Clinical trials: Barrett's Esophagus
Barrett Esophagus, Esophageal Carcinoma
Ursodiol in Treating Patients With Barrett Esophagus and Low-Grade Dysplasia
This pilot phase II trial studies how well ursodiol works in treating patients with Barrett esophagus or cells that look abnormal under a microscope but are not cancer (low-grade dysplasia).
- Trial name
- NCT01097304
- Testing
- Ursodiol, Laboratory Biomarker Analysis
- Where
- 4 sites in United States
- Volunteers
- 36 people
- Sponsor
- National Cancer Institute (NCI)
Barrett's Esophagus, Esophageal Adenocarcinoma
Confocal Endomicroscopy for Barrett's Esophagus
The purpose of this study is to determine if confocal laser endomicroscopy (CLE) can improve detection of Barrett's esophagus, dysplasia, and early esophageal cancer.
- Trial name
- CEBE (NCT00487695)
- Testing
- confocal laser endomicroscopy (CLE), standard endoscopy (EGD)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Johns Hopkins University
Barrett's Esophagus, Esophageal Intraepithelial Neoplasia
Confocal Endomicroscopy for Improved Diagnosis of Barrett's Esophagus and Early Esophageal Cancer(CEBE Study)
Endomicroscopy (EM) can improve the diagnosis Barrett's esophagus (BE) and some early esophageal cancers (Intra Epithelial Neoplasia (IEN)). EM provides optical biopsies comparable to standard histology.
- Trial name
- CEBE (NCT01124214)
- Testing
- endomicroscopy
- Where
- 4 sites in United States, Germany
- Volunteers
- 68 people
- Sponsor
- Johns Hopkins University
Barrett's Esophagus
Acetic Acid Guided Biopsies Compared With High Definition Endoscopy in the Detection of Barrett's Esophagus
Specialized columnar epithelium (SCE) is considered as pathognomonic for Barrett's esophagus. Chromoendoscopy after local acetic acid application enables recognition of the mucosal surface architecture.
- Trial name
- NCT01442506
- Testing
- biopsies, biopsy
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Esophageal Cancer
Celecoxib to Prevent Cancer in Patients With Barrett's Esophagus
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. Celecoxib may be effective in preventing cancer in patients with Barrett's esophagus.
- Trial name
- NCT00005878
- Testing
- celecoxib
- Where
- 8 sites in United States
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Barrett Esophagus, Esophageal Neoplasms
Feasibility of Multi-Spectral Endoscopic Imaging for Detection of Early Neoplasia in Barrett's Oesophagus
Multispectral imaging represents an exciting new field of investigation in endoscopic research. Multispectral imaging uses a specialised camera to detect multiple colours, allowing us to build a rough spectrum from each point in…
- Conditions
- Barrett Esophagus, Esophageal Neoplasms, Reflux Esophagitis
- Trial name
- MuSE (NCT03388047)
- Testing
- Endoscopy with Polyscope (Polydiagnost TM) coupled with Multi-Spectral Imaging light-source
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Cambridge
Esophageal Cancer
Eflornithine to Prevent Cancer in Patients With Barrett's Esophagus
RATIONALE: Chemoprevention therapy is the use of drugs to try and prevent the development or recurrence of cancer. It is not known whether eflornithine is effective in preventing cancer in patients with Barrett's esophagus.
- Trial name
- NCT00003076
- Testing
- eflornithine
- Where
- 5 sites in United States
- Volunteers
- 152 people
- Sponsor
- University of Michigan Rogel Cancer Center
Barrett's Esophagus
Expression and Function of the Renin-Angiotensin System in the Esophagus
Barrett's esophagus (BE) is the major esophageal pre-neoplastic lesion in which dysplastic transformations eventually can lead to cancer development.
- Trial name
- NCT02879721
- Testing
- Candesartan, Enalapril
- Where
- Sweden
- Volunteers
- 33 people
- Sponsor
- Göteborg University
Barrett's Esophagus
Melatonin Associated to Acid Inhibition for Chemoprevention in Barret Esophagus: a Pilot Study
The study consists on determining whether melatonin decreases oxidative stress in Barrett's esophageal mucosa after 6 months of treatment.
- Trial name
- NCT01566474
- Testing
- Omeprazole, Melatonin
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Aragon Institute of Health Sciences
Barrett's Esophagus
Confocal Laser Probe to Treat Barrett's Esophagus
The purpose of this study is to further validate the use of probe-based confocal laser endomicroscopy (pCLE) for the evaluation of Barrett's Esophagus and associated neoplasia in a larger patient base.
- Trial name
- pCLE (NCT02852525)
- Testing
- Confocal laser endomicroscopy (pCLE)
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Virendra Joshi
Barretts Esophagus With Dysplasia
EndoRotor® Ablation of Barrett's Esophagus: Safety and Feasibility Study
The aim of this study is to assess the safety and feasibility of the EndoRotor® for the ablation of Barrett's esophagus.
- Trial name
- NCT03120195
- Testing
- The EndoRotor®
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- Foundation for Liver Research
Barrett Esophagus
Coordinating Center: Natural History of Barrett's Esophagus Using Tethered Capsule Endomicroscopy
The goal of this research is to follow Barrett's Esophagus participants for 3 years using the tethered capsule endomicroscopy device with distal scanning and a compact imaging system in a multi-site clinical study.
- Trial name
- NCT03459339
- Testing
- Tethered Capsule Endomicroscopy (TCE)
- Where
- 5 sites in United States
- Volunteers
- 500 people
- Sponsor
- Massachusetts General Hospital
Esophageal Cancer, Precancerous Condition
A Phase III, Randomized, Study of Aspirin and Esomeprazole Chemoprevention in Barrett's Metaplasia
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of esomeprazole and aspirin may prevent esophageal cancer in patients with Barrett's metaplasia.
- Trial name
- AspECT (NCT00357682)
- Testing
- Esomeprazole, Aspirin
- Volunteers
- 2,557 people
- Sponsor
- University of Oxford
Barrett Esophagus, Esophageal Cancer
Wide-Area Transepithelial Sampling in Endoscopic Eradication Therapy for Barrett's Esophagus
Esophageal cancer is a deadly disease that is becoming increasingly common in the United States. Barrett's esophagus (BE) is a pre-cancerous state that can develop into esophageal cancer, but is highly treatable.
- Trial name
- NCT05056051
- Testing
- WATS-3D tissue sampling prior to forceps biopsies, WATS-3D tissue sampling following forceps biopsies
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Northwestern University
Barretts Esophagus With High Grade Dysplasia, Barrett Adenocarcinoma
Endoscopic Mucosal Resection and Cellular Matrix
This study is being done to test the usefulness of extracellular matrix (ECM) a thin sheet placed over the site after endoscopic mucosal resection to promote healing of the esophagus.
- Trial name
- NCT03240679
- Testing
- Acell MatriStem® Surgical Matrix
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Barrett's Esophagus, Early Esophageal Adenocarcinoma
Endoscopic Mucosal Resection (EMR) in Barrett's Esophagus
Existing records will be reviewed to evaluate the predictors of complications including stricture formation, bleeding or perforation associated with endoscopic mucosal resection
- Trial name
- NCT00586872
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Mayo Clinic
Barrett Esophagus, Esophageal Adenocarcinoma
Efficacy of EsoGuard on Samples Collected Using EsoCheck Versus EGD for the Diagnosis of BE
The study will assess the performance of the combined system, i.e., the use of the EsoGuard assay on cells collected using the EsoCheck 510(k) cleared device, to detect Barrett's Esophagus, with and without dysplasia, and/or…
- Conditions
- Barrett Esophagus, Esophageal Adenocarcinoma, Barretts Esophagus With Dysplasia, Barrett's Esophagus Without Dysplasia
- Trial name
- ESOGUARDBE1 (NCT04293458)
- Testing
- EsoGuard
- Where
- 27 sites in United States, Spain
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Lucid Diagnostics, Inc.
Esophageal Adenocarcinoma, Barrett's Esophagus
Trial to Assess the Effects of an Antimicrobial Mouthwash on the Esophageal Microbiome
This is a randomized, open-label pilot study to assess whether treatment with chlorhexidine mouthwash can alter the esophageal and gastric cardia microbiome
- Conditions
- Esophageal Adenocarcinoma, Barrett's Esophagus, Reflux Esophagitis
- Trial name
- Mouthwash (NCT02513784)
- Testing
- Chlorhexidine gluconate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Columbia University
Barrett Esophagus, Esophageal Adenocarcinoma
Aspirin in Preventing Disease Recurrence in Patients With Barrett Esophagus After Successful Elimination by Radiofrequency Ablation
This randomized phase II trial studies the safety of and how well aspirin works in preventing Barrett's esophagus from returning after it has been successfully eliminated by radiofrequency ablation.
- Trial name
- NCT02521285
- Testing
- Aspirin, Laboratory Biomarker Analysis, Questionnaire Administration
- Where
- 10 sites in United States, Canada
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Barrett Esophagus
Balloon Cryotherapy vs. Radiofrequency Ablation Pain Study
Barrett's esophagus is a condition in which the normal lining of the lower esophagus is replaced with cells that predispose an individual to development of esophageal cancer.
- Trial name
- NCT03387982
- Where
- 4 sites in United States
- Volunteers
- 95 people
- Sponsor
- Geisinger Clinic