Clinical trials: Behçet's Disease
Behcet Disease
Phase III Study in Refractory Behcet's Disease
The purpose of this pivotal trial is to evaluate subcutaneous (SQ) AIN457 as an adjunctive therapy to reduce the rate of exacerbations of posterior uveitis or panuveitis secondary to Behçet's disease during the 24 weeks of study…
- Trial name
- SHIELD (NCT00995709)
- Testing
- AIN457
- Where
- 49 sites in United States, Egypt and 15 more
- Volunteers
- 118 people
- Sponsor
- Novartis Pharmaceuticals
Behçet's Disease, Uveitis
Intravitreal Infliximab in Refractory Uveitis in Behcet's Disease: A Safety and Efficacy Clinical Study
Intravitreal injection of up to 2 mg of infliximab has proved to be safe in animal models (rabbits and primates). These studies have shown no evidence of intraocular inflammation or toxicity by clinical, electrophysiological, and…
- Trial name
- NCT02620618
- Testing
- Intravitreal Infliximab
- Volunteers
- 20 people
- Sponsor
- Cairo University
Behcet Syndrome, Behcet Disease
Low Dose Interferon Alpha Treatment for Oral Ulcers of Behcet's Disease
The purpose of this study is to determine the safety and efficacy of natural human interferon alpha (IFN alpha) on size, number, incidence and pain of oral ulcers associated with Behçet's Disease (BD).
- Conditions
- Behcet Syndrome, Behcet Disease, Mucocutaneous Ulceration
- Trial name
- NCT00483184
- Testing
- Veldona,
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Nobel Pharmaceuticals
Behçet's Syndrome (BS)
Ustekinumab in BEhçet's Syndrome STudy
This non-interventional study is an observational cohort with parallel groups aiming primarily to describe the success of biosimilar of ustekinumab in Behçet's syndrome in whom conventional approaches have failed or are not…
- Trial name
- USBEST (NCT07244614)
- Where
- 11 sites in France
- Volunteers
- 208 people
- Sponsor
- Groupe français d'étude des Maladies Inflammatoires de loeil
Behçet's Disease, Juvenile Psoriatic Arthritis
A Study of Apremilast in Children With Oral Ulcers Associated With Behçet's Disease or Juvenile Psoriatic Arthritis
The primary objective of this study is to evaluate the long-term safety of apremilast in subjects 2 years of age or older with oral ulcers associated with Behçets disease or 5 years of age or older with active juvenile psoriatic…
- Trial name
- NCT05767047
- Testing
- Apremilast
- Where
- 7 sites in Greece, Israel and 2 more
- Volunteers
- 48 people
- Sponsor
- Amgen
Behçet's Disease
A Study of Efficacy and Safety of Hemay005 Tablets in Patients With Behçet's Disease
This is a phase 3, multi-center, randomized, placebo-controlled, double-blind, parallel-group study with an equal randomization among the Hemay005 high dose, lower dose and placebo treatment groups.
- Trial name
- NCT06145893
- Testing
- Hemay005
- Where
- 22 sites in China
- Volunteers
- 162 people
- Sponsor
- Ganzhou Hemay Pharmaceutical Co., Ltd
Behcet Disease
Role of Regulatory B Cells in Behçet's Disease
There are limited data about the role of regulatory B cells in Behcet Disease. In this study we aimed to identify the proportions of total B lymphocytes and their regulatory subset in different Behcet Disease phenotype and…
- Trial name
- NCT04376411
- Testing
- Flow-cytometric assay, 2D Echocardiographic analysis, Two-Dimensional speckle tracking echocardiography
- Where
- Egypt
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Assiut University
Behcet's Uveitis
Efficacy of Gevokizumab in the Treatment of Patients With Behçet's Disease Uveitis (EYEGUARD™-B)
The objective of this study is to demonstrate the superiority of gevokizumab as compared to placebo on top of current standard of care in reducing the risk of Behçet's disease uveitis exacerbations
- Trial name
- EYEGUARD™-B (NCT01965145)
- Testing
- Gevokizumab
- Where
- 2 sites in South Korea, United Kingdom
- Volunteers
- 84 people
- Sponsor
- Institut de Recherches Internationales Servier
Uveitis
38 Week Extension Study to CAIN457C2303
