Clinical trials: Behavioral Modification
Dementia, Alzheimer's Disease
Preventing Loss of Independence Through Exercise (PLIE) in Persons With Dementia
Nearly 1 in 10 older Veterans have dementia, which is a devastating condition that leads to a progressive loss of independence and functional status. Currently available dementia medications do not alter the disease course.
- Trial name
- PLIE-VA (NCT02350127)
- Testing
- Preventing Loss of Independence through Exercise (PLIE), Usual Care
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- VA Office of Research and Development
Temporomandibular Disorders
Biofeedback-Based Cognitive Behavioral Treatment for Temporomandibular Disorders
The purpose of this study is to develop and evaluate a biofeedback-based cognitive behavioral treatment for patients with chronic temporomandibular disorders using a randomized controlled design.
- Trial name
- NCT00769561
- Testing
- Biofeedback-Based Cognitive Behavioral Treatment, Dental treatment with occlusal splint (OS)
- Where
- 2 sites in Germany
- Volunteers
- 58 people
- Sponsor
- Philipps University Marburg
Cancer, Advanced, Cognitive Impairment, Mild
Study of a Behavioral Intervention for Older Advanced Cancer Patients and Their Caregivers
The purpose of this study is to test the feasibility of a telehealth Dyadic Life Review (DLR), adapted from individual Life Review Therapy, with patients and caregivers of older adults with advanced cancer, including those with…
- Trial name
- DLR Pilot (NCT05200572)
- Testing
- Dyadic Life Review (DLR)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Rochester
Weight, Food Choice
Promoting Employee Health Through The Worksite Food Environment
This project tests a scalable and sustainable approach to weight gain prevention in a population of employees by using the worksite environment to deliver personalized feedback about worksite food purchases, daily calorie goals…
- Conditions
- Weight, Food Choice, Nutrition Intake
- Trial name
- ChooseWell 365 (NCT02660086)
- Testing
- Personalized nutrition feedback
- Where
- United States
- Volunteers
- 602 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Schizophrenia, Schizoaffective Disorder
A Study of Varenicline for Prevention of Relapse to Smoking in Patients With Schizophrenia or Bipolar Disorder
Varenicline (Chantix) is a smoking cessation treatment that was approved in 2006 by the FDA for treatment of nicotine dependence and may be particularly beneficial in smokers with schizophrenia or bipolar disorder.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Smoking
- Trial name
- SCRP (NCT00621777)
- Testing
- Varenicline
- Where
- 10 sites in United States
- Volunteers
- 247 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder
Improving Therapeutic Learning in Depression: Proof of Concept
Despite advances in both pharmacotherapy and psychotherapy for major depression, non-response and partial-response remain relatively common outcomes, motivating the search for new treatments.
- Trial name
- NCT02376257
- Testing
- 250 mg DCS, 100 mg Modafinil
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Boston University Charles River Campus
Smoking
Nicotine Pharmacokinetic Profile of the CHTP 1.1 M
The primary objective of this clinical study is to evaluate the pharmacokinetic (PK) profile of nicotine (rate and amount of nicotine absorbed) after single use of the Carbon Heated Tobacco Product 1.1 Menthol (CHTP 1.1 M), a…
- Trial name
- NCT02466412
- Testing
- CHTP 1.1 M, mCC
- Where
- Japan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
HIV Infections
A Stigma Reduction Intervention at Time of Entry Into Antenatal Care to Improve PMTCT Services in Tanzania
This study will pilot test a brief, scalable intervention called Maisha (Swahili for life), to address HIV stigma for women presenting to antenatal care in Tanzania and male partners who accompany them.
- Trial name
- Maisha (NCT03600142)
- Testing
- Mashia
- Where
- Tanzania
- Volunteers
- 1,539 people, healthy volunteers welcome
- Sponsor
- University of Utah
Diet, Healthy, Pregnancy Related
Digital Intervention To Improve Diet Quality
This study will develop a digital intervention ("Healthy Roots") adapted from a previously tested adult digital obesity treatment intervention ("Track").
- Trial name
- NCT04098016
- Testing
- Digital Intervention
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Duke University
Sleep Disorder, Stage IA Breast Cancer
Brief Behavioral Therapy in Improving Sleep Disorders in Patients With Stage I-III Breast Cancer Undergoing Chemotherapy
This randomized phase II trial studies how well brief behavioral therapy works in improving sleep disorders in patients with stage I-III breast cancer undergoing chemotherapy.
- Conditions
- Sleep Disorder, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage II Breast Cancer
- Trial name
- NCT02002533
- Testing
- Brief Behavioral Therapy, Telephone-Based Intervention, Educational Intervention
- Where
- 6 sites in United States
- Volunteers
- 71 people
- Sponsor
- Gary Morrow
Depression
Behavioral Study of Effects of Low-Level Light Therapy on Mood and Reaction Time
The goal of this project is to use low-level light therapy (LLLT) to enhance neural metabolism in the prefrontal cortex of humans, and measure the effects of LLLT on attentional bias change following a single session of attention…
- Trial name
- NCT02390076
- Testing
- Left Low Level Light Therapy, Attention bias modification, Right Low Level Light Therapy
- Volunteers
- 51 people
- Sponsor
- Seth Disner
Chronic Pain, Depression
A Behavioral Intervention for Depression and Chronic Pain in Primary Care
Chronic pain and depression frequently co-exist in late and mid-life and contribute to increased disability, high health care costs, psychiatric comorbidity, and suicide.
- Trial name
- Relief (NCT03265210)
- Testing
- RELIEF
- Where
- 3 sites in United States
- Volunteers
- 73 people
- Sponsor
- Weill Medical College of Cornell University
Anxiety, Separation, Psychomotor Agitation
Cartoon Distraction and Parental Presence on Anxiety in Pediatric Anesthesia
Nearly 50% of young children undergoing surgery exhibit high level of anxiety during induction of anesthesia because of exposure to unfamiliar environment and people and separation from parents.
- Trial name
- NCT02027844
- Testing
- Cartoon, parental presence
- Where
- South Korea
- Volunteers
- 117 people
- Sponsor
- Yeungnam University College of Medicine
PTSD
Written Exposure Therapy Versus Prolonged Exposure: a Non-inferiority Trial
The goal of this study is to examine whether a brief, exposure-based treatment (Written Exposure Therapy) approach is just as effective in the treatment of posttraumatic stress disorder (PTSD) compared with a more commonly used…
- Trial name
- NCT03962504
- Testing
- trauma-focused treatment
- Where
- 3 sites in United States
- Volunteers
- 178 people
- Sponsor
- VA Office of Research and Development
Suicidal Ideation
Cyclical Neuroactive Steroid Changes, Arousal, and Proximal Suicide Risk: An Experimental Approach
Female suicide attempts occur more often in the weeks before and after menses onset, and have been linked to ovarian hormone withdrawal.
- Trial name
- CLEAR-3 (NCT04112368)
- Testing
- Estradiol Transdermal Patch 0.1 mg/24 hrs, Oral Micronized Progesterone 200mg, Inactive Clear Patch
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- University of Illinois Chicago
Obesity
Research Intervention to Support Healthy Eating and Exercise
The primary aim of this study is to test the efficacy of a behavioral economics intervention for weight loss in adults from economically disadvantaged backgrounds.
- Trial name
- RISE (NCT04353258)
- Testing
- Behavioral Economics intervention (BE mHealth), Standard mHealth intervention (mHealth)
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- University of Connecticut
Mild Cognitive Impairment, Adherence, Patient
MI-CBT Adherence Program for Lifestyle Interventions in Older Adults
Objective 1: Assess feasibility and acceptability of all protocol components of a pilot trial testing a 6-week telehealth Mediterranean ketogenic nutrition adherence (KNA) program using motivational interviewing and cognitive…
- Conditions
- Mild Cognitive Impairment, Adherence, Patient, Ketosis
- Trial name
- MI-CBT KNAP (NCT04817176)
- Testing
- Motivational Interviewing-Cognitive Behavioral Therapy Ketogenic Nutrition Adherence Program, Ketogenic Nutrition Program
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Florida State University
Insomnia, Pain
Treatment of Insomnia Secondary to Chronic Pain
Several studies have shown that behavioral therapy for chronic pain can be beneficial for chronic pain and that behavioral therapy for insomnia can be beneficial for insomnia.
- Trial name
- NCT00127790
- Testing
- CBT for Insomnia (CBT-I), CBT for Pain (CBT-P)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Rochester
Knee Osteoarthritis
Discontinuing NSAIDs in Veterans With Knee Osteoarthritis
Knee osteoarthritis (OA) is now recognized as a major health problem. It is the number one cause of lower extremity disability and has significant deleterious effects on quality of life.
- Trial name
- NCT01799213
- Testing
- Meloxicam 15 mg po QD, Cognitive Behavioral Therapy
- Where
- 4 sites in United States
- Volunteers
- 490 people
- Sponsor
- VA Office of Research and Development
Osteoarthritis
Weight Loss and Exercise for Communities With Arthritis in North Carolina
This study aims to develop and demonstrate the effectiveness of a systematic, practical, cost-effective diet-induced weight loss and exercise intervention in both urban and rural communities that can reduce pain and improve other…
- Trial name
- WE-CAN (NCT02577549)
- Testing
- Diet & Exercise, Attention Control
- Where
- 3 sites in United States
- Volunteers
- 823 people, healthy volunteers welcome
- Sponsor
- Wake Forest University