Clinical trials: Benign Hyperplasia of Prostate
Lower Urinary Tract Symptoms, Prostate Obstruction
Intermittent vs Daily Tamsulosin for LUTS/BPH
Background: Lower urinary tract symptoms (LUTS) are common in aging men, most often due to benign prostatic hyperplasia (BPH), and significantly impair quality of life.
- Trial name
- ARAB (NCT07308002)
- Testing
- Daily Tamsulosin, Intermittent Tamsulosin
- Where
- Egypt
- Volunteers
- 288 people
- Sponsor
- Mansoura University
Prostatic Hyperplasia, Lower Urinary Tract Symptoms
TRT on BPH Hypoganadal MetS Patients. Florence-PROTEST
There are many evidences in the literature showing that the metabolic syndrome (MetS) is associated with BPH / LUTS. There are also numerous evidence that hypogonadism is associated with both conditions, thus being one of the…
- Conditions
- Prostatic Hyperplasia, Lower Urinary Tract Symptoms, Hypogonadism
- Trial name
- PROTEST (NCT02366975)
- Testing
- Testosterone gel 2%
- Where
- 2 sites in Italy
- Volunteers
- 143 people
- Sponsor
- University of Florence
Benign Prostatic Hyperplasia, Benign Prostatic Hypertrophy
Safety and Efficacy of OCL 503 in Prostate Artery Embolization
This is a prospective, pilot, open-label, uncontrolled, non-randomized safety and effectiveness study of OCL 503 in men with BPH.
- Trial name
- NCT02509975
- Testing
- Prostate artery embolization.
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- IMBiotechnologies Ltd.
Bladder Outlet Obstruction, Lower Urinary Tract Symptoms
The Value of Multiple Urine Flow Rate Measurements in Male Benign Prostatic Hyperplasia (BPH) Subjects
Crossover comparison of different flow meters with a digital home flow meter as a reference. Main hypothesis: Reapeated home flow measurements with a disposable device will provide a better understanding of the patients urinary…
- Trial name
- NCT00710749
- Testing
- Disposable device, Digital device, Clinic flow measurement
- Where
- 4 sites in United States, Netherlands and 2 more
- Volunteers
- 60 people
- Sponsor
- Wellspect HealthCare
Benign Prostate Hyperplasia
Changes of the Hemodynamic Profiles on Bio Reactance Technique During TURP in Elderly Patients
The purpose of this study is to evaluate the change of the hemodynamic profiles on bio reactance technique during TURP in elderly patients.
- Trial name
- NCT02483819
- Volunteers
- 20 people
- Sponsor
- Yonsei University
Benign Prostatic Hyperplasia, Benign Prostatic Hyperplasia With Lower Urinary Tract Symptoms
Feasibility and Utility of a Prehabilitation Program for Use in Patients With Benign Prostatic Hyperplasia Who Have Elected to Undergo Holmium Laser Enucleation of the Prostate (HoLEP).
Benign prostatic hyperplasia (BPH) is a debilitating condition which is highly prevalent in older males, up to 45% of those over the age of 45 are affected and 80% of those over the age of 70 are affected.
- Conditions
- Benign Prostatic Hyperplasia, Benign Prostatic Hyperplasia With Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia With Outflow Obstruction
- Trial name
- NCT07552961
- Testing
- Comprehensive Prehabilitation Programming
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Benign Prostatic Hyperplasia (BPH)
A Comparative Study of KSO-0400 in BPH Patients With LUTS
The objective of this study is to evaluate the efficacy and safety of KSO-0400 compared to placebo for the treatment of LUTS caused by BPH.
- Trial name
- NCT01222650
- Testing
- KSO-0400, Silodosin
- Where
- Japan
- Volunteers
- 400 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Prostate Cancer, Bladder Cancer
Duke Urology Database and Specimen Bank
The proposed project is aimed to build a Duke University-specific longitudinal urologic surgery database. It will be used as the main resource to support future research within Urology and Duke University.
- Conditions
- Prostate Cancer, Bladder Cancer, Erectile Dysfunction, Incontinence
- Trial name
- NCT00978991
- Where
- United States
- Volunteers
- 87,820 people, healthy volunteers welcome
- Sponsor
- Duke University
Benign Prostatic Hyperplasia, Pupil Anomaly
The Effects of α-adrenergic Receptor Antagonists on Choroid and Pupil
It was aimed to evaluate and investigate the effects of tamsulosin hydrochloride, has preferential selectivity for the α1A receptor in the prostat versus the α1B receptor in the blood vessels, and alfuzosin hydrochloride on…
- Conditions
- Benign Prostatic Hyperplasia, Pupil Anomaly, Choroid Disease
- Trial name
- NCT03144596
- Testing
- Alfuzosin Hydrochloride 10 MG, Tamsulosin Hydrochloride 0.4 MG
- Volunteers
- 63 people
- Sponsor
- Kocatepe University
Prostatic Hyperplasia
Benign Prostatic Hyperplasia Trial With Dutasteride And Tamsulosin Combination Treatment
This study will investigate the efficacy and safety of treatment with dutasteride and tamsulosin, administered once daily for 4 years, alone and in combination, on the improvement of symptoms and clinical outcome in men with…
- Trial name
- NCT00090103
- Testing
- dutasteride 0.5mg once daily for 4 years, tamsulosin 0.4mg once daily for 4 years
- Where
- 503 sites in United States, Argentina and 34 more
- Volunteers
- 4,844 people
- Sponsor
- GlaxoSmithKline
Prostatic Hyperplasia
FLOMAX® Versus HYTRIN® in Patients With the Signs and Symptoms of Benign Prostatic Hyperplasia
1. To study the early onset of symptomatic relief afforded by FLOMAX® capsules, 0.4 mg daily as compared to HYTRIN® capsules, 5 mg (with titration) daily in patients with the signs and symptoms of benign prostatic hyperplasia…
- Trial name
- NCT02244255
- Testing
- FLOMAX® capsules, Ascending doses of HYTRIN® capsules
- Volunteers
- 1,993 people
- Sponsor
- Boehringer Ingelheim
BPH
Urokinase Plasminogen Activator System in Benign Prostatic Hyperplasia
We hypothesize that the absolute or relative serum or urine levels of the urokinase plasminogen activator system, including uPA, uPAR and PAI-1,2 (inhibitors of the uPAR/uPA complex), are associated with inflammation in prostatic…
- Trial name
- NCT00407329
- Testing
- transurethral resection of the prostate
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Queen's University
BPH, Benign Prostatic Hyperplasia
An Observational Study of Tamsulosin in Patients With Benign Prostatic Hyperplasia
In this study, BPH patients visited the institutions during the study period and the effectiveness and safety of the treatment of Tamsulosin(Hanmi Tams® Capsule) in real-practice.
- Trial name
- NCT05422677
- Testing
- Hanmi Tams® Capsule
- Where
- South Korea
- Volunteers
- 4,698 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Benign Prostatic Hypertrophy
The Safety and Efficacy of Ozarelix to Treat Men With Lower Urinary Tract Symptoms Due to Enlargement of the Prostate
This study is to compare the efficacy and safety of ozarelix 15 mg given intramuscular (IM) 2 weeks apart on the improvement of symptoms and the duration of improvement for up to 6 months in men with Benign Prostatic Hypertrophy…
- Trial name
- NCT00427219
- Testing
- Ozarelix
- Where
- 13 sites in United States
- Volunteers
- 74 people
- Sponsor
- Spectrum Pharmaceuticals, Inc
Benign Prostate Enlargement, Benign Prostate Hypertrophy(BPH)
Oxiblume:CoQ10 (Ralivia) Therapy for Benign Prostatic Hyperplasia:
Objectives of the study The aim of the study is to investigate and compare the treatment efficacy and safety of Oxiblume:CoQ10 (Ralivia) therapy vs placebo for BPH patients Study center The study will be coordinated by the…
- Conditions
- Benign Prostate Enlargement, Benign Prostate Hypertrophy(BPH), Benign Prostate Obstruction (BPO)
- Trial name
- NCT07638865
- Testing
- Oxiblume:CoQ10 (Ralivia) therapy
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- G.Gennimatas General Hospital
Urinary Retention, Benign Prostate Obstruction (BPO)
Effect of Catheter Duration on Prostate Laser Enucleation Surgery Outcomes in Patients With Urinary Retention
Benign Prostatic Obstruction (BPO) is a common condition in aging men that can lead to urinary retention, often requiring the use of an indwelling urinary catheter.
- Trial name
- NCT07603011
- Testing
- Laser Enucleation of the Prostate (HoLEP, ThuLEP, ThuFLEP)
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Eskişehir Osmangazi University Medicine Faculty Hospital
Benign Prostatic Hyperplasia, Urinary Tract Infections
Role of Prophylactic Postoperative Antibiotics in HoLEP
The purpose of this study is to investigate whether prescribing a 3-day course of antibiotics after Holmium laser enucleation of the prostate (HoLEP) reduces the risk of urinary tract infection.
- Trial name
- NCT05274672
- Testing
- Nitrofurantoin, Cephalexin, Sulfamethoxazole Trimethoprim Combination
- Where
- 2 sites in United States
- Sponsor
- Baylor Research Institute
Prostate Neoplasm, Inflammation
Protein Kinase A in Prostate Cancer Tissue.
Prostate cancer is the most common malignancy in men. documented risk factors of prostate cancer are age, ethnicity, various genomic mutations and family history of prostate cancer.
- Conditions
- Prostate Neoplasm, Inflammation, Benign Hyperplasia of Prostate
- Trial name
- NCT05460312
- Testing
- prostate biopsy
- Volunteers
- 100 people
- Sponsor
- Ziv Hospital
Benign Prostatic Hyperplasia, Benign Prostatic Hypertrophy
Solifenacin as Add-on Therapy for Overactive Bladder Symptoms in Men Treated for Benign Prostatic Hyperplasia
To evaluate the efficacy and safety of solifenacin succinate as add-on therapy for overactive bladder (OAB) symptoms in men who have been treated for benign prostatic hyperplasia (BPH) with tamsulosin hydrochloride for at least 6…
- Conditions
- Benign Prostatic Hyperplasia, Benign Prostatic Hypertrophy, Overactive Bladder
- Trial name
- NCT00771394
- Testing
- Tamsulosin hydrochloride, Solifenacin succinate
- Where
- 8 sites in Japan
- Volunteers
- 638 people
- Sponsor
- Astellas Pharma Inc
Benign Prostatic Hyperplasia, Prostate Carcinoma
Human Prostate Tissue Model to Maintain and Study Prostate Cancer Stem Cells
This pilot research trial studies the use of a human prostate tissue model to maintain and study prostate cancer stem cells. A human prostate tissue model uses leftover tissue that was removed during surgery from patients with…
- Trial name
- NCT02425800
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Wake Forest University Health Sciences