Clinical trials: Bacteria
Bacteremia, Infective Endocarditis
Reducing Risk for Infective Endocarditis
This clinical trial is studying if bacteria found in a participant's bloodstream after brushing their teeth can be prevented with a dental cleaning and more education on how to best brush and care for their teeth.
- Trial name
- PIE-B (NCT05721781)
- Testing
- Oral Hygiene instruction, Dental Cleaning
- Where
- 6 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Atopic Dermatitis, Atopic Eczema
Double-Blind, Parallel, Randomised Study to Investigate the Effect of Oral Probiotics in Infants With Atopic Dermatitis
To study the effect of supplementation of a hydrolyzed formula with probiotic bacteria on clinical and immunological parameters in infants with AD with and without CMA and to compare effectiveness of different strains of…
- Conditions
- Atopic Dermatitis, Atopic Eczema, Infantile Eczema
- Trial name
- NCT00224432
- Testing
- probiotics: Lactobacillus GG, lactobacillus Rhamnosus
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Groningen Research Institute for Asthma and COPD
Urea in Blood; High
Antibacterial Activity of Urea Against Ocular Bacteria
Antibacterial properties of urea was tested against 35 isolates from ocular infections.
- Trial name
- NCT04020406
- Testing
- Antibacterial Activity
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
A03 - Digestive System, B03 - Bacteria
Survival Plant-Based
The aim of this study is to explore the potential of a mix of 4 freeze-dried bifidobacteria strains from Danone collection to survive in human gastro-intestinal (GI) tract of healthy volunteers after 14 days of consumption.
- Trial name
- Survi PB (NCT06768229)
- Testing
- Consumption of a freeze-dried strains-mix.
- Where
- France
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Mucosa Associated Bacteria in Small Intestine
Changes of Microbiota in Irritable Bowel Syndrome Patients
To investigate the changes of gastrointestinal microbiota in irritable bowel syndrome patients by hydrogen breath test and molecular-based analysis of microbiota in gastrointestinal tract
- Trial name
- NCT01679730
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
GORD, Oesophageal Cancer
The Bacterial Composition of the Stomach in Reflux Disease
Gastric and oesophageal (OG) cancer associated with poor long term outcome as overall less than 25% of patients survive for more than 5 years due to late recognition of the disease.
- Conditions
- GORD, Oesophageal Cancer, Oesophageal Reflux, Gastric Cancer
- Trial name
- NCT03835663
- Testing
- No intervention but patients are undergoing an upper GI endoscopy and biopsies for clinical purposes
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Imperial College London
Microbial Colonization, Bacterial Peritonitis
FEcal Transplant, a Hope to Eradicate Colonization of Patient Harboring eXtreme Drug Resistant Bacteria?
Our trial try to eradicate digestive tract colonization of patient harboring Extreme Drug Resistant (XDR) bacteria by performing a fecal transplantation.
- Conditions
- Microbial Colonization, Bacterial Peritonitis, Faeces Smearing
- Trial name
- FEDEX (NCT03029078)
- Testing
- fecal microbiota transplant
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
NAsal MEthicillin-resistant Staphylococcus
Prevalence of Multi-Drug Resistant Bacteria in Long-term Care Facilities
Antimicrobial resistance (AMR) is recognized as one of the major threats to global health [1], causing up to 25.000 deaths in the European Union every year, longer hospitalizations and increased healthcare costs.
- Trial name
- PreMDRinLTCF (NCT07234734)
- Where
- Italy
- Volunteers
- 581 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Bacteraemia Post Debridement
PVP Iodine Effect on Post Debridement Bacteraemia
The study investigates the effect of supra- and subgingival rinsing of 10% PVP prior to ultrasonic debridement in patients with periodontitis (as compared to rinsing with water) in terms of post treatment bacteraemia.
- Trial name
- PJB 1 (NCT01647347)
- Testing
- Supra- and subgingival rinsing with 10% PVP-iodine, Water
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Resistance Bacterial
Decolonization of Gram-negative Multi-resistant Organisms (MDRO) with Donor Microbiota (FMT)
Colonization by Multiple Drug Resistant Organisms (MDROs) during patient hospitalization requires expensive isolation measures and renders the return or transfer to other departments or institutions often impossible.
- Trial name
- DEKODON (NCT04188743)
- Testing
- Allogenic FMT, Autologous FMT
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- University Hospital, Ghent
Postoperative Wound Infection, Traumatic Wound Infection
Rapid Identification of Key Pathogens in Wound Infection by Molecular Means
The military is subject to traumatic wounds of various types and severity. Such wounds are predisposed to infection because they 1) tend to be extensive and deep, 2) may affect areas of normal carriage of potentially pathogenic…
- Conditions
- Postoperative Wound Infection, Traumatic Wound Infection, Closed Soft Tissue Abscess
- Trial name
- NCT00287599
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- Brentwood Biomedical Research Institute
Gram-negative Bacterial Infections
Surveillance Study - Incidence of Antibiotic Resistance in Serial Gram-negative Bloodstream Isolates
This research is important because it allows for the determination of resistance rates to antibiotics that may not be frequently tested by the clinical microbiology laboratory at University of Pittsburgh Medical Center…
- Trial name
- NCT00394784
- Where
- United States
- Sponsor
- University of Pittsburgh
Tularemia
FY15-14: Tularemia Vaccine Protocol (NDBR Lot 4)
The purpose of this study is to evaluate the safety and immunogenicity of the tularemia vaccine, live, attenuated, NDBR 101, Lot 4, and collect data on the incidence of occupational tularemia infection in vaccinated personnel.
- Trial name
- NDBR (NCT03867162)
- Testing
- Live Attenuated Tularemia Vaccine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Ductal Breast Carcinoma In Situ, Invasive Breast Carcinoma
Effects of Chemotherapy on Intestinal Bacteria in Patients With Newly Diagnosed Breast Cancer
This pilot research trial studies the effects of chemotherapy on intestinal bacteria/organisms (microbiota) in patients newly diagnosed with breast cancer.
- Conditions
- Ductal Breast Carcinoma In Situ, Invasive Breast Carcinoma, Stage I Breast Cancer, Stage IIA Breast Cancer
- Trial name
- NCT02370277
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis, Questionnaire Administration
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Southern California
Probiotics, Enterobacteriaceae Infections
Prevention and Decolonization of Multidrug-resistant Bacteria With Probiotics
This study explores the effect of probiotic administration to decrease colonization by Carbapenem resistant Enterobacteriaceae (CRE) in at-risk populations.
- Trial name
- NCT03967301
- Testing
- Probiotic
- Volunteers
- 228 people
- Sponsor
- Hospital Italiano de Buenos Aires
Saliva Altered, Plaque
Xylitol Chewable Tablets Versus Xylitol Chewing Gum in Geriatric Bedridden Patients
This study will be conducted to evaluate the effectiveness of using dissolving Xylitol chewable tablets versus xylitol chewing gum with bedridden geriatric patients in increasing salivary pH and decreasing bacterial count in both…
- Trial name
- NCT03877705
- Testing
- Listerine ready tabs
- Where
- Egypt
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Cairo University
Intestinal Infections, Dysbacteriosis
Study of the Safety and Tolerability of the Broad-spectrum Probiotic Medicine "AS-Probionorm"
The subject of this clinical trial is the medicine "AS-Probionorm". Pharmacological group - Antidiarrheal drugs. Antidiarrheal microorganisms. Microorganisms that produce lactic acid.
- Trial name
- NCT06252831
- Testing
- "AS-Probionorm"
- Where
- Kazakhstan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Industrial Microbiology LLP
Bacterial Infections
Direct Molecular Characterization of Bacteria From ICU and From the REHAB
Investigators aim to directly investigate the molecular properties of bacteria from tracheal and urinary samples routinely taken in intensive care units (ICU) patients.
- Trial name
- NCT03475472
- Where
- 2 sites in Switzerland
- Volunteers
- 971 people
- Sponsor
- University Hospital, Basel, Switzerland
Complicated Intra-abdominal Infection, Hosptial Acquired Pneumonia
A Study to Determine the Efficacy, Safety and Tolerability of Aztreonam-Avibactam (ATM-AVI) ± Metronidazole (MTZ) Versus Meropenem (MER) ± Colistin (COL) for the Treatment of Serious Infections Due to Gram Negative Bacteria.
A Phase 3 comparative study to determine the efficacy, safety and tolerability of Aztreonam-Avibactam (ATM-AVI) ± Metronidazole (MTZ) versus Meropenem (MER) ± Colistin (COL) for the treatment of serious infections due to Gram…
- Conditions
- Complicated Intra-abdominal Infection, Hosptial Acquired Pneumonia, Ventilator Associated Pneumonia
- Trial name
- REVISIT (NCT03329092)
- Testing
- ATM-AVI, MTZ, MER
- Where
- 157 sites in United States, Argentina and 19 more
- Volunteers
- 422 people
- Sponsor
- Pfizer
Meningitis
Neuroendoscopic Surgery With Ommaya Reservoir Implantation vs. Burr Hole Drainage for Infantile Postmeningitis Subdural Lesions: Superior Efficacy, Critical Impact of Surgical Timing, and Pathogenic Bacteria as Risk Factors for Progression
Globally, approximately 750,000 cases of infantile meningitis occur annually[1]. Clinical data show infantile postmeningitis subdural fluid collection (IPSFC) is the most common complication of infantile bacterial meningitis…
- Trial name
- NCT07320599
- Testing
- Endoscopic Subdural Fluid Collection Evacuation & Ommaya Reservoir Implantation
- Volunteers
- 100 people
- Sponsor
- Shengjing Hospital