Clinical trials: Behavioral Risks of Cancer
Smoking Cessation, Micronuclei
ESTxENDS Trial: MN Substudy - Micronuclei in Buccal Epithelium, a Surrogate Measure of Future Cancer Risk, Induced by Electronic Nicotine Delivery Systems (ENDS/Vaporizer/E-cig)
--> This is a substudy of the main ESTxENDS trial (NCT03589989). Micronuclei in buccal epithelial outcomes should be considered secondary outcomes of the main smoking cessation outcome formulated in NCT03589989.
- Trial name
- ESTxENDS (NCT04244773)
- Testing
- ENDS (vaporizer/e-cig) and smoking cessation counseling, Smoking cessation counseling
- Where
- 5 sites in Switzerland
- Volunteers
- 1,246 people, healthy volunteers welcome
- Sponsor
- University of Bern
Multiple Myeloma
BCMA and CD19 Targeted Fast Dual CART for Chromosomal Abnomalities High-risk BCMA+ Multiple Myeloma
This is a single arm, open label, multi-center prospective study to explory the safety and efficacy of GC012F CAR-T cells in patient diagnosed with high-risk chromosomal abnormalities BCMA+ multiple myeloma(MM).
- Trial name
- NCT04617704
- Testing
- GC012F injection
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Shanghai Changzheng Hospital
Breast Cancer, Overweight and Obesity
Acceptance and Usability of an App Promoting Healthy Behaviours Amongst Young Women at Increased Risk of Breast Cancer
It is estimated that around 20% of breast cancers (BC) in the UK are preventable through adherence to appropriate health behaviours, i.e., healthy diet, physical activity, limited alcohol, not smoking, and that women at increased…
- Conditions
- Breast Cancer, Overweight and Obesity, Diet, Healthy, Weight Gain
- Trial name
- NCT05460650
- Testing
- App Promoting Healthy Behaviours
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Colorectal Cancer
The Biomarkers Of RIsk of Colorectal Cancer (BORICC) Follow-Up (BFU) Study
Worldwide, colorectal cancer is the 3rd most common cancer; risk increases with age and is modified by lifestyle factors notably diet, physical activity and obesity.
- Trial name
- BFU (NCT04005742)
- Where
- United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Suicide, Attempted, Suicidal Ideation
Biomarkers as Predictors of Suicidal Risk in Adolescents
Suicide is one of the most devastating events in society at all levels. The primary goal of this study is to predict suicide in adolescents at risk.
- Conditions
- Suicide, Attempted, Suicidal Ideation, Suicidal Intention, Suicide
- Trial name
- NCT03014518
- Testing
- Clinical assessments and blood samples; follow-up for 12 mos, Clinical assessments and blood samples; no 12mo follow-up
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Health Knowledge, Attitudes, Practice, Alcohol Consumption
Increasing Knowledge of Alcohol as a Risk Factor for Breast Cancer Among Women Attending Breast Screening Services
Alcohol is a major modifiable risk factor for breast cancer in women, yet this is not widely understood by health practitioners or policy makers, let alone the general population.
- Trial name
- Health4Her (NCT04715516)
- Testing
- alcohol brief intervention, lifestyle health promotion
- Where
- Australia
- Volunteers
- 558 people, healthy volunteers welcome
- Sponsor
- Turning Point
Breast Cancer, Cardiovascular Disease
The True Face of the Pyramid; Physical Activity Level and Cardiovascular Risk in Patients With Breast Cancer
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Many risk factors are thought to be important in the development of CVD; however, some risk factors can be controlled.
- Conditions
- Breast Cancer, Cardiovascular Disease, Physical Activity
- Trial name
- NCT06837701
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Hacettepe University
Cancer
ORCA: Opportunities to Raise Cancer Awareness After Referral: Survey of Patient Views
The purpose of this study is to investigate what patients think about increasing provision of advice about how to detect cancer early and how to reduce their future cancer risk after they are discharged from a two-week wait…
- Trial name
- ORCA (NCT05479851)
- Where
- United Kingdom
- Volunteers
- 406 people, healthy volunteers welcome
- Sponsor
- King's College London
Depression, Cancer
Trajectories of Anxiety and Depression in Cancer Patients, Risk and Predictive Factors and Supportive Care; Prognostic Awareness and Shared Decision Making.
To examine the trajectories of anxiety and depression symptoms over the course of oncological disease, and to assess potential predictors-sociodemographic (age, sex, marital status, employment status), clinical (tumor location…
- Conditions
- Depression, Cancer, Anxiety
- Trial name
- NCT07168096
- Testing
- Psychosocial and clinical assessment
- Where
- 18 sites in Spain
- Volunteers
- 540 people
- Sponsor
- Fundación Sociedad Española de Oncologia Médica
Oncology
A Study to Determine the Feasibility and Acceptability of Conducting a Phase III Randomised Controlled Trial Comparing Stereotactic Ablative Radiotherapy With Surgery in paTients With Peripheral Stage I nOn-small Cell Lung Cancer cOnsidered Higher Risk of Complications From Surgical Resection
Stage I non-small cell lung cancer (NSCLC) is curable and surgery is considered the standard of care for fit, good performance status patients.
- Trial name
- SABRTOOTHv1 (NCT02629458)
- Testing
- Treatment by Surgical resection, Stereotactic Ablative Radiotherapy (SABR)
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Colorectal Cancer (Diagnosis), Malnutrition or Risk of Malnutrition
Short-Term Nutritional Enhancement Combined With Health Education in Postoperative Colorectal Cancer Patients: A Randomized Controlled Trial
This clinical study aims to evaluate whether short-term personalized nutritional support, when combined with structured health education, can improve nutritional status, quality of life, and clinical outcomes in patients who have…
- Trial name
- NUTRI-CRC (NCT07087561)
- Testing
- Personalized Oral Nutritional Supplementation, Personalized Parenteral Nutritional Supplementation, Structured Nutrition-Focused Health Education
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Xiaoqin Luo
Cervical Cancer
Increasing Participation in Cervical Cancer Screening and Risk for Beliefs/Attitudes Among Women at Risk
In order to evaluate the effectiveness of nursing interventions aimed at the early detection of cervical cancer, health belief and participation in the screening of women aged 40-55 at risk for the purpose of cervical cancer…
- Trial name
- NCT03076879
- Testing
- Promoting participation in cervical cancer screening
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Sarcopenia, Pediatric Cancer
Determination of Sarcopenia Risk and Related Factors in Pediatric Oncological Patients
In children, both malnutrition and sarcopenia are associated with prolongation of hospital stay, increased morbidity, mortality, and health-related complications.
- Trial name
- NCT05294380
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Trakya University
Feasibility Pilot Study, Compliance
A Low-Insulinemic Dietary Intervention to Reduce Breast Cancer Risk in High-Risk Women
This clinical trial tests whether a new dietary pattern that consists of foods that lower the blood insulin response can reduce breast cancer risk in high-risk women.
- Trial name
- LIN-BRiCK (NCT06635005)
- Testing
- Biospecimen Collection, Dietary Intervention, Medical Device Usage and Evaluation
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Alcohol Use Disorder, Mild, Alcohol Use, Unspecified
My Choices: Efficacy and Implementation Study
The aim of the study is to assess the efficacy of the My Choices - Alcohol program by comparing alcohol-use of people before and after doing the program to people that did not do the program on the same period of time (3 months).
- Trial name
- NCT05358613
- Testing
- My Choices
- Where
- 5 sites in Canada
- Volunteers
- 167 people
- Sponsor
- Université du Québec à Trois-Rivières
Diet Modification, Physical Activity
Denver Garden Environment and Microbiome Study Disease
An interdisciplinary team with extensive garden study experience conducted a pilot randomized controlled clinical trial to see whether gardening reduced risk factors for diseases like cancer and heart disease.
- Conditions
- Diet Modification, Physical Activity, Weight Gain, Chronic Disease
- Trial name
- DGEM (NCT03089151)
- Testing
- Community Garden Intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Intervention
Protocol: Feasibility of an Online Intervention to Increase Awareness of Gynaecological Cancer in UK Students
In the UK more than 2500 young people are diagnosed with cancer each year, including gynaecological cancers) and almost a third will be diagnosed within accident and emergency departments.
- Trial name
- GoCheck (NCT07147283)
- Testing
- Educational film and volitional help sheet
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Leeds Beckett University
Polycystic Ovary Syndrome, Hypothalamic Amenorrhea
Body Fat as Determinant of Female Gonadal Dysfunction
Reproduction requires from women enough energy depots to warrant an adequate nutritional supply to the fetus. Hence, adipose tissue is able to communicate with female hypothalamic-pituitary-ovary axis.
- Trial name
- NCT03841981
- Testing
- Anthropometric and physical examination, Indirect calorimetry, accelerometer and seven-day dietary recall, Biochemical, hormonal and metabolic phenotyping
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Breast Neoplasms, Ovarian Neoplasms
Outcomes of Education and Counseling for BRCA1 Testing
This study will identify how personal beliefs, values and family experiences affect a person's decision as to whether or not to be tested for changes in a gene called BRCA1 or BRCA2.
- Trial name
- NCT00001468
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Breast Neoplasm Female, Nutrition Related Cancer
Study for the Knowledge of Risk Factors Associated With Breast Cancer in Women
Breast cancer is the most frequent tumor in Western women. In Spain about 26,000 new breast cancers are diagnosed each year. This type of tumor is increasing worldwide with an increase in aggressive neoplasms in young women.
- Conditions
- Breast Neoplasm Female, Nutrition Related Cancer, Habits, Diet, Cancer, Breast
- Trial name
- Mamanut (NCT03918668)
- Testing
- Women with recent diagnosis of breast cancer
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz