Clinical trials: Benign Thyroid Nodules
Thyroid Nodule, Thyroid Cancer
Clinical Validation of a Molecular Signature to Detect Cancer in Thyroid Nodules With Indeterminate Cytology
1. Principal objective: The primary objective of this study is to validate the diagnostic performance of a Dx15 molecular test based on molecular transcriptomic signatures previously identified in distincts cohorts of samples to…
- Trial name
- CITHY (NCT02225509)
- Testing
- FNA biopsy for thyroid nodule(s)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Diaxonhit
Dysphagia, Esophageal, Dysphagia, Oral Phase
Post-thyroidectomy Dysphagia: An International Multicentric CONSORT - Compatible RCT
The most common and feared complications of total thyroidectomy are vocal cord paralyses and hypocalcemia. However, post-thyroidectomy dysphagia is not uncommon and has important consequences on the quality of life (QoL).
- Conditions
- Dysphagia, Esophageal, Dysphagia, Oral Phase, Dysphagia Comes and Goes, Thyroiditis
- Trial name
- Dysphagia-TT (NCT04410601)
- Testing
- Total thyroidectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Umraniye Education and Research Hospital
Benign Thyroid Nodule, Thyroid Lump
Comparative Study of Polidocanol and Absolute Alcohol for Percutaneous us Guided Treatment of Benign Thyroid Cyst
This study aims to compare the efficacy and safety of ultrasound-guided percutaneous ethanol injection and percutaneous polidocanol injection for the treatment of benign cystic and predominantly cystic thyroid nodules.
- Conditions
- Benign Thyroid Nodule, Thyroid Lump, Thyroid Cyst
- Trial name
- NCT05798936
- Testing
- Polidocanol, Alcohol
- Volunteers
- 30 people
- Sponsor
- Assiut University
Benign Thyroid Nodules
A Prospective Evaluation of High Intensity Focused Ultrasound (HIFU) in the Treatment of Benign Thyroid Nodules
To evaluate the short-term efficacy of high intensity focused ultrasound (HIFU) in the treatment of benign thyroid nodules
- Trial name
- NCT02658552
- Testing
- Echopulse
- Where
- Hong Kong
- Volunteers
- 22 people
- Sponsor
- The University of Hong Kong
Benign Thyroid Nodule, Quality of Life
Alterations in Quality of Life After Thyroidectomy for Benign Thyroid Disease
To detect any changes in Quality of Life in patients with benign thyroid diseases who undergo thyroidectomy compared to patients with benign thyroid diseases and conservative treatment and healthy subjects.
- Trial name
- NCT03566537
- Testing
- Thyroidectomy
- Where
- Greece
- Volunteers
- 73 people
- Sponsor
- Aristotle University Of Thessaloniki
Thyroid Nodule (Benign)
US-guided RFA vs MWA in the Treatment of Benign Thyroid Nodules
To evaluate the clinical outcomes of RFA and MWA for benign thyroid nodules treatment
- Trial name
- NCT05758038
- Testing
- Radiofrequency ablation/Microwave ablation
- Volunteers
- 50 people
- Sponsor
- Assiut University
Thyroid Nodule (Benign), Graves Disease
Thyroid Artery Goitre Embolization Trial A Pilot Study Investigating Thyroid Artery Embolisation as a Treatment for Large Thyroid Nodules
Large non-cancerous thyroid nodules (lumps in the thyroid gland) can cause pressure or discomfort in the neck or cosmetic issues. The standard treatment options include radiofrequency ablation, radioactive iodine, and surgery.
- Conditions
- Thyroid Nodule (Benign), Graves Disease, Goitre
- Trial name
- TArGET (NCT07046546)
- Testing
- Thyroid artery embolization
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Royal Berkshire NHS Foundation Trust
Benign Thyroid Nodule, Suspicious Malignant Thyroid Nodule
A Prospective Trial Comparing Transoral Endoscopic Thyroidectomy Vestibular Approach (TOETVA) and Conventional Open Thyroidectomy
To determine if transoral endoscopic thyroidectomy vestibular approach (TOETVA) is a safe and effective procedure compared to traditional open thyroidectomy.
- Trial name
- NCT06225765
- Testing
- Transoral endoscopic thyroidectomy vestibular approach (TOETVA), Traditional Open Thyroidectomy
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Tseung Kwan O Hospital, Hong Kong
Thyroid Nodule \(Benign\), Ablation Therapy
MWA vs RFA for the Treatment of Moderate-sized Benign Thyroid Nodules
Thyroid nodule is a common condition that affects up to 60% of the population. There is an estimated 10% lifetime probability of developing a thyroid nodule.
