Clinical trials: Berberine
Pharmacokinetic Study in Healthy Volunteers
Impact of Food Intake on Berberine Kinetics
The influence of genetic variants of the CYP2D6 enzyme and the Organic Cation Transporter 1 (OCT-1) on the kinetics of berberine (BERKI-1) has recently been studied. A significant sex difference was observed.
- Trial name
- BERKI-3 (NCT06273241)
- Testing
- food intake
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Diabetes Mellitus, Chronic Kidney Disease
Berberine Prevent Contrast-induced Nephropathy in Patients With Diabetes
The number of cardiac angiography and percutaneous coronary interventions (PCI) has increased steadily in recent years. This has resulted in the increasing incidence of contrast-induced nephropathy (CIN).
- Trial name
- NCT02808351
- Testing
- Berberine
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Polycystic Ovary Syndrome
Polycystic Ovary Syndrome (PCOS): Effect Of Letrozole and Berberine
Polycystic ovary syndrome (PCOS) is a heterogeneous disorder affecting almost4%-7% of the female population of reproductive age.
- Trial name
- NCT01116167
- Testing
- Letrozole -Berberine, Letrozole, Berberine
- Where
- 18 sites in China
- Volunteers
- 660 people
- Sponsor
- Heilongjiang University of Chinese Medicine
Cirrhosis Due to Hepatitis B, Cirrhosis Due to Hepatitis C
Endoscopic and Microbiological Assessment of the Effect of Carvedilol Combined With Berberine on GOV in Cirrhosis
Carvedilol has been shown to be more potent in decreasing portal hypertension to propranolol. A lot of studies have shown that the imbalance of flora and the progress of portal hypertension are mutually causal.
- Conditions
- Cirrhosis Due to Hepatitis B, Cirrhosis Due to Hepatitis C, Gastroesophageal Varices
- Trial name
- CABER (NCT04543643)
- Testing
- Carvedilol, Berberine
- Where
- China
- Volunteers
- 288 people
- Sponsor
- Tianjin Second People's Hospital
Schizophrenia Therapeutics
Berberine Improving Cognitive Impairments in Schizophrenia
This study is a 12-week, randomized, blank-controlled, assessor-blinded trial. Eligible patients were randomized in a 1:1 ratio to receive either berberine hydrochloride or blank control as an add on to their stable antipsychotic…
- Trial name
- NCT07359209
- Testing
- Berberine
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Tianjin Anding Hospital
Prediabetes
Effects of Berberine Hydrochloride and Bifidobacterium in Prediabetes Prevention and Treatment
The aim of this study is to assess the beneficial effects of Bifidobacterium and Berberine Hydrochloride on lowering glucose and delaying progress to diabetes in patients with prediabetes and to detect the potential mechanism.
- Trial name
- NCT02082756
- Testing
- Bifidobacterium viable pharmaceutics, Berberine Hydrochloride
- Where
- 4 sites in China
- Sponsor
- Xijing Hospital
Obesity & Overweight, Circadian Rhythm Disorders
Effects of Akkermansia Muciniphila and Berberine Supplementation on Insulin Sensitivity in Night-shift Workers
Night shift work is associated with an increased risk of obesity, insulin resistance, and cardiometabolic disorders, largely due to circadian misalignment, disrupted sleep, and altered eating patterns.
- Conditions
- Obesity & Overweight, Circadian Rhythm Disorders, Gut Microbiota Modulation, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
- Trial name
- Shift2Health (NCT07440147)
- Testing
- Verum (A)
- Where
- Austria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- FH Joanneum Gesellschaft mbH
Lung Adenocarcinoma, EGFR Mutation
Gefitinib and Berberine in the First-line Treatment of Lung Adenocarcinoma With EGFR Mutation
Rationale: Advanced non-small-cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor (EGFR) mutations (del19 or L858R) show an impressive progression-free survival between 9 and 11 months when treated with…
- Trial name
- Geber (NCT03486496)
- Testing
- gefitinib, Berberine
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Fujian Cancer Hospital
Gastric Intestinal Metaplasia
Efficacy and Safety of Berberine for Gastric Intestinal Metaplasia
The goal of this clinical trial is to investigate the efficacy of Berberine in treating gastric intestinal metaplasia in Helicobacter pylori-negative adults. It will also learn about the safety of Berberine.
- Trial name
- NCT07129460
- Testing
- Berberine hydrochloride
- Volunteers
- 204 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Type 1 Diabetes Mellitus, Autoimmune Diabetes
Effects Of Berberine Plus Inulin On Diabetes Care in Patients With LADA
The primary purpose of this study is to evaluate the effects of oral berberine (BBR) and inulin combined with insulin therapy on diabetes care in patients with LADA.
- Trial name
- NCT04698330
- Testing
- Berberine, Inulin
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Second Xiangya Hospital of Central South University
Metabolism Disorder, Nutraceutical
A Clinical Trial to Assess the Efficacy and Tolerance of a Berberine-based Nutraceutical Formula to Aid Blood Sugar Regulation and Metabolism
This randomized, triple-blind, placebo-controlled study will evaluate the efficacy of Diaberine, a berberine-based nutraceutical, in aiding blood sugar regulation and metabolism in 80 participants over 24 weeks.
- Trial name
- NCT06700915
- Testing
- Diaberine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ultimate International, Inc.
PreDiabetes, Abdominal Obesity
Effects of Berberine on Preventing Cardiovascular Disease and Diabetes Mellitus
This multicenter, double-blinded, randomized controlled trial aims to evaluate the effect of berberine on preventing cardiovascular disease and diabetes mellitus among individuals with high cardiometabolic risk in China.
- Conditions
- PreDiabetes, Abdominal Obesity, Hypertension, Dyslipidemias
- Trial name
- ABCD (NCT05749874)
- Testing
- Berberine plus lifestyle intervention
- Where
- China
- Volunteers
- 2,024 people
- Sponsor
- China National Center for Cardiovascular Diseases
Cardiovascular Risk Factor
A Mechanistic Randomized Controlled Trial on the Cardiovascular Effect of Berberine
Berberine is extracted from Coptis (Huanglian) and Phellodendron Chinese (Huangbai), to make into berberine tablets.1 Recent studies have shown that berberine has beneficial effects on cardiovascular disease (CVD) risk…
- Trial name
- NCT03770325
- Testing
- Berberine
- Where
- Hong Kong
- Volunteers
- 84 people
- Sponsor
- The University of Hong Kong
Obesity, Overweight
Gene Modulation of NLRP3, IL-1β and TNF-α in Peripheral Blood of Patients With Exogenous Obesity Treated With Berberine
The patients will be invited to participate in a research study aimed at determining the Gene Modulation of NLRP3, IL-1β and TNFα in peripheral blood of patients with exogenous obesity treated with berberine.
- Conditions
- Obesity, Overweight, Berberine
- Trial name
- Obesity-Berber (NCT06703086)
- Testing
- Berberine Hydrochloride group, nutritional plan, controlled moderate aerobic exercise
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Polytechnic Institute, Mexico
Colorectal Adenomas
Primary Chemoprevention of Familial Adenomatous Polyposis With Berberine Hydrochloride
In recent years, Berberine hydrochloride has been reported to inhibit cancer cell proliferation and to be cytotoxic towards cancer cells.
- Trial name
- NCT03333265
- Testing
- 100mg Berberine hydrochloride, 300mg Berberine hydrochloride
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Colorectal Adenoma, Colorectal Cancer Control and Prevention
6-year Follow-up Data After the Berberine Intervention Trial
Colorectal cancer (CRC) is a common malignancy of the digestive tract, which constitutes a major public health burden. Almost 90% of CRC cases progress from precursor adenomatous polyps through adenoma-carcinoma sequence.
- Conditions
- Colorectal Adenoma, Colorectal Cancer Control and Prevention, Colorectal Polyps
- Trial name
- NCT06629051
- Testing
- Berberine Hydrochloride
- Where
- China
- Volunteers
- 891 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Dyslipidemias
The Therapeutic Effects of Statins and Berberine on the Hyperlipemia
Statins are cholesterol-lowering medications that are often prescribed for patients with high cholesterol and who are at risk for cardiovascular disease (CVD).
- Trial name
- NCT01697735
- Testing
- Berberine;Atorvastatin or Rosuvastatin, Atorvastatin or Rosuvastatin
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Wenzhou Medical University
Prediabetes
A Clinical Study to Evaluate the Effects of Akkermansia Muciniphila and Berberine on Prediabetes Among Obese Subjects.
The Akkermania muciniphila may play an important role in the occurrence and development of Prediabetes. The purpose of this study was to evaluate the safety and efficacy of AKK in the treatment of Prediabetes among obese…
- Trial name
- NCT05720299
- Testing
- Akkermansia muciniphila, Berberine
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Yu Chen
Diabetes Mellitus, Obesity
Gymnema Sylvestre vs Berberine in Obesity Gene Expression of Adipokines
Obesity is a disease that affects a large part of the world's population and is a risk factor for the development of metabolic, cardiovascular, oncological, and neurodegenerative diseases.
- Trial name
- GS VS BBR A (NCT06426966)
- Testing
- Berberine, Gymnema sylvestre
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Polytechnic Institute, Mexico
Ulcerative Colitis
Efficacy of Treatment With Berberine to Maintain Remission in Ulcerative Colitis
The research aim to find out whether berberine can reduce the annual recurrence rate of ulcerative colitis in remission. A total of 238 patients with ulcerative colitis in remission will be randomly divided into two groups.One…
- Trial name
- NCT02962245
- Testing
- berberine, regular treatment
- Sponsor
- Xijing Hospital of Digestive Diseases