Clinical trials: Bacterial Vaginoses
Vaginal Health
Garden of Life Once Daily Women's Probiotic: Vaginal pH and Quality of Life Study
This decentralized observational study is designed to understand the effects of daily consumption of once daily woman's probiotic (ODWP) on vaginal pH levels in healthy female populations ages 19-70 years of age across the United…
- Trial name
- NCT05330091
- Testing
- Once Daily Women's Probiotic
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Garden of Life, LLC
Bacterial Vaginosis
A Randomised, Partly-blinded Investigation to Evaluate the Clinical Performance and Safety of pHyph in Adult Women With Bacterial Vaginosis Compared With an Untreated Control Group
This is a randomised, parallel group, partly blinded investigation to evaluate the clinical performance and safety of pHyph in adult women with bacterial vaginosis.
- Trial name
- Nefertiti 2 (NCT06123299)
- Testing
- pHyph
- Where
- 5 sites in Sweden
- Volunteers
- 61 people
- Sponsor
- Gedea Biotech AB
Bacterial Vaginosis
Treatment Comparison of Antibiotics Versus Vaginal Lactic Acid in Non-pregnant Women With Acute Symptomatic Bacterial Vaginosis
Bacterial vaginosis (BV) is the most common cause of vaginitis in women of childbearing age. Women with symptomatic BV may present with malodorous discharge that is off-white, thin, and homogenous and has a fishy smell especially…
- Trial name
- NCT02042287
- Testing
- Vaginal lactic acid and glycogen gel, Metronidazole
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Bacterial Vaginosis
Prevention of Persistence of Bacterial Vaginosis
This purpose of this study will be to conduct a double-blind, randomized, controlled clinical trial to determine the association between intravaginal high dose metronidazole (750mg), intravaginal high dose metronidazole combined…
- Trial name
- NCT00741845
- Testing
- intravaginal metronidazole
- Where
- Peru
- Volunteers
- 117 people
- Sponsor
- Embil Pharmaceutical Co. Ltd
Bacterial Vaginoses
Multi-Gyn ActiGel Plus for Treatment of Bacterial Vaginosis
This is a randomized, double-blind, placebo-controlled clinical investigation. The objective of the study is to confirm the efficacy of Multi-Gyn ActiGel Plus to treat BV as compared to a placebo control.
- Trial name
- NCT04807842
- Testing
- vaginal gel
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- BioClin BV
Vaginosis, Bacterial
Diagnosing Bacterial Vaginosis/Vaginitis (BV) Using the Gynecologene Test Method
This study is designed as a prospective evaluation of the diagnostic performance of the multiplex nucleic acid-based genetic test (Gynecologene Next-Generation Sequencing test) to identify known significant causative organisms in…
- Trial name
- SAGE (NCT02558179)
- Where
- 4 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- American International Biotechnology
Vaginitis
Management of Vaginal Complaints: A Pilot Study Within a Practice-Based Research Network
Many women present in primary care with vaginal complaints. The best way of managing these complaints is unclear. This trial will test two different methods of managing patients with vaginal complaints. This is a pilot trial.
- Trial name
- VCAT (NCT00503542)
- Testing
- Terazol or oral fluconazole for candidal vaginitis, Metronidazole or Clindamycin for Bacterial Vaginosis, Flagyl for definitively diagnosed vaginal trichomoniasis
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Agency for Healthcare Research and Quality (AHRQ)
Bacterial Vaginosis, Vaginal Candidiasis
Multi-Gyn FemiTotal for the Treatment and Prevention of Vulvovaginal Candidiasis Symptoms and Bacterial Vaginosis
The goal of this clinical trial is to assess the safety and efficacy of Multi-Gyn Femitotal to treat and prevent women suffering from bacterial vaginosis and vulvo vaginal candidiasis.
- Trial name
- NCT07234786
- Testing
- Multi-Gyn FemiTotal
- Where
- Mauritius
- Volunteers
- 80 people
- Sponsor
- Karo Pharma AB
Pregnancy, Bacterial Vaginosis
Bacterial Vaginosis in Pregnancy: Detection by Weekly Vaginal pH Testing
Interventional study to assess the effect of early detection and treatment of bacterial vaginosis in pregnancy on preterm delivery rate.
- Conditions
- Pregnancy, Bacterial Vaginosis, Preterm Delivery
- Trial name
- NCT00799500
- Testing
- Screening
- Where
- Spain
- Volunteers
- 1,049 people, healthy volunteers welcome
- Sponsor
- Montse Palacio
Bacterial Vaginosis
Recurrent Bacterial Vaginosis and Vaginal Acidifying Gel Trial
Bacterial vaginosis (BV) is a common, complex clinical syndrome characterized by alterations in the normal vaginal flora. Bacterial vaginosis has been associated with a variety of adverse health outcomes including endometritis…
- Trial name
- NCT00545181
- Testing
- Vaginal acidifying gel (RepHresh), Metronidazole control
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Indiana University
Randomized, Open-label
A Randomized, Multicenter, Open-label, Active-controlled Phase Ib Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Multiple Intravaginal Doses of GenSci142 in Patients With Bacterial Vaginosis (BV)
A randomized, multicenter, open-label, active-controlled Phase Ib study to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of multiple intravaginal doses of GenSci142 in patients with bacterial…
- Conditions
- Randomized, Open-label, Safety, Tolerability
- Trial name
- NCT07663838
- Testing
- GenSci142 capsule, clindamycin phosphate vaginal cream
- Where
- 9 sites in China
- Volunteers
- 42 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Vaginal Discharge
Safety and Clinical and Microbiological Efficacy of the Combination of Fluconazole and Secnidazole for the Treatment of Symptomatic Vaginal Discharge
Genital tract infections (GTIs) have increased in the past decade and there is an association between sexually transmitted infections (STIs) and other infections like bacterial vaginosis (BV), with the HIV transmission.
- Trial name
- NCT02111629
- Testing
- Fluconazole and Secnidazole
- Where
- Colombia
- Volunteers
- 118 people
- Sponsor
- Universidad Nacional de Colombia
Bacterial Vaginosis, Candidiasis
Study of the Management of Vaginal Discharge in West African Using Single Dose Treatments
This randomised controlled trial aimed to verify whether directly observed single dose treatment (with tinidazole+fluconazole) would be as effective as the longer standard treatments (metronidazole for 7 days, plus vaginal…
- Conditions
- Bacterial Vaginosis, Candidiasis, Vaginitis
- Trial name
- NCT00313131
- Testing
- tinidazole+fluconazole vs metronidazole+clotrimazole
- Where
- 7 sites in Ghana, Guinea and 1 more
- Volunteers
- 1,524 people
- Sponsor
- Université de Sherbrooke
Vulvovaginal Candidiasis, Bacterial Vaginosis
Study of the Microbiota, Metabolome, and Environmental Toxins in Relation to Reproductive Health in Rwandan Women
The overall objective of this clinical pilot study is to determine at a random sampling time, the vaginal microbiome and metabolome of pregnant women, and to see if infection (bacterial vaginosis, vulvovaginal candidiasis…
- Trial name
- RVMM (NCT02150655)
- Testing
- Lactobacillus GR-1 and Lactobacillus RC-14 oral capsules
- Where
- Rwanda
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
STI
Comparing a Novel Point-of-care Cytokine Biomarker Lateral Flow Test With Nucleic Acid Amplification Tests for Detection of Sexually Transmitted Infections and Bacterial Vaginosis
1. To evaluate the performance of a lateral flow POC test, namely the Genital InFlammation Test (GIFT), for identifying women with inflammatory STIs and BV, who are at higher risk of HIV infection and reproductive complications…
- Trial name
- GIFT (NCT05723484)
- Testing
- GIFT Device
- Where
- 3 sites in Madagascar, South Africa and 1 more
- Volunteers
- 675 people
- Sponsor
- University of Cape Town
Bacterial Vaginosis
Effect of a Yoghurt Containing Four Probiotic Lactobacillus Strains on Bacterial Vaginosis
The aim of this study is, to investigate, whether the consumption of a probiotic yoghurt containing 4 probiotic strains naturally colonizing the vagina (L. crispatus, L. gasseri, L. rhamnosus, L.
- Trial name
- NCT02744638
- Testing
- probiotic yoghurt, chemically acidified milk, Arilin
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- Clinical Research Center Kiel GmbH
Bacterial Vaginosis, Microbial Colonization
The Genital Microbiome of Male Partners of Women With Recurrent BV Undergoing Vaginal Microbiome Transplantation
There is strong observational evidence that sexual activity plays a key role in Bacterial Vaginosis (BV) acquisition and recurrence.
- Trial name
- NCT05963711
- Testing
- chlorhexidine gluconate 4%
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Recurrent Bacterial Vaginosis (BV)
MOTIF@FRESH: Modifying Organisms Transvaginally in Females @ FRESH
The MOTIF@ FRESH trial will assess the safety and efficacy of "vaginal microbiome transplantation" (VMT). Healthy females will be enrolled to donate vaginal fluid which will be processed and transplanted in females with a history…
- Trial name
- MOTIF@FRESH (NCT07566754)
- Testing
- Vaginal Microbiome Transplantation (VMT), oral metronidazole, Sterile saline solution
- Where
- South Africa
- Volunteers
- 75 people
- Sponsor
- Douglas Kwon
Bacterial Vaginosis
Role of Oral Lactobacilli on Vaginal Flora of Pregnant Women
Bacterial vaginosis (BV) occurs in about 20% of pregnancies and responsible for up to 25% of visits to gynecological clinics. BV is characterized by a shift in vaginal bacterial flora from lactobacilli to pathogenic bacterial…
- Trial name
- NCT04638257
- Testing
- Lactobacilli rhamnosus GR-1 and Lactobacilli fermentum RC-14
- Volunteers
- 49 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Bacterial Vaginosis
Title of the Protocol: Combined Use of Vaginal Clindamycin Cream and Oral Metronidazole Versus Oral Metronidazole
Bacterial vaginosis (BV) constitutes a gynecological condition characterized by an alteration of the vaginal microenvironment and more specifically an alteration of the normal Lactobacillus-dominated vaginal flora, to a flora…
- Trial name
- NCT07247851
- Testing
- Clindamycin Phosphate
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams Maternity Hospital