Clinical trials: Barrett's Esophagus
Barrett's Esophagus, High Grade Dysplasia
Biomarkers in Phototherapy of Barrett's Esophagus
This study is being done to find out if Photodynamic Therapy (treatment with a red light and a drug called photofrin) or Radiofrequency ablation works the same for patients who have biomarkers (abnormalities in molecules of cells…
- Trial name
- BIOBAR (NCT00587600)
- Testing
- Photodynamic therapy, radiofrequency ablation of barrett's esophagus
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- Mayo Clinic
Gastro Esophageal Reflux Disease, Barrett Esophagus
Patient Preferences for Barrett's Esophagus and Esophageal Cancer Screening Tests
This study plans to learn more about what patients think about screening for esophageal cancer (EAC) and Barrett's esophagus (BE); a pre-cancerous condition associated with esophageal cancer.
- Trial name
- NCT06693622
- Testing
- Patient survey
- Where
- United States
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Barrett's Esophagus With Dysplasia
Characterization of the Neo-squamous Epithelial Barrier
To prospectively assess the functional aspects of the the esophageal squamous epithelial barrier and correlate this with tissue inflammation and intercellular space dilation in patients who have successfully completed endoscopic…
- Trial name
- NCT03077594
- Testing
- Mucosal Impedance, Research Biopsies, Volumetric Laser Endomicroscopy
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Mayo Clinic
Barrett Esophagus
Evaluation of Performance Characteristics of Capsule Endoscopy With PillCam UGI Capsule Compared to Standard Endoscopy
This study is to examine the benefits of newly designed capsule with enhanced frame rate and wide angle compared to standard endoscopy, which may help enhance detecting esophageal diseases that otherwise may have been out of…
- Trial name
- NCT03167970
- Testing
- Pill cam, EGD
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Midwest Biomedical Research
Barrett Esophagus
Non-endoscopic Brushing of the Esophagus Using a Non-endoscopic Inflatable Balloon of the Esophagus in Screening for Barrett Esophagus
This pilot clinical trial studies non-endoscopic brushing of the esophagus using a non-endoscopic inflatable balloon for the esophagus in screening for Barrett esophagus, a condition where the lining of the esophagus has changed…
- Trial name
- NCT02451124
- Testing
- non-endoscopic inflatable balloon for the esophagus, Questionnaire Administration, Laboratory Biomarker Analysis
- Where
- 2 sites in United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Barrett Esophagus, Barretts Esophagus With Dysplasia
Natural History of Barrett's Esophagus Using Tethered Capsule Endomicroscopy
The goal of this research is to determine the natural history of Barrett's esophagus (BE) using tethered capsule endomicroscopy (TCE) in participants undergoing surveillance endoscopy.
- Trial name
- NCT02994693
- Testing
- OFDI capsule imaging
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Barrett Esophagus, Esophageal Cancer
Study to Evaluate EnteroTracker® as a Sampling Method to Screen for Barrett's Esophagus/Esophageal Cancer
The purpose of this study is to determine whether the EnteroTracker can obtain biomarkers that have been studied to be significant in screening BE and EAC.
- Trial name
- NCT05706025
- Testing
- EnteroTracker
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Barrett's Esophagus
An Open Label pH Comparison of Esomeprazole and Lansoprazole in Barrett's Esophagus Patients
The purpose of the study is to compare the treatment of esomeprazole 40 mg once daily and lansoprazole 30 mg once daily in controlling intragastric pH in Barrett's Esophagus patients
- Trial name
- NCT00352261
- Testing
- Esomeprazole, Lansoprazole
- Where
- 12 sites in United States
- Volunteers
- 80 people
- Sponsor
- AstraZeneca
Barrett Esophagus, Esophageal Neoplasm
Novel Biomarkers in the Neoplastic Progression of Barrett's Esophagus
The purpose of this study is to determine if there are any early changes in DNA markers of blood and esophageal tissue in people with gastric reflux, Barrett's esophagus or esophageal cancer that can warn of a progression to…
- Conditions
- Barrett Esophagus, Esophageal Neoplasm, Gastroesophageal Reflux
- Trial name
- BE (NCT00431756)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Barrett's Esophagus, Esophageal Cancer
Evaluation of Balloon-based Cryoablation of Human Esophageal Epithelium
The purpose of this study is to evaluate a cryoablation technique used to ablate human esophageal mucosa.
