Clinical trials: Barrett Esophagus
Cancer Risk, Cancer Predisposition Syndrome
InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer
This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member…
- Conditions
- Cancer Risk, Cancer Predisposition Syndrome, Hereditary Cancer Prediction, Childhood Cancer Survivors
- Trial name
- NCT05463796
- Testing
- Samples
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Barrett's Esophagus
Influence of Acid Reflux on Stromal Epithelial Interaction in Barrett's Esophagus
The purpose of this study is to determine the association between acid reflux and cell changes in Barrett's esophagus. Specific aim 1: To test the hypothesis that controlled acid reflux is associated with lesser degree of stromal…
- Trial name
- CR20 (NCT01281618)
- Testing
- 24 hour pH study and upper endoscopy (EGD)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Mayo Clinic
Barrett's Esophagus
Endoesophageal Cryotherapy For Ablating Barrett's Esophagus and Early Stage Esophageal Cancer
In this prospective single center study, up to 25 patients with Barrett's esophagus with LGD or no dysplasia (Group 1), 25 patients with HGD/IMCA (Group 2), 25 patients with esophageal carcinoma confined to the esophageal wall…
- Trial name
- NCT00628784
- Testing
- Endoscopic spray cryotherapy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Dysplastic Barrett's Esophagus, Radiofrequency Ablation
Impact of RFA on Esophageal Distensibility and Mucosal Impedance
Patients undergoing ablative therapy for management of dysplastic Barrett's Esophagus (BE) will have decreased distensibility over the course of treatment, but improvement in mucosal impedance as BE epithelia is replaced by…
- Conditions
- Dysplastic Barrett's Esophagus, Radiofrequency Ablation, Barrett Esophagus
- Trial name
- NCT07126535
- Testing
- Radiofrequency ablation alone
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Barrett Esophagus
Radiofrequency Ablation vs Sham Procedure for Symptomatic Cervical Inlet Patch
Inlet patch is a congenital condition of the upper oesophagus, consisting of stomach lining that is in the wrong place. It affects 5% of the population.
- Trial name
- NCT03471052
- Testing
- Radiofrequency ablation (RFA)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Barretts Esophagus With Dysplasia, Barrett Adenocarcinoma
EMR Versus ESD for Barrett's Neoplasia
Rationale: The optimal technique for removal of visible dysplastic lesions in Barrett's esophagus remains controversial. Endoscopic mucosal resection (EMR) is safe, effective, easy to apply, and has been the most widely used…
- Conditions
- Barretts Esophagus With Dysplasia, Barrett Adenocarcinoma, Esophageal Cancer
- Trial name
- REMOVE-RCT (NCT05276791)
- Testing
- EMR, ESD
- Where
- 6 sites in Netherlands
- Volunteers
- 331 people
- Sponsor
- St. Antonius Hospital
Barrett Esophagus
Efficacy of Potassium-Competitive Acid Blockers in Barrett's Esophagus (PCAB BE Study)
This is a research study to look at how a new medication compares to standard treatment for reducing acid reflux in patients with Barrett's Esophagus. The study drug is Vonoprazan.
- Trial name
- NCT07788742
- Testing
- Potassium-Competitive Acid Blockers (PCABs)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of North Carolina, Chapel Hill
Barrett Esophagus
Evaluation of Performance Characteristics of Capsule Endoscopy With PillCam UGI Capsule Compared to Standard Endoscopy
This study is to examine the benefits of newly designed capsule with enhanced frame rate and wide angle compared to standard endoscopy, which may help enhance detecting esophageal diseases that otherwise may have been out of…
- Trial name
- NCT03167970
- Testing
- Pill cam, EGD
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Midwest Biomedical Research
Esophageal Cancer, Gastric Cancer
Diagnostic Performance Indicators in Upper GI Endoscopy:PROSPERO Study
Cancers of the upper gastro-intestinal tract, including esophagus (gullet), stomach and small bowel, are amongst the deadliest malignancies.
- Conditions
- Esophageal Cancer, Gastric Cancer, Barrett Esophagus, Gastric Atrophy
- Trial name
- PROSPERO (NCT04843397)
- Volunteers
- 1,000 people
- Sponsor
- University of Cambridge
Barrett Esophagus, Esophageal Adenocarcinoma
Trans-Oral Sampling as an Alternative Surveillance of Barrett's Esophagus Pilot
The study aims to address the increasing incidence of esophageal cancer and Barrett's esophagus (BE) in the Western world by exploring a more efficient surveillance method.
