Intestinal Microbiome, Febrile Neutropenia
Choosing the Best Antibiotic to Protect Friendly Gut Bacteria During the Course of Stem Cell Transplant
The purpose of this study is to see how different antibiotics affect the community of friendly bacteria existing in the intestinal tract (gut).
- Trial name
- NCT03078010
- Testing
- Piperacillin-tazobactam, cefepime
- Where
- 2 sites in United States
- Volunteers
- 347 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Gingival Disease Due to Bacteria
Oral Health Status and Diet History Analysis Among Orphan House Children From 10-14 Years in Cairo Governorate.
the purpose of study to determine oral health status and dietary habits among group of orphan children from 10-14 years in Cairo Governorate.
- Trial name
- NCT04167826
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Cairo University
Ulcerative Colitis
Role of Healthy Bacteria in Ulcerative Colitis
Intestinal inflammation seen in inflammatory bowel disease (IBD) results from an altered mucosal immune response to luminal bacterial antigens.
- Trial name
- NCT01479660
- Testing
- Control, Probiotic
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh