Clinical trials: Basic Science
HIV, Substance Abuse
Implementation Research for Vulnerable Women in South Africa
This study sought to implement the Women's Health CoOp (Cooperative) (WHC) intervention into healthcare, antenatal, and substance treatment clinics in South Africa and translated this evidence-based intervention into real-world…
- Trial name
- NCT02733003
- Testing
- Women's Health CoOp (WHC)
- Where
- 2 sites in United States, South Africa
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- RTI International
Grief, Post Traumatic Stress Disorder
Building and Sustaining Interventions for Children: Task-sharing Mental Health Care in Low-resource Settings
The BASIC study will take place in Kanduyi/Bungoma South Sub-County, in western Kenya, and focuses on children orphaned by one or two parents.
- Conditions
- Grief, Post Traumatic Stress Disorder, Depression
- Trial name
- BASIC (NCT03243396)
- Testing
- Trauma-Focused Cognitive Behavioral Therapy
- Where
- Kenya
- Volunteers
- 956 people
- Sponsor
- Duke University
Diabetes type1, Diabetes Mellitus, Type 1
Behavioral Approaches to Reduce Diabetes Distress in Adults With Type 1 Diabetes: A Pragmatic SMART
This study is designed to compare two behavioral approaches to reduce diabetes distress ("the expected burdens, concerns, fears, and threats that arise from the challenges of living with diabetes") in adults with type 1 diabetes.
- Conditions
- Diabetes type1, Diabetes Mellitus, Type 1, Diabetes, Autoimmune, Diabetes Mellitus
- Trial name
- ChargeUp (NCT06405373)
- Testing
- ReCharge, TakeCharge
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of North Carolina, Chapel Hill
Chronic Obstructive Pulmonary Disease
Developing an Intervention to Optimize Virtual Care Adoption for COPD Management
VA is a leader in virtual care (VC), including the patient portal, mobile apps, and telehealth programs. VC has great utility for managing chronic conditions like chronic obstructive pulmonary disease (COPD).
- Trial name
- VC-OPTIONS (NCT05986214)
- Testing
- VC-OPTIONS
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
HIV/AIDS
Translation of Basic Research in Cognitive Science to HIV Risk
A randomized trial was conducted at drug diversion educational programs with a sample of 343 adult drug offenders who volunteered for the study.
- Trial name
- NCT03175250
- Testing
- Health Education, Action Plan, Memory Practice
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- Claremont Graduate University
Depression, Hypertension
Community-based Approach to Lowering Stress Through Mindfulness
The goal of this clinical trial is to test a culturally adapted mindfulness-based stress reduction intervention in a community setting for African American adults with high blood pressure (hypertension) and depression.
- Trial name
- CALM-Chicago (NCT06987799)
- Testing
- Mindfulness-Based Stress Reduction (MBSR; CALM-Chicago Study)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Northwestern University
ICU Patients, Surgical
Implementation of Clinical Nutrition Practice Guidelines in Surgical ICUs
The goal of this interventional clinical trial is to evaluate whether the implementation of an evidence-based, context-adapted clinical nutrition practice guideline can improve clinical nutrition management in surgical intensive…
- Conditions
- ICU Patients, Surgical, Nutrition Intervention, Enteral Nutrition
- Trial name
- NCT07337798
- Testing
- Guideline Implementation
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Blood Pressure
Placebo Effects on Blood Pressure
A relevant reduction of blood pressure (BP) in placebo-treated control groups is a phenomenon often observed in pharmacological studies of hypertension.
- Trial name
- NCT00570271
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Obesity, Abdominal, Weight Loss
The Effect of Fermented and Non-fermented Soy Based Food in Appetite and Satiety Biomarker Among Young Obesity
Limited data are available regarding the satiety effects from fermented and non-fermented soy-based food. The aim of this study was to compare fermented (tempeh) and non-fermented soy-based diets high in protein in increasing…
- Trial name
- NCT04425109
- Testing
- meal test response
- Where
- Indonesia
- Volunteers
- 13 people
- Sponsor
- Universitas Diponegoro
Breast Cancer, Ovarian Cancer
Navigation Intervention for Adolescent and Young Adult Cancer Survivors
The investigators propose to: 1) Adapt an evidence-based cancer-focused patient navigation (PN) program for the Adolescent and Young Adult (AYA) cancer survivor population; and 2) Plan and conduct an effectiveness-implementation…
- Conditions
- Breast Cancer, Ovarian Cancer, Cervical Cancer, Testicular Cancer
- Trial name
- NCT07406087
- Testing
- Adapted patient navigation program targeting adolescent and young adult cancer survivors
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Kaiser Permanente
Airway Disease
Therapeutic Effects of Jing Si Herbal Tea for COPD
Chronic obstructive pulmonary disease (COPD), a leading cause of global mortality, significantly impairs health-related quality of life (HRQL). COPD is characterized by airway inflammation and lung tissue damage.
