Clinical trials: Benign Tumors
Prostate Cancer
Comparing Water Vapour Thermal Therapy (Rezūm) and TURP
This is a randomized controlled trial using a non-inferiority design with the subjects randomized 1:1 to either water vapour thermal treatment (REZUM) arm or transurethral resection of prostate (TURP) arm.
- Trial name
- NCT05762198
- Testing
- Rezūm, TURP
- Where
- Hong Kong
- Volunteers
- 108 people
- Sponsor
- Chinese University of Hong Kong
Grade I Meningioma, Grade II Meningioma
Hypofractionated Proton Therapy for Benign Intracranial Brain Tumors, the HiPPI Study
This phase II trial studies how well hypofractionated proton or photon radiation therapy works in treating patients with brain tumors.
- Conditions
- Grade I Meningioma, Grade II Meningioma, Grade III Meningioma, Intracranial Neoplasm
- Trial name
- HiPPI (NCT04278118)
- Testing
- Hypofractionated Radiation Therapy, Photon Beam Radiation Therapy, Proton Beam Radiation Therapy
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Emory University
Benign Brain Tumor
Nausea Induced by Radiation of the Dorsal Vagal Complex for Benign Brain Tumors (NausiCAA)
Patients irradiated to the brain frequently experience nausea. The dorsal vagal complex (DVC) area is a specific brainstem zone and has been identified as likely responsible for nausea.
- Trial name
- NausiCAA (NCT06506578)
- Testing
- Radiation
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Bordeaux
Benign Colon Tumors
Comparison of Cold and Hot Loop Resection Techniques for the Removal of Medium-sized Benign Colon Tumors
Widespread introduction of high-resolution videocolonoscopy into clinical practice has led to an increase in the detection of epithelial lesions of the colon, a significant portion of which are small (<10 mm) and miniature (≤5…
- Trial name
- chs (NCT07041255)
- Testing
- Cold endoscopic mucosal resection, Hot endoscopic mucosal resection
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Pirogov Russian National Research Medical University
Benign Tumor of Uterus, Surgical Approaches
A Clinical Study Comparing the Effectiveness and Safety of Two Surgical Pathways for Laparoscopic Total Hysterectomy
Enhanced recovery after surgery (ERAS) is a multidisciplinary strategy to improve perioperative outcomes and accelerate patient recovery.
- Conditions
- Benign Tumor of Uterus, Surgical Approaches, Enhanced Recovery After Surgery
- Trial name
- NCT06817460
- Testing
- Transumbilical Laparoendoscopic Single-Site Surgery, Multi-Port Laparoscopic Surgery
- Where
- China
- Volunteers
- 312 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Liver Tumor
Exploration of Noninvasive Differential Diagnosis of Benign and Malignant Liver Tumors
To explore an effective noninvasive method for differential diagnosis of liver tumors.
- Trial name
- NCT06524557
- Testing
- with chronic liver disease
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xijing Hospital
Benign Neuronal Desease
Multiparametric Imaging for Analysis of MVNT (Multinodular and Vacuolating Neuronal Tumor)
Differential diagnoses of MVNT include DNT (dysembryoplastic neuroepithelial tumor), low-grade gliomas, cortical dysplasias or even hamartomas.
- Trial name
- MIAM (NCT04103190)
- Testing
- cerebral MRI
- Where
- 7 sites in France
- Volunteers
- 71 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Ovarian Cyst Benign
Save the Ovaries - Surgical Management of Simple Ovarian Cysts in Children and Adolescents
The purpose of this study is to evaluate which operative technique should be used for managing simple ovarian cysts in girls and adolescents.
- Trial name
- NCT06852313
- Testing
- Laparoscopic ovarian cyst surgery
- Where
- 2 sites in Switzerland
- Volunteers
- 80 people
- Sponsor
- University Children's Hospital, Zurich
Benign Pancreatic Neoplasm, Chronic Pancreatitis
A Surgical Procedure (Total Pancreatectomy) With a Transplant Procedure (Islet Cell Autotransplantation) for the Treatment of Chronic Pancreatitis and Benign Pancreatic Tumors
This phase I/II trial assesses the safety and effectiveness of total pancreatectomy with islet cell autotransplantation for the treatment of patients with long-term pancreatic inflammation (chronic pancreatitis) and non-cancerous…
- Conditions
- Benign Pancreatic Neoplasm, Chronic Pancreatitis, Recurrent Acute Pancreatitis
- Trial name
- NCT05453851
- Testing
- Pancreatectomy, Quality-of-Life Assessment, Treatment Planning
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- OHSU Knight Cancer Institute
Healthy People, Benign Prostatic Hyperplasia
The Application of Multimodal Artificial Intelligence Systems in Prostate Cancer Diagnosis and Prognosis Analysis
Prostate-specific antigen (PSA) testing has limited specificity for prostate cancer diagnosis, leading to a high rate of unnecessary biopsies.
