Clinical trials: Basic Science
Health Behavior
Training LHDs to Disseminate Evidence-Based Interventions to Small Worksites
The proposed project will advance implementation science by comparing the effectiveness of different levels of technical support in an important but understudied community-based setting: local health departments.
- Trial name
- NCT03930420
- Testing
- Connect to Wellness
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Washington
no Condition, Basic Science
Effects of Prazosin on the Attention-Enhancing Effects of Nicotine
To test whether specific aspects of the attention-enhancing effects of nicotine may be mediated by down-stream activation of alpha1 adrenoceptors, the interaction of nicotine and the alpha1 adrenergic antagonist prazosin on…
- Trial name
- NCT03416569
- Testing
- Nicotine, Prazosin, Nicotine + Prazosin
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Cancer, Exercise
From Exercise Oncology Research to Clinical Practice
Building on previous research that shows the benefits of exercise, this study aims to find out how best to implement exercise in real-world settings.
- Conditions
- Cancer, Exercise, Implementation of Evidence Based Programs, Cost Effectiveness
- Trial name
- PAC ICare (NCT07635589)
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Melanie Keats
Sleep Deprivation, Critical Illness
Sleep Harmonization Via Bundled Team-Based Interventions in the ICU
SHANTI-ICU compares the effectiveness of two evidence-based multicomponent ICU sleep promotion bundles on delirium and patient-reported sleep quality in critically ill adults. Bundle A is a non-pharmacologic strategy.
- Conditions
- Sleep Deprivation, Critical Illness, Sleep-Wake Disorders, Bundle Care
- Trial name
- SHANTI-ICU (NCT07840560)
- Testing
- Nighttime noise & light reduction, Clustering patient-care interactions, Non-pharmacologic sleep aids
- Where
- 8 sites in United States, Puerto Rico
- Volunteers
- 62,500 people
- Sponsor
- University of California, San Diego
Episodic Memory
Episodic Memory Integration and Interference
The purpose of this study is to assess how emotional memories integrate and interfere with one another over time. We will be using a multi-session experimental paradigm consisting of two encoding sessions and one retrieval…
- Trial name
- NCT05974371
- Testing
- emotional context similarity
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Boston College
Cervical Cancer Screening, HIV
Home-based Self-sampling for Cervical Cancer Prevention Education Intervention in Ghana
The investigators propose to develop and/or adapt implementation strategies and a structured implementation plan to translate the HOPE intervention into existing healthcare practice in Ghana.
- Conditions
- Cervical Cancer Screening, HIV, Self-sampling, Implementation Science
- Trial name
- HOPE-inG (NCT06800664)
- Testing
- Health providers and management at IG sites will receive ISS (i.e., management support, capacity-building, and social network support) and training on the HOPE implementation plan, Control Group
- Where
- Ghana
- Volunteers
- 1,500 people
- Sponsor
- Baylor University
Severe Mental Disorder, Schizophrenia
Community-based Mental Health Care for People With Severe and Enduring Mental Ill Health (RECOVER-E) Croatia
To contribute to improving the level of functioning and quality of life and mental health outcomes for people with severe and enduring mental ill health (SMI) (schizophrenia, bipolar disorder, depression) by adapting and up…
- Conditions
- Severe Mental Disorder, Schizophrenia, Bipolar Disorder, Severe Depression
- Trial name
- RECOVER-E (NCT03862209)
- Testing
- Community mental health team
- Where
- Croatia
- Volunteers
- 200 people
- Sponsor
- Klinički Bolnički Centar Zagreb
Covid19, Vaccines
Text-based Reminders to Promote COVID-19 Vaccinations
This study investigates whether and which type of text-based reminders affect the take-up of the COVID-19 vaccine.
- Trial name
- NCT04801524
- Testing
- Self-benefit, Prosocial-benefit, Early access
- Where
- United States
- Volunteers
- 250,000 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Sedentary, Elderly
Intervention to Increase Physical Activity in Older Adults Using Citizen-science and Modern Technology
To develop and implement a physical activity promotion intervention for older adults with or without chronic disease living in an urban environment.
- Conditions
- Sedentary, Elderly, Physical Activity
- Trial name
- NCT02744924
- Testing
- Physical activity intervention
- Where
- Switzerland
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Migraine Headache
TelemEdiciNe-bAsed Cognitive TherapY for Migraines
The goal of this pilot study is to evaluate a bundle of implementation strategies at three Veteran Affairs Medical Centers (VAMCs) to facilitate the referral and adoption of a telehealth based, cognitive behavioral therapy…
- Trial name
- TENACITY (NCT04613362)
- Testing
- TENACITY Telehealth Cognitive Behavioral Therapy for Migraine, Behavioral Usual Care
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Implementation Science, Diet, Food, and Nutrition
Sustainability Via Active Garden Education Wellness Implementation Strategies in Early Care and Education
This project compares four SAGE implementation strategies to evaluate effectiveness in implementation, sustainability, cost, and child health outcomes.