- Conditions
- Barrett Esophagus, Esophageal Adenocarcinoma, Diagnosis
- Trial name
- TOSS pilot (NCT07490340)
- Testing
- trans oral sampling: endosign
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Barrett Esophagus, GERD
Patient Acceptance and Preference Among Screening Modalities for Detection of Barrett's Esophagus
To assess patient acceptance and preference among screening modalities, Esophagogastroduodenoscopy (EGD), Transnasal Esophagoscopy (TNE), and Cytosponge for Barrett's esophagus (BE).
- Trial name
- NCT04301986
- Testing
- Cytosponge, Transnasal Endoscopy (TNE), Esophagogastroduodenoscopy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Barrett Esophagus, Esophageal Cancer
Esomeprazole Magnesium With or Without Aspirin in Preventing Esophageal Cancer in Patients With Barrett Esophagus
This randomized phase II trial is studying the effect of esomeprazole magnesium and aspirin on tissue PGE2 levels compared with esomeprazole and placebo.
- Trial name
- NCT00474903
- Testing
- acetylsalicylic acid, esomeprazole magnesium
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- National Cancer Institute (NCI)
Gastroesophageal Reflux Disease, Barrett's Esophagus
Survey Study on Barrett's Esophagus Screening
The goal of this study is to optimize Barrett's Esophagus (BE) screening to reduce the incidence, morbidity, and mortality of Esophageal Adenocarcinoma (EAC).
- Conditions
- Gastroesophageal Reflux Disease, Barrett's Esophagus, Esophagus Adenocarcinoma
- Trial name
- SCREEN-BE (NCT04408105)
- Testing
- Primary Care Provider Survey, Gastroenterologist Survey, Patient Survey
- Where
- 7 sites in United States
- Volunteers
- 725 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Non-erosive Reflux Disease, Barrett's Esophagus
The Changes of Ryodoraku and HRV After PPI Treatment in GERD Patients
Gastroesophageal reflux disease(GERD) mainly related to the reflux of stomach content induced by the dysfunction of lower esophageal sphincter.
- Trial name
- NCT02149914
- Testing
- Ryodoraku, ANSWatch, UGI endoscopy
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taichung Tzu Chi Hospital
Barrett's Esophagus
The Role of the Fujinon Intelligent Chromo Endoscopy (FICE™) in Barrett's Esophagus
The purpose of this study to assess post ablation, if there are areas of Barrett's mucosa post ablation and to assess the ability of the Fujinon FICE system to detect this, as compared to white light endoscopy.
- Trial name
- NCT01084629
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Barrett's Esophagus
Surveillance and Image-Guided Biopsy of the Esophagus Using an OFDI Capsule
The purpose of this research is to test the feasibility, sensitivity, and specificity of the marking Optical Frequency Domain Imaging (OFDI) capsule for diagnosing Barrett's Esophagus (BE).
- Trial name
- NCT02422433
- Testing
- OFDI Capsule Marking
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Massachusetts General Hospital
Barrett Esophagus, Esophageal Adenocarcinoma
Minimally Invasive Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Cancer, SOS5C Trial
This clinical trial studies how well minimally invasive approaches (an artificial intelligence [AI] powered risk tool, nurse navigation, and a sponge on a string [SOS] test) work in diagnosing patients with Barrett's esophagus…
- Trial name
- NCT07206589
- Testing
- Cancer Screening, Computer-Assisted Intervention, Endoscopic Procedure
- Where
- 3 sites in United States
- Volunteers
- 1,010 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Barrett Esophagus, Barretts Esophagus With Dysplasia
CLUE: CLinical Utility Study of EsoGuard
Utilize real-world data from the commercial use of EsoGuard testing on samples collected with EsoCheck (EC/EG) to evaluate the impact of EsoGuard results on health care provider's decision for endoscopy referral.
- Conditions
- Barrett Esophagus, Barretts Esophagus With Dysplasia, Esophagus Adenocarcinoma
- Trial name
- PR-0410 (NCT06030180)
- Testing
- EsoGuard
- Where
- 8 sites in United States
- Volunteers
- 566 people
- Sponsor
- Lucid Diagnostics, Inc.
Barrett Esophagus, Esophageal Stenosis
Barretts oEsophageal Resection With Steroid Therapy Trial
Barretts mucosa is a premalignant condition of the oesophagus, which can progress to cancer. Oesophageal cancer is aggressive, with a 5 year survival of only ~15%.
- Trial name
- BERST (NCT02004782)
- Testing
- Prednisolone
- Where
- Australia
- Sponsor
- Professor Michael Bourke
Barrett's Esophagus, GERD
Acid Reflux and Stromal Fibroblasts in Barrett's Esophagus
Patients with Barrett's Esophagus are known to have excessive distal esophageal acid exposure comparable to patients with erosive esophagitis.
- Trial name
- NCT00573911
- Testing
- Endoscopy and pH study
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Mayo Clinic