Clinical trials: Bacteria
Necrotizing Pancreatitis
Molecular Analysis of Microbial DNA in Infected Necrotizing Pancreatitis
Necrotizing pancreatitis is a severe form of inflammation of the pancreas with subsequent destruction of the pancreas (necrosis).
- Trial name
- NCT01815489
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Venous Insufficiency, Venous Reflux
Effects of Non Contact Low Frequency Ultrasound in Healing Venous Leg Ulcers
This trial is a prospective, randomized, controlled, multi-center study of subjects presenting with chronic lower extremity venous ulcers.
- Conditions
- Venous Insufficiency, Venous Reflux, Lower Extremity Ulcer
- Trial name
- NCT01549860
- Testing
- MIST Therapy
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Celleration, Inc.
Human Microbiome
Xylitol and Sorbitol Effects on the Oral Microbiome
Chewing gum containing xylitol may help prevent caries by reducing levels of mutans streptococci (MS) and lactobacilli in saliva and plaque. Very little is known about other species which are possibly beneficial to oral health.
- Trial name
- NCT03668015
- Testing
- Xylitol then Sorbitol gum, Sorbitol then Xylitol gum
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Healthy
CABALA Diet & Health Study
During digestion of fatty foods, the liver produces a substance called bile which helps with the absorption of fat in the gut (small intestine).
- Trial name
- CABALA (NCT03369548)
- Testing
- Apple, Oats, Lactobacillus reuteri NCIMB 30242
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Reading
Infection Due to Resistant Bacteria
International Travel and the Spread of Extended-spectrum Beta-lactamase-producing Escherichia Coli
It is not clear why multi-resistant E. coli (also known as ESBL-producing) have recently became such important causes of infections in patients living and residing in the community.
- Trial name
- NCT01296165
- Testing
- Analysing the behaviours of travellers while visiting India
- Where
- Canada
- Volunteers
- 173 people
- Sponsor
- Johann DD Pitout
Bacterial Infections
Impact of a Carrier (Infection, Colonization) of Highly Bacteria Resistance on the Patient's Quality of Life Hospital Environment
The quality of life of carriers detected infected or colonized by emerging highly resistant bacteria (BHRe) following the implementation of specific hygiene measures during the discovery of the microorganism has been little…
- Trial name
- QALYBHRe (NCT04226001)
- Testing
- Quality of life questionnaire
- Sponsor
- Hospices Civils de Lyon
Recurrent Urinary Tract Infections, Chronic Urinary-catheter-carrier
Comparison of Three Different Antibiotic Treatments Against Recurrent Urinary Tract Infections in Catheterized Patients
Recurrent urinary tract infections (UTI) in the patients chronically catheterized are serious challenges clinically. The pathogens are often multidrug-resistant bacteria and such UTIs are actually biofilm infections.
- Conditions
- Recurrent Urinary Tract Infections, Chronic Urinary-catheter-carrier, Biofilm Infection, Antibiotic Treatment
- Trial name
- NCT05402319
- Testing
- Antibiotic combination therapy
- Volunteers
- 150 people
- Sponsor
- University of Southern Denmark
Candidiasis
Effect of Probiotic Bacteria on Oral Candida in Frail Elderly
The aim of this study is to investigate the effect of daily intake of the probiotic Lactobacillus Reuteri on the prevalence and counts of oral Candida in frail elderly living in nursery homes.
- Trial name
- NCT02391532
- Testing
- L. reuteri DSM 17938/ATCC PTA
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy
Impact of Soluble Arabinoxylan and Rice Bran Fiber on the Gut Microbiome in Healthy Adults
The importance of the gut microbiota for general health has been recently elucidated, but little is known about the impact of different types of nutrients on the gut microbiota.
