Clinical trials: Benign Lung Disease
BPH, Nocturia
Use of Autologous Adipose-Derived Stem/Stromal Cells (AD-cSVF) in Symptomatic Benign Prostate Hypertrophy
Benign prostate hypertrophy (BPH) and inflammation are common non-cancerous enlargement of the prostate, which result in urinary interference and incomplete drainage of the bladder.
- Conditions
- BPH, Nocturia, BPH With Urinary Obstruction, Prostatism
- Trial name
- SVF-BPN (NCT02961114)
- Testing
- Microcannula Harvest Adipose, Centricyte 1000, IV Sterile Normal Saline
- Where
- 2 sites in United States
- Sponsor
- Robert W. Alexander, MD, FICS
Benign Breast Disease
VITamin D and OmegA-3 TriaL: Effects on Mammographic Density and Breast Tissue
The VITamin D and OmegA-3 TriaL (VITAL; NCT 01169259) is an ongoing randomized clinical trial in 25,875 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids…
- Trial name
- VITAL (NCT02239874)
- Testing
- Vitamin D and fish oil
- Where
- United States
- Volunteers
- 3,894 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Pulmonary Disease
Cryospray Therapy Versus Standard of Care for Benign Airway Stenosis (CryoStasis)
Benign central airway stenosis (BCAS) is an important cause of both pulmonary morbidity and mortality. Notable causes include post-intubation stenosis, collagen vascular diseases, airway trauma, infectious and idiopathic…
- Trial name
- NCT04996173
- Testing
- Spray cryotherapy, Ballon Dilation, Radial Incision
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Lung Cancer, Lung; Node
Molecular Analysis of Endoscopic Cytology Samples Supernatant in Pulmonary Nodules
Lung cancer screening is based on low dose CT scan (LDCT), a highly sensitive but poorly specific tool. Complementary specific approaches are thus strongly needed, among which cell-free DNA (cfDNA) genotyping has been proven…
- Trial name
- KOBE (NCT05306912)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Toulouse
Pulmonary Coin Lesion, Colon Cancer Liver Metastasis
Optical Detection of Malignancy During Percutaneous Interventions
Investigation of application possibilities of optical spectroscopy within the field of oncology. Optical spectroscopy enables the possibility to specifically differentiate between different (human) tissues.
- Conditions
- Pulmonary Coin Lesion, Colon Cancer Liver Metastasis, Breast Cancer
- Trial name
- NCT01730365
- Testing
- Core biopsy procedure
- Where
- Netherlands
- Volunteers
- 104 people
- Sponsor
- Philips Healthcare
Pulmonary Nodules, Lung Neoplasms
A Multicenter Cohort Study of AI-Based Methods for Pulmonary Nodule Diagnosis and Follow-up
This is an observational, multicentre study. The primary objective of this study was to evaluate the diagnostic performance and clinical applicability of artificial intelligence models for pulmonary nodule segmentation…
- Conditions
- Pulmonary Nodules, Lung Neoplasms, Artificial Intelligence (AI)
- Trial name
- NCT07815483
- Volunteers
- 16,880 people
- Sponsor
- Shanghai East Hospital
Obstructive Airway Disease
Study of Interventional Pulmonologic Treatment of Benign Central Airway Fibrotic Stricture
The purpose of this study is to evaluate the efficacy and safety of four interventional pulmonology techniques for the treatment of fibrotic central airway stricture.
- Trial name
- NCT02287389
- Testing
- balloon dilation, cryotherapy, spiculiform electrosurgery
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Tang-Du Hospital
Solitary Pulmonary Nodule
Evaluate the Auxiliary Diagnostic Value of Circulating Tumor Cells in Benign and Malignant Lung Nodules
By testing the CTC number of new solitary pulmonary nodule patient, evaluating the correlation of CTC number and benign and malignant lung nodules auxiliary diagnosis, the correlation of CTC number and the size of lung nodules of…
- Trial name
- NCT02653859
- Volunteers
- 50 people
- Sponsor
- GenoSaber
Pulmonary Nodule, Solitary, Whole-genome Methylation Sequencing
Benign/Malignant Pulmonary Nodule Classification Based on High-throughput Whole-genome Methylation Sequencing(GM-seq)
Lung cancer is the first cancer in China in terms of morbidity and mortality. The problem of early diagnosis/treatment has always been concerned.
- Trial name
- NCT05415670
- Testing
- Whole-genome Methylation Sequencing(GM-seq)
- Where
- 2 sites in China
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Geneplus-Beijing Co. Ltd.
Chronic Obstructive Pulmonary Disease
Factors to Obstructive Granulation Tissue Formation After Ultraflex Stenting in Benign Tracheal Narrowing
This study is aimed to determine factors leading to obstructive granulation tissue formation after placement of Self-Expandable Metallic Stent (SEMS) in patients with benign tracheal diseases.