- Trial name
- NCT06426563
- Testing
- Ablation treatment of thyroid nodule
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- The University of Hong Kong
Thyroid Nodules
The Outcomes of Ultrasound-guided Thermal Ablation for Benign Thyroid Nodules
1. To evaluate the clinical outcomes of ultrasound-guided thermal ablationfor the treatment of benign thyroid nodules; 2. To develop and validate a artificial intelligence model to predict the outcomes of ultrasound-guided…
- Trial name
- NCT06340945
- Testing
- ultrasound-guided thermal ablation
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Chinese PLA General Hospital
Thyroid Nodule
HIFU Reapplication in Benign Nodules
High Intensity Focused Ultrasound (HIFU) is a new approach in treating benign thyroid nodule without surgery. It is proven effective and safe relative to traditional surgery.
- Trial name
- NCT03331172
- Testing
- Echopulse
- Where
- Hong Kong
- Volunteers
- 28 people
- Sponsor
- The University of Hong Kong
Benign Thyroid Nodule
Percutaneous Thermo-ablation for the Treatment of Benign Thyroid Nodules
The goal of this observational study is to learn if radiofrequency ablation (RFA), a minimally invasive thermoablation technique, can safely reduce symptoms and improve quality of life in adults with symptomatic benign thyroid…
- Trial name
- BIRRO-TA (NCT07237373)
- Testing
- Percutaneous radiofrequency ablation
- Where
- 3 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ghent
Thermal Ablation, Fine Needle Aspiration Biopsy
Ultrasound and Cytological Evaluation 3 Years After Radiofrequency Thermal Ablation of Benign Thyroid Nodules : a Prospective Exploratory Cohort of 180 Nodules
There is no scientific data on post-thermal ablation cytological aspects, but treated nodules that grow back significantly after a procedure justify a new cytology in order not to ignore a neoplastic process.
- Conditions
- Thermal Ablation, Fine Needle Aspiration Biopsy, Thyroid Nodules
- Trial name
- CYTOTHYRAF (NCT05726981)
- Testing
- Fine needle aspiration biopsy (FNAB)
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Low Risk, Papillary Thyroid Cancer
Radiofrequency Ablation for Management of Benign/Indeterminate Thyroid Nodules and Low Risk Papillary Thyroid Cancers
To track the outcomes of patients who have been treated with RFA and its long-term effectiveness, and to learn more about the quality of life of patients who have received RFA in this study.
- Conditions
- Low Risk, Papillary Thyroid Cancer, Radiofrequency Ablation
- Trial name
- NCT07140757
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center
Diabetes Mellitus, Type 2, Thyroid Nodule (Benign)
Efficacy of Metformin Versus Sitagliptin on Benign Thyroid Nodules in Type 2 Diabetes
A 2-years prospective, randomized and multicentric study will be performed to assess the efficacy of metformin compared to sitagliptin on benign thyroid nodules size ≥ 2 cm, in newly diagnosed patients with type 2 diabetes.
- Trial name
- METNODTHYR (NCT04298684)
- Testing
- METFORMIN, Sitagliptin
- Where
- 4 sites in France, Guadeloupe and 1 more
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Benign Thyroid Nodules
Study of the Feasibility of Radiofrequency Ablation of Benign Thyroid Nodules
The purpose of the present protocol is to evaluate the response rate to treatment of these symptomatic benign nodules with radiofrequency as an alternative to surgical treatment.
- Trial name
- TRAF (NCT03646383)
- Testing
- Radiofrequency ablation
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Toulouse
Benign Thyroid Nodule
Drainless Thyroidectomy by the Sutureless Technique for Benign Thyroid Diseases
This randomized controlled trial evaluates the safety and feasibility of drainless thyroid surgery for benign thyroid diseases using a sutureless hemostatic technique.
- Trial name
- NCT07625865
- Testing
- sutureless thyroidectomy without drain, sutureless thyroidectomy with drain
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Minia University
Thyroid Nodule
Percutaneous Laser Ablation in Benign Thyroid Nodules.Long Term Results
Thyroid nodule pathologies occur frequently and represent a clinical issue for the endocrinologists, surgeons, nuclear physicians as well as the general practitioners.
- Trial name
- NCT00858104
- Testing
- Percutaneous Laser Ablation
- Where
- 4 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Elesta S.R.L.
Thyroid Nodule
Percutaneous Ethanol Injection for Benign Cystic Thyroid Nodules
Use of ethanol injection in treatment of cystic thyroid nodule
- Trial name
- NCT03257930
- Testing
- ethanol injection
- Where
- Egypt
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- hassan harby mohamed
Thyroid Cancer, Papillary, Leptin Levels
Leptin Levels in Papillary Thyroid Cancer
The purpose of this study is to evaluate Leptin levels in females, in the setting of papillary thyroid cancer, benign thyroid nodules, and in normal females without thyroid disease.
- Trial name
- LL-PTC (NCT01659385)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Nebraska