- Trial name
- NCT06873204
- Testing
- Soluble Arabinoxylan, Rice Bran
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Purdue University
Dental Deposits, Tooth Discoloration
Phototherapy Remediation of Black Stain
This study investigates the remediation of black-stained tooth surfaces using antimicrobial photodynamic therapy. In this crossover trial, a cohort of patients received standard dental prophylactic cleaning to remove the black…
- Conditions
- Dental Deposits, Tooth Discoloration, Dental Prophylaxis
- Trial name
- NCT03309748
- Testing
- Dental prophylaxis, Dental prophylaxis + antimicrobial photodynamic therapy
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University
Soft Tissue Infections
Daptomycin in the Treatment of Patients With Renal Insufficiency and Complicated Skin and Skin Structure Infections
This is a Phase 4, randomized, open-label, multicenter, comparative study designed to further evaluate the pharmacokinetics of intravenous (i.v.) daptomycin and the safety and efficacy of daptomycin relative to comparator in the…
- Trial name
- NCT00102947
- Testing
- daptomycin (up to 14 days)
- Where
- 12 sites in United States
- Volunteers
- 72 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Septic Shock
Advanced Mesenchymal Enhanced Cell THerapY for SepTic Patients
Bacterial sepsis occurs in patients with severe infections. The condition is caused by toxic substances (toxins) released from bacteria and the patient's elevated inflammatory response to those toxins.
- Trial name
- AMETHYST (NCT04961658)
- Testing
- GEM00220
- Where
- 4 sites in Canada
- Volunteers
- 11 people
- Sponsor
- Northern Therapeutics
Periodontal Diseases, Periodontitis
Interaction Between Immune Cells and Bacteria Associated With Periodontitis
This study evaluates the interaction between host immune cells and bacteria associated with periodontitis. It comprises biological material from donors with and without periodontal disease.
- Conditions
- Periodontal Diseases, Periodontitis, Aggressive Periodontitis, Immunologic Disease
- Trial name
- NCT03225950
- Testing
- In vitro stimulation of blood with periodontitis-associated- and control bacteria, Anti-CCP- and anti-P.g.-antibodies titers, Analysis of selected single nucleotide polymorphisms (SNPs)
- Where
- 2 sites in Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Mercury--Toxicology
Mercury Metabolism by Bacteria in Humans
The purpose of this study is to evaluate how the bacteria in your gut can improve the break-down and de-toxification of non-harmful levels of a naturally occurring form of mercury (methylmercury) that comes with eating fish.
- Trial name
- NCT04060212
- Testing
- Tuna fish, prebiotic
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Gastrointestinal Microbiota
Study on the Effects of Resistant Potato Starch on Gut Bacteria in Healthy Adults
The goal of this clinical trial is to evaluate how taking Resistant Potato Starch affects the gut microbiota compared to a placebo, in healthy adults.
- Trial name
- NCT06949631
- Testing
- Resistant Potato Starch
- Where
- Canada
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- MSP Starch Products Inc.
Visual Acuity
Ex-vivo Adhesion of Bacteria to Different Contact Lens Materials
This is a single-site, 4-visit, contralateral, dispensing, open-label, randomized study. Each eligible subject will be randomized into one of two sequence groups to wear two lens types contralaterally (Test on the right eye and…
- Trial name
- NCT04108286
- Testing
- 1-DAY ACUVUE MOIST, DAILIES AQUA COMFORT PLUS
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Bone Resorption, Bacteria Caused Disease
0.2% Chx Gel vs Implant Bacterial Contamination
The objective of this human randomized, double blind, placebo-control (RDBPC) study is to evaluate the efficacy of a 0.2% chlorhexidine (CHX) gel on reducing bacterial load and peri-implant inflammation at implant-abutment…
- Trial name
- NCT03431766
- Testing
- 0.20% chlorhexidine gel
- Where
- Italy
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Kidney Failure
Different Dialysis Modalities and Diet on Gastrointestinal Biome and Azotaemic Toxins
. This is a prospective observational pilot study to analyse gastrointestinal tract bacterial populations in peritoneal dialysis and haemodialysis patients under the care of the Royal Free Hospital with chronic kidney disease who…
- Trial name
- NCT04714853
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College, London
Dental Caries
Alkaline Water and Salivary Bacterial Count
This study will be aimed to examine the effect of alkaline water on salivary streptococcus mutans bacteria which is the main cause of dental caries and comparing its effect with chlorohexidine mouthwash on the children aged…
- Trial name
- NCT06511336
- Testing
- Alkaline water (FLO water- Bottled drinking water- the Egyption Saudi Company for natural water- made in Egypt
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pharos University in Alexandria
Dietary Fat Metabolism
Sparking Gut Bacteria Production of Bioactive Xenolipids in Situ
Long-chain cyclopropane fatty acids (CpFAs) are microbially-derived lipids (fats), some of which can be found in select foods and appear to be produced naturally in the gut from dietary fatty acid precursors.
- Trial name
- NCT06313606
- Testing
- Dietary fat positive control, Dietary fat negative control
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Davis