Clinical trials: Bariatric Surgery
Type 2 Diabetes
Vascular Endothelium Changes After Bariatric Surgery (Endothelial Progenitor Cells)
Improvement in cardiovascular mortality is related to changes in pathologic autoantibodies and in the number of circulating functional replicative competent endothelial progenitor cells (EPC's) after bariatric surgery.
- Trial name
- EPC (NCT01213940)
- Testing
- pre-bariatric weight loss program, bariatric surgery
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of South Alabama
Diabetes Mellitus, Type 2, Obesity
CARAT: Canagliflozin vs. Placebo for Post Bariatric Patients With Persistent Type 2 Diabetes
This is a prospective, randomized clinical trial for patients with recurrent type 2 diabetes post-gastric bypass surgery that will compare a 6 month course of canagliflozin monotherapy vs.
- Trial name
- NCT02912455
- Testing
- canagliflozin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- The Cleveland Clinic
Pain, Postoperative
Nicotine Administration and Post-operative Opioid Use With Bariatric Surgery
This prospective, randomized, double-blind study will enroll nonsmoking female subjects undergoing laparoscopic bariatric surgery under general anesthesia.
- Trial name
- NCT01194089
- Testing
- Nasal Nicotine Spray, Nasal Normal Saline Spray
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Toby Weingarten
Anesthesia
Optimizing Post-operative Recovery in Bariatric Patients With Obstructive Sleep Apnea Undergoing Outpatient Surgery: A Comparison of Sugammadex and Neostigmine
This study assesses the efficacy of sugammadex against neostigmine for hastening recovery from neuromuscular blockade and optimizing pulmonary function in obese patients with obstructive sleep apnea presenting for outpatient…
- Trial name
- NCT04570150
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of California, San Diego
Bariatric Surgery Candidate
Influence of the Sleep Pattern in Patients Submitted to Bariatric Surgery
The present study has a prospective, longitudinal and observational character, will be performed with patients attending a private clinic specialized in the treatment of obesity and bariatric surgery.
- Trial name
- NCT03485352
- Where
- Brazil
- Volunteers
- 122 people
- Sponsor
- Federal University of Uberlandia
Loss-of-control Eating, Obesity/Overweight
Pharmacological and Behavioral Treatment After Bariatric Surgery: Medication Change for Non-Responders (Stage 2b)
This study will test the effectiveness of lisdexamfetamine medication as a treatment for loss-of-control eating and weight following bariatric surgery.
- Trial name
- NCT04599504
- Testing
- Lisdexamfetamine Dimesylate (Medication)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Yale University
Nausea, Postoperative
Effects of Aromatherapy on Nausea Levels
Aromatherapy is the therapeutic use of essential oils from plants for the improvement of physical, emotional, and spiritual well-being. Healthcare providers play an important role in improving the care of patients with nausea.
- Trial name
- NCT04882501
- Testing
- QUEASEEase aromatherapy quick tab
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Inova Health Care Services
Post-operative Pain
Preoperative Pain Control in Gastric Bypass Surgery Patients
Randomized clinical trial to evaluate whether a single pre-operative dose of Pregabalin will alleviate post-operative pain and decrease post-operative analgesic requirements in morbidly obese patients undergoing laparoscopic…
- Trial name
- NCT01801189
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Legacy Health System
Type 2 Diabetes, Obesity
Metabolomic Analysis of Hepatic Insulin Resistance
This is a pilot study to show that it is possible to identify the specific types of fats in blood, adipose tissue, and liver tissue.
- Trial name
- NCT01833403
- Testing
- Hyperinsulinemic-euglycemic clamp
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Morbid Obesity, Postoperative Pain
Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery
This prospective randomized controlled trial aims to compare the clinical effectiveness and safety of opioid-free anesthesia (OFA) versus traditional opioid-based anesthesia (OBA) in adult patients undergoing laparoscopic…
- Conditions
- Morbid Obesity, Postoperative Pain, Opioid Free Anesthesia, Bariatric Surgery
- Trial name
- NCT07337135
- Testing
- Opioid-Based Anesthesia (Remifentanil-Based Protocol), Opioid-Free Anesthesia (Dexmedetomidine-Ketamine-Lidocaine Protocol)
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Hospital dos Lusíadas
Obesity, Diabetes Mellitus, Type 2
Longitudinal Phenotyping of Bariatric Surgery Patients
Recent studies have shown that bacteria within the gut play an important role in diabetes improvement after bariatric (weight-loss) surgery.