- Trial name
- NCT01293448
- Testing
- Cryoballoon Ablation
- Where
- 4 sites in United States, Netherlands
- Volunteers
- 21 people
- Sponsor
- Pentax Medical
Barrett's Esophagus, Esophageal Cancer
CryoSpray Ablation (TM) GI Patient Registry
The purpose of this study is to create a patient registry to collect and analyze post-510K approval information on subjects treated endoscopically with the CryoSpray Ablation™ System.
- Trial name
- NCT00747448
- Where
- 6 sites in United States
- Volunteers
- 199 people
- Sponsor
- CSA Medical, Inc.
Barrett's Esophagus, GERD
Barrett's Esophagus & Gastroesophageal Reflux Disease
This is a study of Barrett's Esophagus (BE) and Gastroesophageal Reflux Disease (GERD). It aims to look at the long term efficacy of evidence-based cutting edge diagnostic and therapeutic algorithms and techniques such as…
- Trial name
- NCT00513331
- Testing
- Endoscopy, Radiofrequency ablation protocol, Endoscopic mucosal resection protocol
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Valley Health System
Barrett's Esophagus, Intestinal Metaplasia
The Prevalence, Risk Factors and Optimal Biopsy Protocol of BE
Detections of goblet cells and dysplasia are crucial for diagnosis and determining the surveillance program of Barrett's esophagus (BE).
- Trial name
- NCT05818072
- Testing
- One biopsy, Three biopsy, Seattle protocol
- Where
- Taiwan
- Volunteers
- 165 people
- Sponsor
- E-DA Hospital
Gastroesophageal Reflux Disease (GERD)
Anthropometry in Gastroesophageal Reflux Disease and Esophageal Injury
Is waist to hip ratio (WHR), waist circumference (WC), (as markers of visceral adiposity) associated with an increase in acidic and non acidic reflux as well as systemic inflammation involving esophageal mucosa, thereby…
- Trial name
- NCT01570842
- Testing
- Anthropometric measurements, Tissue samples
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Barrett Esophagus, Esophageal Stenosis
Barretts oEsophageal Resection With Steroid Therapy Trial
Barretts mucosa is a premalignant condition of the oesophagus, which can progress to cancer. Oesophageal cancer is aggressive, with a 5 year survival of only ~15%.
- Trial name
- BERST (NCT02004782)
- Testing
- Prednisolone
- Where
- Australia
- Sponsor
- Professor Michael Bourke
Barrett's Esophagus, CIS
Study of Photodynamic Therapy (PDT) Using HPPH in Barrett's Esophagus
A Study to identify toxicity and optimal photodynamic treatment parameters using the photosensitizer 2-[1-hydroxyethyl]-2-devinylpyropheophorbide-a (HPPH) in high grade dysplasia, carcinoma-in-situ, or early adenocarcinoma in…
- Conditions
- Barrett's Esophagus, CIS, High Grade Dysplasia
- Trial name
- NCT01236443
- Testing
- HPPH
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Roswell Park Cancer Institute
Precancerous Condition
Risk Factors for Barrett's Esophagus in Patients With BE, Gastroesophageal Reflux, or Gastrointestinal Bleeding
RATIONALE: A study that evaluates DNA changes and other disease-related health information in patients with Barrett's esophagus, gastroesophageal reflux, or gastrointestinal bleeding may help doctors learn more about the risk…
- Trial name
- NCT00445653
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- Massachusetts General Hospital
Barrett Esophagus, Esophageal Cancer
Clinical Utility of Methylation-based Prognostic Assay for Barrett's Esophagus
Capsulomics has developed a prognostic assay for patients with diagnosed Barrett's esophagus (BE). This study will measure how gastroenterologists make surveillance and treatment management decisions when presented with different…
- Trial name
- NCT05846971
- Testing
- Educational materials on validated methylation assay
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Capsulomics, Inc.
Gastroesophageal Reflux Disease, Gastritis
Analysis of Biopsies From the Upper Gastrointestinal Tract
Multicenter study to correlate histological findings in the upper gastrointestinal tract with endoscopic and clinical data.
- Trial name
- histoGERD (NCT01576289)
- Testing
- Histological analysis
- Where
- Austria
- Volunteers
- 600 people
- Sponsor
- Medical University of Graz
Barrett Esophagus
Photoacoustic Endoscopy of Barrett's Esophagus
Endoscopy is an important technique in medicine to diagnose internal organs. Video endoscopy has been the most common technique providing clear, real time video images of organs' surfaces.
- Trial name
- NCT02606292
- Testing
- Photoacoustic endoscopy, Endoscopic ultrasound (standard of care), Endoscopic surgery (standard of care)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Washington University School of Medicine