Clinical trials: Bacterial Infections
Bacterial Vaginosis and Vaginal Candidiasis At Pregnancy
Oral Probiotics for the Treatment and Prevention of Vulvovaginal Infections in Pregnancy - Double-blind, Randomized, Placebo-controlled Study
During pregnancy, bacterial vaginosis (BV), abnormal vaginal flora (AVF) and vulvovaginal candidiasis (VVC) are associated with serious complications and discomfort. Yet, treatment options are limited.
- Trial name
- NCT02795845
- Testing
- Probiotic Capsule containing L. acidophilus, L. Paracasei, L. Rhamnosus, streptococcus thermophilus and Bifidobacterium bifidum
- Where
- 3 sites in Israel
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Gonorrhea
New AntiBiotic Treatment Options for Uncomplicated Anogenital GOnorrhoea
This study evaluates the efficacy of three experimental antibiotics in the treatment of uncomplicated anogenital gonorrhoea. Participants will be randomized to one of four study arms and will receive either one of the three…
- Trial name
- NABOGO (NCT03294395)
- Testing
- Ertapenem 1000 MG, Fosfomycin Oral Suspension, Gentamicin Sulfate, Injectable
- Where
- Netherlands
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- Public Health Service of Amsterdam
Lyme Disease, Borrelia Infection
Persistent Lyme Empiric Antibiotic Study Europe
The purpose of the study is to establish whether prolonged antibiotic treatment of patients diagnosed with proven or presumed PLD (as endorsed by the international ILADS guidelines) leads to better patient outcome than short-term…
- Trial name
- PLEASE (NCT01207739)
- Testing
- Doxycycline, Clarithromycin and hydroxychloroquine
- Where
- 2 sites in Netherlands
- Volunteers
- 280 people
- Sponsor
- Radboud University Medical Center
Bacteremia, Antimicrobial Stewardship
Knowledge Attitude and Practice Regarding Bloodstream Bacterial Infections and Antibiotics Usage Among Doctors.
This study is designed to use a questionnaire to assess doctors' knowledge, attitudes, and practices regarding bloodstream bacterial infections and antibiotic use in Tawam and Al Ain tertiary Hospitals (both hospitals have the…
- Conditions
- Bacteremia, Antimicrobial Stewardship, Antibiotic Use, Antibiotic Abuse
- Trial name
- NCT06605677
- Testing
- Questionnaire
- Where
- United Arab Emirates
- Volunteers
- 100 people
- Sponsor
- Abu Dhabi Health Services Company
Plague
One Year Study to Evaluate Three Different Adjuvanted Doses of the Recombinant Plague Vaccine (rF1 and rV Antigens)
One hundred and five subjects will be recruited into three groups. Each subject will receive two doses of recombinant plague vaccine at one of three dose levels (rF1 and rV recombinant antigen proteins).
- Trial name
- NCT00246467
- Testing
- Alhydrogel, rF1 and rV protein antigens
- Where
- 10 sites in United States, United Kingdom
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- PharmAthene UK Limited
Hidradenitis Suppurativa (HS)
Efficacy and Safety Study of Adalimumab in Treatment of Hidradenitis Suppurativa
A study to evaluate the safety and efficacy of treatment with adalimumab in adults with moderate to severe hidradenitis suppurativa (HS).
- Trial name
- PIONEER I (NCT01468207)
- Testing
- adalimumab
- Volunteers
- 307 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Infective Endocarditis, Endocarditis, Bacterial
Combined Rehabilitation and Nutritional Support vs. Standard Care in In-Hospital Endocarditis Treatment
Infective endocarditis (IE) is associated with high morbidity and mortality. Patients with IE are affected by a lengthy hospitalization, leading to physical deconditioning and a rapid decline in physical fitness, muscle mass and…
- Conditions
- Infective Endocarditis, Endocarditis, Bacterial, Infection; Heart, Bacteremia
- Trial name
- ENDOCARE (NCT06563609)
- Testing
- Intensive physical Therapy, Probiotic treatment, Individualised Nutritional Support
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Johannes Grand
Infectious Disease
Reduction of Staph Aureus Carriage by Non-Antibiotic NOZIN® Nasal Sanitizer® Antiseptic
The purpose of this study is to determine the extent to which bacterial growth in the nostrils by S. aureus, a common bacteria that is found in hospital environment, can be reduced by NOZIN® Nasal Sanitizer® antiseptic nasal…
- Trial name
- NCT01861457
- Testing
- Nozin® Nasal Sanitizer®
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Relapsing Fever, Tick-Borne
Postexposure Prophylaxis With Single Dose Doxycycline for the Prevention of Tick-borne Relapsing Fever
The goal of this clinical trial is to compare standard treatment (5 days of doxycycline) vs single dose doxycycline for the prevention of tick-borne relapsing fever in soldiers who found bite marks on their bodies after an…
- Trial name
- NCT06045481
- Testing
- administration of single dose of doxycycline
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Tinea Corporis
An Open Label Pharmacokinetic Study of Naftin for Tinea Corporis
This is an open label, multi-center, multi-application pharmacokinetic study in pediatric subjects with tinea corporis.
- Trial name
- NCT02466867
- Testing
- Naftin® Cream, 2% (younger pediatric cohort), Naftin® Cream, 2% (older pediatric cohort)
- Where
- 3 sites in United States, Dominican Republic and 1 more
- Volunteers
- 27 people
- Sponsor
- Merz North America, Inc.
