Clinical trials: Basic Science
Inflammatory Bowel Diseases, Crohn Disease
Quantify the Value of Transmural Inflammation in the Treatment of Crohn's Disease With Ustekinumab:an Analysis Based on Imaging Science
Crohn's disease(CD),a type of inflammatory bowel disease(IBD), is a chronic intestinal recurrent inflammatory disease involving the entire digestive tract.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Biologics
- Trial name
- NCT05642247
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
HIV/AIDS, Mobile Health
Evaluation of a Multi-Component Intervention to Support HIV Testing and Linkage to Services Among MSM in Peru
This study is testing a new program designed to improve access to HIV testing and help connect people with available treatment or prevention services, based on their test result.
- Conditions
- HIV/AIDS, Mobile Health, Feasibility Studies, Qualitative Research
- Trial name
- MERCURY (NCT07074899)
- Testing
- Multi-component HIV testing and linkage-to-services intervention
- Where
- 2 sites in Peru
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Obesity, Abdominal, Weight Loss
The Effect of Fermented and Non-fermented Soy Based Food in Appetite and Satiety Biomarker Among Young Obesity
Limited data are available regarding the satiety effects from fermented and non-fermented soy-based food. The aim of this study was to compare fermented (tempeh) and non-fermented soy-based diets high in protein in increasing…
- Trial name
- NCT04425109
- Testing
- meal test response
- Where
- Indonesia
- Volunteers
- 13 people
- Sponsor
- Universitas Diponegoro
Frailty Syndrome
PREhabilitation of Frail Elderly PAtients Undergoing majoR surgEry at HOME (PREPARE-HOME) Using Smart Wearables
The goal of this clinical trial is to evaluate whether a prehabilitation program using wearable technology can improve physical function and postoperative outcomes in elderly patients (65 years or older) undergoing major elective…
- Trial name
- PREPARE@HOME (NCT06633614)
- Testing
- Supervised prehabilitation programme
- Volunteers
- 190 people
- Sponsor
- Singapore General Hospital
Basic Science: Safety, Tolerability, Efficacy of CLP
Evaluation of Cross-Linked Polyelectrolyte (CLP) in Healthy Volunteers
This is a dose-escalation study to determine the effect of CLP in normal healthy volunteers.
- Trial name
- NCT01944007
- Testing
- Cross-Linked Polyelectrolyte (CLP)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sorbent Therapeutics
Mammography, Medical Overuse
A Multi-Level Strategy for De-implementing Mammography Overuse Among Older Women
This project aims to advance methodological and theoretical approaches for developing, selecting, refining, and piloting a multilevel de-implementation strategy to reduce the overuse of screening mammography in women aged ≥75…
- Conditions
- Mammography, Medical Overuse, Evidence-based Practice, Older Adults
- Trial name
- NCT07511621
- Testing
- Enhanced Usual Care (EUC), Multilevel De-Implementation Strategy
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Columbia University
Alcohol Use, Underage Drinking
Parent-Focused Alcohol Prevention Program for Hispanic Families in Faith-Based Settings
The goal of this clinical trial is to determine whether Guiando Buenas Decisiones, a parent-focused alcohol prevention program, can help prevent or delay alcohol initiation and use among Hispanic immigrant adolescents ages 12 to…
- Conditions
- Alcohol Use, Underage Drinking, Parenting Intervention, Prevention
- Trial name
- NCT07869550
- Testing
- Guiando Buenas Decisiones (GBD)
- Where
- United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Diabetes, Pharmacist-Patient Relations
Refinement and Testing of Recruitment Methodology for Behavioral Medication Adherence Interventions Using Behavioral Science-based Approaches
The overarching goal of the proposed research is to prepare the clinical pharmacist intervention for sustainable implementation and dissemination.
- Conditions
- Diabetes, Pharmacist-Patient Relations, Medication Adherence
- Trial name
- STIC2IT-2 (NCT06569290)
- Testing
- Primer postcard, Control recruitment letter, Behavioral theory-informed recruitment letter (prospect theory)
- Where
- United States
- Volunteers
- 590 people
- Sponsor
- Brigham and Women's Hospital
Hypertension, Diabetes
Group-Care for Hypertension and Diabetes Management in Nepal
Hypertension and diabetes represent significant and growing public health challenges in Nepal, particularly in underserved communities.
- Trial name
- GCHD- Nepal (NCT07439380)
- Testing
- Low Intensity Community-Based Group NCD Care, High Intensity Community-Based Group NCD Care
- Where
- Nepal
- Volunteers
- 1,110 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Atrial Fibrillation (Prevention of Stroke), Arrythmia, Cardiac
Pharmacy-based Opportunistic Atrial Fibrillation Screening Integrated With Emergency Services (NUMAPLUS-FA)
This study evaluates the feasibility and fidelity of an opportunistic atrial fibrillation (AF) screening programme conducted in 38 community pharmacies in Seville (Spain), using the Kardias® 6-lead portable ECG device…
- Conditions
- Atrial Fibrillation (Prevention of Stroke), Arrythmia, Cardiac, Mass Screening, Pharmacies
- Trial name
- Numaplus_FA (NCT07598903)
- Testing
- Integrated pharmacy-based AF screening circuit
- Where
- Spain
- Volunteers
- 380 people
- Sponsor
- Centro de Emergencias Sanitarias 061 Andalucía
Childhood Obesity, Evidence-Based Practice
Network-Based Support to Help Community Coalition Members Choose and Use Strategies to Improve Child Health
Community coalitions bring together residents and organizations to improve child health, but they may need support to identify and put research-supported strategies into practice.
- Conditions
- Childhood Obesity, Evidence-Based Practice, Food Systems, Food Policy
- Trial name
- NCT07804550
- Testing
- Catalyzing Communities, FICAS Implementation Intervention
- Where
- United States
- Volunteers
- 3,300 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Unplanned Hospitalizations
Sustainable Improvement of INTERprofessional Care for Better Resident Outcomes
INTERCARE is an interprofessional nurse-led care model developed specifically for long-term care facilities (LTCFs) in Switzerland that has been shown to successfully reduce unplanned transfers for residents.
- Trial name
- INTERSCALE (NCT06473051)
- Testing
- Original set, Adapted set
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Basel
Child Behavior Disorders
Teachers Leading the Frontlines (Tealeaf) - a Hybrid Effectiveness, Implement, and Context Trial
Purpose: The overall aim of this study is to evaluate the effectiveness, implementation, and contextual influences of a teacher-delivered transdiagnostic model of child mental health care (Tealeaf) for school-aged children in…
- Trial name
- Tealeaf (NCT05179759)
- Testing
- Tealeaf, Enhanced Usual Care
- Where
- India
- Volunteers
- 20,160 people
- Sponsor
- University of North Carolina, Chapel Hill
Breast Cancer, Breast Fibroadenoma
Exploring a Breast Cancer Early Screening Model Based on cfDNA
The goal of this observational study is to use cfDNA multi-omics technology to explore a new breast cancer early detection model to improve the accuracy of early diagnosis in breast cancer patients.
- Conditions
- Breast Cancer, Breast Fibroadenoma, Breast Hypoplasia
- Trial name
- NCT06016790
- Testing
- cfDNA sequencing
- Where
- 8 sites in China
- Volunteers
- 839 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Diabetes type1, Diabetes Mellitus, Type 1
Behavioral Approaches to Reduce Diabetes Distress in Adults With Type 1 Diabetes: A Pragmatic SMART
This study is designed to compare two behavioral approaches to reduce diabetes distress ("the expected burdens, concerns, fears, and threats that arise from the challenges of living with diabetes") in adults with type 1 diabetes.
- Conditions
- Diabetes type1, Diabetes Mellitus, Type 1, Diabetes, Autoimmune, Diabetes Mellitus
- Trial name
- ChargeUp (NCT06405373)
- Testing
- ReCharge, TakeCharge
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of North Carolina, Chapel Hill