- Trial name
- NCT02421055
- Testing
- Laparoscopic Roux-en-Y Gastric Bypass, Laparoscopic Sleeve Gastrectomy
- Where
- United Kingdom
- Volunteers
- 158 people
- Sponsor
- Imperial College London
Bariatric Surgery Candidate
The Use of Intraperitoneal Ropivacaine in Bariatric Bypass Surgery
This is a pilot study in a randomized, controlled, double-blinded format and will evaluate the ability of a local anesthetic, Ropivacaine, to decrease pain after gastric bypass surgery.
- Trial name
- INOPAIN (NCT02154763)
- Testing
- Ropivacaine, Normal Saline
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Ottawa Hospital Research Institute
Obesity, Metabolic Surgery
Qsymia as an Adjunct to Surgical Therapy in the Superobese
This study tests the efficacy of the medication, Qsymia, as an adjunct therapy in superobese individuals planning to undergo weight loss surgery.
- Conditions
- Obesity, Metabolic Surgery, Weight Loss, Bariatric Surgery Procedures
- Trial name
- NCT02301416
- Testing
- Phentermine/topiramate, low calorie diet
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Wake Forest University Health Sciences
Postoperative Complications
Risk Factors Predicting Serious Complications With Laparoscopic Gastric Bypass Surgery
The rate of serious complications are relatively low in bariatric surgery today, but still 3-4 % will suffer from a serious complication.
- Trial name
- NCT01862159
- Testing
- laparoscopic gastric bypass surgery
- Where
- Sweden
- Volunteers
- 25,038 people
- Sponsor
- Region Örebro County
Morbid Obesity
Evaluation of the Safety and Effectiveness of Stomaphyx for Transoral Incisionless Reduction of the Enlarged Gastric Pouch and Stoma
Executive Summary Aims and Hypotheses of the Study: The aim of the study will be to evaluate the safety, effectiveness and early outcome of the StomaphyX procedure for reducing the enlarged gastric pouch and stoma in…
- Trial name
- NCT01025076
- Testing
- StomaphyX
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of Alberta
Acute Pain, Arthropathy of Knee
NSS-2-BRIDGE Study for Total Knee and Hip Arthroplasties, Bariatric, and Kidney Transplant Surgeries
The current opioid epidemic has led to a renewed interest in exploring non-pharmacological techniques to treat post-operative pain.
- Conditions
- Acute Pain, Arthropathy of Knee, Arthropathy of Hip, Pain, Postoperative
- Trial name
- NCT03834142
- Testing
- NSS-2 Bridge
- Where
- 3 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jacques E. Chelly
Hepatic Steatosis, Bariatric Surgery Candidate
Hepatic Mitochondrial Function in Youth
Assess the impact of bariatric surgery on hepatic energy metabolism and glucose and insulin dynamics in obese youth
- Conditions
- Hepatic Steatosis, Bariatric Surgery Candidate, Adolescent Obesity, Obesity
- Trial name
- MANGO (NCT03587727)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Systemic Hypertension, Obesity
GAstric Bypass to Treat obEse Patients With steAdy hYpertension
Phase 3, unicentric, randomized clinical trial, with allocation concealment and intention-to-treat analysis to evaluate the efficacy of videolaparoscopic Roux-en-Y Gastroplasty to decrease the prescription of antihypertensive…
- Trial name
- GATEWAY (NCT01784848)
- Testing
- Laparoscopic Roux-en-Y gastric bypass (LRYGB), Clinical treatment
- Where
- 3 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital do Coracao
Hypoglycemia, Reactive, Hypoglycemia
Continuous Glucose Monitoring to Reduce Hypoglycemia and Improve Safety After Gastric Surgery
The purpose of this study is to see if the use of a continuous glucose monitor (CGM) by people who experience low blood sugars (hypoglycemia) after gastric surgery can help reduce the number and severity of low blood sugar…
- Trial name
- NCT03353415
- Testing
- Dexcom CGM masked, Dexcom CGM unmasked
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Joslin Diabetes Center
Diabetes, Weightloss
The WISE (Weightloss Intervention Surgical Effects) Brain Study
This study is being done to learn about the changes that weight loss causes on brain function, memory and thinking ability in adults. The study does NOT cover any costs associated with bariatric surgery.
- Trial name
- WISEBrain (NCT02137070)
- Testing
- Bariatric Surgery Candidates, Non surgical/Community volunteers
- Where
- United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- University of Florida