- Conditions
- Implementation Science, Diet, Food, and Nutrition, Child Care, Motor Behavior
- Trial name
- SAGE WISE (NCT07228819)
- Testing
- SAGE Basic, SAGE e-support, SAGE in-person support
- Where
- United States
- Volunteers
- 871 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Falls Prevention
Walk On! National Council on Aging Innovation Lab
This is a multi-site, one-arm type-2 hybrid-effectiveness implementation trial. The goal of this clinical trial is to learn if the Walk On! program helps prevent falls in older adults who have trouble moving around or feel…
- Trial name
- Walk On! NCOA (NCT07368907)
- Testing
- Walk On! Program
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Wake Forest University Health Sciences
No Condition, Basic Science
Effects of Post-activation Performance Enhancement Protocols on Judo-specific Performance: a Randomized Crossover Trial
The study aimed to investigate the post-activation performance enhancement (PAPE) of the special judo fitness test (SJFT) of youth judo athletes using upper-body (isometric push-ups), lower-body (standing broad jumps), or their…
- Trial name
- NCT06768723
- Testing
- Warm-up (specifically, Post-Activation Performance Enhancement)
- Where
- Portugal
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Atrial Fibrillation, Arrhythmias, Cardiac
Predicting Risk of Atrial Fibrillation and Association With Other Diseases
Atrial fibrillation (AF) is a major public health issue: it is increasingly common, incurs substantial healthcare expenditure, and is associated with a range of adverse outcomes.
- Conditions
- Atrial Fibrillation, Arrhythmias, Cardiac, Heart Diseases, Cardiovascular Diseases
- Trial name
- FIND-AF (NCT05837364)
- Testing
- Development of an algorithm
- Where
- United Kingdom
- Volunteers
- 2,159,663 people
- Sponsor
- University of Leeds
Basic Science: Visual Attention in Healthy Participants, Attention
Probing the Role of Feature Dimension Maps in Visual Cognition: Manipulations of Relevant Locations on Salience Processing? (Expt 3.1 Pilot)
How do we know what's important to look at in the environment? Sometimes, we need to look at objects because they are 'salient' (for example, bright flashing lights of a police car, or the stripes of a venomous animal), while…
- Trial name
- NCT06852521
- Testing
- Stimulus Properties: Target Location, Stimulus Properties: Distractor Presence, Stimulus properties: Cue Validity
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of California, Santa Barbara
Basic Science: Visual Attention in Healthy Participants, Basic Science: Neural Representations of Location
Probing the Role of Feature Dimension Maps in Visual Cognition: Impact of Task Demands and Spatial Attention (Expt 2.2)
How does one know what to look at in a scene? Imagine a "Where's Waldo" game - it's challenging to find Waldo because there are many 'salient' locations in the picture, each vying for one's attention.
- Trial name
- NCT07572630
- Testing
- Stimulus properties: task-defining feature
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, Santa Barbara
Psychological Distress, Stress Psychological
A Community-based, Peer-led Counseling Service: A Hybrid Type 3 Effectiveness-implementation Study
The goal of this observational study is to learn how a community-based peer counselling service works in everyday practice and whether it helps people who are going through a psychologically difficult time.
- Conditions
- Psychological Distress, Stress Psychological, Mental Health, Recovery
- Trial name
- NCT07879443
- Volunteers
- 65 people
- Sponsor
- St.Gallen University of Applied Sciences
Chronic Pain, Musculoskeletal Pain
Lessons in Affect Regulation to Keep Stress and Pain UndeR Control (LARKSPUR R34)
Chronic pain affects millions of Americans but integrative as well as conventional treatments fall short in terms of alleviating this pain.
- Trial name
- LARKSPUR (NCT03699553)
- Testing
- LARKSPUR; Online Positive Emotions Skills for Individuals with Chronic Musculoskeletal Pain, Emotion Reporting Control Group
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
Health Personnel, Communication Skills
Evaluation of Health Sciences Professionals
Introduction: The physician-patient relationship (PPR) is a core element of clinical practice. It affects both patients (e.g., satisfaction, treatment adherence) and healthcare professionals (e.g., reduced conflict, improved…
- Conditions
- Health Personnel, Communication Skills, Physician-Patient Relationship, Clinical Competence
- Trial name
- COMMED (NCT07491692)
- Testing
- quasi-experimental pretest-posttest:Effectiveness of an Intervention Based on Communication Skills and Cognitive Distortions to Improve the Doctor-Patient Relationship
- Where
- Spain
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Basic Science, Orthodontic Appliance Complication
Clinical Effectiveness of the Calcium Chloride (CaCl2) Surface- Treated Orthodontic Mini Implant (OMI)
The goal of this split mouth, randomised control study was to compare the clinical effectiveness of surface treated Calcium Chloride orthodontic mini implant in orthodontic patients.
- Conditions
- Basic Science, Orthodontic Appliance Complication, Malocclusion
- Trial name
- NCT06607536
- Testing
- calcium chloride surface treatment in mini implant, Acid Etched
- Where
- Malaysia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Universiti Teknologi Mara