Clinical trials: Bacterial Vaginosis
Bacterial Vaginosis
Open-Label Study to Evaluate Safety of A Single Dose of SYM-1219
This is a Phase 3, multi-center, prospective, open-label study to evaluate the safety of SYM-1219 granules containing 2 grams of secnidazole in women and postmenarchal adolescent girls with bacterial vaginosis.
- Trial name
- NCT02452866
- Testing
- SYM-1219
- Where
- 40 sites in United States
- Volunteers
- 325 people
- Sponsor
- Symbiomix Therapeutics
Infection, Bacterial, Infection, Fungal
Point-of-care Tests for Bacterial Vaginosis and Candidosis
Vaginal infection in early pregnancy is associated with an increased risk of spontaneous preterm delivery and late miscarriage. Most studies presume that vaginal infections are responsible for up to 40% of preterm birth.
- Conditions
- Infection, Bacterial, Infection, Fungal, Preterm Birth
- Trial name
- NCT04287504
- Testing
- SavvyCheck Vaginal Yeast Test, OSOM BVBLUE Test
- Where
- Austria
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Bacterial Vaginoses
The Temporo-spatial Dynamics of Genital Tract Microbiota - an Observational Study in Oocyte Donors
The investigators aim to examine the endometrium with state of the art sequencing techniques to investigate the endometrial microbiota.
- Trial name
- NCT04393857
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Peter Humaidan
Bacterial Vaginosis, Recurrence
Oral Metronidazole With Lactobacillus Vaginal Suppositories to Prevent Recurrence of Bacterial Vaginosis
We are trying to determine if Oral Metronidazole with Lactobacillus Vaginal Suppositories is better than Oral Metronidazole in Preventing the Recurrence of Bacterial Vaginosis
- Trial name
- NCT03099408
- Testing
- Metronidazole Oral, "Metronidazole" and "Lactobacillus"
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Peking University Shenzhen Hospital
Bacterial Vaginoses
Evaluate the Safety of a Single Oral Dose of Solosec™ (Secnidazole) 2g for the Treatment of Adolescent Girls With BV
A multi-center, open-label study to evaluate the treatment of one oral dose of 2g Solosec™ (Secnidazole) in adolescent girls with BV
- Trial name
- NCT03937869
- Testing
- Secnidazole
- Where
- 9 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lupin Research Inc
Bacterial Vaginosis
Role of Oral Lactobacilli on Vaginal Flora of Pregnant Women
Bacterial vaginosis (BV) occurs in about 20% of pregnancies and responsible for up to 25% of visits to gynecological clinics. BV is characterized by a shift in vaginal bacterial flora from lactobacilli to pathogenic bacterial…
- Trial name
- NCT04638257
- Testing
- Lactobacilli rhamnosus GR-1 and Lactobacilli fermentum RC-14
- Volunteers
- 49 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Bacterial Vaginosis
A Phase 2 Study of SYM-1219 to Treat Bacterial Vaginosis
The purpose of this research study is to test the safety and effectiveness of the oral investigational new drug, SYM-1219, for the treatment of bacterial vaginosis.
- Trial name
- NCT02147899
- Testing
- SYM-1219
- Where
- 16 sites in United States
- Volunteers
- 215 people
- Sponsor
- Symbiomix Therapeutics
Non Specific Vaginitis
Use of Vagitories Based on St. John's Wort, Tea Tree Oil and Shepherd's Purse in the Treatment of Vaginal Inflammation
There are more and more herbal preparations that are used for the purpose of treatment and improvement of the clinical picture of vaginitis by patients themselves, but also by healthcare professionals. Plant species, St.
- Trial name
- NCT04558697
- Testing
- Shepherd's Purse extractum oleosum vagitories, Tea tree oil vagitories, Hyperici extractum oleosum vagitories
- Where
- Bosnia and Herzegovina
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Sarajevo
Bacterial Vaginosis
Safety Study of Lactobacillus Administered Vaginally to Healthy Women
The purpose of this study is to compare the safety, tolerability, and acceptability of LACTIN-V (Active Ingredient: Lactobacillus crispatus CTV-05) with a matching placebo at three doses using pre-filled vaginal applicators in…
- Trial name
- NCT00537576
- Testing
- Low dose LACTIN-V applicator, Medium dose LACTIN-V applicator, High dose LACTIN-V applicator
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Osel, Inc.
Vaginitis Gardnerella
Treatment of Gardnerella Vaginalis Vaginal Colonization With Amoxicillin
This is a randomized, double-blind, placebo-controlled Phase 2 study designed to determine if amoxicillin will eradicate vaginal colonization/infection with Gardnerella vaginalis (GV) when administered to women who are…
- Trial name
- NCT03211156
- Testing
- Amoxicillin
- Where
- 2 sites in United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Recurrent Bacterial Vaginosis
Randomized Controlled Trial of Treatment of Male Partners of Women With BV
Male partners of womoen with recurrent bacteria vaginosis are randomized to treatment with metronidazole or placebo to compare the rates of recurrent BV in the women
- Trial name
- NCT02209519
- Testing
- Metronidazole (male partner), Placeob (male partner)
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- University of Alabama at Birmingham
Bacterial Vaginosis
Trial of Trimosan Gel Effect on Pessary-associated Bacterial Vaginosis
The primary objective of this prospective, randomized, controlled study is to assess the effect of Trimo-San vaginal gel on the rate of bacterial vaginosis in women who use pessaries.
