Clinical trials: Bacteria
Bloodstream Infection, Gram Negative Infections
Antibiotic Duration and Outcomes in High-Risk Febrile Neutropenia Patients
The goal of this clinical trial is to learn if a personalized duration of antibiotic therapy, based on clinical stability, is as effective as a standard duration of at least 10 days in hospitalized patients with hematologic…
- Conditions
- Bloodstream Infection, Gram Negative Infections, Bacteraemia Caused by Gram-Negative Bacteria, Febrile Neutropenia (FN)
- Trial name
- PERaSTrA (NCT07372131)
- Testing
- Clinical Stability-Driven Antibiotic Discontinuation Strategy, Standard of Care Antibiotic Duration
- Where
- Italy
- Volunteers
- 172 people
- Sponsor
- Valeria Cento
Advanced Solid Tumor
First in Human Study of T3P-Y058-739 (T3P)
This is a first in human, phase I/II open-label, dose-finding, safety, and proof-of-concept clinical trial of T3P-Y058-739, a genetically-modified, live attenuated strain of the bacterium Yersinia enterocolitica, in patients with…
- Trial name
- NCT05120596
- Testing
- Pembrolizumab+T3P-Y058-739, T3P-Y058-739 (IV), T3P-Y058-739 (IT)
- Where
- 15 sites in Spain, Switzerland and 1 more
- Volunteers
- 100 people
- Sponsor
- T3 Pharmaceuticals AG
Health, Children, Only
Characteristics of Intestinal Bacteria and Their Effects on Growth and Immune Function in Children at High Altitude
Microbes and the human body maintain a complex relationship of interaction and influence. Different regions, altitudes, and dietary habits have different degrees of influence on the composition of children's intestinal flora.
- Conditions
- Health, Children, Only, Gut Microbiota
- Trial name
- NCT06157346
- Where
- China
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
No Dental Disease, Non-smoking
Effects of Daily Nitrate Consumption on Oral Bacteria Composition, Blood Pressure and Vascular Function
Diseases of the heart and blood vessels, including raised blood pressure, are one of the leading causes of death worldwide. Higher intakes of dietary nitrate, found abundantly in root vegetables such as beetroot, have been shown…
- Trial name
- REBOC2 (NCT03784742)
- Testing
- Nitrate rich beetroot juice
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Reading
Bacteremia Sepsis
Nanomotion-based Resistell AST to Determine the Antibiotic Susceptibility of Gram-negative Bacteria Causing Bacteremia and/or Sepsis
Blood culture samples from bacteremia patients positive for Gram-negative bacteria will be tested for antibacterial susceptibility using Resistell Phenotech device.
- Trial name
- NANO-RAST (NCT05002413)
- Testing
- Resistell AST
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- Resistell AG
ICU-ecology (Multidrug Resistant Bacteria), ICU-acquired Bacteraemia
Ecological Effects of Decolonisation Strategies in Intensive Care
Previous research has shown that applying certain treatments can reduce both the number of infections and the presence of resistant bacteria in the intensive care (ICU) and its patients.
- Trial name
- RGNOSIS (NCT02208154)
- Testing
- Chlorhexidine oral care (CHX-Oro), Selective oropharyngeal decontamination (SOD), Selective Digestive Decontamination (SDD)
- Where
- 13 sites in Belgium, Italy and 4 more
- Volunteers
- 8,665 people
- Sponsor
- MJM Bonten
Bacteraemia Caused by Gram-Negative Bacteria
Antibiotic Durations for Gram-negative Bacteremia
Gram-negative bacteremia (GNB) is a frequent hospital \& community-acquired infection, yet there is as yet no evidence from randomized studies on the optimal duration of antibiotic therapy.
- Trial name
- PIRATE (NCT03101072)
- Testing
- "Fixed long" antibiotic course of 14 days, "Fixed short" antibiotic course of 7 days, "Individualized duration" of antibiotic therapy
- Where
- 3 sites in Switzerland
- Volunteers
- 504 people
- Sponsor
- University of Geneva, Switzerland
Scalp Dermatitis, Dermatitis
Effects on the Scalp Microbiota of a 1% Selenium Disulfide and 1% Salicylic Acid Shampoo After 2% Ketaconazole Foaming Gel Treatment for Scalp Seborrheic Dermatitis
The aim of this study was to investigate the changes in the scalp bacterial and fungal microbiota in subjects afflicted with a scalp seborrheic dermatitis (SSD) during a 2% ketoconazole-based treatment followed by a maintenance…
- Trial name
- NCT04057950
- Testing
- cosmetic product
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- L'Oreal
Urinary Tract Infection, Infection Due to ESBL Bacteria
Extended Spectrum Betalactamase Producing Bacteria; Epidemiology and Treatment in Non-hospitalized Patients
This project aims at investigating the duration of human fecal carriage of bacteria harboring plasmid-borne resistance genes expressing Extended Spectrum beta-lactamases (ESBL), risk factors for infections with such bacteria and…
- Conditions
- Urinary Tract Infection, Infection Due to ESBL Bacteria, Environmental Contamination of ESBL
- Trial name
- ESCAPE (NCT01838213)
- Volunteers
- 760 people
- Sponsor
- Vestre Viken Hospital Trust
Constipation
Effects of Lubiprostone on Small Bowel and Colonic Bacteria: A Correlation Study With Segmental and Whole Gut Transit
Patients with constipation often have bloating and abdominal distension. It is unclear if this is related to intestinal bacteria.
- Trial name
- NCT00844831
- Testing
- Lubiprostone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Louisville
ADHD - Attention Deficit Disorder With Hyperactivity, ADD/ADHD
Effects of Lactic Acid Bacteria in Patients With Attention-Deficit/Hyperactivity Disorder
The study aims to evaluate whether postbiotics supplementation can improve ADHD symptoms, such as mood and sleep, in children. Furthermore, salivary biochemical profiles will be analyzed and dietary habits will be recorded to…
- Trial name
- NCT07419659
- Testing
- postbiotics
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- I-Ching Chou
Helicobacter Pylori Eradication
Effect of Probiotics on Helicobacter Pylori Eradication
The purpose of this clinical trial is to evaluate the clinical efficacy of Bifidobacterium quadruple live bacteria tablets (Si Lian Kang) on reducing the incidence rate of adverse reactions of Helicobacter pylori quadruple…
- Trial name
- NCT04034641
- Testing
- Bifidobacterium tetrad live bacteria tablet plus Helicobacter pylori quadruple eradication therapy
- Where
- 2 sites in China
- Volunteers
- 238 people
- Sponsor
- Hangzhou Grand Biologic Pharmaceutical, Inc.
Root Canal Infection
Prevalence of Bacteria Following Endodontic Treatment
Sampling of accessed root canals with endodontic paper points during treatment and immediately pre-obturation of endodontic root canals was carried out.
- Trial name
- NCT03055975
- Testing
- Detection of residual vital bacteria in the root canal space
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- King's College London
Burns, Wounds
A New Method for Detection of Bacteria in the Bloodstream
The primary aim is to determine if this new technique will detect and identify bacteria in the blood sooner than standard blood cultures or identify patients who may be septic without growing bacteria in their cultures.
- Trial name
- NCT02323165
- Testing
- Molecular Detection of Bacteria in the Bloodstream
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Florida
Colorectal Adenoma and Carcinoma
Investigation of the Role of the Microbiome in the Pathogenesis of Colorectal Adenoma and Carcinoma
The purpose of this study is the investigation of new host-microbiome interactions promoting adenoma formation and adenocarcinoma progression.
- Trial name
- NCT02947607
- Testing
- Colon biopsies
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 799 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Periimplant Crestal Bone Level Changes
Influence of Platform-switching on Bone Level Alterations: a 3 Year Randomized Clinical Trial (RCT).
The concept of platform-switching has been introduced to implant dentistry based on clinical observations of reduced periimplant crestal bone loss.
- Trial name
- NCT01917305
- Testing
- platform-shifted implant
- Volunteers
- 25 people
- Sponsor
- Søren Jepsen
Elderly
Catechin Mouth-washing for Removal of Intraoral Bacteria
The Purpose of this study is to evaluate the effects of catechin mouth-washing on the removal of intraoral bacteria in the elderly
- Trial name
- NCT00377507
- Testing
- catechin extracts
- Where
- Japan
- Volunteers
- 36 people
- Sponsor
- Masahiro Morikawa
Anemia
How Precision Diets, Through Gut Bacteria, Affect Anemia in Nepalese Adolescent
This study aims to evaluate whether a food-based nutrition intervention using goat liver can improve anemia among adolescent girls in Kathmandu, Nepal, and compare its effectiveness with the current standard iron and folic acid…
- Trial name
- NCT07661602
- Testing
- Iron folic acid supplement, Goat liver supplementation, Nutrition education on anemia prevention and control
- Where
- Nepal
- Volunteers
- 60 people
- Sponsor
- Southern Medical University, China
Bacterial Urinary Tract Infection
MicroUDxTM: a Rapid Diagnostic Tool That Will Prevent Death and Disability From Common Infections
Background \& Rational: Antibiotics are a major underpinning of modern medicine. The global rise of antimicrobial resistant (AMR) organisms is a serious world health problem.
- Trial name
- MicroUDxTM (NCT04228081)
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- University of Calgary
Sepsis, Gram-Positive Bacteremia
CRP and PCT as Predictors of Sepsis Cause
The aim of this retrospective study is to determine the predictive role of serum level of procalcitonin (PCT) and c-reactive protein (CRP) in determining the causative agent of sepsis in surgical intensive care unit (ICU)…
- Conditions
- Sepsis, Gram-Positive Bacteremia, Gram-negative Bacteremia
- Trial name
- NCT05605275
- Testing
- PCT levels, CRP levels, White blood cell count
- Where
- Croatia
- Volunteers
- 81 people
- Sponsor
- Osijek University Hospital