Clinical trials: Benign Hyperplasia of Prostate
BPH (Benign Prostatic Hyperplasia), Lower Urinary Track Symptoms
New Treatment Strategies and Epigenetic Biomarker for Management of Benign Prostatic Hyperplasia
SRD5A2 is a critical enzyme for prostatic development and growth, and the SRD5A2 inhibitor, finasteride, is used to treat benign prostatic hyperplasia (BPH).
- Trial name
- NCT06944145
- Testing
- raloxifene, Finasteride
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- Beth Israel Deaconess Medical Center
Benign Prostatic Hyperplasia (BPH), Minimal Invasive Surgery
Minimally Invasive Prostate Interventions Registry (MIST Study)
This study is a multicenter prospective patient registry designed to evaluate clinical, functional, and safety outcomes after minimally invasive prostate interventions (MIST) performed for benign prostatic obstruction (BPO)…
- Conditions
- Benign Prostatic Hyperplasia (BPH), Minimal Invasive Surgery, LUTS
- Trial name
- MIST (NCT07242807)
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 2,000 people
- Sponsor
- Necmettin Erbakan University
Benign Prostatic Hyperplasia
Safety and Efficacy of Botulinum Toxin Type A to Treat Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia
This study will evaluate the safety and efficacy of intraprostatic administration of botulinum toxin Type A (BOTOX®) compared with placebo to treat urinary tract symptoms due to benign prostatic hyperplasia.
- Trial name
- NCT01107392
- Testing
- botulinum toxin Type A, Normal saline
- Where
- 8 sites in United States, Canada and 6 more
- Volunteers
- 315 people
- Sponsor
- Allergan
Benign Prostatic Hyperplasia
Bipolar TURP Versus Bipolar Enucleation for BPH Management
To compare the surgical outcomes at 12 months post-surgery between Bipolar TURP and BipoLEP in men with BPH and prostate volumes between 30-80 grams.
- Trial name
- NCT06758466
- Testing
- Prostate surgery
- Volunteers
- 180 people
- Sponsor
- Kasr El Aini Hospital
Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms
UK Post-market Waterjet Ablation Therapy for Endoscopic Resection of Prostate Tissue
A post-market, non-interventional, two-arm, long-term follow-up study of patients previously enrolled in the WATER Study (NCT02505919) - which was a prospective multi-centre randomized blinded study comparing Aquablation of the…
- Trial name
- NCT04658056
- Where
- United Kingdom
- Volunteers
- 46 people
- Sponsor
- PROCEPT BioRobotics
Benign Prostatic Hyperplasia
A Study to Investigate the Effects on Blood Pressure and Pulse Rate of a Single 100mg Dose of Sildenafil in Patients With Benign Prostatic Hyperplasia Who Are Being Treated With Doxazosin
To investigate the effects of a single dose of sildenafil (100 mg) or placebo on blood pressure and pulse rate in subjects taking doxazosin for benign prostatic hyperplasia (BPH).
- Trial name
- NCT00645034
- Testing
- sildenafil
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Benign Prostate Hypertrophy(BPH)
Evaluation of the Application Effect of a Surgical Navigation System in HoLEP Surgery
3D imaging-assisted surgical navigation system was established using the following specific procedures: 1) Prostate MRI Acquisition and 3D Reconstruction: patient prostate MRI images are acquired, and professional engineers…
- Trial name
- NCT07251621
- Testing
- use the 3D imaging-assisted surgical navigation system during surgery
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chinese PLA General Hospital
Benign Prostatic Hypertrophy
Comparison of Different Energy Sources During TUR-P
With this study, it is aimed to compare the operative results and complication rates in transurethral resection of the prostate (TUR-P) performed by resectoscopes with two different bipolar and a monopolar energy sources.
- Trial name
- NCT02533687
- Testing
- Bipolar TURP-1, Bipolar TURP-2, Monopolar TURP
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Selcuk University
Acute Urinary Retention, Benign Prostate Hypertrophy(BPH)
Study of Teverelix DP on Prostate Volume, Urinary Function and Clinical Outcomes Following Acute Urinary Retention
This randomized, double-blind, placebo-controlled Phase 2 study is evaluating Teverelix DP in men following a first episode of acute urinary retention (AUR) associated with benign prostatic hyperplasia (BPH), a population at risk…
- Trial name
- NCT07733934
- Testing
- Teverelix DP
- Volunteers
- 126 people
- Sponsor
- Antev Ltd.
Benign Prostatic Hypertrophy With Outflow Obstruction, Benign Prostatic Hyperplasia
Clinical Results of Odyliresin (Iresine Celosia) in Symptomatic Benign Prostatic Hyperplasia
Odyliresin (Iresine Celosia) is a cytochrome-flavoprotein with a powerful anti-oxydant action on cells, has a therapeutic effect on BPH-related LUTS, reducing symptoms, prostate volume, improving the patient's quality of life and…
- Trial name
- Odyliresin (NCT02977832)
- Testing
- Odyliresin, Alfuzosin
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Benign Prostatic Hyperplasia
Study of Tadalafil Once-a Day for 12 Weeks in Men With Signs and Symptoms of Benign Prostatic Hyperplasia
This is a randomized, double-blind, placebo-controlled, parallel-design, multinational, 12-week study to compare the efficacy, dose response, and safety of tadalafil once a day versus placebo in men with signs and symptoms of…
- Trial name
- NCT00384930
- Testing
- tadalafil
- Where
- United States
- Volunteers
- 1,058 people
- Sponsor
- Eli Lilly and Company
Benign Prostatic Hyperplasia With Lower Urinary Tract Symptoms
Registry of MIUS for Benign Prostatic Obstruction
This national, multicenter, prospective registry aims to collect standardized perioperative and follow-up data on patients undergoing minimally invasive surgical management for benign prostatic obstruction (BPO) in Turkey.
- Trial name
- ReMIUS-BPO (NCT07159165)
- Testing
- Minimally invasive surgical treatment for benign prostatic obstruction
- Where
- Turkey (Türkiye)
- Volunteers
- 10,000 people
- Sponsor
- Ondokuz Mayıs University
Benign Prostate Hypertrophy(BPH)
Transurethral Focal Laser Ablation Versus Transurethral Prostatectomy For Management Of Benign Prostatic Obstruction
Introduction and objectives: Laser prostatectomy has become an increasingly popular and effective alternative to transurethral resection of the prostate (TURP) for the treatment of benign prostatic hyperplasia (BPH).-.
- Trial name
- NCT07196475
- Testing
- FOCAL LASER ABLATION OF PROSTATE
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms
Omega Study: Evaluation of the Safety and Efficacy of the Omega System for the Treatment of BPH
The ProArc Medical Omega system is a prostatic reshaping device that is designed to treat Lower Urinary Tract Symptoms (LUTS) due to BPH.
- Trial name
- NCT04627701
- Testing
- Omega
- Where
- 4 sites in Israel, New Zealand
- Volunteers
- 26 people
- Sponsor
- ProArc Medical
Benign Prostatic Hyperplasia (BPH)
Safety and Initial Efficacy Study of the Vortx Rx for Treatment of Benign Prostatic Hyperplasia (US)
The HistoSonics' Histotripsy BPH Device, the Vortx Rx, is a portable ultrasound therapy device. The purpose of this study is to assess and monitor the performance of the Vortx Rx for initial safety and efficacy for the treatment…
- Trial name
- NCT01896973
- Testing
- Vortx Rx - Histotripsy BPH Device
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- HistoSonics, Inc.
BPH Without Urinary Obstruction and Other Lower Urinary Tract Symptoms (LUTS)
The Effect of BRIZO on Lower Urinary Tract Symptoms (LUTS) Related to Benign Prostatic Hypertrophy (BPH)
A randomized, placebo controlled double-blind, 12-week treatment trial in men with moderate to severe symptoms of benign prostatic hyperplasia.
- Trial name
- NCT05227508
- Testing
- BRIZO
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Se-cure Pharmaceuticals Ltd.
Benign Prostatic Hyperplasia, Bladder Outlet Obstruction
Thulium Laser Enucleation With Bladder Neck Incision for Small-Volume Benign Prostatic Hyperplasia
This study will evaluate the safety and effectiveness of different surgical treatments for men with small-volume benign prostatic hyperplasia (BPH).
- Conditions
- Benign Prostatic Hyperplasia, Bladder Outlet Obstruction, Lower Urinary Tract Symptoms (LUTS)
- Trial name
- ThuLEP-BNI (NCT07569874)
- Testing
- Thulium Laser Enucleation of the Prostate Combined With Bladder Neck Incision, Thulium Laser Enucleation of the Prostate, Transurethral Resection of the Prostate
- Where
- China
- Volunteers
- 932 people
- Sponsor
- Chinese PLA General Hospital
Benign Prostate Hypertrophy(BPH), Prostate Cancer (Adenocarcinoma)
Investigation of the Diagnostic Role of miRNAs in PCa and BPH
Prostate cancer(PCa) is the second most common cause of cancer-related death in men after lung cancer. Diagnostic methods such as measurement of serum Prostate-specific antigen (PSA) levels used in the clinic still cannot…
- Trial name
- NCT06726070
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Alanya Alaaddin Keykubat University
BPH (Benign Prostatic Hyperplasia), Lower Urinary Tract Symptoms (LUTS)
Butterfly Pivotal Study
A prospective, multicenter, blind randomized (2:1) controlled study comparing the International Prostate Symptom Score (IPSS) of the Active arm to the IPSS of the control arm at the 3 months follow-up and active arm IPSS score…
- Trial name
- NCT05341661
- Testing
- Butterfly Prostatic Retraction Device
- Where
- 3 sites in United States
- Volunteers
- 245 people
- Sponsor
- Butterfly Medical Ltd.
Lower Urinary Tract Symptoms, Prostatic Hyperplasia
To Evaluate LUTS and Complications Between Indwelling Catheter and Temporary Prostatic Stent in Patients Undergoing Minimally Invasive Procedures for the Treatment of Localized Prostate Cancer or Benign Prostatic Hyperplasia (HERMES)
The goal of this single-centre prospective randomized clinical trial is to compare the post-operative use of temporary prostatic stent (Group 1) vs indwelling catheter (Group 2) in patients undergoing cryotherapy for targeted…
- Conditions
- Lower Urinary Tract Symptoms, Prostatic Hyperplasia, Prostatic Cancer, Urinary Retention
- Trial name
- HERMES (NCT05851521)
- Testing
- Temporary prostatic stent (Exime®), Indwelling catheter
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Lyx Institute