Clinical trials: Balance; Disorder, Fluid
Septic Shock, Fluid Resuscitation
Evolution of Tissue Perfusion and Venous Congestion Markers in Fluid-Responsive Septic Shock Patients
Septic shock remains a leading cause of mortality in intensive care, and while fluid resuscitation (FR) is a cornerstone of early management, its benefit-risk balance is highly variable.
- Conditions
- Septic Shock, Fluid Resuscitation, Congestion, Venous
- Trial name
- FLUID-IMPACT (NCT06958809)
- Testing
- Echography
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospital Ambroise Paré Paris
Fluid Therapy, Postoperative Period
Effects of Restrictive Fluid Strategy on Postoperative Oliguric Pancreatic Surgery Patients
Reduced urinary output is a common postoperative issue for patients going through major surgery such as pancreatic surgery. Commonly this is treated by increasing fluid administration to the patients and sometimes also diuretics.
- Conditions
- Fluid Therapy, Postoperative Period, Postoperative Complications, Pancreas Disease
- Trial name
- NCT03553394
- Testing
- Ringer's Acetate
- Where
- Sweden
- Volunteers
- 53 people
- Sponsor
- Uppsala University
Fluid Retention, Sodium Retention
The Effect of AMP Human Sodium Bicarbonate Lotion on Dehydrated Heat Stress
The primary purpose of the proposed study is to evaluate the effects of a topical sodium bicarbonate lotion (PR Lotion, AMP Human, Park City, UT) on measures of hydration status and fluid balance in humans when exposed to the…
- Conditions
- Fluid Retention, Sodium Retention, Heat Stress, Dehydration (Physiology)
- Trial name
- AMP2 (NCT05092854)
- Testing
- PR Lotion - AMP Human Performance, AminoVital - Rapid Recovery
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Brain Injuries
Comparison of an Isotonic Balanced Fluid, Sterofundin® , With 0.9% Saline in Traumatic Brain Injury(TBI)
The main objective of this study is to compare the clinical outcomes of TBI patients receiving only Sterofundin or 0.9% saline as main fluid therapy.
- Trial name
- FLUID (NCT02866604)
- Testing
- Sterofundin, 0.9% saline
- Where
- Malaysia
- Volunteers
- 160 people
- Sponsor
- University of Malaya
Respiratory Insufficiency Requiring Mechanical Ventilation, Fluid Overload
The Efficient PICU Fluid Care Evaluation
The goal of this clinical trial is to evaluate and prevent fluid overload in critically ill, mechanically ventilated children. The main questions it aims to answer are: 1.
- Conditions
- Respiratory Insufficiency Requiring Mechanical Ventilation, Fluid Overload, Fluid Balance
- Trial name
- LESSER-2 (NCT06644508)
- Testing
- Strict adherence to European guidelines
- Where
- 3 sites in Netherlands
- Volunteers
- 90 people
- Sponsor
- Radboud University Medical Center
Head Trauma
Interest of Using Balanced Fluid for Infusion at the Early Phase of an Acute Cranial Trauma for Limiting Hyperchloremic Acidosis
isotonic NaCl serum is the first intent solution for infusion during the initial phase of reanimation for an acute cranial traumatism.
- Trial name
- IsoTC (NCT00847977)
- Testing
- use of a non balced fluid and of a macromolecular fluid, use of balanced crystalloids fluid and macromolecular fluid
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Nantes University Hospital
Coronary Artery Disease, Anemia
Clinical and Chemical Outcomes Following Cardiac Surgery: The Post-Operative Effects of MUF
It is hypothesized that on-line modified ultrafiltration (MUFF) post-cardiopulmonary bypass will result in improved patient outcomes over the 12-hour post-operative period as compared to control and off-line MUFF.
- Trial name
- MUF (NCT01864395)
- Testing
- Centrifugation Method, Online MUF, Offline MUF
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University of Saskatchewan
ESRD
Calcium Mass Balance and Dialytic Efficiency of a New cITRate-containing and Acetate-free Dialysis flUidS: CITRUS Study
This study aimed to evaluate the effect on the calcium balance of a concentrate with 1 mM citrate and locate the equivalent concentration of calcium (Ca_eq) at a concentration of 3 mM acetate and traditional with 1.5 mM calcium…
- Trial name
- CITRUS (NCT02848937)
- Testing
- Bath with citrate, Bath with citrate and Ca_eq
- Where
- Italy
- Volunteers
- 62 people
- Sponsor
- Azienda Ospedaliera, Ospedale Civile di Legnano
Diabetic Ketoacidosis
Balanced Multi-Electrolyte Solution Versus Saline Trial for Diabetic KetoAcidosis
The goal of this blinded, cluster cross-over, randomised controlled trial is to determine whether fluid therapy with Plasma-Lyte® 148 increases the number of days alive and days out of hospital to day-28 compared to 0.9% sodium…
- Trial name
- BEST-DKA (NCT05752279)
- Testing
- Plasma-Lyte 148, 0.9% sodium chloride
- Where
- 21 sites in Australia
- Volunteers
- 547 people
- Sponsor
- The George Institute
Hemodialysis
Copeptin Concentration Measured in Plasma Samples and Intradialytic Blood Pressure Variation
Vasopressin is a key regulator of water and vascular homeostasis, acting through V2 receptors to control renal water reabsorption and through V1a receptors to influence vascular tone.
- Trial name
- CODIALHYP (NCT07438925)
- Testing
- Routine biology samples et blood pressure mesures
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Central Hospital, Nancy, France
Intraabdominal Infections, Fluid Balance; Disorder
Intra-Abdominal Sepsis and Relationship Between Cumulative Fluid Balance and Serum Sodium and Chloride Levels and In-Hospital Mortality
Intra-abdominal sepsis and septic shock in critically ill surgical patients have a high mortality rate. Fluid therapy is one of the initial resuscitation measures, but it can contribute to poor treatment outcomes through fluid…
- Conditions
- Intraabdominal Infections, Fluid Balance; Disorder, Sodium Disorder, Chloride Disorder
- Trial name
- NCT06838585
- Testing
- infusion therapy
- Where
- Serbia
- Volunteers
- 100 people
- Sponsor
- Clinical Center of Vojvodina
Acute Respiratory Distress Syndrome, Hemodynamic Instability
Thoracic Fluid Content by Bioimpedance-based Starling System
The Starling system is a completely non-invasive hemodynamic monitoring technique. It is able to measure the thoracic fluid content (TFC). The TFC is supposed to reflect the total content of fluid in the thorax.
- Conditions
- Acute Respiratory Distress Syndrome, Hemodynamic Instability, Shock, Fluid Overload Pulmonary Edema
- Trial name
- TFC-Bio (NCT05676723)
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Bicetre Hospital
Septic Shock, Fluid Therapy
Fluid Balance in the ICU - Interventions to Minimize Fluids in Patients With Septic Shock
The purpose of the study is to determine if a protocol that assesses patients' daily fluid intake and output can decrease the overall amount of fluid patients receive during the first five days in the ICU.
- Conditions
- Septic Shock, Fluid Therapy, Hypotension
- Trial name
- NCT02473718
- Testing
- Fluid minimization protocol, Ultrasound
- Volunteers
- 82 people
- Sponsor
- Washington University School of Medicine
Heart Failure, Hyponatremia
The Effect of Fluid Restriction in Congestive Heart Failure Complicated With Hyponatremia
The purpose of this study is to determine the effect of fluid restriction and the neurohormonal mechanisms in the development of hyponatremia in patients with congestive heart failure and hyponatremia.
- Trial name
- Decongest (NCT01748331)
- Testing
- Fluid restriction
- Where
- 2 sites in Denmark
- Volunteers
- 40 people
- Sponsor
- Finn Gustafsson
Respiratory Insufficiency
Description of Fluid Balance in Patients With Acute Respiratory Failure
The specific aim of this study is to gather data on fluid balance, intravenous medication administration, electrolyte balance, and diuretic and dialysis use in patients with acute respiratory failure who might benefit from a…
- Trial name
- NCT02523872
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Smiths Medical, ASD, Inc.
Phosphorus Metabolism Disorders, Acid-Base Balance Disorder
The Effect of Bicarbonate Profiling in Dialysis Fluid on Phosphate Removal During Hemodialysis and Blood pH
Hyperphosphatemia is still an unresolved problem among hemodialysis patients and significantly increases the risk of death from cardiovascular diseases.
- Trial name
- NCT05861700
- Testing
- Group 1: B) Dbic 35 -30 mmol/L C) Dbic 30- 35 mmol/L, Group 2: C) Dbic 30 -35 mmol/L B) Dbic 35- 30 mmol/L
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- Medical University of Warsaw
Metabolic Acidosis, CKD
Explorative Study to Investigate the Acid-base Response to Sodium and Potassium Salts in Patients With Chronic Kidney Disease.
With this research the investigators want to study how patients with chronic kidney disease respond to different sodium- and potassium salts.
- Conditions
- Metabolic Acidosis, CKD, Electrolyte and Fluid Balance Conditions
- Trial name
- 5S (NCT06237712)
- Testing
- Dietary supplement consisting of 40 mmol/daily of potassium chloride, Dietary supplement consisting of 40 mmol/daily of potassium gluconate, Dietary supplement consisting of 40 mmol/daily of potassium bicarbonate
- Where
- Netherlands
- Volunteers
- 31 people
- Sponsor
- Erasmus Medical Center
Fluid Imbalance
Comparing Pleth Variability Index (PVI) Measurements at Different Sensing Locations
The purpose of this study is to assess the suitability of the ear and forehead as a better site for measure of fluid responsiveness.
- Trial name
- NCT02124551
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of California, Irvine
Fetal Growth Abnormality, Amniotic Fluid; Disorder
Serial Third Trimester Abdominal Circumference and Amniotic Fluid Measurements Versus Routine Care
The purpose of this study us to compare the rate of prenatal identification of abnormal fetal growth or amniotic fluid between clinical evaluation of uterine size by symphysis fundal height (SFH) measurements versus point-of-care…
- Trial name
- STAR (NCT03857659)
- Testing
- Point-of-care ultrasound (POC-US), Routine antenatal care, Formal ultrasound
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- The University of Texas Health Science Center, Houston
Liver Cirrhosis
PiCCO Guided Therapy in Liver Cirrhosis
Prospective comparison of standard therapy in liver cirrhosis versus standard therapy plus intensified hemodynamic monitoring using the PiCCO system.
- Trial name
- NCT00232427
- Testing
- Hemodynamic monitoring system PiCCO
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Heidelberg University