Clinical trials: Bacteria
Articular Disease
Spectrum of Bacterial Infections in Rheumatology
Retrospective study of patients with a proved non-tuberculous osteoarticular infection (OAI) diagnosed in a rheumatology department during the years 2010-2020.
- Trial name
- SIBERIE (NCT05007405)
- Testing
- Groups/Cohortes
- Where
- France
- Volunteers
- 81 people
- Sponsor
- Hôpital NOVO
Trauma Injury, Trauma
OCT in Open Fracture and Infected Fracture
This is a pilot prospective, observational study of patients with open or infected fracture evaluating the feasibility and acceptability of OCT, a light-based imaging modality that requires no drug or contrast agent.
- Conditions
- Trauma Injury, Trauma, Open Fracture, Fracture Infection
- Trial name
- NCT05785182
- Testing
- Open Fracture, Infected Fracture
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Respiratory Distress Syndrome, Adult, Multi-antibiotic Resistance
Multi-drug Resistant Gram-negative Bacteria and Veno-venous Extracorporeal Membrane Oxygenation (ECMO)
Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a life-support technique used in patients with most severe acute respiratory distress syndrome (ARDS).
- Trial name
- MDR-ECMO (NCT06199141)
- Where
- Italy
- Volunteers
- 279 people
- Sponsor
- University of Padova
Polymyxin B, Ventilator-associated Pneumonia
Comparison of Epithelial Lining Fluid and Blood Pharmacokinetics and Pharmacodynamics of Intravenous and Intravenous Plus Nebulized Polymyxin B in Multidrug Resistant Bacteria Ventilator-associated Pneumonia Patients
The goal of this observational study is to investigate whether intravenous polymyxin B combined with nebulisation achieves better antimicrobial efficacy and clinical outcomes than intravenous use alone in patients with…
- Conditions
- Polymyxin B, Ventilator-associated Pneumonia, Multidrug Resistant Bacterial Infection, Pharmacogenomic Drug Interaction
- Trial name
- NCT06076603
- Testing
- nebulized polymyxin B
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Southeast University, China
Asthma, Rhinitis
Oral Bacteria and Allergic Disease in Children
This study will see if bacteria differ between children who have allergies or asthma and children who do not have allergies or asthma. Previous research suggests that some bacteria may protect against allergies and asthma.
- Conditions
- Asthma, Rhinitis, Eczema, Respiratory Sounds
- Trial name
- NCT00438646
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Halitosis
Clinical and Microbiological Effects of a Mouthwash Containing Chlorine Dioxide
Previous research has shown the oxidizing properties and microbiological efficacies of chlorine dioxide (ClO2). However, no clinical studies have investigated its microbiological efficacies on periodontal and malodorous bacteria.
- Trial name
- NCT00748943
- Testing
- Chlorine Dioxide
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Tokyo Medical and Dental University
Intestinal Bacteria Flora Disturbance
Use Babyguard® Breast Milk Probiotics to Verify the Authenticity of the Gut-Breast Axis Hypothesis
In order to understand the life history of the breast milk flora, explore its composition, source of strains, and ability to colonize the baby's intestinal environment, to find out strains with the potential of probiotics in…
- Trial name
- NCT04672889
- Testing
- Babyguard® Breast Milk Probiotics
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Wisdom Teeth, Oral Surgery
Microbial Growth in the Suture Thread, After Application of Different Antiseptic Gels in Mandibular Third Molars Extraction
This is a randomized clinical trial in which investigators will compare the antimicrobial effect and inducer of cicatrization as well as the degree of postoperative pain in patients who are extracted the lower third molars.
- Conditions
- Wisdom Teeth, Oral Surgery, Third Molar Surgery, Bioadhesive Gel
- Trial name
- NCT03188289
- Testing
- Clorhexidine gel, Clorhexidine-Chitosan gel, Hyaluronic Acid gel
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Lyme Disease
Detection of Borrelia Bacteria in Early Stage Lyme Borreliosis Using the T2Lyme Panel
The T2Lyme assay will be compared to Borrelia culture from erythema migrans (EM) biopsy and/or detection of the C6 antigen in serum collected prospectively from patients suspected of early Lyme disease.
- Trial name
- NCT03581279
- Testing
- T2Lyme Panel testing
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- T2 Biosystems
Acute Watery Diarrhea
Comparison of Bacillus Clausii and Saccharomyces Boulardii for Acute Diarrhea at Day 3
THIS STUDY WILL BE CONDUCTED ON OPD PATIENTS IN CENTRAL PARK TEACHING HOSPITAL LAHORE TO SEE THE EFFECT OF PROBIOTICS ON DIARRHEA ALL PATIENTS INCLUDED WILL HAVE ACUTE WATERY DIARRHEA AND THE OUTCOME WILL BE CHECKED ON THE THIRD…
- Trial name
- NCT07853846
- Testing
- Bacillus clausii, Saccharomyces boulardii
- Where
- Pakistan
- Volunteers
- 86 people
- Sponsor
- Syeda Sabeen Fatima Naqvi
Ventilator Associated Pneumonia
A Multi-Center Observational Surveillance Study of VAP Causing Bacteria
Detect the clinical causitive pathogen of Ventilator Associated Pneumonia (VAP) patients by the bronchoalveolar lavage (BAL) method.
- Trial name
- NCT00484588
- Volunteers
- 500 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Cesarean Section; Infection, Surgical Site Infection
Vaginal Preparation With Chlorhexidine-alcohol vs. Povidine-iodine vs. Saline
The purpose of this study is to see whether chlorhexidine is superior to povidine-iodine vaginal antisepsis at reducing bacteria colony counts in pregnant women by comparing three groups: vaginal washing with…
- Trial name
- NCT03640507
- Testing
- Chlorhexidine-alcohol, Povidine-iodine, Sterile saline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Columbia University
Orthodontic Appliance Complication
The Effect of Different Remineralizing Agents on White Spot Lesions and Dental Plaque During Orthodontic Retention
Dental caries is a decay process that breaks down the tooth. The earliest clinical signs of active dental caries is seen as 'white spot lesions' (WSLs).
- Trial name
- NCT04788550
- Testing
- Fluoridated toothpaste, fluoride varnish (5% sodium fluoride), CPP-ACP plus crème group
- Where
- Malaysia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Hepatocellular Carcinoma, Hepatocellular Cancer
Nivolumab (Anti-PD1), Tadalafil and Oral Vancomycin in People With Refractory Primary Hepatocellular Carcinoma or Liver Dominant Metastatic Cancer From Colorectal or Pancreatic Cancers
Background: A most common liver cancer in adults is hepatocellular carcinoma. Other kinds of liver cancer happen when colorectal or pancreatic cancer spreads to the liver.
- Conditions
- Hepatocellular Carcinoma, Hepatocellular Cancer, Metastatic Pancreatic Cancer, Metastatic Colorectal Cancer
- Trial name
- NCT03785210
- Testing
- nivolumab, tadalafil, oral vancomycin
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Cancer Institute (NCI)
Chronic Otitis Media, Age Determined Bacteria
Bacterial Assessment of Middle Ear Fluid in Children Undergoing Ventilation Tube Placement Surgery
Children with chronic otitis media have more resistant bacteria that require surgical intervention to eradicate the infections. The study will evaluate the dominant bacteria and their sensitivities to antibiotics.
- Trial name
- NCT01157910
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hillel Yaffe Medical Center
Wounds
Observational Study of Clinical Performance of a Sterile, Bacteria-binding, Super-absorbent Wound Dressing
This prospective, multicenter, single-arm observational study aims to document the clinical performance and safety of a sterile, bacteria-binding, super-absorbent wound dressing for the intended use in a daily clinical practice.
- Trial name
- NCT02662218
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- BSN Medical GmbH
Aging
Resistant Starch and Non-starch Polysaccharide (Dietary Fibre) Intake and the Colonic Microbiome in Older People
The development of preventative nutritional strategies to promote healthy ageing is becoming increasingly important. Elevated thresholds for taste and smell, coupled with swallowing difficulties and masticatory dysfunction, often…
- Trial name
- NCT02384174
- Testing
- Resistant starch, Dietary fibre (arabinogalactan, gum guar, pectin)
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Dundee
Infection With MRSA Bacteria
Analysis of Methicillin Resistant Staphylococcus Aureus (MRSA) Obtained Through the Emergency Department in a Tertiary Care Hospital in Vancouver Canada From 2001-2005
To analyze microbiological data from MRSA samples obtained through the emergency department from 2001-2005. There is a strong clinical suspicion that we are now seeing an outbreak of a new strain of MRSA and we plan to better…
- Trial name
- NCT00247858
- Where
- Canada
- Volunteers
- 97 people
- Sponsor
- University of British Columbia
Microbial Colonization
Colonisation Efficacy of Oral Probiotic Fast Melt Powder
To evaluate the colonisation efficacy (i.e. ability of the probiotic bacteria to remain in your mouth) of a fast melt powder that quickly dissolves in the mouth.
- Trial name
- NCT05367518
- Testing
- Probiotic Streptococcus salivarius K12 Fast Melt Powder 1 Billion colony forming units /g), Probiotic Streptococcus salivarius K12 Fast Melt Powder 100 Million colony forming units /g)
- Where
- New Zealand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- BLIS Technologies Limited
Family Research
The PEARL-AGE Study. Multigenerational Gut Bacteria Transmission and Its Stability in Families.
Investigators will recruit up to 4-generations of human family cohorts, in order to characterize the microbiome and its changes across different generations.
- Trial name
- NCT05346016
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- Quadram Institute Bioscience