- Trial name
- TBVAP (NCT01471457)
- Testing
- Trimo-San gel
- Where
- 2 sites in United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Bacterial Vaginoses
Effects of Lactobacillus Pentosus KCA1 on the Gut and Vaginal Microbiome of Women With Bacterial Vaginosis
Bacterial vaginosis (BV) is under-reported, misdiagnosed and inappropriately treated in Nigeria. Treatment option rely on antibiotics that eliminates both good and pathogenic bacteria, with gross impact on the gut and vaginal…
- Trial name
- NCT04329338
- Testing
- Lactobacillus pentosus KCA1
- Where
- Nigeria
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Nnamdi Azikiwe University
Bacterial Vaginosis, HIV
The Effect of Norethisterone Enanthate on Recurrent Bacterial Vaginosis
The proposed study, Hormonal Contraception \& BV (HCBV), will investigate the effect of NET-EN and DMPA on recurrent BV, vaginal microbiota and inflammatory markers among women at high risk for HIV in Kampala, Uganda.
- Trial name
- HCBV (NCT02905890)
- Testing
- Norethisterone enantate, Condoms
- Where
- Uganda
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Bacterial Vaginosis
LACTIN-V Study for Recurrent Bacterial Vaginosis
This Phase 2b trial is designed to provide a screening evaluation for the hypothesis that, following a 5-day treatment with MetroGel® to treat BV, L.
- Trial name
- NCT02766023
- Testing
- Lactobacillus crispatus CTV-05, Metronidazole
- Where
- 4 sites in United States
- Volunteers
- 228 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bacterial Vaginosis
Bacterial Vaginosis Home Screening to Prevent STDs
The purpose of this study is to determine whether regular screening (every 2 months) and treatment for bacterial vaginosis (BV [infection of the vagina]) will reduce the number of incidences of chlamydia and gonorrhea (sexually…
- Trial name
- NCT00667368
- Testing
- Metronidazole
- Where
- 7 sites in United States
- Volunteers
- 1,370 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bacterial Vaginosis
Analysis of Ameliorative Effects of Oral Probiotics on Bacterial Vaginosis
The purpose of this study is to analyze the ameliorative effects of oral probiotics on bacterial vaginosis.
- Trial name
- NCT03116789
- Testing
- probiotics
- Where
- Taiwan
- Volunteers
- 43 people
- Sponsor
- GenMont Biotech Incorporation
Trichomonal Vaginitis, Bacterial Vaginosis
Evaluation of Efficacy and Safety of Gynomax® XL Ovule
Efficacy and safety of Gynomax® XL ovule in the treatment of trichomonal vaginitis, bacterial vaginosis, candidal vulvovaginitis and mixed vaginal infections will be evaluated in this open label, single-arm, multicentral study.
- Conditions
- Trichomonal Vaginitis, Bacterial Vaginosis, Candidal Vulvovaginitis, Mixed Vaginal Infections
- Trial name
- Gyno-Türk (NCT03839875)
- Testing
- Gynomax® XL Vaginal Ovule
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people
- Sponsor
- Exeltis Turkey
BACTERIAL VAGINOSIS, Signs and Symptoms to be Evaluated and Recorded Include
A Multi-center, Double-blind, Randomized Study, Comparing Clindamycin Phosphate Vaginal Cream 2% (Watson Laboratories, Inc.) to Clindesse® (Ther-Rx™, Clindamyin Phosphate Vaginal Cream 2%) and Both Active Treatments to a Placebo Control in the Treatment of Bacterial Vaginosis in Non-pregnant Women
A multi-center, double-blind, randomized, placebo controlled, parallel-group study, comparing Clindamycin phosphate vaginal cream 2% (Watson Laboratories, Inc.) to Clindesse® (Ther-Rx™, Clindamyin Phosphate Vaginal Cream 2%) and…
- Conditions
- BACTERIAL VAGINOSIS, Signs and Symptoms to be Evaluated and Recorded Include, Vaginal Discharge Color, Odor, and Consistency, Vulvovaginal Itching and Irritation (Subjective) Absent, Mild, Moderate, or Severe
- Trial name
- NCT02210689
- Testing
- clindamycin phosphate vaginal cream 2%
- Where
- 18 sites in United States, Dominican Republic and 1 more
- Volunteers
- 604 people
- Sponsor
- Actavis Inc.
Bacterial Vaginosis
Study Evaluating the Equivalence of GDC-229 and Metronidazole Vaginal Gel 0.75% in the Treatment of Bacterial Vaginosis
This research study is being done to compare the safety and efficacy of GDC-229 (test drug) against the currently marketed reference drug (metronidazole 0.75% vaginal gel) and to establish that these two drugs work better than…
- Trial name
- NCT03091777
- Testing
- GDC-229, Metronidazole Vaginal Gel 0.75%
- Where
- United States
- Volunteers
- 871 people
- Sponsor
- Balmoral Medical company