Clinical trials: Benzodiazepines
Benzodiazepines Deprescribing, Sleep Problems
Improving Patient Safety by Supporting Older Adults in Managing Sleep Problems.
Among older adults (≥65 years), use of sleeping pills, such as benzodiazepines and other sedative-hypnotics, to treat sleep problems is common.
- Trial name
- BE-SAFE (NCT06584513)
- Testing
- Specific tapering plan for sleep medication, educational and cognitive behavioural therapy elements
- Where
- 6 sites in Belgium, Greece and 4 more
- Volunteers
- 470 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Atherosclerosis, Healthy
PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Carotid Atherosclerosis
Inflammation in the vascular wall is important in atherosclerosis and the blockage of the artery. The peripheral benzodiazepine receptor is involved in inflammation and in this protocol we will attempt to take pictures, using PET…
- Trial name
- NCT00547976
- Testing
- [C-11]PBR28
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression in Old Age
Study of the Reduction of the Prescriptions of Benzodiazepines and Related
The significant consumption of Benzodiazepines and related drugs in the elderly outside of good practice recommendations is a major issue in the care of the elderly.
- Trial name
- BZD (NCT06107283)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Strasbourg, France
Substance-Related Disorders
Rapid Benzodiazepine Detoxification Using Flumazenil - 1
The purpose of this study is to verify the hypothesis that the benzodiazepine antagonist, flumazenil, will reduce acute benzodiazepine withdrawal.
- Trial name
- NCT00000246
- Testing
- Flumazenil
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Oxytocin, Lorazepam, Anti-Anxiety Agents, Physiological Effects of Drugs
Effects of Oxytocin and Lorazepam on Fear-related Intra-amygdalar Activity
High-potency benzodiazepines have strong anxiolytic effects accompanied by significant adverse effects including impaired cognitive function, drowsiness, dizziness and impaired motoric abilities.
- Trial name
- NCT03829839
- Testing
- Oxytocin, Lorazepam 1 mg
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Epilepsy
Pharmacodynamics of Nasal and Buccal Midazolam Using EEG
Approximately 3 million individuals suffer from epilepsy in America alone and about 200,000 new cases of epilepsy in America are diagnosed each year (Epilepsy Foundation, 2005).
- Trial name
- nMDZ-EEG (NCT01316445)
- Testing
- nasal Midazolam
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Columbia University
Pregnancy Related, Benzodiazepines Causing Adverse Effects in Therapeutic Use
Maternal and Neonatal Outcomes Following Exposure to Benzodiazepines During Pregnancy
This is a nationwide cohort study to assess maternal and neonatal outcomes following exposure to benzodiazepines during pregnancy.
- Conditions
- Pregnancy Related, Benzodiazepines Causing Adverse Effects in Therapeutic Use, Congenital Anomaly
- Trial name
- NCT04856436
- Testing
- Benzodiazepine
- Where
- South Korea
- Volunteers
- 3,094,227 people, healthy volunteers welcome
- Sponsor
- Sungkyunkwan University
Depression, Anxiety, Fear
Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression
This mechanistic study uses an anti anxiety drug and brain imaging to study the threat processing system and associated brain circuits in people with depression, anxiety disorders and comorbid depression and anxiety disorders.
- Conditions
- Depression, Anxiety, Fear, Depression, Anxiety and Fear
- Trial name
- NCT06004115
- Testing
- Lorazepam
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Benzodiazepine Dependence, Anxiety Disorders
Anxiety Lowering and Deprescribing Through Emotion Regulation
The goal of this clinical trial is to test ALDER (Anxiety Lowering and Deprescribing through Emotion Regulation), an online self-guided positive emotion intervention, in patients over the age of 65 who are candidates for…
- Conditions
- Benzodiazepine Dependence, Anxiety Disorders, Sleep Disturbance
- Trial name
- ALDER (NCT06359314)
- Testing
- ALDER
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Psychiatric Disorder, Benzodiazepine Withdrawal
Influence of Olfaction Essential Oils on the Consumption of Benzodiazepine Receptor Agonists & Z-Drugs (BZRAs) Prescribed as " if Needed " in Psychiatric Outpatients (HECBA-PSY).
The goal of this interventional study is to test the use of olfactory Essential Oils through a nasal stick as one of the non-medicinal strategies to propose to the patient to reduce the consumption of medication in a population…
- Trial name
- HECBA-PSY (NCT05583240)
- Testing
- Essences and Essential Oils
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Etablissement Public de Santé Barthélemy Durand
Post Traumatic Stress Disorder
Clonazepam and Paroxetine for Rapid Treatment of Post-Traumatic Stress Disorder
Post-Traumatic Stress Disorder (PTSD) is an anxiety disorder that follows exposure to an extremely traumatic stressors. PTSD is associated with serious symptoms.
- Trial name
- NCT00025740
- Testing
- clonazepam and paroxetine
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- National Institute of Mental Health (NIMH)
Obstructive Sleep Apnea
Continuous Positive Airway Pressure (CPAP) Promotion And Prognosis - the Army Sleep Apnea Program (ASAP)
The purpose of this study is to assess the efficacy of Eszopiclone in improving short and intermediate-term compliance with continuous positive airway pressure (CPAP) in patients newly diagnosed with obstructive sleep apnea (OSA).
- Trial name
- CPAPASAP (NCT00612157)
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Walter Reed Army Medical Center
Benzodiazepine Dependence, Benzodiazepine Dependent
Blended Care for the Discontinuation of Benzodiazepine Use
This study aims to compare two strategies performed by GPs to help patients taking benzodiazepines on a daily basis for at least six months to discontinue their use.
- Conditions
- Benzodiazepine Dependence, Benzodiazepine Dependent, Benzodiazepine Withdrawal
- Trial name
- Big Bird (NCT03937180)
- Testing
- Blended care, Usual care
- Where
- 110 sites in Belgium
- Volunteers
- 924 people
- Sponsor
- Kristien Coteur
Autism Spectrum Disorder, Catatonia
Management of Catatonic Features in Adolescents With Profound Autism
The goal of this clinical trial is to learn if benzodiazepines and ECT can treat Catatonic features in Adolescents with Autistic spectrum disorder, it will also learn about Safety and efficacy of benzodiazepines and ECT.
- Trial name
- MOCFAPA (NCT07498387)
- Testing
- Intranasal Midazolam (Benzodiazepine Challenge Test), Oral Clonazepam, Electroconvulsive Therapy (ECT)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Neurocysticercosis, Healthy
PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Neurocysticercosis Using [F-18]FB
The purpose of this protocol is to measure peripheral benzodiazepine receptors in the brain using positron emission tomography (PET) and compare the imaging results between patients and healthy people.
- Trial name
- NCT00527579
- Testing
- [F-18]FBR
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Mental Health (NIMH)
Anxiety, Insomnia
Remote Yoga Nidra for Deprescribing BZRAs
The overall goal of this application is to assess feasibility and impact of a remotely delivered guided meditation practice called Yoga Nidra, for reducing or stopping use of Benzodiazepine Receptor Agonists (BZRAs) for insomnia…
- Trial name
- NCT06353919
- Testing
- Yoga Nidra, Sleep Hygiene, Anxiety, and Benzodiazepine Receptor Agonist Education
- Volunteers
- 40 people
- Sponsor
- National University of Natural Medicine
Benzodiazepine Dependence
Electroacupuncture for Tapering Off Long-term Benzodiazepine Use
This study aims to examine the efficacy of electroacupuncture for tapering benzodiazepines in long-term users. All eligible subjects will be randomized in a ratio of 1:1 to (1) Electroacupuncture combined with gradual tapering…
- Trial name
- NCT02475538
- Testing
- Electroacupuncture
- Where
- 3 sites in China
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Generalized Anxiety Disorder
Drug Treatment Validation of Functional Magnetic Resonance Imaging in Generalized Anxiety Disorder
The purpose of this study is to find out how an anti-anxiety drug or placebo affects the activity of your brain when you are at rest and when you are viewing emotional material, such as, emotional faces and pictures.
- Trial name
- GAD (NCT00662259)
- Testing
- Alprazolam (Xanax)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, San Diego
Polysubstance Abuse
Opioid/Benzodiazepine Polydrug Abuse
Benzodiazepine (BZD)/opioid polysubstance abuse (PSA) dramatically increases risks of overdose, disability and death; however, little is known about phenotypes that could be targeted to decrease this use and these associated…
- Trial name
- NCT03696017
- Testing
- Multi-domain assessment battery
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Wayne State University