Clinical trials: Benign Neoplasm
Renal Cancer, Tumor, Solid
The HistoSonics Edison™ System for Treatment of Primary Solid Renal Tumors Using Histotripsy (#HOPE4KIDNEY)
The purpose of this trial is to evaluate the effectiveness and safety of the HistoSonics Edison System for the destruction of kidney tissue by treating primary solid renal tumors.
- Conditions
- Renal Cancer, Tumor, Solid, Kidney Cancer, Tumor
- Trial name
- #HOPE4KIDNEY (NCT05820087)
- Testing
- HistoSonics Edison System
- Where
- 15 sites in United States
- Volunteers
- 67 people
- Sponsor
- HistoSonics, Inc.
Benign Neoplasm, Malignant Neoplasm
Intraoperative Tumor Margin Identification With ICG Dye Imaging
In this research study we want to learn more about the use of indocyanine green (ICG) during bone or soft tissue mass resections. Indocyanine green (ICG) is a type of dye that is used in medical diagnostics.
- Trial name
- NCT04752137
- Testing
- Indocyanine green, SPY-PHI
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Adnexal Mass, Adnexal Tumor
Masses in Young Patients - International Ovarian Tumour Analysis (MY-IOTA)
This multicenter observational study aims to validate the IOTA Simple Rules, Benign Descriptors, and ADNEX model in a cohort of patients equal or under the age of 20.
- Conditions
- Adnexal Mass, Adnexal Tumor, Adnexal Cyst, Adnexal Masses in Young Girls and Adolescents
- Trial name
- MY-IOTA (NCT06693596)
- Testing
- Group 2: Conservative management (follow-up), Group 1: Surgical management
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Breast Neoplasms
Contrast Enhanced Mammography in Diagnosing Patients With Suspicious Breast Findings
This pilot trial studies how well contrast enhanced mammography works in diagnosing patients with suspicious breast findings. Diagnostic procedures, such as contrast enhanced mammography, may help to reclassify findings seen on…
- Trial name
- NCT03929783
- Testing
- Contrast Enhanced Digital Mammography
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Thomas Jefferson University
Tumors, Central Nervous System, Pediatric Brain Tumor
National Wide Cross-sectional Study in Paediatric Central Nervous System Tumours in China -- the CNOG-MC001 Registry
Tumours of central nervous system (CNS) is the most common type of solid tumour in childhood. In China, there is limited epidemiology information.
- Conditions
- Tumors, Central Nervous System, Pediatric Brain Tumor, Malignant Brain Tumor, Benign Brain Tumor
- Trial name
- NCT04351035
- Testing
- Tumour resection
- Where
- 38 sites in China
- Volunteers
- 4,303 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Adnexal Mass
The Use of International Ovarian Tumor Analysis and Assessment of Adnexal Neoplasia in Differentiating Malignant and Benign Adnexal Masses
All participants will be subjected to Serum measurements of CA-125 by the immunoradiometric assay, Ultrasound evaluation of the Adnexal masses which is described according to origin (ovarian/extraovarian); position…
- Trial name
- NCT03442881
- Testing
- Excision of adnexal mass through laprotomy
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders
Collecting and Storing Blood Samples From Patients With Cancer
RATIONALE: Collecting and storing samples of blood from patients with cancer to test in the laboratory may help the study of cancer in the future.
- Conditions
- Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00900120
- Sponsor
- University of Medicine and Dentistry of New Jersey
Breast Cancer Detection, Dense Breast Parenchyma
Delphinus SoftVue™ ROC Reader Study (DMT SV RRS3)
The purpose of this multi-reader, multi-case (MRMC) reader study is to evaluate reader performance when SoftVue™ automated breast ultrasound and screening mammography are combined, compared to screening mammography alone, in…
- Conditions
- Breast Cancer Detection, Dense Breast Parenchyma, Benign Breast Findings, Normal Breast Screening
- Trial name
- DMT SV RRS3 (NCT04260620)
- Testing
- Reading of Automated Breast Ultrasound in conjunction with Screening Mammography
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Delphinus Medical Technologies, Inc.
Thyroid Nodule (Benign), Thyroid Nodule (Diagnosis)
Mortality Benefit of Ultrasound for Thyroid Nodules Identified With PET Imaging: Non-Inferiority Emulated Target Trial
The investigators hypothesize that all-cause mortality in patients with an incidental thyroid nodule on PET-CT who did not have thyroid ultrasound (the exposure) within 3 months of the PET-CT is non-inferior within a 5% margin to…
- Conditions
- Thyroid Nodule (Benign), Thyroid Nodule (Diagnosis), Thyroid Cancer
- Trial name
- NCT07255482
- Testing
- Thyroid Ultrasound
- Where
- United States
- Volunteers
- 874 people
- Sponsor
- Brigham and Women's Hospital
Renal Cell Carcinoma (Kidney Cancer), Benign Renal Neoplasm
Symptomatic and Incidental RCC Detection
Evaluation of the frequency of symptomatic and incidental detection of renal carcinoma at different stages depending on the imaging modality used
- Conditions
- Renal Cell Carcinoma (Kidney Cancer), Benign Renal Neoplasm, Renal Carcinoma
- Trial name
- KIDCaD (NCT07004426)
- Testing
- Surgical treatment of renal lesions
- Where
- Czechia
- Volunteers
- 1,000 people
- Sponsor
- Charles University, Czech Republic
Solitary Pulmonary Nodule
Evaluate the Auxiliary Diagnostic Value of Circulating Tumor Cells in Benign and Malignant Lung Nodules
By testing the CTC number of new solitary pulmonary nodule patient, evaluating the correlation of CTC number and benign and malignant lung nodules auxiliary diagnosis, the correlation of CTC number and the size of lung nodules of…
- Trial name
- NCT02653859
- Volunteers
- 50 people
- Sponsor
- GenoSaber
Malignant Neoplasm of Salivary Gland, Benign Neoplasm of Salivary Gland
Diagnostic Accuracy of Human Transcriptional Activator(MYB) Expression by ELISA Technique Versus Immmunohistochemistry in Detecting Salivary Gland Carcinomas
in this resarch we will use ELISA Technique to estimate Human Transcriptional Activator(MYB) Expression .compare it by Immmunohistochemistry analysis of MYB Expression in the malignant and benign salivary gland tumor
- Trial name
- NCT03687294
- Testing
- enzyme linked immunosorbent assay (ELISA)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Benign Solitary Solid, Cystic Thyroid Nodules
Laser Therapy of Benign Thyroid Nodules
Nodular goitre is common in the general population and less than 5% of the patients who undergo surgery for solitary thyroid nodules have cancer, in absence of clinical suspicion.
- Trial name
- NCT00150150
- Testing
- Interstitial laser photocoagulation
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Odense University Hospital
Cancer, Thyroid
Use of an In Vivo Optical Probe to Discriminate Benign From Malignant Thyroid Nodules
This study will investigate the usefulness of an optical probe in the differentiation of thyroid cancer from normal thyroid tissue in a thyroidectomy specimen.
- Trial name
- NCT01401855
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Breast Cancer
NIR Fluorescent Molecular Probe for the Identification of Breast Tissue
Accurate evaluation of tumor boundaries in breast-conserving surgery is critical to reducing the second operation of patients. Near-infrared (NIR) fluorescence imaging using molecular agents has shown promise for in situ imaging…
- Trial name
- NIR (NCT05708144)
- Testing
- ICG-SG incubation solution
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Xiang'an Hospital of Xiamen University
Pancreatic Cancer, Secondary Malignant Neoplasm of Lymph Node
Clinical Impact of EUS Elastography Mean Strain Histograms (SH) and Contrast Peak-enhancement in Focal Pancreatic Masses and Lymph Nodes
The study protocol is based on a multi-center semi-quantitative approach of EUS elastography data in combination with contrast-enhanced EUS, consisting of measuring SR and SH for focal pancreatic masses and lymph nodes, as well…
- Conditions
- Pancreatic Cancer, Secondary Malignant Neoplasm of Lymph Node, Benign Neoplasm of Lymph Nodes, Benign Pancreatic Tumors
- Trial name
- ADVEUS (NCT02459041)
- Testing
- Elastography, contrast enhancement
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- University of Medicine and Pharmacy Craiova
Lung Cancer, Image, Body
Classification of Benign and Malignant Lung Nodules Based on CT Raw Data
The employ of medical images combined with deep neural networks to assist in clinical diagnosis, therapeutic effect, and prognosis prediction is nowadays a hotspot.
- Trial name
- NCT04241614
- Testing
- No interventions
- Where
- China
- Volunteers
- 626 people
- Sponsor
- Chinese Academy of Sciences
Arthroplasty
Total Temporomandibular Joint Replacement System Post Approval Study
Post-Approval Study (PMA CoA) in Order to Obtain Additional Long Term Safety and Effectiveness Data [PMA P020016]
- Trial name
- NCT00762944
- Testing
- Biomet TMJ Replacement System
- Where
- 4 sites in United States
- Volunteers
- 93 people
- Sponsor
- Zimmer Biomet
Solitary Pulmonary Nodule, Lung Neoplasms
Radiomics for Distinguishing Benign and Malignant Lung Nodules
Differentiating between benign (non-cancerous) and malignant (cancerous) pulmonary nodules is a critical step in determining appropriate patient management and cancer treatment planning.
- Conditions
- Solitary Pulmonary Nodule, Lung Neoplasms, Multiple Pulmonary Nodules
- Trial name
- NCT07852000
- Volunteers
- 255 people
- Sponsor
- Assiut University
Genital Diseases, Female, Hysterotomy; Affecting Fetus
Effect of Salpingectomy During Conservative Hysterectomy
The study compares the effect of bilateral salpingectomy associated with conservative hysterectomy on ovarian function to the standard hysterectomy with conservation of both ovaries and tubes in terms of hormone assays, ovarian…
- Conditions
- Genital Diseases, Female, Hysterotomy; Affecting Fetus, Leiomyomata Uteri, Adenomyosis, Endometriosis
- Trial name
- SALPINGOVA (NCT01628432)
- Testing
- conservative hysterectomy I, Conservative hysterectomy II
- Where
- 7 sites in France
- Volunteers
- 350 people
- Sponsor
- University Hospital, Tours