Clinical trials: Barrett's Esophagus
Gastroesophageal Reflux Disease
Clinical Studies on Bile Acids in Barrett's Esophagus
This study has two major goals: 1. To determine the effects of bile salts on causing DNA injury and activating signaling pathways that promote growth in cells from the esophagus of patients who have gastroesophageal reflux…
- Trial name
- NCT00858858
- Testing
- Ursodeoxycholic Acid
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- US Department of Veterans Affairs
Barrett's Esophagus, Early Esophageal Adenocarcinoma
The Effect of Ablation Therapy on Barrett's Esophagus
To assess the effect of ablative therapy (Photodynamic Therapy or Radiofrequency ablation ) on Barrett's Esophagus
- Trial name
- ablation IN BE (NCT00587314)
- Testing
- Biopsy
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Mayo Clinic
Barrett Esophagus, Transoral Incisionless Fundoplication
Outcomes After Transoral Incisionless Fundoplication (TIF) Following Successful Endoscopic Ablation for Barrett's Esophagus
Barrett's esophagus (BE) is a precancerous lesion characterized by the replacement of the normal stratified squamous epithelium of the distal esophagus by intestinal metaplasia (IM).
- Trial name
- NCT04457193
- Testing
- TIF
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins University
Barrett Esophagus, GERD
Patient Acceptance and Preference Among Screening Modalities for Detection of Barrett's Esophagus
To assess patient acceptance and preference among screening modalities, Esophagogastroduodenoscopy (EGD), Transnasal Esophagoscopy (TNE), and Cytosponge for Barrett's esophagus (BE).
- Trial name
- NCT04301986
- Testing
- Cytosponge, Transnasal Endoscopy (TNE), Esophagogastroduodenoscopy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Barrett's Esophagus, High Grade Dysplasia
Study of CryoSpray Ablation of Low Grade or High Grade Dysplasia Within Barrett's Esophagus
The purpose of this study is to evaluate the safety and effectiveness of the CryoSpray Ablation System to treat esophageal low grade dysplasia (LGD) or high grade dysplasia (HGD) within Barrett's Esophagus (BE).
- Conditions
- Barrett's Esophagus, High Grade Dysplasia, Low Grade Dysplasia
- Trial name
- ICE (NCT00526786)
- Testing
- CryoSpray Ablation System (510(k) NO: K070893)
- Where
- 16 sites in United States
- Volunteers
- 78 people
- Sponsor
- CSA Medical, Inc.
Barrett Esophagus
Early Detection of Barrett's Esophagus Through Deep Image Retrieval
Barrett's oesophagus is a condition in which the area between the oesophagus and stomach no longer closes, allowing acidic contents of the stomach to enter the oesophagus and damage the lining.
- Trial name
- NCT04478929
- Testing
- Gastroscopy
- Where
- United Kingdom
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Leigh Taylor
Superficial Esophageal Cancer, Oesophageal Adenocarcinoma
Multicenter Prospective Cohort on Esophageal Endoscopic Submucosal Dissection
In France in 2018, there were an estimated 2,074 new cases of esophageal adenocarcinoma and 3,224 cases of squamous cell carcinoma.
- Conditions
- Superficial Esophageal Cancer, Oesophageal Adenocarcinoma, Oesophageal Squamous Cell Carcinoma, Barretts Esophagus With Dysplasia
- Trial name
- FEO (NCT07343869)
- Where
- France
- Volunteers
- 750 people
- Sponsor
- Société Française d'Endoscopie Digestive
Gastro Esophageal Reflux Disease, Barrett Esophagus
Patient Preferences for Barrett's Esophagus and Esophageal Cancer Screening Tests
This study plans to learn more about what patients think about screening for esophageal cancer (EAC) and Barrett's esophagus (BE); a pre-cancerous condition associated with esophageal cancer.
- Trial name
- NCT06693622
- Testing
- Patient survey
- Where
- United States
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Barrett's Esophagus
A Dose-Optimization Study for the Initial Treatment of Dysplastic Barrett's Esophagus With trūFreeze™ Spray Cryotherapy
The primary objective of this study is to determine the percentage segment regression after spray cryotherapy in a dose-escalation study performed in patients with dysplastic Barrett's Esophagus (BE) using trūFreeze™ spray…
- Trial name
- DOSE (NCT01845454)
- Testing
- trūFreeze™ Spray Cryotherapy
- Where
- 6 sites in United States
- Volunteers
- 36 people
- Sponsor
- CSA Medical, Inc.
Barrett's Esophagus, Intraepithelial Neoplasia
Endoscopic Multispectral Imaging for the Early Detection of Barrett's Neoplasia
The overall objective of this pilot study is to determine whether multispectral imaging increases the diagnostic accuracy of the current standard of high-definition white-light endoscopy for the detection of Barrett's-associated…
- Trial name
- NCT01384864
- Testing
- proflavine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Anandasabapathy, Sharmila, M.D.
