Clinical trials: Behavioral Addiction
Addiction
Leveraging Technology to Address Unhealthy Drug Use in Primary Care Settings
This study will develop a clinical decision support tool that assists primary care providers in carrying out substance use interventions, and then compare (in Phase 2) two clinical scenarios, screening only (SO) vs.
- Trial name
- NCT02893514
- Testing
- Screening Only (SO) condition, SUSIT Condition
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Smoking, Cannabis
Imaging the Neurochemistry of Drug Addiction With PET
The investigators' project has two overarching goals. 1) The investigators will use newly developed positron emission tomography (PET) technology to investigate the dopaminergic neurochemistry of drugs of abuse including…
- Trial name
- NCT02817698
- Testing
- cannabis
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Yale University
Opioid Dependence
An Open Label Study To Assess The Safety And Tolerability Of BEMA® Buprenorphine NX In Opioid Dependent Subjects
This is an open label study in opioid dependent subjects maintained on a stabilized dose of Suboxone tablets or films. The purpose is to assess the safety and tolerability of BEMA Buprenorphine NX administered once daily for 12…
- Trial name
- NCT01666119
- Testing
- BEMA Buprenorphine NX films
- Where
- 10 sites in United States
- Volunteers
- 249 people
- Sponsor
- BioDelivery Sciences International
Cocaine Dependence
Vigabatrin for Treatment of Cocaine Dependence
The objective of this study is to demonstrate that a larger proportion of vigabatrin-treated subjects than placebo-treated subjects will be cocaine-free in the last 2 weeks of treatment.
- Trial name
- NCT00611130
- Testing
- vigabatrin
- Where
- 11 sites in United States
- Volunteers
- 186 people
- Sponsor
- Catalyst Pharmaceuticals, Inc.
Opioid Withdrawal
Dexmedetomidine in the Treatment of Symptoms Of Acute Opioid Withdrawal
This Phase 1b/2 inpatient study assessed the safety, pharmacokinetics, and early signs of efficacy of escalating doses of BXCL501 versus placebo following discontinuation of morphine maintenance.
- Trial name
- NCT04470050
- Testing
- Dexmedetomidine
- Where
- 3 sites in United States
- Volunteers
- 225 people
- Sponsor
- BioXcel Therapeutics Inc
Cocaine Dependence
Cocaine Use Reduction With Buprenorphine
The aim of this study is to investigate the safety and effectiveness of buprenorphine in the presence of naltrexone for the treatment of cocaine dependence.
- Trial name
- CURB (NCT01402492)
- Testing
- Buprenorphine + Naltrexone
- Where
- 11 sites in United States
- Volunteers
- 302 people
- Sponsor
- University of California, Los Angeles
Smoking Cessation, Smoking, Tobacco
Helping Poor Smokers Quit
Using a 2x2 randomized factorial design, we will conduct a statewide field trial in Missouri to compare the relative and combined effects of these two strategies for augmenting an existing, evidence-based tobacco quitline…
- Conditions
- Smoking Cessation, Smoking, Tobacco, Smoking, Cigarette, Smoking, Pipe
- Trial name
- NCT03194958
- Testing
- Specialized Quitline, Basic Needs Navigator
- Where
- United States
- Volunteers
- 1,944 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Methamphetamine Dependence
Effects of Modafinil in Methamphetamine Dependence
Methamphetamine dependence is a serious public health problem with no pharmacologic treatments currently available. Relapse rates are high in this population.
- Trial name
- NCT00751023
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical University of South Carolina
Addiction
Safety and Tolerability of Cannabidiol Among Persons With Opioid Use Disorder Receiving Methadone or Buprenorphine
The overarching goal of this study is to evaluate the potential of Cannabidiol (CBD) as an adjunctive treatment for comorbid opioid use disorder (OUD) and chronic pain.
- Trial name
- NCT05076370
- Testing
- CBD Day 1, CBD Day 2, CBD Day 3
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Yale University
Intimate Partner Violence, Substance Abuse/Addiction
Intimate Partner Violence and Fatherhood Intervention in Residential Substance Abuse Treatment
The proposed stage 1 intervention development study is designed to address two significant co-occurring issues for fathers with substance abuse (SA) problems: Intimate partner violence (IPV) and child maltreatment (CM).
- Conditions
- Intimate Partner Violence, Substance Abuse/Addiction, Child Maltreatment
- Trial name
- NCT02979262
- Testing
- Fathers for Change, Parent Education
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of South Florida
Smoking Cessation, Nicotine Addiction
Innovative Digital Therapeutic for Smoking Cessation
This study is comparing the efficacy of two smoking cessation apps.
- Conditions
- Smoking Cessation, Nicotine Addiction, Drug Addiction, Drug Dependence
- Trial name
- NCT03694327
- Testing
- CT-101-M, QuitGuide
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- My Digital Study
Nicotine Addiction
Acute and Chronic Nicotine Modulation of Reinforcement Learning
The purpose of this study is to use functional magnetic resonance imaging (fMRI) to investigate the acute and chronic effects of nicotine on motivational behavior and prediction error-related neural activation.
- Trial name
- NicLearning (NCT01830842)
- Testing
- Nicotine polacrilex, satiety, abstinence
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Duke University
Opioid-use Disorder, Opioid-Related Disorders
Substance Use Treatment and Recovery Team
This study is a multi-site, randomized pragmatic trial being conducted at three diverse sites. The study, called the Substance Use Treatment and Recovery Team (START), will evaluate whether a collaborative care team increases the…
- Trial name
- START (NCT05086796)
- Testing
- Substance Use Treatment and Recovery Team (START)
- Where
- 3 sites in United States
- Volunteers
- 325 people
- Sponsor
- Cedars-Sinai Medical Center
Opioid Use Disorders
mHealth to Help Pregnant and Postpartum Women in Recovery for Opioid Use Disorder
The opioid epidemic has resulted in widespread detrimental consequences among vulnerable populations in Missouri, especially among pregnant and postpartum women (PPW) with opioid use disorder (OUD).
- Trial name
- NCT06701123
- Testing
- uMAT-R mobile app with coaching component
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Washington University School of Medicine
Addiction
Evaluating Improvement Strategies in Addiction Treatment
Addiction treatment is often characterized by long delays between first contact and treatment as well as high no-show and drop out rates leading to unused capacity in apparently full agencies.
- Trial name
- NIATx 200 (NCT00934141)
- Testing
- Learning Session, Interest Circle Calls, Coaching
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alcohol Use Disorder
Does Oxytocin Alter Tolerance to or Motivation for Alcohol
This pilot study is intended to demonstrate feasibility and acquire preliminary data. If successful, this data could support a future project studying the effect of oxytocin on tolerance and alcohol seeking in humans.
- Trial name
- NCT05312008
- Testing
- Intranasal oxytocin
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Indiana University
Drug Addiction, Smoking Cessation
Examining the Effect of the Nicotine Patch in Male and Female Smokers - 3
Treatment studies have demonstrated that current smoking cessation techniques are less effective for women. The purpose of this study is to determine the role that gender plays in the effectiveness of nicotine replacement…
- Trial name
- NCT00390559
- Testing
- nicotine transdermal system, Nicotine containing cigarette
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Nicotine Dependence
Study Two on the Effectiveness of Mindfulness Training for Smokers
The MTS2 study enrollment goal is N=240 adult smokers randomized to study treatments. The study design includes two randomized arms to compare matched intensive interventions and a third non-randomized option for participants who…
- Trial name
- MTS2 (NCT01299909)
- Testing
- Integrated Training for Smokers, Mindfulness Training for Smokers, Quitline
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- University of Wisconsin, Madison
Hepatitis C, Medication Adherence
Patient-Centered Models of HCV Care for People Who Inject Drugs
People who inject drugs (PWID) have higher rates of hepatitis C virus (HCV) than do other groups. Effective, safe new treatments called direct-acting antiviral agents (DAAs) have been developed recently.
- Trial name
- HERO (NCT02824640)
- Testing
- Patient Navigation, modified Directly Observed Therapy
- Where
- United States
- Volunteers
- 755 people
- Sponsor
- Prisma Health-Upstate
Addiction
Cognitive Effects of Atomoxetine in Humans: Genetic Moderators
The overall goal of this study is to determine if atomoxetine treatment improves selective cognitive functions in abstinent cocaine users, compared to healthy controls.
- Trial name
- NCT01498549
- Testing
- Atomoxetine, Sugar Pill
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Yale University