Clinical trials: Basic Science
Basic Science Study of the Mechanisms of Attentional Enhancement by Compounds Acting on the Nicotinic Receptor
Low-Dose Galantamine to Potentiate the Attention-Enhancing Effects of Low-Dose Nicotine
The aim of this study is to test whether the attention-enhancing effects of low-dose nicotine can be enhanced by the drug galantamine, FDA-approved for the treatment of Alzheimer's disease.
- Trial name
- GalaNic (NCT02420327)
- Testing
- Nicotine patch and galantamine capsule
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Mental Health
Novel Methods for Implementing Measurement-Based Care for Youth in Low-resource Environments
This study will visit 4 community mental health clinics in Washington state and work with clinic staff to find out if staff are regularly evaluating clinical outcomes using questionnaires (which is also called measurement-based…
- Trial name
- NIMBLE (NCT05644756)
- Testing
- IMPACT Methods to Identify and Prioritize Determinants (Challenge I), Challenge and Match strategies to Prioritized Determinants (Challenge II)
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
HIV Infections
Scientific Evaluation of Peer Education and STD Treatment to Reduce the Spread of HIV in Zimbabwe
The purpose of this study is to determine whether community-based peer education and condom distribution combined with improved treatment of sexually transmitted infections are effective in reducing the spread of HIV infection in…
- Trial name
- NCT00390949
- Testing
- Peer education among commercial sex workers and clients, Condom distribution and promotion, Syndromic treatment of sexually transmitted infections
- Where
- Zimbabwe
- Volunteers
- 9,454 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Health Behavior
Training LHDs to Disseminate Evidence-Based Interventions to Small Worksites
The proposed project will advance implementation science by comparing the effectiveness of different levels of technical support in an important but understudied community-based setting: local health departments.
- Trial name
- NCT03930420
- Testing
- Connect to Wellness
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Washington
Basic Science
The Effects of Buprenorphine on Responses to Verbal Tasks
In this study, the investigators will examine the effects of buprenorphine, as compared to placebo, upon physiological, subjective, and hormonal responses to a stressful speech task and a non-stressful control task in healthy…
- Trial name
- NCT01860287
- Testing
- Buprenorphine 0.2 MG Sublingual Tablet, Buprenorphine 0.4 MG Sublingual Tablet
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Implementation Science
An Exposure-Based Implementation Strategy to Decrease Clinician Anxiety Around Suicide Prevention
Study objectives are to design and pilot test a novel, exposure-based implementation strategy (EBIS) directly targeting clinician anxiety and low self-efficacy for use of evidence-based suicide screening, assessment, and…
- Trial name
- NCT05172609
- Testing
- Exposure Based Implementation Strategy (EBIS), Implementation as Usual (IAU)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Implementation, Behavioral Symptoms
Working to Implement and Sustain Digital Outcome Measures
This study will investigate the effects of an organizational implementation strategy called Leadership and Organizational Change for Implementation (LOCI), relative to training and technical assistance only, on fidelity to, and…
- Trial name
- WISDOM (NCT04096274)
- Testing
- Leadership for Organization Change and Implementation (LOCI), Training and Technical Assistance Only
- Where
- 4 sites in United States
- Volunteers
- 686 people, healthy volunteers welcome
- Sponsor
- Boise State University
Basic Science
Frontal and Parietal Contributions to Proprioception and Motor Skill Learning
The purpose of this study is to understand how the different regions of the brain affect our sense of limbs in space (proprioception) and in turn our hand movements (motor skill learning).
- Trial name
- NCT05739994
- Testing
- Theta burst transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Indiana University
Basic Science
Neural Basis of Sensory and Motor Learning: Functional Connections
The purpose of this study is to understand how the sensory and motor areas of the brain work together to keep a person's hand movements accurate (sensorimotor learning).
- Trial name
- NCT05124301
- Testing
- Perceptual learning
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Indiana University
Diabetes
Using Practice Facilitation and Operationalizing Referral Information Technology to Increase DSMES Utilization
This is a pilot and feasibility study of a pragmatic cluster randomized trial that utilizes health information technology and practice facilitation to address referral barriers and increase clinician awareness and motivation to…
- Trial name
- NCT05472142
- Testing
- UP FOR IT - practice facilitation, UP FOR IT - health information technology
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Mary Lacy
Basic Science: Visual Attention in Healthy Participants, Attention
Probing the Role of Feature Dimension Maps in Visual Cognition: Impact of Salience Level (Eye-tracking Follow-up Study)
How does one know what to look at in a scene? Imagine a "Where's Waldo" game - it's challenging to find Waldo because there are many 'salient' locations in the picture, each vying for one's attention.
- Trial name
- NCT06852534
- Testing
- Stimulus properties: salience-defining feature, Stimulus properties: magnitude of salience
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Santa Barbara
Independent Living
Implementation of CAPABLE in the Michigan Medicaid Waiver
Main study: Nearly half of older adults report problems with function, which can lead to difficulty with activities of daily living and nursing home placement.
- Trial name
- NCT03634033
- Testing
- MiCAP with IF (Main Study), MiCAP with IF and EF (Main Study), MiCAP with IF and Caregiver Engagement (Administrative Supplement)
- Where
- 18 sites in United States
- Volunteers
- 7,777 people, healthy volunteers welcome
- Sponsor
- Grand Valley State University
Covid19
Community-engaged Approaches to Testing in Community and Healthcare Settings for Underserved Populations
The pandemic caused by the novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has resulted in substantial global morbidity and mortality including in Oklahoma and caused unprecedented interruptions…
- Trial name
- CATCH-UP (NCT04870307)
- Testing
- Dissemination and Implementation Research
- Where
- United States
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma