Clinical trials: Behavior and Behavior Mechanisms
Substance Use Disorders
Mindfulness Based Relapse Prevention: Efficacy and Mechanisms
The broad, long-term objective of the proposed randomized clinical trial is to evaluate the efficacy, moderators and mechanisms of change of two cognitive-behavioral aftercare treatments for alcohol and other drug (AOD) use…
- Trial name
- MBRP (NCT01159535)
- Testing
- Mindfulness Based Relapse Prevention, Relapse Prevention, Treatment as Usual
- Where
- United States
- Volunteers
- 286 people
- Sponsor
- University of Washington
Substance-related Disorders
Women's Treatment and Early Recovery
Approximately 25 million Americans struggle with alcohol or drug problems annually. Abuse of alcohol and drugs is costly to our nation, exacting more than $428 billion in costs related to crime, lost work productivity and health…
- Trial name
- MBRP-W (NCT02977988)
- Testing
- Mindfulness Meditation, Brain and Recovery (B&R)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Southern California
Alcohol Use Disorder
Zonisamide Treatment of Alcohol Use Disorder: an Evaluation of Efficacy and Mechanism of Action
This is a randomized, placebo-controlled, double-blind, 16 week trial of the medication zonisamide for the treatment of heavy drinking alcoholic civilians.
- Trial name
- Z-Comp (NCT02900352)
- Testing
- Zonisamide
- Where
- 4 sites in United States
- Volunteers
- 156 people
- Sponsor
- Virginia Commonwealth University
Alcoholism
A Study on the Biobehavioral Mechanisms of Baclofen and Alcohol Drinking
This pilot trial has the goal to demonstrate the feasibility of a study to test the effects of baclofen in a laboratory experiment using cue-reactivity and alcohol-self administration paradigms in non-treatment seeking…
- Trial name
- NCT01076283
- Testing
- Baclofen, Cyproheptadine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Brown University
Overweight and Obesity, Eating Behavior
Examination of Bromocriptine on Homeostatic and Hedonic Mechanisms of Food Intake in Individuals at High Risk for T2DM
The current project applies an integrative three-prong approach to investigate the potential of the dopamine D2 receptor (DRD2) agonist bromocriptine to: 1) increase homeostatic satiation signaling, 2) alter neural circuitry to…
- Trial name
- NCT05405244
- Testing
- Bromocriptine-QR
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Depression
A Study of Infliximab for Treatment Resistant Major Depression
Major depression is increasingly recognized to be a chronic and highly recurrent condition, which results in significantly increased health problems.
- Trial name
- Infliximab (NCT00463580)
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Emory University
PTSD
Yoga and Physical Activity for Veterans
Posttraumatic stress disorder (PTSD) is a major health problem for the nation's Veterans, leading to significant physical and mental health morbidity and mortality.
- Trial name
- NCT03509909
- Testing
- Hatha yoga, Supportive physical activity
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- VA Office of Research and Development
Smoking Cessation
Mechanisms of Mindfulness for Smoking Cessation
The purpose of this study is to understand brain mechanisms of app-based mindfulness training in smokers ages 21 to 65 years.
- Trial name
- NCT02943499
- Testing
- App/Training, Smartphone
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Brown University
Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder
Network Control TMS fMRI
This study uses different types of functional magnetic resonance imagining (fMRI) to generate individual transcranial magnetic stimulation (TMS) targets.
- Conditions
- Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder, Working Memory
- Trial name
- NCT05736458
- Testing
- Transcranial Magnetic Stimulation (TMS), High controllability TMS target
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Physical Inactivity, Overweight or Obesity
eMOTION Formative Study
The eMOTION Study is a two-part ORBIT model phase 1 trial. The first part, called the Formative Study, will assess acceptability and feasibility of a novel physical activity intervention in adults at increased risk for cancer due…
- Conditions
- Physical Inactivity, Overweight or Obesity, Cancer
- Trial name
- NCT06125964
- Testing
- Intensity-Based Goals, Affect-Based Goals, TYPE/CONTEXT Enhancement
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Stress, Behavior
Brain and Meditation (BAM) Study
This study is a randomized controlled trial to test the impact of an app-based meditation program on perceived stress and behavioral correlates of stress with known neurobiological correlates.
- Trial name
- NCT05215314
- Testing
- mHealth Meditation
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison