Clinical trials: Behavioral Inhibition
Bipolar Disorder (BD), Suicidality
Neural Correlates of Ketamine's Anti-suicidal Effects in Bipolar Depression
Bipolar disorder is characterized by manic episodes and episodes of extreme depressive feelings, also known as bipolar depression (BD).
- Trial name
- DEEPP (NCT05177146)
- Testing
- Intravenous Ketamine (IV)
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Centre for Addiction and Mental Health
Depression - Major Depressive Disorder, Behavioral Activation
VR-Based Behavioral Activation in Adults
Study Overview This study aims to evaluate the effectiveness of a newly developed Virtual Reality (VR) behavioral activation software program for individuals experiencing symptoms of depression.
- Conditions
- Depression - Major Depressive Disorder, Behavioral Activation, Virtual Reality Therapy, Behavioral Inhibition
- Trial name
- VR-Dep (NCT07703397)
- Testing
- Virtual Reality Behavioral Activation Software, Waitlist Control and Psychoeducation
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- KTO Karatay University
Attentional Control Switching, Task Switching Between Modalities
Yoga Practice, Stress and Cognitive Performance
It has been indicated in recent research that Mindfulness-based interventions may offer possibilities of promoting human stress processing and reducing anxiety or depression.
- Conditions
- Attentional Control Switching, Task Switching Between Modalities, Inhibition, Stress
- Trial name
- NCT05232422
- Testing
- Hatha yoga course
- Where
- Austria
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Cocaine Addiction
Effects of tDCS on Craving, Relapse and Cognitive Functions Among Patients With Cocaine Use Disorder
Repetitive bilateral (left cathodal/ right anodal) transcranial Direct Current Stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) reduces craving and seems to decrease relapse risk in addiction.
- Trial name
- NCT03025321
- Testing
- transcranial Direct Current Stimulation (tDCS)
- Where
- Netherlands
- Volunteers
- 59 people
- Sponsor
- Erasmus Medical Center
Smoking Cessation
Smoking Response Inhibition Training
The current study tests a response inhibition retraining program, implemented on a mobile device, as a mechanism to increase relapse prevention during a smoking cessation attempt.
- Trial name
- NCT02218944
- Testing
- Response Inhibition Training
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- North Dakota State University
Idiopathic Parkinson's Disease
Dopamine Effect on Inhibitory Control
The effect of Levodopa medication on inhibitory control in Parkinson's patients is extremely debated despite the fact that this has potential clinical and therapeutic implications.
- Trial name
- DEI (NCT03665493)
- Testing
- PD patients H&Y=1.5-2 Medications ON, PD patients H&Y=1.5-2 Medications OFF, Healthy age-matched controls
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Giovanni Mirabella
Attention Deficit Disorder With Hyperactivity
Efficacy of the Apollo System for Children With ADHD
To determine the extent to which the Apollo System is effective in reducing symptomatology associated with ADHD.
- Trial name
- NCT05308706
- Testing
- 8 weeks of home based use.
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Michigan State University
Parkinson Disease
Investigation of the Benefits of Electrical Non-invasive Stimulation on Cognitive Symptoms in Parkinson's Disease
Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's disease. It is mostly characterized by the presence of motor difficulties.
- Trial name
- STIMPARK (NCT05808504)
- Testing
- Neuropsychological assessment, Neurological assessment, Cognitive task
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Social Anxiety
Virtual Reality Exposure for Socially Anxious Adolescents
Overall in this project, the primary goal is to evaluate the efficacy of virtual reality exposure (VRE) for adolescents with elevated social anxiety using a three-arm randomized controlled trial: (1) virtual reality exposure…
- Trial name
- VIRTUS (NCT06379633)
- Testing
- In vivo exposure, (Virtual reality) exposure
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- KU Leuven
Multiple Sclerosis
Neuroproprioceptive "Facilitation, Inhibition" and Brain Plasticity
This study investigates whether neuroproprioceptive "facilitation, inhibition" physical therapy induces plastic and adaptive processes of the CNS (white matter integrity changes), if they relate to clinical improvement, and…
- Trial name
- NEFAI (NCT04355663)
- Testing
- Motor program activating therapy, Vojta's reflex locomotion, Functional electric stimulation
- Volunteers
- 92 people
- Sponsor
- Charles University, Czech Republic
Lung Cancer
An Open-Label Phase 1/2 Study of Itacitinib in Combination With Osimertinib in Subjects With Non-Small Cell Lung Cancer
The purpose of this study is to evaluate the safety and tolerability of itacitinib in combination with osimertinib in subjects with locally advanced or metastatic non-small cell lung cancer (NSCLC).
- Trial name
- NCT02917993
- Testing
- Itacitinib, Osimertinib
- Where
- 31 sites in United States, South Korea and 2 more
- Volunteers
- 59 people
- Sponsor
- Incyte Corporation
Kidney Transplantation, Renal Transplant Recipients
Selective CD28 Blockade in Renal Transplant Recipients
The aim of this study is to evaluate the safety and efficacy of lulizumab, a CD28-specific domain antibody (CD28 dAb), compared to tacrolimus, as the primary immunosuppressant in first-time renal transplant recipients.
- Trial name
- NCT04903054
- Testing
- Lulizumab, Tacrolimus, Thymoglobulin®
- Where
- United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
The Ability to Delay Gratification
Development, Attention, and Inhibition Study
The goal of this clinical trial is to test the associations of young children's early life experiences with delaying behaviors and links with later life outcomes.
- Trial name
- DAISY (NCT06605001)
- Testing
- Delay of Gratification
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Total Knee Arthroplasty, Osteoarthritis
Electrical Stimulation After Total Knee Arthroplasty
Total knee arthroplasty (TKA) is performed more than 300,000 times a year in the United States, most often for osteoarthritis (OA).
- Trial name
- NCT00224913
- Testing
- Neuromuscular electrical stimulation, Voluntary exercise
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Peripheral Nerve Sheath Tumor
Tazemetostat in Malignant Peripheral Nerve Sheath Tumors
This phase 2, open label, single arm study will investigate the use of tazemetostat in patients with recurrent/refractory and/or metastatic malignant peripheral nerve sheath tumors.
- Trial name
- NCT04917042
- Testing
- Tazemetostat
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Florida
Smoking Cessation
The Approach and Avoidance Task (AAT) in Smoking Cessation
The approach and avoidance task (AAT) has evolved as a promising treatment add-on in the realm of psychology. Certain psychiatric diseases, such as behavioural addictions, social anxiety disorder, and arachnophobia, are…
- Trial name
- NCT04190810
- Testing
- Inhibition, Classical AAT, Control
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Child Development, Executive Functions (EF)
Sharing Tales That Teach: Shared Picturebook Reading for Early Childhood Emotional and Cognitive Development
Sharing Tales That Teach is a randomised study of a shared picturebook reading programme for 4- to 5-year-old children and their primary caregivers.
- Conditions
- Child Development, Executive Functions (EF), Emotion Regulation
- Trial name
- STTT (NCT07666802)
- Testing
- Emotion-Focused Shared Picturebook Reading, Standard Dialogic Picturebook Reading
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Greenwich
Piriformis Syndrome
Comparasion of Autogenic Inhibition and Reciprocal Inhibition Muscle Energy Techniques (METS) in Piriformis Syndrome
To compare the effects of Autogenic Inhibition and Reciprocal Inhibition Muscle Energy Techniques (METS) in Piriformis Syndrome
- Trial name
- NCT06460675
- Testing
- Autogenic Inhibition Muscle Energy Technique, Reciprocal Inhibition Muscle Energy Technique
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Depression Disorders, Non-suicidal Self-injury
The Impact of Beta-band Transcranial Alternating Current Stimulation (tACS) on Impulse Inhibition in Adolescents With Non-suicidal Self-injury
This clinical trial aims to determine whether beta-band transcranial alternating current stimulation (tACS) can improve impulse inhibition in adolescents with non-suicidal self-injury (NSSI) and to evaluate its safety.
- Trial name
- NCT07152925
- Testing
- Beta-frequency transcranial alternating current stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Anhui Medical University
Chronic Coronary Insufficiency, Smoking
Coagulation Profile in Patients Undergoing Coronary Angiography and Percutaneous Coronary Intervention
The activated clotting time (ACT), global thrombosis test (GTT-3), platelet inhibition P2Y12 (VerifyNow) test and serum coagulation factors will be measured in patients undergoing coronary angiography (CA) and percutaneous…
- Trial name
- GlobalACT (NCT05336669)
- Volunteers
- 40 people
- Sponsor
- Centre of Postgraduate Medical Education