Clinical trials: Basic Science, active
Basic Science
Neural Basis of Sensory Learning: Brain Regions
The purpose of this study is to understand how the sensory and motor areas of the brain work together to keep a person's hand movements accurate (sensorimotor learning).
- Trial name
- NCT05079516
- Testing
- Theta burst transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Indiana University
Sleep Deprivation, Critical Illness
Sleep Harmonization Via Bundled Team-Based Interventions in the ICU
SHANTI-ICU compares the effectiveness of two evidence-based multicomponent ICU sleep promotion bundles on delirium and patient-reported sleep quality in critically ill adults. Bundle A is a non-pharmacologic strategy.
- Conditions
- Sleep Deprivation, Critical Illness, Sleep-Wake Disorders, Bundle Care
- Trial name
- SHANTI-ICU (NCT07840560)
- Testing
- Nighttime noise & light reduction, Clustering patient-care interactions, Non-pharmacologic sleep aids
- Where
- 8 sites in United States, Puerto Rico
- Volunteers
- 62,500 people
- Sponsor
- University of California, San Diego
Basic Science
LSD Occupancy of the Serotonin 2A Receptor in the Human Brain
The investigators wish to quantify the relation between administered dose of lysergic acid diethylamide (LSD), plasma LSD levels, and occupancy at the serotonin 2A receptor (5-HT2AR) using [11C]CIMBI-36 positron emission…
- Trial name
- dOccLS (NCT05953038)
- Testing
- Lysergic Acid Diethylamide Tartrate
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Prostate Cancer, Risk Assessment
PROstate Cancer Risk Calculator for ACTionable Clinical Decision-making in Nigeria
This study is a pilot trial that builds on findings from the validation of prostate cancer risk calculators in Nigerian men. The goal of the overall study is to improve the early detection of prostate cancer in a high-risk…
- Conditions
- Prostate Cancer, Risk Assessment, Clinical Decision Support Systems, Predictive Value of Tests
- Trial name
- PROACT (NCT07733440)
- Testing
- (a) Training and (b) Supported risk assessment
- Where
- Nigeria
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Ahmadu Bello University
Neurodevelopmental Disorders
WHO Mental Health Gap Action Program (mhGAP) for Improving Child Mental and Behavioral Disorder Service Quality in China
The goal of this clinical trial is to learn if the adapted mhGAP intervention guide (mhGAP-IG) can improve quality of child mental and behavioral disorders (CMBDs) services in China.
- Trial name
- mhGAP (NCT06702410)
- Testing
- mental health gap action program intervention guide (mhGAP-IG)
- Where
- 9 sites in China
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Falls Prevention
Walk On! National Council on Aging Innovation Lab
This is a multi-site, one-arm type-2 hybrid-effectiveness implementation trial. The goal of this clinical trial is to learn if the Walk On! program helps prevent falls in older adults who have trouble moving around or feel…
- Trial name
- Walk On! NCOA (NCT07368907)
- Testing
- Walk On! Program
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Wake Forest University Health Sciences
Suicide
TEEM-GIFTS: A Gamified mHealth to Reduce Post-Discharge Suicide Risk
Patients with mental disorders are at significantly higher risk of suicide after discharge compared to the general population and patients with other diseases.
- Trial name
- NCT06358339
- Testing
- TEEM
- Where
- China
- Volunteers
- 640 people
- Sponsor
- Shenzhen Kangning Hospital
Stress, Postpartum Depressive Disorder
Powerly - Science-based Digital Intervention Preventing Postpartum Depression and Anxiety
The goal of this clinical trial is to determine if the Powerly app can help prevent postpartum depression and anxiety in healthy pregnant women.
- Conditions
- Stress, Postpartum Depressive Disorder, Postpartum Anxiety
- Trial name
- POWERLY app (NCT06610552)
- Testing
- Powerly
- Where
- Switzerland
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Marta Marciniak
Chronic Diseases in Children, Chronic Diseases in Adolescence
Transmural Care for Chronically Ill Children: Scientific Guidance and Evaluation of Pilot Projects
The goal of this Realist Evaluation is to evaluate the implementation of pilot projects for transmural care in chronically ill children.
- Conditions
- Chronic Diseases in Children, Chronic Diseases in Adolescence, Health Personnel, Parents
- Trial name
- PETRACA (NCT06679595)
- Testing
- Pilot project paediatric transmural care
- Where
- 11 sites in Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Preterm Labor
Development and Clinical Evaluation of an Innovative Medical Device to Predict Preterm Birth (PrediMAP)
The purpose of this study is to clinically validate the predictive performance (sensitivity and specificity) of the PrediMAP in-vitro diagnostic medical device to predict delivery within 7 days in the target population of women…
- Trial name
- PrediMAP (NCT05586334)
- Testing
- Collection of vaginal secretions, Collection of the placenta and the membranes, Administration of EPDS questionnaire
- Where
- France
- Volunteers
- 3,600 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Dermatological Conditions, Eczema
A Randomised Controlled Trial of ePROM-Guided Flexible Scheduling in Dermatology
The goal of this clinical trial is to evaluate whether an electronic patient-reported outcome measure (ePROM)-guided flexible scheduling system can improve outpatient clinic resource utilisation in patients attending dermatology…
- Conditions
- Chronic Dermatological Conditions, Eczema, Urticaria, Psoriasis
- Trial name
- NCT07481019
- Testing
- Flexible ePROM-guided Scheduling System, electronic patient reported outcome measures (ePROMs)
- Volunteers
- 250 people
- Sponsor
- National University Hospital, Singapore
Osteoblast, Vascular Calcification
Use of Discarded Surgery Human Tissue Specimens for Basic Science Research
Although it is now established that calcification process result from the joint and coordinated action of different cell types, many areas of shadow remain regarding the spatio-temporal implementation of these events.
- Trial name
- HumTisRes (NCT04753593)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Basic Science
Evaluation of the Bioequivalence of RAY1225 Injection in Healthy Participants
This is a single-center, randomized, open, parallel-designed bioequivalence study aimed at evaluating the pharmacokinetic differences of RAY1225 injection after site and batch changes compared to before the changes.
- Trial name
- NCT07827027
- Testing
- RAY1225
- Volunteers
- 68 people
- Sponsor
- Guangdong Raynovent Biotech Co., Ltd
HIV Infections, HIV Prevention
Community-based Outreach and Navigation for Nurse-led Engagement in HIV Care and Treatment
Many people who are experiencing homelessness are at high risk for HIV, but they often have trouble getting HIV prevention or treatment.
- Conditions
- HIV Infections, HIV Prevention, Homeless Persons, Homelessness
- Trial name
- CONNECT (NCT07870603)
- Testing
- CONNECT (status-neutral, nurse-led on-site HIV service delivery), Standard of Care (referral-based outreach)
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Donaldson Conserve
HIV Infections, Breast Cancer
The MARVIN Chatbots to Provide Information for Different Health Conditions
This research is a continuation of a usability study with the MARVIN chatbot. The investigators aim to adapt the MARVIN chatbot to open it to other health domains (e.g. breast cancer) and populations (e.g. pharmacists).
- Conditions
- HIV Infections, Breast Cancer, Pediatric Emergency Medicine
- Trial name
- NCT05789901
- Testing
- MARVIN, MARVIN-Pharma, MARVINA
- Where
- 2 sites in Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Coronary Heart Disease, Coronary Artery Disease
A Study on Yiyang Huoluo Decoction in the Treatment of Coronary Heart Disease
The goal of this clinical trial is to learn if Yiyang Huoluo Decoction (a custom Chinese herbal medicine) works safely and effectively to treat coronary heart disease with atherosclerosis in older adults.
- Conditions
- Coronary Heart Disease, Coronary Artery Disease, Atheroscleroses
- Trial name
- NCT07493603
- Testing
- Yiyang Huoluo Decoction, conventional western medicine treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xia Liang
Implementation Science, Type 1 Diabetes in Adolescence
Pilot Implementation Trial of Implementation Toolkits for Diabetes Coaching
The goal of this study is to learn if toolkits of implementation strategies (e.g., provider and staff education, clear plan for how to refer and bill) help pediatric type 1 diabetes medical and psychology providers deliver a…
- Conditions
- Implementation Science, Type 1 Diabetes in Adolescence, Implementation Strategies
- Trial name
- NCT07766811
- Testing
- Base Implementation Toolkit (BIT), BIT-Enhanced, BIT-Sustainment
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Mental Health
Novel Methods for Implementing Measurement-Based Care for Youth in Low-resource Environments
This study will visit 4 community mental health clinics in Washington state and work with clinic staff to find out if staff are regularly evaluating clinical outcomes using questionnaires (which is also called measurement-based…
- Trial name
- NIMBLE (NCT05644756)
- Testing
- IMPACT Methods to Identify and Prioritize Determinants (Challenge I), Challenge and Match strategies to Prioritized Determinants (Challenge II)
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
PreDiabetes
Small Steps for Big Changes - Healthy Cities Implementation Science
Small Steps for Big Changes (SSBC) is a diet and exercise counselling program that significantly reduces the risk of developing Type 2 Diabetes (T2D).
- Trial name
- HCIS (NCT06440395)
- Testing
- Behavioural: Small Steps for Big Changes Diabetes Prevention Program
- Where
- 12 sites in Canada
- Volunteers
- 4,400 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Implementation Science, Delirium
Behavioral Economic & Staffing Strategies in the ICU
The overarching goal of this study is to support the "real world" assessment of strategies used to foster adoption of several highly efficacious evidence-based practices in healthcare systems that provide care to critically ill…
- Conditions
- Implementation Science, Delirium, Critical Illness, Mechanical Ventilation Complication
- Trial name
- BEST-ICU (NCT06184945)
- Testing
- Realtime audit and feedback, RN Implementation Facilitator
- Where
- 3 sites in United States
- Volunteers
- 16,500 people
- Sponsor
- University of Nebraska