Barrett Esophagus
Tethered Capsule Endoscope in Screening Patients With Barrett Esophagus
This pilot clinical trial studies how well tethered capsule endoscope works in screening patients with Barrett esophagus (BE), a condition where the lining of the esophagus has changed or has been replaced with abnormal cells…
- Trial name
- NCT02729948
- Testing
- Survey Administration, Tethered Capsule Endoscope
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Washington
Barrett Esophagus
A Minimally-Invasive Sponge on a String Device for Screening for Barrett's Esophagus
This study is being done to collect data on the potential use of a sponge on a string device as a non-invasive tool in evaluating patients with Barrett's Esophagus compared to healthy controls.
- Trial name
- NCT02560623
- Testing
- Biopsy, Biospecimen Collection, Endoscopic Procedure
- Where
- 6 sites in United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Barrett's Oesophagus
The Use of Biomarkers to Guide Management of Patients Treated With Radiofrequency Ablation for Early Oesophageal Neoplasia
This prospective cohort study aims to assess the utility of a panel of molecular biomarkers for predicting the risk of relapse of Barrett's Oesophagus after endoscopic treatment of early oesophageal neoplasia with RadioFrequency…
- Trial name
- PROBAN (NCT04155242)
- Testing
- Cytosponge test, Assessment of the panel of molecular biomarkers: IM-SCORE, TFF3 protein expression, methylation panel, p53 mutation, Oesophagogastroduodenoscopy
- Where
- United Kingdom
- Volunteers
- 147 people
- Sponsor
- University of Cambridge
Barrett Esophagus
Evaluation of Performance Characteristics of Capsule Endoscopy With PillCam UGI Capsule Compared to Standard Endoscopy
This study is to examine the benefits of newly designed capsule with enhanced frame rate and wide angle compared to standard endoscopy, which may help enhance detecting esophageal diseases that otherwise may have been out of…
- Trial name
- NCT03167970
- Testing
- Pill cam, EGD
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Midwest Biomedical Research
Barrett's Esophagus
Imaging Enhanced Endoscopy for the Screening of Barrett's Esophagus
Imaging enhanced endoscopy can improve the efficacy of screening of Barrett's esophagus and predict its invasiveness. There is potentially molecular change over the Barrett's esophagus in this Chinese population.
- Trial name
- NCT01976351
- Where
- Taiwan
- Volunteers
- 51 people
- Sponsor
- National Taiwan University Hospital
Barrett Esophagus, Proton Pump Inhibitor
On-demand PPI Therapy is Effective on Controlling Symptoms in Patients With Barrett's Esophagus.
On-demand PPI therapy is feasible for the long-term treatment of patients with Barrett's esophagus.
- Conditions
- Barrett Esophagus, Proton Pump Inhibitor, Symptom, Reflux
- Trial name
- NCT04329000
- Testing
- Esomeprazole 40mg, Esomeprazole
- Volunteers
- 218 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Barrett Esophagus
Ablation of Intestinal Metaplasia Containing Dysplasia
The purpose of this study is to determine if the intervention of a 510(k)-cleared endoscopically-guided (Halo Ablation systems), ablation system plus anti-secretory therapy is better than anti-secretory therapy alone in clearing…
- Trial name
- NCT00282672
- Testing
- Ablation System plus anti-secretory medication
- Where
- 19 sites in United States
- Volunteers
- 127 people
- Sponsor
- Medtronic - MITG
Barrett's Esophagus, GERD
Acid Reflux and Stromal Fibroblasts in Barrett's Esophagus
Patients with Barrett's Esophagus are known to have excessive distal esophageal acid exposure comparable to patients with erosive esophagitis.
- Trial name
- NCT00573911
- Testing
- Endoscopy and pH study
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Mayo Clinic
GORD, Oesophageal Cancer
The Bacterial Composition of the Stomach in Reflux Disease
Gastric and oesophageal (OG) cancer associated with poor long term outcome as overall less than 25% of patients survive for more than 5 years due to late recognition of the disease.
- Conditions
- GORD, Oesophageal Cancer, Oesophageal Reflux, Gastric Cancer
- Trial name
- NCT03835663
- Testing
- No intervention but patients are undergoing an upper GI endoscopy and biopsies for clinical purposes
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Imperial College London
Barrett Esophagus
Detection of Early Esophageal Cancer by NIR-FME.
To improve detection of esophageal (pre)malignant lesions during surveillance endoscopy of patients at risk of developing malignancies, for example in Barrett's Esophagus (BE), there is a need for better endoscopic visualization…
- Trial name
- ESCEND (NCT03877601)
- Testing
- Bevacizumab-IRDye800CW, Fluorescence endoscopy
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen