Clinical trials: Bacterial Diseases
Diabetes Mellitus, Tuberculin (Skin Test) Positive
Efficacy, Security, Adherence, Tolerability and Cost Effectiveness of Latent TB Treatment in Patients With TB/DM2 (TBL)
Researchers will evaluate the efficacy, toxicity, adherence and cost effectiveness of treatment with isoniazid or rifampicin in patients with diabetes mellitus type two (DM2) and latent TB (LTB).
- Trial name
- TBL (NCT03278483)
- Testing
- Isoniazid 300 mg Oral Tablet, Rifampin 600 mg Oral Tablet
- Where
- Mexico
- Volunteers
- 396 people
- Sponsor
- Instituto Nacional de Salud Publica, Mexico
Recurrent Erysipelas
Prophylaxis of Recurrent Erysipelas in Lower Limbs: compreSsion thErapy vs aNTibiotics and Compression Therapy.
Erysipelas (superficial cellulitis) is a frequent streptococcal bacterial infection. Each episode of erysipelas may worsen preexisting lymphedema and evolve to life-threatening necrotizing soft-tissue infection.
- Trial name
- PRESENT (NCT07549594)
- Testing
- elastic stockings, Phenoxymethylpenicillin
- Where
- 25 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Tours
Tuberculosis (TB), Pulmonary TB
Xpert MTB/RIF Ultra Trial
Tuberculosis (TB) is the leading cause of death caused by infectious agent globally. Estimated 10 million people get ill with TB every year and in 2022 globally there was an increase in Tuberculosis cases, first time since 2010.
- Trial name
- NCT07135622
- Testing
- Xpert® MTB/RIF Ultra, Referral to the specialized TB clinics
- Where
- Georgia
- Volunteers
- 778 people
- Sponsor
- Nestani Tukvadze
Clostridium Enterocolitis, Antibiotic-Associated Diarrhea
Efficacy of Metronidazole Versus Metronidazole and Rifampin in CDAD Treatment
What is the difference between the use of one drug (Oral Metronidazole) versus the use of this same drug combined with another drug (Rifampin) in treatment of bacteria and infection-associated diarrhea in patients? This infection…
- Conditions
- Clostridium Enterocolitis, Antibiotic-Associated Diarrhea, Pseudomembranous Colitis, Pseudomembranous Enterocolitis
- Trial name
- NCT00182429
- Testing
- Metronidazole and Rifampin
- Where
- 4 sites in Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Spinal Cord Injury, Urinary Tract Infection
Colonizing Neurogenic Bladders With Benign Flora
The purpose of the research is to determine whether we can get harmless bacteria to live in the bladders of persons with spinal cord injury who practice intermittent bladder catheterization.
- Trial name
- NCT00371631
- Testing
- Insertion of urinary catheters coated with E. coli 83972
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- US Department of Veterans Affairs
Tuberculosis, Diagnoses Disease
Rapid and Accurate Diagnosis of Paediatric TB (RaPaed-AIDA-TB)
This study will serve as a platform to evaluate new diagnostics in children suspected to have TB, establish diagnostic performance (sensitivity and specificity) and calculate positive and negative predictive values in a real-life…
- Trial name
- RaPaed (NCT03734172)
- Testing
- Sample collection
- Where
- 5 sites in India, Malawi and 3 more
- Volunteers
- 974 people
- Sponsor
- Michael Hoelscher
Tuberculosis, Pulmonary
Integrated Discovery and Development of Innovative TB Diagnostics
The long term goal of this project is to provide information critical to the development and use of a low-cost, point-of-care, rapid, simple, and highly accurate diagnostic tool that can help clinicians make a microbiological…
- Trial name
- (CETR) (NCT06624501)
- Testing
- Observational cohort study
- Volunteers
- 1,450 people, healthy volunteers welcome
- Sponsor
- Harvard University Faculty of Medicine
Diphtheria, Tetanus
Study of the DTaP-IPV-Hep B-PRP~T Combined Vaccine Following a Primary Series of DTacP IPV-HepB-PRP-T or Infanrix Hexa™
This is a follow-up of Study A3L11 (NCT00404651). Immunogenicity To describe the antibody persistence following a primary series vaccination of either DTaP-IPV-Hep B-PRP~T or Infanrix hexa™.
- Conditions
- Diphtheria, Tetanus, Pertussis, Hepatitis B
- Trial name
- NCT00654901
- Testing
- DTaP-IPV-Hep B-PRP~T vaccine (Batch 1), DTaP-IPV-Hep B-PRP~T vaccine (Batch 2), DTaP-IPV-Hep B-PRP~T vaccine (Batch 3)
- Where
- 4 sites in Mexico
- Volunteers
- 881 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Invasive Candidiasis
Early Discontinuation of Empirical Antifungal Therapy and Biomarkers
Empirical antifungal therapy (EAT) is frequently prescribed to septic critically ill patients with risk factors for invasive Candida infections (ICI).
- Trial name
- SEAT (NCT03538912)
- Testing
- Biomarker strategy, Routine strategy
- Where
- 10 sites in France
- Volunteers
- 192 people
- Sponsor
- University Hospital, Lille
Tuberculosis
A Phase Ⅱ Clinical Trial of the Recombinant Mycobacterium Tuberculosis Vaccine Freeze-dried (AEC/BC02)
The safety, tolerability and immunogenicity of lyophilized recombinant tuberculosis vaccine (AEC/BC02) were studied in a randomized, blind, controlled phase ⅱ A clinical study in patients 18 years and older with latent infection…
- Trial name
- NCT05284812
- Testing
- Low-dose freeze-dried recombinant tuberculosis vaccine (AEC / BC02), High-dose freeze-dried recombinant tuberculosis vaccine (AEC / BC02), High-dose adjuvant for freeze-dried recombinant tuberculosis vaccine (AEC / BC02)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.
Doxycycline STI PEP
Doxycycline PEP and 4CMenB as a Comprehensive Prevention Strategy in MSM and TGW at High Risk for Bacterial STIs Within the Swiss HIV Cohort Study
The study aims at assessing effectiveness of offering event-driven Doxy PEP and 4CMenB immunization in MSM/TGW at high STI risk.
- Trial name
- DOXY-MEN (NCT06242730)
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University of Zurich
Pneumonia, Pneumonia - Bacterial
Derivation and Validation of the Risk Evaluation Score for Pneumonia Involving Resistant Entities (RESPIRE)
This is a single-center, non-profit observational study with two sequential phases: an initial retrospective phase followed by a prospective phase. Patients were enrolled during two consecutive, non-overlapping periods.
- Conditions
- Pneumonia, Pneumonia - Bacterial, Multi Drug Resistant, Multi Drug Resistant Organisms
- Trial name
- RESPIRE (NCT07425561)
- Testing
- RESPIRE score
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Influenza Like Illness, Asthma
How Does the Clinical Tool 'What's Going Around' Affect Clinical Practice
Previous work has shown that the epidemiological context of a patient's presentation can provide important information for clinicians to aid in diagnosis and treatment.
- Conditions
- Influenza Like Illness, Asthma, Group A Streptococcal Infection, Pertussis
- Trial name
- WGA (NCT01979588)
- Testing
- What's Going Around tool, Control
- Where
- United States
- Volunteers
- 206,703 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Drug Safety
Ertapenem Versus Meropenem/Imipenem for ESBL+ Gram-negative Infections
Adult patients with ESBL-producing Gram negative infections are randomized to receive ertapenem or meropenem/imipenem. Clinical and microbiological responses between both groups are compared.
- Trial name
- NCT01297842
- Testing
- Ertapenem, Meropenem or Imipenem
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Mahidol University
Urinary Tract Infection, Cellulitis
Clinical Efficacy of Stopping Oral Antibiotics When Symptoms Stop, Compared to 'Finishing the Course'
The aim of the StopStop@HITH study is to see if stopping antibiotics when symptoms stop is as good as finishing the course of antibiotics.
- Conditions
- Urinary Tract Infection, Cellulitis, Respiratory Tract Infections, Lymphadenitis
- Trial name
- StopStop@HITH (NCT07532941)
- Testing
- Antibiotics for duration of symptoms, Antibiotics for duration of prescribed course
- Where
- Australia
- Volunteers
- 200 people
- Sponsor
- Murdoch Childrens Research Institute
Otitis Media
Vaccination for Middle Ear Infection
Acute otitis media (OM) and OM with effusion are common childhood diseases. Otitis media is a condition marked by inflammation of the middle ear.
- Trial name
- NCT00001605
- Testing
- Nontypeable Haemophilus influenzae
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Infections, Bacterial
Gram-negative Bacilli and MRSA Screening in ICU in China
Carbapenem-resistant Gram-negative bacilli [Carbapenem-resistant Acinetobacter baumannii (CRAB), Carbapenem-resistant Klebsiella pneumoniae (CRKP), and Carbapenem-resistant Pseudomonas aeruginosa (CRPsA) ] and…
- Trial name
- NCT04310722
- Testing
- None intervention. This is an observational study.
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sir Run Run Shaw Hospital
Urinary Tract Infections
A Study in Pediatric Participants Aged ≥2 to <12 Years With a Suspected or Confirmed Bacterial Infection or Receiving Prophylaxis Antibiotics
The study will be conducted to evaluate how a single oral dose of Gepotidacin is processed in the body over time along with safety monitoring in hospitalized pediatric participants who are receiving a standard of care treatment…
- Trial name
- NCT07371429
- Testing
- Gepotidacin, SOC
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- GlaxoSmithKline
Congenital Syphilis
Congenital Syphilis in Switzerland
A retrospective national epidemiological Swiss study was conducted to establish a real prevalence and description of congenital syphilis, and to better classify the reported congenital syphilis.
- Trial name
- NCT05975502
- Testing
- Epidemiological study
- Where
- Switzerland
- Volunteers
- 265 people
- Sponsor
- University Hospital, Geneva
Staphylococcus Aureus, Methicillin-resistant Staphylococcus Aureus
Volatile Organic Compounds in Staphylococcus Aureus Patients
The zNose® MRSA test is a non-invasive breath test for markers of Staphylococcus aureus, which may predict the probability of bacterial organisms in the anterior nares, throat and respiratory tract, wounds, and anus and therefore…
- Conditions
- Staphylococcus Aureus, Methicillin-resistant Staphylococcus Aureus, Nosocomial Disease
- Trial name
- MRSAVOC (NCT01379053)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Landon Pediatric Foundation
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