- Trial name
- NCT01006200
- Where
- Taiwan
- Volunteers
- 67 people
- Sponsor
- Chang Gung Memorial Hospital
Solitary Pulmonary Nodule, Oncology
18F-2-fluoro-2-deoxy-D-glucose in Positron Emission Tomography Computed Tomography
The study objectives are as follows: To determine the safety of trial 18F-2-fluoro-2-deoxy-D-glucose, produced by a new manufacturer, by surveillance for adverse events in patients having Positron Emission Tomography Computed…
- Conditions
- Solitary Pulmonary Nodule, Oncology, 18F-2-fluoro-2-deoxy-D-glucose, Adverse Event
- Trial name
- NCT04615156
- Testing
- 18F-2-fluoro-2-deoxy-D-glucose
- Volunteers
- 10,000 people
- Sponsor
- Eastern Health, Canada
Lung Cancer (Diagnosis), Fragmentomics
Noninvasive Detection of Lung Nodule Malignancy Using cfDNA Fragmentomics
The goal of this observational study is to learn if cfDNA fragmentomics can noninvasively diagnose whether lung nodules are benign or malignant in adults with imaging-detected lung nodules.
- Trial name
- SHC2408 (NCT07399210)
- Testing
- This study did not include intervention between two cohorts
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Baohui Han
Breast Cancer, Benign Breast Disease
An Investigation Into Dielectric Assessment of Permittivity and Conductivity in Human Using a Novel Electrical Capacitance Tomography Scanner
The goal of this observational study is to investigate the ability of a the Z-scanner to identify and differentiate cancer and benign lesions from healthy breast tissue based on permittivity.
- Trial name
- DiCECT (NCT06264934)
- Testing
- Breast scan using the Z-scanner
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zedsen Limited
Pulmonary Nodule, Solitary
Methylation of cfDNA in Diagnosing and Monitoring Pulmonary Nodule
Patients found pulmonary nodules by CT screening by will be enrolled in this study prospectively. Plasma cfDNA sequencing of these patients will be used to diagnose and monitor benign and malignant pulmonary nodules.
- Trial name
- NCT03989219
- Testing
- plasma cfDNA methylation
- Where
- China
- Volunteers
- 401 people
- Sponsor
- Jiayuan Sun
Benign Joint Hypermobility Syndrome, Wheezing
A Study to Assess Benign Joint Hypermobility Syndrome in Children With a History of Wheezing or Asthma
The purpose of this study is to assess benign joint hypermobility syndrome (BJHS) in children with a history of wheezing or asthma.
- Conditions
- Benign Joint Hypermobility Syndrome, Wheezing, Asthma
- Trial name
- NCT02163096
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- University of Louisville
Lung Nodules, Early Lung Cancer, Artificial Intelligence, Chest CT, Minimally Invasive Surgery, Lung Image Analysis Software
AI Determine Malignancy of GGO on Chest CT
Research Objectives To use AI computer-aided detection software to assist physicians in reading CT scans of lung nodules, providing auxiliary diagnostic tools for medical decision-making.
- Trial name
- NCT06282068
- Testing
- AI computer-aided detection software
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chung Shan Medical University
Lung Cancer, Tracheal Neoplasm
Airway and/or Pulmonary Vessels Transplantation
First study (BRONC-ART) The purpose of this prospective study is to evaluate the 90-day morbidity and mortality rates of bronchial transplantation using cryopreserved aortic allograft in proximal lung cancer surgery.
- Conditions
- Lung Cancer, Tracheal Neoplasm, Tracheal Stenosis
- Trial name
- TRACHBRONCAR (NCT01331863)
- Testing
- Airway and/or pulmonary Vessels Transplantation
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lung Cancer, Emphysema
CryoSpray Ablation(tm)Thoracic Patient Registry
The purpose of this study is to create a patient registry to collect and analyze information on subjects treated with the CryoSpray Ablation™ System post-510K approval.
- Conditions
- Lung Cancer, Emphysema, Chronic Bronchitis, COPD
- Trial name
- NCT00785239
- Sponsor
- CSA Medical, Inc.
Pulmonary Nodules
Diagnostic and Monitoring Significance of ctDNA Methylation Analysis by NGS in Benign and Malignant Pulmonary Nodules
AnchorDx is using circulating tumor DNA (ctDNA) methylation analysis by next-generation sequencing (NGS) to develop a blood-based assay for differentiating benign and malignant pulmonary nodules early.
- Trial name
- NCT03651986
- Testing
- ctDNA methylation analysis by NGS
- Where
- 23 sites in China
- Volunteers
- 10,560 people, healthy volunteers welcome
- Sponsor
- AnchorDx Medical Co., Ltd.
Cancer, Liver Cirrhosis
Collection of Blood From Healthy Patients, Patients With Benign Disease and Patients With Cancer
To acquire blood samples from subjects for various purposes, including: i) determining the sensitivity and specificity of select DNA methylation markers for the detection of various types of cancer, ii) identifying benign…
- Conditions
- Cancer, Liver Cirrhosis, Chronic Hepatitis, Hepatitis B
- Trial name
- ELITE (NCT05181826)
- Testing
- Multi-analyte Blood Test
- Where
- 7 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- Helio Genomics