Clinical trials: Bariatric Surgery, open to volunteers
Obesity, Diabetes Mellitus, Type 2
The Effect of Bariatric Surgery on Insulin Sensitivity and Energy Metabolism
The purpose of this study is: 1. To explore to what extent insulin sensitivity, energy metabolism and ectopic lipid storage can be improved by bariatric surgery 2.
- Trial name
- BARIA-DDZ (NCT01477957)
- Testing
- surgery
- Where
- Germany
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Morbid Obesity
Stool Analysis After Sleeve Gastrectomy vs Gastric Bypass
The goal of this observational study is to learn whether routine stool tests can detect changes in gut function 6 months after two common types of weight loss surgery: sleeve gastrectomy and gastric bypass (including mini gastric…
- Trial name
- NCT07461610
- Testing
- Laparoscopic Sleeve Gastrectomy, Mini Gastric Bypass, Roux-en-Y Gastric Bypass
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Obesity Postoperative Pain, Obesity Morbid Obesity Postoperative Pain
Comparison of Paragastric Nerve Block and Erector Spinae Plane Block on Postoperative Pain After Sleeve Gastrectomy
Background: Laparoscopic sleeve gastrectomy is one of the most commonly performed bariatric procedures for the treatment of obesity.
- Trial name
- PGB-ESP (NCT07811206)
- Testing
- Paragastric Nerve Block (PGNB), ESPB, Active Comparator
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Atlas University
Morbid Obesity
Semaglutide 2.4 mg Once Weekly for Recurrent Weight Gain After Metabolic and Bariatric Surgery (RESURGE)
Metabolic and bariatric surgery (MBS) is the most effective durable treatment for severe obesity, yet a clinically meaningful proportion of patients experience recurrent weight gain after an initially successful operation.
- Trial name
- NCT07859150
- Testing
- Semaglutide weekly injection, Placabo
- Where
- Egypt
- Volunteers
- 104 people
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Cardiovascular Complication, Bariatric Surgery Candidate
Bariatric Surgery for the Reduction of cArdioVascular Events Randomized Controlled Trial
The primary objective of this study is to evaluate if, in patients with severe obesity (body mass index (BMI) ≥30 kg/m2) and high-risk cardiovascular disease (CVD), bariatric surgery compared to medical weight management (MWM)…
- Trial name
- BRAVE (NCT05531474)
- Testing
- Bariatric Surgery, Medical Weight Management
- Where
- Canada
- Volunteers
- 700 people
- Sponsor
- Population Health Research Institute
Obesity, Weight Loss
Evaluating Anti-Obesity Medications 6 Months After Metabolic Surgery
This clinical trial aims to evaluate the weight-loss efficacy and safety of efsubaglutide alfa in patients who remain obese 6 months after metabolic surgery.
- Conditions
- Obesity, Weight Loss, Metabolic Surgery
- Trial name
- NCT07163650
- Testing
- Efsubaglutide Alfa Injection, Diet and exercise guidelines
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Obesity, Bariatric Surgery Candidate
Persistent Organic Pollutants and Mechanical Discharge: Limiting the Impact of Bariatric Surgery Through Personalized Adapted Physical Activity
For the most severe cases of obesity, recourse to bariatric surgery is the ultimate solution. Although highly beneficial to individual health, this massive loss of body mass could also have negative effects on metabolism and…
- Trial name
- PERSIST-APA (NCT06597617)
- Testing
- Adapted physical activity with aerobic training [GEA], Adapted physical activity with strength training [GRM]
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Bariatric Surgery, Hormonal Response
Comparison of Hormonal Response to a Mixed-Meal Tolerance Test After Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy With Duodenojejunal Bypass in Patients With Super Morbid Obesity
Obesity is a major global health problem. Bariatric surgery is the most effective treatment, leading to substantial weight loss and improvement in obesity-related comorbidities.
- Conditions
- Bariatric Surgery, Hormonal Response, Post Bariatric Hypoglycemia
- Trial name
- CU BYPASS-DJB (NCT07747779)
- Testing
- Sleeve gastrectomy with duodenojejunal bypass, Roux-en-Y gastric bypass
- Where
- Thailand
- Volunteers
- 32 people
- Sponsor
- Chulalongkorn University
Morbid Obesity
Metabolic Responses to Bariatric Surgery
Research the genetic and biomechanical markers of human adipose tissue on patients with morbid obesity. Additional tissue/fluid collection is also gathered during the time of surgery.
- Trial name
- NCT02024542
- Testing
- Surgery
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of California, Davis
Obesity (Disorder), Morbid Obesity
Chrono-ALIGN: A Chronotype-Based Chrono-Nutrition Intervention in Post-Bariatric Patients
This randomized controlled trial will evaluate the impact of chrono-nutrition, a dietary approach that aligns meal timing with the body's circadian rhythms, on weight change, metabolic outcomes, appetite, and gut microbiota in…
- Conditions
- Obesity (Disorder), Morbid Obesity, Bariatric Sleeve Gastrectomy, Meal Time
- Trial name
- Chrono-ALIGN (NCT07324044)
- Testing
- Standard Post-Bariatric Care (Control), Early Time-Restricted Eating (eTRE), Chronotype-Based Chrono-Nutrition (CB-CN)
- Where
- Saudi Arabia
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- King Saud University
Bariatric Surgery Patients
The Metabolic and Genetic Drivers of Body Composition Changes Following Weight Loss Surgery
Weight loss surgery is very good at reducing body weight but it can also cause the loss of both muscle and strength. Some patients undergoing weight loss surgery do not achieve their weight loss goals and regain the weight they…
- Trial name
- NCT07178704
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Bariatric Surgery Candidate, NAFLD
Effectiveness of Bariatric Surgery for NAFLD/NASH
This is a prospective, multicenter cohort study, which subjects were obese patients requiring bariatric surgery. This study aims to explore the the effectiveness of bariatric surgery for NAFLD/NASH with fribrosis, to explore the…
- Conditions
- Bariatric Surgery Candidate, NAFLD, NASH With Fibrosis
- Trial name
- NCT04366999
- Testing
- SG, RYGB, OAGB
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Beijing Friendship Hospital
Sleeve Gastrectomy
Alcohol After Bariatric Surgery 2
The goal of this observational study is to learn how the body processes ingested alcohol and how alcohol affects mood and blood sugar in both men and women after undergoing sleeve gastrectomy.
- Trial name
- ABS2 (NCT06257771)
- Testing
- Alcohol (Ethanol)
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Illinois at Urbana-Champaign
Obesity, Adolescent Obesity
Physiologic Response to Bariatric Surgery and the Impact of Adjunct Semaglutide in Adolescents
The study plans to learn more about what happens to the body after bariatric surgery in people 12 to 24 years old. The study aims to understand why people respond differently to bariatric surgery and how to define success beyond…
- Conditions
- Obesity, Adolescent Obesity, Body-Weight Trajectory, Weight Loss Trajectory
- Trial name
- PRESSURE (NCT06575738)
- Testing
- Injectable semaglutide or injectable tirzepatide, Standard postoperative care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Bariatric Surgery
Monitoring Changes in Endotracheal Tube Cuff Pressure During Laparoscopic Bariatric Surgery
This prospective observational cohort study was designed to assess the relationship between ETT cuff pressures and airway pressures in obese patients undergoing laparoscopic bariatric surgery.
- Trial name
- NCT06738875
- Testing
- manometre
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Obesity, Weight Loss
Gastric Ultrasound in Patients Who Have Undergone Bariatric Surgery
This is a nonrandomized prospective study. The purpose is to describe how to image the stomachs of patients after the patients have had bariatric surgery.
- Conditions
- Obesity, Weight Loss, Gastrectomy
- Trial name
- NCT07310875
- Testing
- Gastric Point of Care Ultrasound
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pain Management
Laparoscopic Preperitoneal Local Anesthetic Infiltration Versus Ultrasound Guided Quadratus Lumborum Block in Laparoscopic Bariatric Surgery
preperitoneal local anesthetic infiltration is effective for relief of postoperative pain in patients undergoing laparoscopic bariatric surgery.
- Trial name
- NCT06488183
- Testing
- preperitoneal local anesthetic infiltration in group p , quadratus lamborum block in group Q
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- sarah mohamed
Obesity, Bariatric Surgery Candidate
Halitosis, Sleep and Mental Health in Bariatric Surgery Candidates
This study aims to evaluate psychological distress, sleep quality, and halitosis in obese patients during the preoperative period of bariatric surgery.
- Conditions
- Obesity, Bariatric Surgery Candidate, Halitosis, Sleep Disorder
- Trial name
- NCT07175142
- Volunteers
- 110 people
- Sponsor
- University of Nove de Julho
Morbid Obesity Requiring Bariatric Surgery
Can Pre-operative Lean Mass Predict Weight Loss After Roux-en-Y Gastric Bypass?
The goal of this observational study is to evaluate whether preoperative fat-free mass predicts post-operative weight loss in patients undergoing Roux-En-Y gastric bypass.
- Trial name
- FLAG (NCT07565051)
- Where
- Switzerland
- Volunteers
- 91 people
- Sponsor
- University Hospital, Geneva
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Valsartan
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03535376
- Testing
- Valsartan
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology