Clinical trials: Behaviour
Opioid Use Disorder, Chronic Pain
An Adaptive Walking Intervention to Manage Chronic Pain in Veterans With Opioid Use Disorder Engaged in Opioid Agonist Treatment
Severe chronic pain and opioid use disorder (OUD) occur at significantly higher rates in Veterans compared to the general population.
- Trial name
- NCT05051644
- Testing
- Steps 2 Change (S2C), Control
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Smoking, Withdrawal Nicotine
Association Between Smoking, Brain Activity, Genes, and ADHD
The study investigated the underlying mechanisms of smoking in young adults by examining the associations between smoking, brain activity, dopamine genes, and attention deficit hyperactivity disorder (ADHD).
- Conditions
- Smoking, Withdrawal Nicotine, ADHD
- Trial name
- NCT00915798
- Testing
- Cigarette smoking, Abstinence
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Alcohol Use Disorder
Lacosamide Effects on Alcohol Self Administration and Craving in Heavy Drinkers
This is a double-blind, randomized, placebo-controlled, crossover design trial tested the effect of lacosamide on alcohol self-administration and craving following a priming dose of alcohol.
- Trial name
- NCT03271528
- Testing
- Lacosamide
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Boston Medical Center
Abdominal Obesity
Multi-component Workplace Energy Balance Intervention
The purpose of the WorkACTIVE-P study is to assess the outcome of an innovative multi-component intervention focused on increasing energy expenditure and re-balancing the disrupted energy balance equation of sedentary workplaces…
- Trial name
- WorkACTIVE-P (NCT02561611)
- Testing
- Intervention Group
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Pennington Biomedical Research Center
PreDiabetes, Weight Loss
The National Diabetes Prevention Program in Rural Communities
The purpose of this pilot trial is to compare feasibility and effectiveness of remote delivery (social media or video conferencing) of the National Diabetes Prevention Program (N-DPP) to adults in rural communities.
- Conditions
- PreDiabetes, Weight Loss, Lifestyle Risk Reduction
- Trial name
- Rural NDPP (NCT05387434)
- Testing
- Diabetes Prevention Program-Remote (DPP-R), Diabetes Prevention Program-Facebook (DPP-FB)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Kansas Medical Center
Postpartum Depression, Small for Gestational Age at Delivery
Happy Mother-Healthy Baby: An Anxiety-focused Early Prenatal Intervention
In the proposed study the investigators will develop an early prenatal preventive intervention targeting anxiety and conduct a randomized controlled trial in Pakistan to test its efficacy in reducing generalized anxiety disorder…
- Conditions
- Postpartum Depression, Small for Gestational Age at Delivery, Preterm Birth, Anxiety
- Trial name
- HMHB (NCT03880032)
- Testing
- Cognitive Behavioral Therapy Intervention for Anxiety
- Where
- Pakistan
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Obsessive-Compulsive Disorder
Risperidone or Cognitive-Behavioral Therapy for Improving Medication Treatment for Obsessive-compulsive Disorder
This study will compare the short- and long-term effectiveness of two common therapies in improving serotonin reuptake inhibitor treatment in people with obsessive-compulsive disorder.
- Trial name
- NCT00389493
- Testing
- Risperidone, Exposure/ritual prevention therapy (EX/RP)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- New York State Psychiatric Institute
Hearing Loss, Emergency Service
Hearing Impairment, Strategies, and Outcomes in Emergency Departments
Aim 1: Establish the feasibility of screening for hearing loss in the ED Aim 2: Determine the acceptability of the screening procedure (among the ED population) Aim 3: Derive a preliminary estimate of the effect size of primary…
- Conditions
- Hearing Loss, Emergency Service, Hospital Readmission
- Trial name
- Hear-VA (NCT03594500)
- Testing
- PockeTalker, No PockeTalker
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- VA Office of Research and Development
Tobacco Dependence
Multiple-dose Nicotine Pharmacokinetics With a New Oral Nicotine Replacement Product.
A comparison of three products for oral nicotine replacement with respect to pharmacokinetics after multiple-doses of nicotine.
- Trial name
- NCT01084707
- Testing
- Oral Nicotine, Nicotine Lozenge, Nicotine gum
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- McNeil AB
Amputation, Limb Loss
Self-management to Improve Function Following Amputation
Lower extremity amputations are a significant cause of morbidity, mortality, loss of function and reduced quality of life. Self-management (defined as the process by which an individual adopts an active role in managing the…
- Trial name
- VETPALS (NCT02163811)
- Testing
- VETPALS, Individual Education Support Program
- Where
- 5 sites in United States
- Volunteers
- 182 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
Long Duration Activity and Metabolic Control After Spinal Cord Injury
Skeletal muscle is the largest endocrine organ in the body, playing an indispensable role in glucose homeostasis. Spinal cord injury (SCI) prevents skeletal muscle from carrying out this important function.
