Clinical trials: Bacterial
Acute Respiratory Distress Syndrome, Viral or Bacterial Infections
Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia.
A Phase 2a, randomized, double-blind, placebo-controlled, multiple ascending dose study in patients who are hospitalized with presumed pneumonia requiring supplemental oxygen therapy.
- Conditions
- Acute Respiratory Distress Syndrome, Viral or Bacterial Infections, Pneumonia, Pneumonia, Viral
- Trial name
- NCT05123755
- Testing
- AV-001 Injection
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Vasomune Therapeutics, Inc.
Pleural Infection Bacterial, Pleural Infections
Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema
The goal of this clinical trial is to find out if giving certain medications once a day works just as well as giving them twice a day to treat infections around the lungs (called pleural infections).
- Conditions
- Pleural Infection Bacterial, Pleural Infections, Pleural Infections and Inflammations, Empyema, Pleural
- Trial name
- ONLY ONCE (NCT07095361)
- Testing
- Fibrinolytic once daily, Fibrinolytic twice daily, DNA degradation once daily
- Where
- 11 sites in United States
- Volunteers
- 270 people
- Sponsor
- University of North Carolina, Chapel Hill
Bacterial Vaginosis
Impact of Clinician-administered Vaginal Live Biotherapeutic Product
This is an open-label, single-arm, Phase Ib trial assessing the consistency of response and colonization kinetics of a vaginally inserted live biotherapeutic intervention with optimized adherence.
- Trial name
- NCT07305844
- Testing
- LC106
- Where
- 2 sites in United States, South Africa
- Volunteers
- 26 people
- Sponsor
- Caroline Mitchell
Enterobacteriaceae, Swabs
Diagnostic Performance and Acceptability of Rectal Swab for Screening of ESBL Enterobacterales
The goal of this interventional study without drugs and medical devices is to assess the accuracy of the self-administered rectal swab compared to the "gold standard" performed by healthcare professionals used for the diagnosis…
- Conditions
- Enterobacteriaceae, Swabs, Beta Lactam Resistant Bacterial Infection
- Trial name
- ReSWAB (NCT07847606)
- Testing
- Rectal swab collection procedure performed by the patient (or the caregiver) and then by the nurse
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Bacterial Vaginoses
Vaginal Microbiome Transplantation for Recurrent Bacterial Vaginosis
Vaginal Microbiome Transplantation (VMT) may be beneficial in treating the most severe cases of recurrent and antibiotics-nonresponsive cases of BV.
- Trial name
- NCT04517487
- Testing
- Vaginal Microbiome Transplantation (VMT)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Hadassah Medical Organization
Hospital-acquired Bacterial Pneumonia, Ventilator-associated Bacterial Pneumonia
A Clinical Trial to Assess the Safety and PK of OMN6 in HABP or VABP Caused by Acinetobacter Baumannii Complex
This is a phase 2a, multinational, multicenter, double-blind, randomized, placebo-controlled, dose-ranging safety, tolerability and PK study in patients with HABP (Hospital Acquired Bacterial Pneumonia) or VABP (Ventilator…
- Trial name
- NCT06087536
- Testing
- OMN6
- Where
- 15 sites in Greece, Israel
- Volunteers
- 54 people
- Sponsor
- Omnix Medical Ltd
Urinary Tract Infections
A Study in Pediatric Participants Aged ≥2 to <12 Years With a Suspected or Confirmed Bacterial Infection or Receiving Prophylaxis Antibiotics
The study will be conducted to evaluate how a single oral dose of Gepotidacin is processed in the body over time along with safety monitoring in hospitalized pediatric participants who are receiving a standard of care treatment…
- Trial name
- NCT07371429
- Testing
- Gepotidacin, SOC
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- GlaxoSmithKline
Pneumonia, Bacterial
A Trial to Evaluate the Safety and Reactogenicity of an Investigational Pneumococcal Vaccine in Toddlers 12 to 15 Months of Age Receiving a Single Booster Dose
The main purpose of this study is to assess the safety and reactogenicity of a single dose of the new pneumococcal vaccine (called Pn-MAPS30plus) in toddlers who have previously completed a two-dose primary vaccination series…
- Trial name
- NCT07406334
- Testing
- Pn-MAPS30plus, PCV20
- Where
- 2 sites in South Africa
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Bacterial Infections
A Study to Investigate Safety and Pharmacokinetics of Intravenous Cefiderocol/Xeruborbactam in Participants With Renal Impairment
A Phase 1, Open-label, Single-dose Study to Determine the Safety and Pharmacokinetics of Intravenous Cefiderocol/Xeruborbactam (S-649228) in Participants with Renal Impairment
- Trial name
- NCT07104162
- Testing
- Cefiderocol/Xeruborbactam
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Qpex Biopharma, Inc.
Multidrug Resistant Bacterial Infection, Enterobacteriaceae Infections
PMT for MDRO Decolonization
This is a randomized, open label, comparative Phase II trial being conducted to determine whether fecal microbiota transplant using Penn Microbiome Therapy (PMT) products helps standard therapy eradicate antibiotic-resistant…
- Conditions
- Multidrug Resistant Bacterial Infection, Enterobacteriaceae Infections, Pseudomonas Aeruginosa, VRE Infection
- Trial name
- NCT05632315
- Testing
- PMT
- Where
- 3 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of Pennsylvania
Bacterial Vaginosis, Microbial Colonization
The Genital Microbiome of Male Partners of Women With Recurrent BV Undergoing Vaginal Microbiome Transplantation
There is strong observational evidence that sexual activity plays a key role in Bacterial Vaginosis (BV) acquisition and recurrence.
- Trial name
- NCT05963711
- Testing
- chlorhexidine gluconate 4%
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Bacterial Vaginosis
Photobiomodulation With Blue LED in Recurrent Bacterial Vaginosis
Introduction: Bacterial vaginosis (BV) is the most prevalent vaginal dysbiosis in women of reproductive age and is associated with adverse gynecological and obstetric outcomes; therefore, its diagnosis and appropriate treatment…
- Trial name
- NCT07835815
- Testing
- Metronidazole, Blue Light-Emitting Diode (LED)
- Volunteers
- 40 people
- Sponsor
- Patricia Lordelo
Acute Bacterial Skin and Skin Structure Infections
Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections
This was a randomized, double-blind, active-controlled, parallel-group, multicenter study in adult hospitalized patients to establish the safety and efficacy of ceftobiprole medocaril compared with vancomycin plus aztreonam in…
- Trial name
- NCT03137173
- Testing
- ceftobiprole medocaril, vancomycin+aztreonam
- Where
- 34 sites in United States, Bulgaria and 2 more
- Volunteers
- 679 people
- Sponsor
- Basilea Pharmaceutica
Pneumonia - Bacterial
Impact of BioFire FilmArray Pneumonia Panel vs Routine Diagnostics on Antimicrobial Outcomes (DOOR-MAT)
Multidrug-resistant bacterial infections are a growing global health concern. Hospital-acquired pneumonia is one of the most common infections occurring during hospitalization and can be associated with high mortality, reaching…
- Trial name
- NCT07585604
- Testing
- Multiplex PCR-based pneumonia panel (BIOFIRE® FILMARRAY® Pneumonia Panel)
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Blood-Brain Barrier, Bacterial Meningitis
Exploring the Combination of Intracalvariosseous and Intravenous Antibiotics for Moderate to Severe Bacterial Meningitis
Multiple preclinical and clinical studies, including the investigators' published work and the ongoing SOLUTION series trials, have consistently demonstrated that intracalvariosseous (ICO) injection can markedly increase drug…
- Trial name
- SPARK (NCT07826351)
- Testing
- Intracalvariosseous injection vancomycin/tigecycline/polymyxin B, Intravenous injection vancomycin/tigecycline/polymyxin B, Conventional treatment
- Where
- China
- Volunteers
- 9 people
- Sponsor
- yilong Wang
Skin Diseases, Bacterial
Study Comparing the Safety and Efficacy of Tigecycline With Ampicillin-Sulbactam or Amoxicillin-Clavulanate to Treat Skin Infections
The purpose of this study is to compare the safety and efficacy of the antibiotic tigecycline with other antibiotics, ampicillin-sulbactam, and amoxicillin-clavulanate in the treatment of a complicated skin and/or skin structure…
- Trial name
- NCT00368537
- Testing
- Tigecycline, ampicillin-sulbactam
- Where
- 57 sites in United States, Canada and 10 more
- Volunteers
- 550 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Small Intestinal Bacterial Overgrowth Syndrome (SIBO)
Comparison of the Efficacy of Saccharomyces Boulardii and Rifaximin in the Treatment of Small Intestinal Bacterial Overgrowth
This multicenter randomized controlled study aims to systematically evaluate the efficacy and safety of Saccharomyces boulardii sachets versus rifaximin in the treatment of small intestinal bacterial overgrowth (SIBO), with a…
- Trial name
- NCT07815548
- Testing
- Saccharomyces boulardii sachets, Rifaximin (Xifaxan)
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Shandong University
Urinary Tract Infections, Recurrent Urinary Tract Infections
WMT for Multidrug-Resistant Organism UTI
This is a single-center, prospective, single-arm, exploratory clinical study to evaluate the efficacy, safety, and potential mechanisms of washed microbiota transplantation (WMT) in patients with recurrent urinary tract…
- Conditions
- Urinary Tract Infections, Recurrent Urinary Tract Infections, Multidrug-Resistant Bacterial Infections, Bacteriuria
- Trial name
- NCT07816913
- Testing
- Washed Microbiota Transplantation (WMT)
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Sepsis, Bloodstream Infection
Microbiology Operations & Time Optimization in Sepsis
The goal of this study is to simulate turn-around times of blood cultures from blood culture collection to final communication of the result.
- Conditions
- Sepsis, Bloodstream Infection, Bacterial Infections, Septic Shock
- Trial name
- MOTION-Sepsis (NCT07817043)
- Testing
- laboratory infrastructure
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University Medicine Greifswald
Nephrotoxicity, Bacterial Infections
Differentiating True Nephrotoxicity From Pseudo-nephrotoxicity: A Prospective Comparative Study of Vancomycin Plus Piperacillin-Tazobactam vs. Meropenem Using Serum Creatinine and Cystatin-C
This prospective comparative observational study will compare the incidence of true nephrotoxicity in adult patients receiving vancomycin in combination with either piperacillin-tazobactam or meropenem.
- Conditions
- Nephrotoxicity, Bacterial Infections, Acute Kidney Injury, Renal Impairment
- Trial name
- NCT07818265
- Where
- Saudi Arabia
- Volunteers
- 304 people
- Sponsor
- King Faisal Specialist Hospital & Research Center