- Conditions
- Healthy People, Benign Prostatic Hyperplasia, Prostate Cancer
- Trial name
- NCT06589154
- Testing
- Multi-modal artificial intelligence model (BEAM)
- Where
- 10 sites in China
- Volunteers
- 1,651 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Endometrial Carcinoma, Prostate Carcinoma
Screening and Staging of Benign vs Malignant Pelvic Abnormalities
This study evaluates whether newly developed non-FDA approved image processing techniques [Adaptive Image Reconstruction (AIR Recon) Deep Learning (DL) and Sonic DL] can provide improved quality and decreased time compared to…
- Trial name
- NCT07407959
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Ovarian Cancer
Ultrasound RF Data for Discriminating Between Benign and Malignant Ovarian Masses
Ultrasound imaging provides useful information for the characterization of ovarian masses as benign or malignant. The most accurate mathematical model to categorize ovarian masses is the IOTA ADNEX model.This model estimates the…
- Trial name
- RFDATA (NCT06473766)
- Testing
- RF data extraction
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cholangiocarcinoma, Benign Biliary Stricture
ncRNAs in Exosomes of Cholangiocarcinoma
Exosomes are part of extracellular vesicles(EVs), and can be secreted into the environment by many types of cells. It has been demonstrated that the content and function of exosomes depends on the originating cell and the…
- Trial name
- NCT03102268
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Lung Cancers, Pulmonary Lymphomas
PET/CT-Based Image Analysis and Machine Learning of Hypermetabolic Pulmonary Lesions
First, we analyse the types, imaging findings and relevant treatment responses based on PET/CT to complete a more comprehensive view of pulmonary lymphomas.
- Conditions
- Lung Cancers, Pulmonary Lymphomas, Pulmonary Metastases, Benign Pulmonary Diseases
- Trial name
- NCT06602674
- Testing
- Observe the medical images, Feature extraction
- Where
- China
- Volunteers
- 647 people
- Sponsor
- Ruijin Hospital
Pulmonary Nodules
Clinical Study of ctDNA and Exosome Combined Detection to Identify Benign and Malignant Pulmonary Nodules
This study through the detection of EGFR、ALK、ROS1、KRAS、HER2、BARF、NTRG1 seven ctDNA and exosome RNA in the blood and alveolar lavage of lung nodules patients and heavy smoking healthy population.
- Trial name
- ctDNA (NCT04182893)
- Testing
- ctDNA and Exosome Combined Detection
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Benign Breast Lesions, Malignant Breast Tumours
Photo-Acoustic and Ultrasonographic Mammoscope
The aim of this study is to evaluate the negative predictive value of the Photo Acoustic Imager 3+ (PAM3+) in the detection of female breast lesions (malignant and benign)in an outpatient setting.
- Trial name
- PAUS (NCT07492589)
- Testing
- Photo-Acoustic Mammoscope Imager 3+
- Where
- Netherlands
- Volunteers
- 180 people
- Sponsor
- Franciscus Gasthuis & Vlietland (Hospital)
Benign Neoplasm of Cervix Uteri, Gynecological Laparoscopy
The Effects of CO2 Pneumoperitoneum at Different Temperature in Laparoscopic Surgery
Objective: It is recommended to heat and humidify CO2 in laparoscopic surgery to prevent postoperative pain and hypothermia but information about its effects on hemodynamic and respiratory parameters is limited.
- Trial name
- NCT04508387
- Testing
- Group HH (heated-humidified)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ege University
Gastric GIST, Submucosal Tumor of Stomach
Laparoscopic Management of Gastrointestinal Stromal Tumor of Stomach
Gastric GISTs are rare neoplasms that require excision for cure. Although the feasibility of laparoscopic resection of gastric GIST less than 2cms has been established, the feasibility, safety and long-term efficacy of these…
- Trial name
- NCT03722056
- Testing
- Laparoscopic resection
- Volunteers
- 42 people
- Sponsor
- GEM Hospital & Research Center
Leakage, Anastomotic, Colon Cancer
COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine Green
COLOFLOW is a prospective observational study investigating whether Laser Speckle Contrast Imaging (LSCI), a dye-free and objective perfusion imaging technique, corresponds with the currently used subjective assessment of…
- Conditions
- Leakage, Anastomotic, Colon Cancer, Colon Anastomosis, Colon and Rectal Cancer
- Trial name
- COLOFLOW (NCT07720505)
- Testing
- Laser Speckle Contrast Imaging
- Volunteers
- 30 people
- Sponsor
- Leiden University Medical Center
Pituitary Tumor Benign, Surgery
Extended Support for Persons With Pituitary Tumours After Surgery
Patients with pituitary tumours often live with life-long consequences of their disease. Treatment options include surgery, radiotherapy and medical therapy.
- Trial name
- NCT03927183
- Testing
- person-centred practice
- Where
- Sweden
- Volunteers
- 86 people
- Sponsor
- Göteborg University