Clinical trials: Basic Science, open to volunteers
Inappropriate Prescribing, Implementation Science
Reduction of Low-value Prescribing Through Audit and Feedback
The objective is to estimate the effect attributable to a primary care pharmacist-led audit and feedback (AF) strategy compared to the currently used AF strategy as a management tool to evaluate healthcare performance focusing on…
- Conditions
- Inappropriate Prescribing, Implementation Science, Behavioral Sciences
- Trial name
- AFFAP (NCT07336550)
- Testing
- Usual AF, Facilitated AF
- Where
- Spain
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Basque Health Service
Pregnant Women, Breastfeeding
Impact of Podcast-Based Breastfeeding Education During Pregnancy on Breastfeeding Self-Efficacy in Pregnant Women
Women who meet the sampling selection criteria will be introduced and informed about the study. Considering the patients who meet the research criteria and accept the study, patients will be divided into groups according to…
- Trial name
- NCT06844929
- Testing
- Podcast Group, Brochure Group
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Mammography, Medical Overuse
A Multi-Level Strategy for De-implementing Mammography Overuse Among Older Women
This project aims to advance methodological and theoretical approaches for developing, selecting, refining, and piloting a multilevel de-implementation strategy to reduce the overuse of screening mammography in women aged ≥75…
- Conditions
- Mammography, Medical Overuse, Evidence-based Practice, Older Adults
- Trial name
- NCT07511621
- Testing
- Enhanced Usual Care (EUC), Multilevel De-Implementation Strategy
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Columbia University
Coronary Heart Disease, Coronary Artery Disease
A Study on Yiyang Huoluo Decoction in the Treatment of Coronary Heart Disease
The goal of this clinical trial is to learn if Yiyang Huoluo Decoction (a custom Chinese herbal medicine) works safely and effectively to treat coronary heart disease with atherosclerosis in older adults.
- Conditions
- Coronary Heart Disease, Coronary Artery Disease, Atheroscleroses
- Trial name
- NCT07493603
- Testing
- Yiyang Huoluo Decoction, conventional western medicine treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xia Liang
Breast Cancer
Developing a Comprehensive Exercise Service for Breast Cancer Process
"Moving Together" (Juntas en Movimiento) is a hospital-based, comprehensive, and personalized exercise service designed for women diagnosed with breast cancer.
- Trial name
- NCT07380971
- Testing
- Supervised in-person exercise training, Supervised Online Exercise Training, Home-Based Autonomous Exercise Program
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- GO fit Lab- Ingesport
Implementation Science, Type 1 Diabetes in Adolescence
Pilot Implementation Trial of Implementation Toolkits for Diabetes Coaching
The goal of this study is to learn if toolkits of implementation strategies (e.g., provider and staff education, clear plan for how to refer and bill) help pediatric type 1 diabetes medical and psychology providers deliver a…
- Conditions
- Implementation Science, Type 1 Diabetes in Adolescence, Implementation Strategies
- Trial name
- NCT07766811
- Testing
- Base Implementation Toolkit (BIT), BIT-Enhanced, BIT-Sustainment
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
CRBSI - Catheter Related Bloodstream Infection, Evidence-based Nursing Practice
Multicenter Clinical Translational Study of "ICU-NO CRBSI" Based on Improvement Science
The goal of this type of study is to construct the continuous quality promotion project "ICU-NO CRBSI(Catheter-Related Bloodstream Infection , CRBSI)" based on improvement science, and to verify its effect in the prevention of…
- Conditions
- CRBSI - Catheter Related Bloodstream Infection, Evidence-based Nursing Practice, Central Venous Catheter Related Bloodstream Infection, Central Venous Catheter Associated Bloodstream Infection
- Trial name
- NCT06085690
- Testing
- evidence-based intervention Plan for the Prevention of CRBSI in ICU patients
- Where
- China
- Volunteers
- 8,050 people, healthy volunteers welcome
- Sponsor
- Fudan University
Acute Coronary Syndrome (ACS), Myocardial Infarction
TeleheartCR vs. Clinic-Based Cardiac Rehabilitation After Acute Coronary Syndrome
Cardiac rehabilitation (CR) is an effective evidence-based intervention that improves outcomes in patients with acute coronary syndrome (ACS), but many eligible patients do not complete the program.
- Trial name
- NCT07541014
- Testing
- Telehealth-enhanced Hybrid CR, Traditional Cardiac Rehabilitation
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Columbia University
Papillomavirus Vaccines, HPV Vaccines
HPV Vaccine Integrated Service Implementation Research in Ethiopia
The goal of this implementation research study is to understand whether a package of community-based interventions can increase access to and uptake of the human papillomavirus (HPV) vaccine among very young adolescent girls in…
- Conditions
- Papillomavirus Vaccines, HPV Vaccines, HPV Vaccine Acceptability, HPV Vaccine Attitudes
- Trial name
- HPV-VISION (NCT06667323)
- Testing
- Integrated health service delivery for very young adolescent girls
- Volunteers
- 1,140 people, healthy volunteers welcome
- Sponsor
- Population Services International
Basic Science
The Neurobiological Effect of 5-HT2AR Modulation
The investigators wish to investigate neurobiological effects of serotonin 2A receptor modulation in healthy volunteers, contrasting effects of an agonist (psilocybin) and an antagonist (ketanserin).
- Trial name
- NeuroPharm2 (NCT03289949)
- Testing
- Psilocybine, Ketanserin
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Gitte Moos Knudsen
Depression, Hypertension
Community-based Approach to Lowering Stress Through Mindfulness
The goal of this clinical trial is to test a culturally adapted mindfulness-based stress reduction intervention in a community setting for African American adults with high blood pressure (hypertension) and depression.
- Trial name
- CALM-Chicago (NCT06987799)
- Testing
- Mindfulness-Based Stress Reduction (MBSR; CALM-Chicago Study)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Northwestern University
Falls Prevention
Walk On! National Council on Aging Innovation Lab
This is a multi-site, one-arm type-2 hybrid-effectiveness implementation trial. The goal of this clinical trial is to learn if the Walk On! program helps prevent falls in older adults who have trouble moving around or feel…
- Trial name
- Walk On! NCOA (NCT07368907)
- Testing
- Walk On! Program
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Wake Forest University Health Sciences
Childhood Obesity, Evidence-Based Practice
Network-Based Support to Help Community Coalition Members Choose and Use Strategies to Improve Child Health
Community coalitions bring together residents and organizations to improve child health, but they may need support to identify and put research-supported strategies into practice.
- Conditions
- Childhood Obesity, Evidence-Based Practice, Food Systems, Food Policy
- Trial name
- NCT07804550
- Testing
- Catalyzing Communities, FICAS Implementation Intervention
- Where
- United States
- Volunteers
- 3,300 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Atrial Fibrillation (Prevention of Stroke), Arrythmia, Cardiac
Pharmacy-based Opportunistic Atrial Fibrillation Screening Integrated With Emergency Services (NUMAPLUS-FA)
This study evaluates the feasibility and fidelity of an opportunistic atrial fibrillation (AF) screening programme conducted in 38 community pharmacies in Seville (Spain), using the Kardias® 6-lead portable ECG device…
- Conditions
- Atrial Fibrillation (Prevention of Stroke), Arrythmia, Cardiac, Mass Screening, Pharmacies
- Trial name
- Numaplus_FA (NCT07598903)
- Testing
- Integrated pharmacy-based AF screening circuit
- Where
- Spain
- Volunteers
- 380 people
- Sponsor
- Centro de Emergencias Sanitarias 061 Andalucía
Endometriosis
" Development of Primary Cultures of Diaphragmatic Myoblasts for Basic Research Purposes "
Neuromuscular diseases (NMDs) affecting motor neurons (MN) induce progressive muscle denervation, and become fatal when respiratory muscles e.g. the diaphragm are affected and can no longer contract.
- Trial name
- MYODiaph (NCT07380308)
- Testing
- During the surgery planned as part of the routine care of the patient, a part of the tissue sample will be saved in order to carry out the analysis planned for the research.
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV Infections, HIV Prevention
Community-based Outreach and Navigation for Nurse-led Engagement in HIV Care and Treatment
Many people who are experiencing homelessness are at high risk for HIV, but they often have trouble getting HIV prevention or treatment.
- Conditions
- HIV Infections, HIV Prevention, Homeless Persons, Homelessness
- Trial name
- CONNECT (NCT07870603)
- Testing
- CONNECT (status-neutral, nurse-led on-site HIV service delivery), Standard of Care (referral-based outreach)
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Donaldson Conserve
Episiotomy, Episiotomy Extended by Laceration
Evaluation of Interventions Based on Behavioral Sciences to Reduce Episiotomy Use
This pilot study seeks to analyze the impact of interventions based on behavioral economics theory (e.g., feedback and information) on episiotomy use.
- Conditions
- Episiotomy, Episiotomy Extended by Laceration, Episiotomy Infection, Episiotomy Wound
- Trial name
- NCT06625866
- Testing
- Feedback and information
- Volunteers
- 2 people
- Sponsor
- Universidad Panamericana
Alcohol Misuse, Tobacco Use
A Mindfulness-based Intervention for Sexual Assault Survivors
The goal is this pilot randomized trial is to learn if intervention 1 is feasible and acceptable. A secondary aim is to learn if intervention 1 reduces alcohol misuse and tobacco use in sexual assault survivors.
- Conditions
- Alcohol Misuse, Tobacco Use, Mindfulness, Stress
- Trial name
- NCT07515586
- Testing
- mindfulness-based intervention, comparison intervention
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Georgia State University
Psychological Distress, Stress Psychological
A Community-based, Peer-led Counseling Service: A Hybrid Type 3 Effectiveness-implementation Study
The goal of this observational study is to learn how a community-based peer counselling service works in everyday practice and whether it helps people who are going through a psychologically difficult time.
- Conditions
- Psychological Distress, Stress Psychological, Mental Health, Recovery
- Trial name
- NCT07879443
- Volunteers
- 65 people
- Sponsor
- St.Gallen University of Applied Sciences
Healthy Volunteers, no Condition, Basic Science
Transcranial Ultrasonic Neuromodulation of Primary Visual Cortex and Primary Auditory Cortex in Humans
There are a number of disorders of the brain that have limited treatment options, such as chronic pain, addiction, and major depression.
- Trial name
- NCT07508722
- Testing
- Transcranial Focused Ultrasound Stimulation, Electroencephalography, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts Institute of Technology