A 38-week extension to a 24 week multicenter, randomized, double-masked, placebo controlled study to assess the difference in the rate of recurrent exacerbations in Behçet's patients with posterior or panuveitis treated with…
- Trial name
- SHIELD (NCT01093846)
- Testing
- AIN457
- Where
- 25 sites in United States, Egypt and 12 more
- Volunteers
- 59 people
- Sponsor
- Novartis Pharmaceuticals
Behcet Syndrome
Dietary Interventions and Butyrate Production in Behçet's Patients
A dietary intervention trial will be performed on patients affected by Behçet's syndrome. Three different diets will be compared, analyzing their effects on the gut microbiota composition, on endogenous butyrate production and on…
- Trial name
- NCT03274648
- Testing
- Oral butyrate, Vegetarian diet, Habitual diet
- Where
- Italy
- Volunteers
- 17 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Behçet's Disease
Relation Between Nail Fold Capillaroscopy, Optical Coherence Tomography Angiography, and Femoral Vein Wall Thickness in Behçet's Disease Relation Between Nail Fold Capillaroscopy, Optical Coherence Tomography Angiography, and Femoral Vein Wall Thickness in Behçet's Disease
Relation between Nail Fold Capillaroscopy, Optical Coherence Tomography Angiography, and Femoral Vein Wall Thickness in Behçet's Disease
- Trial name
- NCT06296004
- Testing
- Nail Fold Capillaroscopy, Optical Coherence Tomography Angiography, and Femoral Vein Wall Thickness by U.S
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Behçet Disease
Serum EBI-3 Protein Levels in Behçet's Disease
This cross-sectional study aims to evaluate serum Epstein-Barr virus-induced gene 3 (EBI-3) protein levels in patients with Behçet's disease compared with healthy controls.
- Trial name
- NCT07845162
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Behçet Disease, Uveitis
Interferon α2a Versus Cyclosporine for Refractory Behçet's Disease Uveitis
Brief summary: This study compares the long-term efficacy and safety of interferon (IFN) α2a and cyclosporine (cyclosporin A, CsA) following suppression of acute attack by high-dose oral glucocorticosteroid in patients with…
- Trial name
- NCT03209219
- Testing
- Interferon Alfa-2A, Cyclosporine Pill
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Peking Union Medical College Hospital
Chronic Uveitis
Long-term Safety of Gevokizumab in the Treatment of Patients With Chronic Non-infectious Uveitis (EYEGUARD-X)
The objective of this study is to evaluate long-term safety of gevokizumab in patient with chronic non-infectious uveitis who previously well tolerated the study drug and may benefit from longterm treatment with gevokizumab.
- Trial name
- EYEGUARD-X (NCT02375685)
- Testing
- Gevokizumab
- Where
- 13 sites in Australia, Austria and 11 more
- Volunteers
- 71 people
- Sponsor
- Institut de Recherches Internationales Servier
Behçet's Disease
Behçet's Disease and Eosinophil Cationic Protein
Eosinophil cationic protein (ECP) is a matrix protein of eosinophils and has been reported to reflect eosinophil activity. Few studies have examined the role of eosinophils in the pathogenesis of Behçet's disease.
- Trial name
- NCT01584778
- Testing
- eosinophil cationic protein
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Behcet Syndrome
Randomized Controlled Multicenter Study Comparing Steroid Therapy Plus Anticoagulants to Steroid Therapy Alone in Deep Venous Thrombosis of Behçet's Syndrome
In patients with Behçet's syndrome (BS), deep venous thrombosis (DVT) is thought to result from inflammation of the vessel wall rather than hyper coagulability.
- Trial name
- ACTOR (NCT06780462)
- Testing
- Corticosteroids + Rivaroxaban, Corticosteroids alone
- Where
- 17 sites in France
- Volunteers
- 134 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Oral Ulcer
Lenalidomide in the Treatment of Mucosal Behçet's Syndrome
The study is to evaluate the efficacy and safety of lenalidomide in the treatment of oral ulcers in adult patients with refractory mucosal Behcet's syndrome.
- Trial name
- NCT05449548
- Testing
- Lenalidomide 10 mg
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Peking Union Medical College Hospital