Bacterial Endocarditis, Bacteremia
Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus
The purpose of this study is to compare the safety and efficacy of daptomycin, an antibiotic, to standard therapy in subjects who have infective endocarditis or bacteremia due to Staphylococcus aureus (S. aureus).
- Trial name
- NCT00093067
- Testing
- daptomycin
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Clostridium Difficile Infection
IMT for Primary Clostridium Difficile Infection
This is a randomized controlled trial to compare the effect of a 10-day course of per oral metronidazole versus a one-time rectal instillation of an anaerobically cultivated human intestinal microbiota for the treatment of a…
- Trial name
- NCT02301000
- Testing
- Intestinal microbiota therapy, Metronidazole
- Where
- 7 sites in Norway
- Volunteers
- 21 people
- Sponsor
- Oslo University Hospital
Lung Tuberculosis, MDR TB
Tuberculosis Research of INA-RESPOND On Drug Resistance
This study is a prospective observational cohort study of TB patients who are treated or evaluated at 10 study sites. Patients presenting with cough for 2 weeks or longer with at least one additional TB symptom and a chest X-ray…
- Trial name
- TRIPOD (NCT02758236)
- Testing
- No Intervention
- Where
- 7 sites in Indonesia
- Volunteers
- 490 people
- Sponsor
- Ina-Respond
Haemophilus Influenzae Type b, Neisseria Meningitidis
Comparison of GSKBiologicals' Hib-MenCY-TT Vaccine vs Licensed Hib Conjugate or Meningococcal Vaccine
This study is evaluating the safety and immunogenicity of GSK Biologicals' Hib-MenCY-TT vaccine compared to a control group receiving licensed Hib conjugate vaccine, each administered at 2, 4, and 6 months of age, and compared to…
- Trial name
- NCT00129129
- Testing
- GSK Biologicals' Haemophilus influenza type b and Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine 792014 vaccine, ActHIB, Pediarix
- Where
- 27 sites in United States
- Volunteers
- 756 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chlamydia Trachomatis Infection, Neisseria Gonorrheae Infection
Clinical Evaluation of the ID NOW™ CT/NG Test
The objective of this study is to determine the performance of the ID NOW™ CT/NG test in male urine, female urine, and self-collected vaginal swabs when tested by intended users (i.e., untrained operators).
- Conditions
- Chlamydia Trachomatis Infection, Neisseria Gonorrheae Infection, Asymptomatic Condition
- Trial name
- NCT06395675
- Testing
- ID NOW™
- Where
- United States
- Volunteers
- 7,100 people, healthy volunteers welcome
- Sponsor
- Abbott Rapid Dx
Acute Bacterial Skin and Skin Structure Infections
Comparative Study of NXL103 Versus Linezolid in Adults With Acute Bacterial Skin and Skin Structure Infections (ABSSSI)
The objective of this study is to evaluate the efficacy and safety of oral NXL103 vs. established treatment of acute bacterial infection in adults.
- Trial name
- NCT00949130
- Testing
- NXL103, Linezolid
- Where
- 15 sites in United States, Guatemala
- Volunteers
- 180 people
- Sponsor
- Novexel Inc
Inflammation, Bacterial Infections
Sub-Tenon's Injection of Triamcinolone and Ciprofloxacin in a Controlled-Release System for Cataract Surgery
The purpose of this study is to compare one intraoperative sub-Tenon's capsule injection of triamcinolone and ciprofloxacin in a biodegradable controlled-release system with conventional prednisolone and ciprofloxacin eye drops…
- Trial name
- NCT00431028
- Testing
- slow delivery ciprofloxacin + triamcinolone
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- Federal University of São Paulo
Pneumonia - Bacterial, Pseudomonas Aeruginosa Infection
MP101 in Adults With Acute Pseudomonas Aeruginosa Pneumonia
The purpose of this study is to evaluate the safety and tolerability of a single intravenous dose of MP101 administered in addition to standard antibiotic therapy in adult patients with acute Pseudomonas aeruginosa pneumonia.
- Trial name
- MP101-1001 (NCT07492771)
- Testing
- MP101, Antibiotics
- Where
- South Korea
- Volunteers
- 18 people
- Sponsor
- MicrobiotiX Co., Ltd
Onychomycosis
Cumulative Irritation Test
The purpose of this study is to determine the cumulative irritation potential of the products listed by the Sponsor.
- Trial name
- NCT00680095
- Testing
- AN2690, AN2690 Solution, Vehicle, Sodium Lauryl Sulfate, 0.5%
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Pfizer
Candidiasis, Oral, HIV Infections
Comparative Randomized Study of the Efficacy, Safety, and Toleration of Fluconazole Oral Suspension or Nystatin Oral Suspension in the Treatment of Patients With Oropharyngeal Candidiasis in Association With the Acquired Immunodeficiency Syndrome
To compare the efficacy, safety, and toleration of fluconazole as a single daily oral suspension for 14 days versus nystatin oral suspension 4 times daily for 14 days in the treatment of oropharyngeal candidiasis in patients with…
- Trial name
- NCT00002112
- Testing
- Nystatin, Fluconazole
- Where
- 5 sites in United States
- Sponsor
- Pfizer