Clinical trials: Bacterial Keratitis
Bacterial Keratitis, Fungal Keratitis
Safety and Efficacity of Corneal Collagen Crosslinking in Infectious Keratitis (Bacterial and Fungal ): Randomized,Controlled, Prospective Study. (CXL)
The corneal collagen cross linking is currently used in the treatment of keratoconus but this procedure has also a sterilizing non-specific effect on bacteria and fungus.
- Trial name
- CXL (NCT02088970)
- Testing
- Crosslinking, antibiotic treatment
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Nantes University Hospital
Keratoconus, Unstable, Bacterial Keratitis
Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking
To determine whether the Peschke PXL-330 system is safe and effective in the treatment of corneal thinning conditions.
- Conditions
- Keratoconus, Unstable, Bacterial Keratitis, Ectasia of Cornea
- Trial name
- NCT03918408
- Testing
- PXL-330 Platinum device for crosslinking with Peschke ribofflavin solution
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Pacific Clear Vision Institute
Keratitis; Infectious Disease (Manifestation)
Pseudomonal Type Three Secretion System and Contact Lens Associated Microbial Keratitis
Microbial infection of the cornea, also known as microbial keratitis, causes severe corneal inflammation that could result in permanent visual loss.
- Trial name
- NCT01925846
- Where
- Taiwan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Fungal Keratitis
Therapeutic Exploratory Study of Comparing Natamycin and Voriconazole to Treat Fungal Corneal Ulcer
We evaluated whether voriconazole is a superior treatment to natamycin for filamentous fungal keratitis in a randomized, masked, controlled trial.
- Trial name
- MUTT_TE (NCT00557362)
- Testing
- Natamycin 5%, Voriconazole, Corneal de-epithelialization
- Where
- 2 sites in India
- Volunteers
- 120 people
- Sponsor
- University of California, San Francisco
Bacterial Keratitis
Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction II
Rose Bengal Electromagnetic Activation with Green light for Infection Reduction II (REAGIR II) is a randomized, double-masked feasibility study.
- Trial name
- REAGIR II (NCT06271772)
- Testing
- Difluprednate Ophthalmic, Rose Bengal, Moxifloxacin Ophthalmic
- Where
- 2 sites in Brazil, India
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Bacterial Keratitis
Besifloxacin in Bacterial Keratitis
This is a study comparing a new treatment for bacterial keratitis (also known as corneal ulcers) with the current standard of care.
- Trial name
- NCT02497365
- Testing
- Besifloxacin, Tobramycin and Cefazolin
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Corneal Ulcer, Eye Infections, Fungal
The Mycotic Ulcer Treatment Trial II: A Randomized Trial Comparing Oral Voriconazole vs Placebo
The purpose of this study is to determine if the addition of oral voriconazole to topical treatment regimens results in lower rates of perforation in severe fungal corneal ulcers.
- Trial name
- MUTTII (NCT00997035)
- Testing
- Voriconazole
- Where
- 7 sites in United States, India and 1 more
- Volunteers
- 240 people
- Sponsor
- University of California, San Francisco
Corneal Ulcer, Fusarium Infection
Fusarium Keratitits in Spain 2012 to 2014
The aim of this study was to describe the clinical-epidemiological characteristics of a series of cases of fungal keratitis associated with Fusarium spp., In Spain during the years 2012 to 2014.
- Trial name
- NCT02984904
- Testing
- survey
- Volunteers
- 23 people
- Sponsor
- Miguel Armando Mosquera Gordillo, MD
Bacterial Keratitis
Prospective, Randomized Multi-Center Study of Using the Hyper-CL™ Lens in Subjects Suffering From Bacterial Keratitis
This study is a prospective, randomized, open-label, two arms, clinical study aim to evaluate the efficacy and safety of treatment with Hyper-CL™ lens + Antibiotics compared with treatment with Antibiotics only, in subjects with…
- Trial name
- NCT03845374
- Testing
- Hyper-CL™ lens
- Where
- 2 sites in Israel
- Volunteers
- 12 people
- Sponsor
- Eye-yon Medical
Bacterial Keratitis, Recalcitrant Infectious Keratitis
Intrastromal Moxifloxacin as an Adjunctive Therapy in Recalcitrant Bacterial Keratitis
Bacterial keratitis is a potentially sight-threatening corneal infection that is commonly treated with intensive topical antibiotics.
- Conditions
- Bacterial Keratitis, Recalcitrant Infectious Keratitis, Corneal Ulcer
- Trial name
- NCT07394257
- Testing
- Intrastromal moxifloxacin injection plus standard topical moxifloxacin therapy, Standard topical moxifloxacin therapy alone
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Corneal Opacity
Comparison of Ultrasonic Pachymetry With Orbscan in Corneal Haze
This study is planned to compare the results of ultrasonic and Orbscan pachymetry in corneal haze not related to surgery. Corneal haze is graded with slit-lamp by a single examiner.
- Trial name
- NCT00439114
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Baskent University
Infected Corneal Ulcers, Bacterial Keratitis
A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers
Bacterial corneal ulcers are a leading cause of pediatric blindness in underdeveloped countries due to a lack of antibiotic availability and affordability, among other reasons.
- Conditions
- Infected Corneal Ulcers, Bacterial Keratitis, Corneal Ulcer, Childhood Blindness
- Trial name
- NCT00386958
- Testing
- Povidone-Iodine
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Bacterial Keratitis, Antibiotic-resistant Bacteria
Novel Antisense Oligonucleotide Eye Drops for Treating Antibiotic-Resistant Bacterial Keratitis
The purpose of this study is to evaluate the safety and efficacy of GP-asPNA for in vivo treatment of severe antibiotic resistant bacterial keratitis.
- Conditions
- Bacterial Keratitis, Antibiotic-resistant Bacteria, Infections, Bacterial, Corneal Diseases
- Trial name
- ASOTARI (NCT06451172)
- Testing
- ASO
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Bacterial Keratitis, Fungal Keratitis
The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study
This study is an observational prospective cohort study which aims to generate an antibiogram and to assess the clinical responses and outcomes of microbial keratitis patients, treated with empiric topical antimicrobial…
- Conditions
- Bacterial Keratitis, Fungal Keratitis, Mixed Bacterial and Fungal Keratitis, Microbial Keratitis
- Trial name
- NCT05655689
- Testing
- Moxifloxacin Ophthalmic 0.5% Ophthalmic Solution, Ceftazidime 5% + vancomycin 5%, Gentamicin 1.4% + vancomycin 5%
- Where
- Egypt
- Volunteers
- 123 people
- Sponsor
- Alexandria University
Infection, Fungal
Combination Treatment of 5% Natamycin and 1% Voriconazole in Fungal Keratitis
OBJECTIVE To evaluate the efficacy and safety of the concurrent treatment of 5% Natamycin and 1% Voriconazole in patients affected by fungal keratitis METHODS AND MATERIALS STUDY POPULATION Patients with smear and or culture…
- Trial name
- NATA_VORI (NCT03230058)
- Testing
- Group 1 Natamycin 5% Suspension + voriconazole 1% eye drops; Group 2 Natamycin 5% Suspension + Vehicle eye drops
- Where
- India
- Volunteers
- 55 people
- Sponsor
- L.V. Prasad Eye Institute
Acute Bacterial Corneal Ulcers, Bacterial Keratitis
Safety and Efficacy Study of Gatifloxacin Compared With Ciprofloxacin in Patients With Acute Bacterial Corneal Ulcers
This study evaluates the safety and efficacy of gatifloxacin 0.3% ophthalmic solution compared with ciprofloxacin 0.3% ophthalmic solution in patients with acute bacterial corneal ulcers
- Trial name
- NCT00651586
- Testing
- Gatifloxacin 0.3% ophthalmic solution, Ciprofloxacin 0.3% ophthalmic solution
- Where
- 2 sites in United States, India
- Volunteers
- 129 people
- Sponsor
- Allergan
Corneal Ulcer
Studying the Relationship Between Contact Lens Packaging Solutions and Bacterial Binding to Surface Eye Cells
The goal of this study is to investigate the overall theory that the use of chemically preserved solutions associated with contact lenses promotes an increase in bacterial infection.
- Trial name
- NCT01104961
- Testing
- Contact lens packaging solution, Balanced salt solution (BSS)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center