- Trial name
- NCT06584786
- Testing
- Jing Si herbal tea (JSHT)
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Cystinosis, Cystinosis, Nephropathic
Genetic Newborn Screening for Cystinosis and Spinal Muscular Atrophy
Newborn screening in Germany is a voluntary program. Cystinosis and spinal muscular atrophy (SMA) are rare autosomal recessive diseases. They are inherited in an autosomal recessive manner, i.e.
- Conditions
- Cystinosis, Cystinosis, Nephropathic, Spinal Muscular Atrophy
- Trial name
- GENESIS1 (NCT06027385)
- Testing
- molecular-based screening
- Where
- 4 sites in Germany
- Volunteers
- 300,000 people
- Sponsor
- Cystinose Stiftung
Obesity, Diabetes
Lifestyle Changes Through Exercise and Nutrition
The goal of The LEAN project intervention is to promote weight loss, healthy dietary habits, increased physical activity, improved blood glucose and cholesterol, and weight related quality of life in obese African American adults…
- Trial name
- LEAN (NCT02863887)
- Testing
- Weight loss intervention
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Pennington Biomedical Research Center
Healthy
Evaluation of Four Different Dosing Regimens of Cross-Linked Polyelectrolyte (CLP) in Healthy Volunteers
This is a study to determine the effect of four different dosing regimens of CLP in normal healthy volunteers.
- Trial name
- NCT02079233
- Testing
- Cross-Linked Polyelectrolyte (CLP)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sorbent Therapeutics
Pain, Incontinence, Urinary
Sumamos Excelencia 2022
There is a gap between research and clinical practice, leading to variability in decision-making. Clinical audits are an effective strategy for improving implementation of best practices.
- Conditions
- Pain, Incontinence, Urinary, Obesity, Childhood, Breastfeeding
- Trial name
- NCT05466656
- Testing
- Continuous quality improvement cycle model
- Where
- Spain
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Teresa Moreno Casbas
Humans, Simulation Training
Using 'Guided-Discovery-Learning' to Optimize and Maximize Transfer of Surgical Simulation
The study is a randomized experimental study comparing two forms of learning; guided-discovery-learning and traditional instructional learning.
- Conditions
- Humans, Simulation Training, Problem-Based Learning, Clinical Competence
- Trial name
- GDLEFFICACY (NCT03684720)
- Testing
- Discover followed by direct instruction [DD]
- Where
- Denmark
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Copenhagen Academy for Medical Education and Simulation
Headache, Migraine
Carbon Monoxide Migraine-inducing Effects in Patients With Migraine Without Aura.
To investigate headache score and accompanying symptoms during and after inhalation of carbon monoxide.
- Trial name
- NCT03075020
- Testing
- Carbon monoxide, AIR
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Basic Science: Safety, Tolerability, Efficacy of CLP
Evaluation of Cross-Linked Polyelectrolyte (CLP) in Healthy Volunteers
This is a dose-escalation study to determine the effect of CLP in normal healthy volunteers.
- Trial name
- NCT01944007
- Testing
- Cross-Linked Polyelectrolyte (CLP)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sorbent Therapeutics
Frailty Syndrome
PREhabilitation of Frail Elderly PAtients Undergoing majoR surgEry at HOME (PREPARE-HOME) Using Smart Wearables
The goal of this clinical trial is to evaluate whether a prehabilitation program using wearable technology can improve physical function and postoperative outcomes in elderly patients (65 years or older) undergoing major elective…
- Trial name
- PREPARE@HOME (NCT06633614)
- Testing
- Supervised prehabilitation programme
- Volunteers
- 190 people
- Sponsor
- Singapore General Hospital
Type2 Diabetes Mellitus
Clinical Study to Assess the Safety, Efficacy and In-Use Tolerability of Herbal-Based Sugar Support Effervescent Tablets in Type-2 Diabetes Mellitus Patients
This is a Proof-of-Science, exploratory, prospective, single-treatment, two-group, clinical safety, efficacy and tolerability study of herbal based Sugar support effervescent tablets on the patients with Type 2 Diabetes Mellitus.
- Trial name
- NCT06961019
- Testing
- Sugar support effervescent Tablets
- Where
- India
- Volunteers
- 14 people
- Sponsor
- NovoBliss Research Pvt Ltd