- Trial name
- NCT03139344
- Testing
- Low-frequency Exercise, High-frequency Exercise
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Richard K Shields
Nicotine Dependence
Coping Skills Treatment for Smoking Cessation
The primary purpose of this study is to evaluate the efficacy of a new type of exposure- and acceptance-based smoking cessation treatment vs.
- Trial name
- Project-WIN (NCT01061528)
- Testing
- Transdermal Nicotine
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Butler Hospital
Depression, Mild Cognitive Impairment
Combination Treatment Study for Memory Impairment and Depression
Patients presenting with depression (DEP) and cognitive impairment (CI), represent a unique, understudied population that is difficult to diagnose, treat and estimate prognosis.
- Trial name
- DEP-CI (NCT01658228)
- Testing
- Donepezil, Citalopram, Venlafaxine
- Where
- 2 sites in United States
- Volunteers
- 86 people
- Sponsor
- New York State Psychiatric Institute
Medication Adherence, High Blood Pressure
Social Forces to Improve Statin Adherence (Study A)
To assess the effectiveness of reporting statin adherence patterns to a Medication Adherence Partner (MAP) in improving the outcome of statin adherence versus usual care as measured by an electronic pill bottle.
- Conditions
- Medication Adherence, High Blood Pressure, Diabetes
- Trial name
- NCT02018809
- Testing
- Medication Adherence Partner, Electronic pill bottle
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Pennsylvania
Tobacco Use Cessation
Project Q Pilot: Smoking Cessation for Light Smokers
The purpose of this pilot study is to evaluate the feasibility, acceptability, and preliminary efficacy of an intervention to promote smoking cessation among light smokers.
- Trial name
- NCT03416621
- Testing
- Cognitive behavioral cessation counseling, Counseling and active drug intervention
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Duke University
Distress, Emotional, Anxiety
Self-compassion Therapist-led Online Group Treatment for Adolescents With Distress, Anxiety, and Depression
Background: Distress, anxiety and depression are highly prevalent in school health care or primary care. Many of these conditions remain undiscovered and/or untreated.
- Conditions
- Distress, Emotional, Anxiety, Depression
- Trial name
- CUST (NCT05448014)
- Testing
- Compassion focused group therapy online
- Where
- Sweden
- Volunteers
- 42 people
- Sponsor
- Umeå University
Depressive Disorder, Major
A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Fixed Dose Study Evaluating the Efficacy and Safety of Orvepitant in Subjects With Major Depressive Disorder
This is a 6-week, randomised, multicenter, double-blind, placebo controlled, fixed dose parallel group study to assess the efficacy and safety of orvepitant (30 and 60 mg/day) versus placebo in subjects with a diagnosis of a…
- Trial name
- orvepitant MDD (NCT00880399)
- Testing
- orvepitant
- Where
- 20 sites in United States, Canada
- Volunteers
- 328 people
- Sponsor
- GlaxoSmithKline
Compliance Behavior
Beta Glucosylceramide for Treatment of NASH
Oral administration of betaglucosylceramide was shown effective in reducing inflammation in animal models and was found safe in humans.
- Trial name
- NCT02126306
- Testing
- Beta Glucosylceramide
- Volunteers
- 23 people
- Sponsor
- Hadassah Medical Organization
Attention Deficit Hyperactivity Disorder
An Open-Label Study of Naltrexone in Adults With Attention Deficit Hyperactivity Disorder.
The primary aim of this study is to assess whether naltrexone as a monotherapy is effective in treating Attention Deficit Hyperactivity Disorder (ADHD) in adults.
- Trial name
- NCT01873729
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Massachusetts General Hospital
Depression, Major Depressive Disorder
Relapse-Prevention Study With Levomilnacipran ER (F2695 SR) in Patients With Major Depressive Disorder
The purpose of this study is to evaluate the safety and efficacy of Levomilnacipran ER relative to placebo in the prevention of depression relapse in patients with major depressive disorder (MDD).
- Trial name
- NCT01085812
- Testing
- Levomilnacipran ER
- Where
- 35 sites in United States, Canada
- Volunteers
- 734 people
- Sponsor
- Forest Laboratories
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