Clinical trials: Behavioral Risks of Cancer
Lung Cancer, COPD (Chronic Obstructive Pulmonary Disease) With Acute Lower Respiratory Infection
Lung Cancer Prevention Screening Programme in Italy
This prospective randomized multicentered clinical study aims at implementing early diagnosis of lung cancer in high-risk heavy smokers in the Italian population.
- Conditions
- Lung Cancer, COPD (Chronic Obstructive Pulmonary Disease) With Acute Lower Respiratory Infection, Cardiovascular Diseases
- Trial name
- RISP (NCT05766046)
- Testing
- early lung cancer detection, blood test
- Where
- Italy
- Volunteers
- 7,324 people, healthy volunteers welcome
- Sponsor
- Ugo Pastorino
Prostate Cancer, Shared Decision Making
RCT of NLP-Based Feedback for Improving SDM in Men With Localized Prostate Cancer
The purpose of the research is to assess the impact of a natural language processing + artificial intelligence (NLP+AI)-based risk communication feedback system to improve quality of risk communication of key tradeoffs during…
- Conditions
- Prostate Cancer, Shared Decision Making, Risk Communication
- Trial name
- NLP RCT (NCT06856694)
- Testing
- NLP+AI Report
- Where
- United States
- Volunteers
- 283 people
- Sponsor
- Cedars-Sinai Medical Center
Thyroid Carcinoma, Dyslipidemias
Lipid Metabolic Status in Thyroid Carcinoma
The continuous increase of the incidence of the thyroid cancer in the last years has taken this neoplasia among the first 4 frequent cancers in the cancer registry of the Institute of Oncology "Prof.Ion Chiricuţă" from…
- Conditions
- Thyroid Carcinoma, Dyslipidemias, Risk Reduction Behavior, Hormone Replacement
- Trial name
- LITCA (NCT01487057)
- Where
- Romania
- Volunteers
- 52 people
- Sponsor
- Prof. Dr. I. Chiricuta Institute of Oncology
Breast Neoplasm, Primary Prevention
Project Breast47: Effect of an Educational Intervention
Breast cancer is the most frequently diagnosed malignant tumor in women. In 2018, in Spain, the estimated incidence was 101/100,000 women.
- Conditions
- Breast Neoplasm, Primary Prevention, Risk Factors, Telemedicine
- Trial name
- Breast47 (NCT05267171)
- Testing
- Web access
- Where
- Spain
- Volunteers
- 451 people, healthy volunteers welcome
- Sponsor
- University of Oviedo
Breast Cancer, Psychosocial Effects of Cancer and Its Treatment
Assessing Women's Attitudes About the Risk of Infertility Related to Adjuvant Therapy for Early Breast Cancer
RATIONALE: Adjuvant therapy given after surgery for early breast cancer may cause infertility. Assessing young women's attitudes and feelings about the risk of infertility may help improve the ability to plan effective treatment.
- Conditions
- Breast Cancer, Psychosocial Effects of Cancer and Its Treatment, Sexual Dysfunction and Infertility, Sexuality and Reproductive Issues
- Trial name
- NCT00062400
- Testing
- psychosocial assessment and care
- Where
- 27 sites in Belgium, Chile and 13 more
- Volunteers
- 385 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Bronchial Dysplasia, Tobacco Smoking
Nivolumab for the Reversal of Squamous Dysplasia in High Risk Current and Former Smokers
The goal of this clinical research study is to determine whether the PD-1 inhibitor (Programmed cell death protein 1) nivolumab improves premalignant bronchial dysplastic lesions in subjects that are at high risk for the…
- Conditions
- Bronchial Dysplasia, Tobacco Smoking, History of Non-Small Cell Lung Cancer, History of Head and Neck Cancer
- Trial name
- NCT03347838
- Testing
- Nivolumab
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- University of Colorado, Denver
Cancer Screening, Early Detection of Cancer
Risk Reduction Program for Women Having High Risk of Breast Cancer
An intervention program involving education, guidance, counseling, case management and surveillance based on the Health Belief Model will be implemented on women with high risk of breast cancer.
- Conditions
- Cancer Screening, Early Detection of Cancer, Breast Cancer, Preventive Health Care
- Trial name
- BrCaRRP (NCT04304404)
- Testing
- Breast Cancer Risk Reduction Program (BrCaRRP)
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Breast Cancer, Prostate Cancer
Researching the Effect of Exercise on Cancer
Researchers think that exercise may be able to prevent cancer from coming back by lowering ctDNA levels. The purpose of this study is to explore how aerobic exercise (exercise that stimulates and strengthens the heart and lungs…
- Conditions
- Breast Cancer, Prostate Cancer, Colorectal Cancer, Stage I Breast Cancer
- Trial name
- NCT04589468
- Testing
- Exercise
- Where
- 9 sites in United States
- Volunteers
- 51 people
- Sponsor
- City of Hope Medical Center
Cardiovascular Risk Factor, Diabetes Mellitus, Type 2
Evaluation of a Physical Activity Referral Scheme
The study will evaluate the effectiveness of a co-developed exercise referral scheme. Participants will be recruited to one of three groups 1. Co-developed exercise referral scheme, 2. Usual care exercise referral scheme, 3.
- Conditions
- Cardiovascular Risk Factor, Diabetes Mellitus, Type 2, Anxiety, Depression
- Trial name
- NCT03490747
- Testing
- Physical activity referral scheme, Usual care exercise referral scheme
- Where
- United Kingdom
- Volunteers
- 68 people
- Sponsor
- Paula Watson
Current Smoker, Former Smoker
Acetylsalicylic Acid Compared to Placebo in Treating High-Risk Patients With Subsolid Lung Nodules
This randomized phase II trial studies acetylsalicylic acid compared to placebo in treating high-risk patients with subsolid lung nodules. A nodule is a growth or lump that may be malignant (cancer) or benign (not cancer).
- Conditions
- Current Smoker, Former Smoker, Multiple Pulmonary Nodules, Tobacco Use Disorder
- Trial name
- NCT02169271
- Testing
- Aspirin, Laboratory Biomarker Analysis
- Where
- 2 sites in United States, Italy
- Volunteers
- 109 people
- Sponsor
- National Cancer Institute (NCI)
Cancer, Cardiovascular Diseases
Healthy Lifestyles After Cancer for Adolescents and Young Adults: A Program to Reduce Cardiovascular Risk Factors
There are close to 700,000 survivors of adolescent and young adult (AYA) cancer (aged 15 to 39 at diagnosis) in the US. Survivorship for AYAs is often complicated by long-term and late-effects.
- Conditions
- Cancer, Cardiovascular Diseases, Weight Management, Pain
- Trial name
- HEALTHY-AYA (NCT05869604)
- Testing
- HEALTHY AYA, Education Control
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Duke University
Cancer of the Colon
Behavioral Economic Incentives and Cancer Health Risk Assessment
This is an RCT among UPHS employees between ages 50-64 comparing no incentive and a loss-framed incentive for completing cancer health risk assessment.
- Trial name
- NCT03068052
- Testing
- No incentive, Incentive
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Breast Cancer, Smoking Cessation
Brief Intervention for Tobacco and Alcohol Risk Reduction for Couple During Breast Cancer Treatment.
This study will examine the benefits of involving partner in a Screening, Brief Intervention and Referral to Treatment (SBIRT) program for tobacco and alcohol for women treated for breast cancer.
- Conditions
- Breast Cancer, Smoking Cessation, Alcohol Use, Unspecified
- Trial name
- IBMC (NCT04007549)
- Testing
- Brief motivational interview on tobacco/alcohol risk reduction
- Where
- France
- Sponsor
- Institut Bergonié
Breast Cancer, Physical Activity
Supervised Resistance TRaining amONG Women at Risk of Breast Cancer Related Lymphedema
Breast cancer (BC) is the most common neoplasm in Chile, and its medical treatment leads to high survival. One-third of survivors will develop BC-related lymphedema.
- Conditions
- Breast Cancer, Physical Activity, Lymphedema of Upper Arm
- Trial name
- STRONG-B (NCT04821609)
- Testing
- Resistance Training
- Where
- Chile
- Volunteers
- 106 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Breast Cancer, Risk Reduction
Restore-B: A Trial Comparing Prepectoral Implant-based Breast Reconstruction With and Without Mesh
The goal of this feasibility randomised controlled clinical trial (RCT) is to compare mesh-assisted to no-mesh pre-pectoral implant based immediate breast reconstruction in women undergoing mastectomy for treatment of breast…
- Trial name
- NCT06112977
- Testing
- Prepectoral implant-based immediate breast reconstruction
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Oxford
Diet Habits, Cancer Prevention
Dietary Fiber and Time Restricted Eating
This study is seeking to examine combinations of two different dietary interventions on cancer risk.
- Trial name
- FIBER+TRE (NCT07219706)
- Testing
- Time Restricted Eating, Group education, Counseling
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Alcohol Drinking, Heavy Drinking
Reset Challenge: Reducing High-risk Drinking for Cancer Prevention
This is a single-arm, non-randomized, prospective study to evaluate the feasibility and preliminary efficacy of a 30-day mobile Health (mHealth) Reset Challenge for reducing high-risk drinking.
- Conditions
- Alcohol Drinking, Heavy Drinking, Binge Drinking
- Trial name
- NCT07591428
- Testing
- 30-Day Alcohol Abstinence Challenge
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Oklahoma
Chemotherapy-induced Febrile Neutropenia
Study Investigating How Physicians Assess the Risk of Patients Developing Febrile Neutropenia During Chemotherapy.
This is a prospective observational study investigating how physicians assess the risk of febrile neutropenia (FN) developing in patients who will receive chemotherapy.
- Trial name
- NCT01813721
- Where
- 90 sites in Australia, Austria and 9 more
- Volunteers
- 1,007 people
- Sponsor
- Amgen
Diabetes, Hypercholesterolaemia
The Effect of Providing Genetic Risk Information on Lifestyle Behaviors in African Americans
Cardiovascular disease (CVD) is a major and persistent health disparity for African Americans. Linking GAINS is a randomized pilot and feasibility study designed to evaluate whether receiving genetic risk information early in a…
- Conditions
- Diabetes, Hypercholesterolaemia, Hypertension, Obesity Type 2 Diabetes Mellitus
- Trial name
- LINKING GAINS (NCT07833384)
- Testing
- Color Genomics Genetic Testing Panels
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Breast Cancer, Lymphoma
International Travel Patterns and Risk Behaviour of Breast Cancer, Lymphoma Patients and Bone Marrow Transplant Recipients
This study also aims to raise awareness among both patients and health-care providers about the importance of pre-travel health consultation and preventive interventions prior to international travel.
- Trial name
- NCT01111201
- Testing
- questionnaires
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Memorial Sloan Kettering Cancer Center